Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

BMC Genetics

Volumn 11, Issue , 2010, Pages

  Docherty, Sophia J ^a   Kovas, Yulia ^a,b   Petrill, Stephen A ^c   Plomin, Robert ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; CHILD; COGNITION; GENETIC MARKER; HUMAN; MATHEMATICS; READING; SINGLE NUCLEOTIDE POLYMORPHISM; VALIDATION STUDY;

AGE FACTORS; CHILD; COGNITION; GENETIC MARKERS; HUMANS; MATHEMATICS; POLYMORPHISM, SINGLE NUCLEOTIDE; READING; VALIDATION STUDIES AS TOPIC;

EID: 77954151003     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-11-61     Document Type: Article

References (49)

1. Thompson LA, Detterman DK, Plomin R. Associations between cognitive abilities and scholastic achievement: Genetic overlap but environmental differences. Psych Sci 1991, 2:158-165.
2. Wadsworth SJ, DeFries JC, Fulker DW, Plomin R. Covariation among measures of cognitive ability and academic achievement in the Colorado Adoption Project: Sibling analysis. Person individ Diff 1995, 18:63-73.
3. Loehlin JC, Nichols J. Heredity, environment and personality 1976, Austin: University of Texas.
4. Light JG, DeFries JC, Olson RK. Multivariate behavioral genetic analysis of achievement and cognitive measures in reading-disabled and control twin pairs. Hum Biol 1998, 70:215-237.
5. Alarcón M, Knopik VS, DeFries JC. Covariation of mathematics achievement and general cognitive ability in twins. Journal of School Psychology 2000, 38:63-77.
6. Oliver B, Harlaar N, Hayiou-Thomas ME, Kovas Y, Walker SO, Petrill SA, Spinath FM, Plomin R. A twin study of teacher-reported mathematics performance and low performance in 7-year-olds. Journal of Educational Psychology 2004, 96:504-517.
7. Kovas Y, Haworth CMA, Petrill SA, Plomin R. Mathematical ability of 10-year-old boys and girls: Genetic and environmental etiology of normal and low performance. Journal of Learning Disabilities 2007, 40:554-567. 10.1177/00222194070400060601, 18064980.
8. Husén T. Psychological twin research 1959, Stockholm: Almqvist & Wiksell.
9. Kovas Y, Haworth CMA, Dale PS, Plomin R. The genetic and environmental origins of learning abilities and disabilities in the early school years. Monogr Soc Res Child Dev 2007, 72:1-144. 2784897, 17661895.
10. Alarcón M, DeFries JC, Light JG, Pennington BF. A twin study of mathematics disability. Journal of Learning Disabilities 1997, 30:617-623. 10.1177/002221949703000605, 9364899.
11. Plomin R, Kovas Y. Generalist genes and learning disabilities. Psychol Bull 2005, 131:592-617. 10.1037/0033-2909.131.4.592, 16060804.
12. Kovas Y, Petrill SA, Plomin R. The Origins of Diverse Domains of Mathematics: Generalist Genes but Specialist Environments. Journal of Educational Psychology 2007, 99:128-139. 10.1037/0022-0663.99.1.128, 2743325, 19756208.
13. Haworth CMA, Kovas Y, Petrill SA, Plomin R. Developmental origins of low mathematics performance and normal variation in twins from 7 to 9 years. Twin Research and Human Genetics 2007, 10:106-117. 10.1375/twin.10.1.106, 2648067, 17539370.
14. Markowitz EM, Willemsen G, Trumbetta SL, van Beijsterveldt TCEM, Boomsma DI. The Etiology of Mathematical and Reading (Dis)ability Covariation in a Sample of Dutch Twins. Twin Research and Human Genetics 2005, 8:585-593. 10.1375/twin.8.6.585, 16354500.
15. Kovas Y, Harlaar N, Petrill SA, Plomin R. 'Generalist genes' and mathematics in 7-year-old twins. Intelligence 2005, 33:473-489. 10.1016/j.intell.2005.05.002, 2659657, 19319204.
16. Knopik VS, Alarcón M, DeFries JC. Comorbidity of mathematics and reading deficits: Evidence for a genetic etiology. Behav Genet 1997, 27:447-453. 10.1023/A:1025622400239, 9336081.
17. Plomin R, Kovas Y, Haworth CMA. Generalist Genes: Genetic Links Between Brain, Mind, and Education. Mind, Brain, and Education 2007, 1:11-19.
18. Docherty SJ, Davis OSP, Kovas Y, Meaburn EL, Dale PS, Petrill SA, Schalkwyk LC, Plomin R. A genome-wide association study identifies multiple loci associated with mathematics ability and disability 2009,
19. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678. 10.1038/nature05911, 2719288, 17554300, Wellcome Trust Case Control Consortium.
20. Manolio TA. Cohort studies and the genetics of complex disease. Nat Genet 2009, 41:5-6. 10.1038/ng0109-5, 19112455.
21. Haworth CMA, Meaburn EL, Harlaar N, Plomin R. Reading and Generalist Genes. Mind, Brain, and Education 2007, 1:173-180.
22. Harlaar N, Butcher L, Meaburn E, Craig IW, Plomin R. A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds. J Child Psychol Psychiat 2005, 46:1097-1107. 10.1111/j.1469-7610.2005.01515.x, 16178934.
23. Loehlin JC, Horn JM, Willerman L. Modeling IQ change: Evidence from the Texas Adoption Project. Child Development 1989, 60:993-1004. 10.2307/1131039, 2758892.
24. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. Regulation of matrix metalloproteinases: An overview. Molecular and Cellular Biochemistry 2003, 253:269-285. 10.1023/A:1026028303196, 14619979.
