Effect of regulatory T cells and adherent cells on the expansion of HBcAg-specific CD8+ T cells in patients with chronic hepatitis B virus infection

Cellular Immunology

Volumn 264, Issue 1, 2010, Pages 42-46

  Li, Xuefen ^a   Chen, Yu ^b   Ma, Zhaowen ^c   Ye, Bo ^a   Wu, Wei ^b   Li, Lanjuan ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZaoZhuang Maternity and Child Health Hospital   (China)

Author keywords

Adherent cell; Chronic HBV infection; HBc18 27 specific CD8+ T cells; Regulatory T cell

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HEPATITIS B CORE ANTIGEN; HLA A2 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; VIRUS DNA;

ADHERENT CELL; ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELL EXPANSION; CELL ISOLATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MIXED LYMPHOCYTE REACTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL COMMUNICATION; CELL COUNT; CELL LINE; CELL PROLIFERATION; FEMALE; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HLA-A2 ANTIGEN; HUMANS; IMMUNOMODULATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, REGULATORY;

HEPATITIS B VIRUS;

EID: 77954142171     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.04.009     Document Type: Article

References (37)

1. Shimada N., Yamamoto K., Kuroda M.J., Terada R., Hakoda T., Shimomura H., Hata H., et al. HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells. J. Clin. Immunol. 2003, 23:223-232.
2. Guidotti L.G., Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 2006, 1:23-61.
3. Sprengers D., van der Molen R.G., Kusters J.G., De Man R.A., Niesters H.G., Schalm S.W., Janssen H.L. Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans. J. Hepatol. 2006, 45:182-189.
4. Wan Y., Han Y., Li J. The association between antigen-specific cytotoxic lymphocytes response and different clinical status in patients with hepatitis B. Clin. J. Infect. Dis. 2009, 27:287-291. (Chinese).
5. Dieckmann D., Plottner H., Berchtold S., Berger T., Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 2001, 193:1303-1310.
6. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001, 193:1285-1294.
7. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22:531-562.
8. Tadokoro C.E., Shakhar G., Shen S., Ding Y., Lino A.C., Maraver A., Lafaille J.J., et al. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J. Exp. Med. 2006, 203:505-511.
9. Franzese O., Kennedy P.T., Gehring A.J., Gotto J., Williams R., Maini M.K., Bertoletti A. Modulation of the CD8+T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J. Virol. 2005, 79:3322-3328.
10. Joffre O., Nolte M.A., Spörri R., Reis e Sousa C. Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol. Rev. 2009, 227:234-247.
11. Tsai S.L., Lee T.H., Chien R.N., Liao S.K., Lin C.L., Kuo G.C., Liaw Y.F. A method to increase tetramer staining efficiency of CD8+ T cells with MHC-peptide complexes: therapeutic applications in monitoring cytotoxic T lymphocyte activity during hepatitis B and C treatment. J. Immunol. Methods 2004, 285:71-87.
12. Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association The guideline of prevention and treatment for chronic hepatitis B. Chin. J. Hepatol. 2005, 3:881-889.
13. Bienzle D., Reggeti F., Clark M.E., Chow C. Immunophenotype and functional properties of feline dendritic cells derived from blood and bone marrow. Vet. Immunol. Immunopathol. 2003, 96:19-30.
14. Freer G., Matteucci D., Mazzetti P., Bozzacco L., Bendinelli M. Generation of feline dendritic cells derived from peripheral blood monocytes for in vivo use. Clin. Diagn. Lab. Immunol. 2005, 12:1202-1208.
15. Schmidt E.G., Buus S., Thorn M., Stryhn A., Leisner C., Claesson M.H. Peptide specific expansion of CD8(+) T cells by recombinant plate bound MHC/peptide complexes. J. Immunol. Methods 2009, 340:25-32.