25. Bortolotto ZA, Clarke VRJ, Delany CM, Parry MC, Smolders I, Vignes M, Ho KH, Miu P, Brinton BT, Fantaske R, et al. Kainate receptors are involved in synaptic plasticity. Nature 1999, 402:297-301. 10.1038/46290, 10580501.
26. Huettner JE. Kainate receptors and synaptic transmission. Progress in Neurobiology 2003, 70:387-407. 10.1016/S0301-0082(03)00122-9, 14511698.
27. Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, et al. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2009, 150B:808-816.
28. Woo TU, Shrestha K, Amstrong C, Minns MM, Walsh JP, Benes FM. Differential alterations of kainate receptor subunits in inhibitory interneurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. Schizophrenia Research 2007, 96:46-61. 10.1016/j.schres.2007.06.023, 2712609, 17698324.
29. Hornef N, Olbrich H, Horvath J, Zariwala MA, Fliegauf M, Loges NT, Wildhaber J, Noone PG, Kennedy M, Antonarakis SE, et al. DNAH5 Mutations Are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects. Am J Respir Crit Care Med 2006, 174:120-126. 10.1164/rccm.200601-084OC, 2662904, 16627867.
30. Ibanez-Tallon I, Pagenstecher A, Fliegauf M, Olbrich H, Kispert A, Ketelsen UP, North A, Heintz N, Omran H. Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. Hum Mol Genet 2004, 13:2133-2141. 10.1093/hmg/ddh219, 15269178.
31. Rubin DB. Multiple Imputation for Nonresponse in Surveys 1987, New York: John Wiley & Sons, Inc.
32. Palmer L, Scurrah K, Tobin M, Patel S, Celedon J, Burton P, Weiss S. Genome-wide linkage analysis of longitudinal phenotypes using 2A random effects (SSARs) fitted by Gibbs sampling. BMC genetics 2003, 4:S12. 10.1186/1471-2156-4-S1-S12, 1866446, 14975080.
33. Friedman NP, Miyake A, Young SE, DeFries JC, Corley RP, Hewitt JK. Individual differences in executive functions are almost entirely genetic in origin. Journal of Experimental Psychology General 2008, 137:201. 10.1037/0096-3445.137.2.201, 2762790, 18473654.
34. Kovas Y, Plomin R. Generalist genes: Implications for cognitive sciences. Trends in Cognitive Science 2006, 10:198-203.
35. Trouton A, Spinath FM, Plomin R. Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behaviour problems in childhood. Twin Research 2002, 5:444-448. 10.1375/136905202320906255, 12537874.
36. Oliver B, Plomin R. Twins Early Development Study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behaviour problems from childhood through adolescence. Twin Research and Human Genetics 2007, 10:96-105. 10.1375/twin.10.1.96, 17539369.
37. Harlaar N, Spinath FM, Dale P, Plomin R. Genetic influences on early word recognition abilities and disabilities: A study of 7-year-old twins. J Child Psychol Psychiat 2005, 46:373-384. 10.1111/j.1469-7610.2004.00358.x, 15819646.
38. Meaburn EL, Harlaar N, Craig IW, Schalkwyk LC, Plomin R. Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Mol Psychiatry 2007, 13:729-740. 10.1038/sj.mp.4002063, 17684495.
39. Butcher LM, Davis OSP, Craig IW, Plomin R. Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes Brain Behav 2008, 7:435-446. 10.1111/j.1601-183X.2007.00368.x, 2408663, 18067574.
40. Haworth CMA, Kovas Y, Harlaar N, Hayiou-Thomas ME, Petrill SA, Dale PS, Plomin R. Generalist genes and learning disabilities: a multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins. J Child Psychol Psychiat 2009, 50:1318-1325. 10.1111/j.1469-7610.2009.02114.x, 19573035.
41. QCA National Curriculum in Action, Mathematics Level Descriptions. 2001, http://curriculum.qcda.gov.uk/key-stages-1-and-2/subjects/mathematics/ke ystage2/index.aspx, Accessed 01/09/2006, [This information can currently be accessed at http://curriculum.qcda.gov.uk/key-stages-1-and-2/subjects/mathematics/ke ystage2/index.aspx], QCA.
42. Hoge RD, Coladarci T. Teacher-based judgments of academic achievement: A review of literature. Review of Educational Research 1989, 59:297-313.
43. Haworth CM, Harlaar N, Kovas Y, Davis OS, Oliver BR, Hayiou-Thomas ME, Frances J, Busfield P, McMillan A, Dale PS, et al. Internet Cognitive Testing of Large Samples Needed in Genetic Research. Twin Res Hum Genet 2007, 10:554-563. 10.1375/twin.10.4.554, 17708696.
44. nferNelson Maths 5-14 Series 2001, London: nferNelson Publishing Company Ltd, nferNelson.
45. Markwardt FC. Peabody Individual Achievement Test-Revised (Normative Update) Manual 1997, Circle Pines: American Guidance Service.
46. Wechsler D. Wechsler intelligence scale for children - Third Edition UK (WISC-IIIUK) Manual 1992, London: The Psychological Corporation.
47. Raven JC, Court JH, Raven J. Manual for Raven's Progressive Matrices and Vocabulary Scales 1996, Oxford: Oxford University Press.
48. R Development Core Team R: A Language and Environment for Statistical Computing. 2008, R Foundation for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0, R Development Core Team., http://www.R-project.org/
49. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003, 19:149-150. 10.1093/bioinformatics/19.1.149, 12499305.