16. Sprague W.S., Pope M., Hoover E.A. Culture and comparison of feline myeloid dendritic cells vs macrophages. J. Comp. Pathol. 2005, 133:136-145.
17. Szodoray P., Papp G., Horvath I.F., Barath S., Sipka S., Nakken B., Zeher M. Cells with regulatory function of the innate and adaptive immune system in primary Sjögren's syndrome. Clin. Exp. Immunol. 2009, 157:343-349.
18. Maini M.K., Boni C., Ogg G.S., King A.S., Reignat S., Lee C.K., Larrubia J.R., Webster G.J., McMichael A.J., Ferrari C., Williams R., Vergani D., Bertoletti A. Direct ex vivo analysis of hepatitis B virus-specific CD8+T cells associated with the control of infection. Gastroenterology 1999, 117:1386-1396.
19. Maini M.K., Casorati G., Dellabona P., Wack A., Beverley P.C. T-cell clonality in immune responses. Immunol. Today 1999, 20:262-266.
20. Wesselborg S., Janssen O., Kabelitz D. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 1993, 150:4338-4345.
21. Guidotti L.G., Ishikawa T., Hobbs M.V., Matzke B., Schreiber R., Chisari F.V. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996, 4:25-36.
22. Matsumura S., Yamamoto K., Shimada N., Okano N., Okamoto R., Suzuki T., Hakoda T., et al. High frequency of circulating HBcAg-specific CD8 T cells in hepatitis B infection: a flow cytometric analysis. Clin. Exp. Immunol. 2001, 124:435-444.
23. Rehermann B., Fowler P., Sidney J., Person J., Redeker A., Brown M., Moss B., et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J. Exp. Med. 1995, 181:1047-1058.
24. Sobao Y., Takiguchi M. The role of hepatitis B and C virus-specific CTL in the control of viral replication. Nihon Rinsho Meneki Gakkai Kaishi 2002, 25:79-88.
25. Bertoletti A., Gehring A.J. The immune response during hepatitis B virus infection. J. Gen. Virol. 2006, 87:1439-1449.
26. Maini M.K., Boni C., Lee C.K., et al. The role of virus specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. 2000, 191:1269-1280.
27. Altman J.D., Moss P.A., Goulder P.J., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., McMichael A.J., et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996, 274:94-96.
28. Seth A., Ourmanov I., Kuroda M.J., Schmitz J.E., Carroll M.W., Wyatt L.S., Moss B., et al. Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer. Proc. Natl. Acad. Sci. USA 1998, 95:10112-10116.
29. Baumert T.F., Thimme R., von Weizsäcker F. Pathogenesis of hepatitis B virus infection. World J. Gastroenterol. 2007, 13:82-90.
30. Camara N.O., Sebille F., Lechler R.I. Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation. Eur. J. Immunol. 2003, 33:3473-3483.
31. Azuma T., Takahashi T., Kunisato A., Kitamura T., Hirai H. Human CD4+ CD25+ regulatory T cells suppress NKT cell functions. Cancer Res. 2003, 63:4516-4520.
32. Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. CD4+CD25 high regulatory cells in human peripheral blood. J. Immunol. 2001, 167:1245-1253.
33. van der Molen R.G., Sprengers D., Binda R.S., de Jong E.C., Niesters H.G., Kusters J.G., Kwekkeboom J., et al. Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. Hepatology 2004, 40:738-746.
34. Stoop J.N., van der Molen R.G., Baan C.C., van der Laan L.J., Kuipers E.J., Kusters J.G., Janssen H.L. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005, 41:771-778.
35. Smithberg S.R., Lankford S.M., Tompking M.B., et al. In vivo depletion of CD4+CD25+ regulatory T cells in cats [J]. J. Immunol. Methods 2008, 329:81-91.
36. Misra N., Bayry J., Lacroix-Desmazes S., Kazatchkine M.D., Kaveri S.V. Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen presenting function of dendritic cells. J. Immunol. 2004, 172:4676-4680.
37. Sakaguchi S. Regulatory T cells mediating compromises between host and parasite [J]. Nat. Immunol. 2003, 4:10-11.