A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human γδ T lymphocytes

Cellular Immunology

Volumn 264, Issue 1, 2010, Pages 71-77

  Jameson, Julie M ^a   Cruz, John ^b   Costanzo, Anne ^a   Terajima, Masanori ^b   Ennis, Francis A ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Activation; Gamma delta; IFN ; Infection; Influenza; Mevalonate; PBMC; Peripheral blood; T cell; TCR

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; MEVALONIC ACID;

ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H2N2; INFLUENZA VIRUS A H3N2; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; UPREGULATION; VACCINIA VIRUS;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIGENS, VIRAL; CROSS REACTIONS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERFERON-GAMMA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LECTINS, C-TYPE; LOVASTATIN; LYMPHOCYTE ACTIVATION; MEVALONIC ACID; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPECIES SPECIFICITY; T-LYMPHOCYTES;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE; VACCINIA VIRUS;

EID: 77954142065     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.04.013     Document Type: Article

References (29)

1. Ennis F.A., Cruz J., Jameson J., Klein M., Burt D., Thipphawong J. Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS). Virology 1999, 259:256-261.
2. Jameson J., Cruz J., Ennis F.A. Human cytotoxic T-lymphocyte repertoire to influenza A viruses. J. Virol. 1998, 72:8682-8689.
3. Jameson J., Cruz J., Terajima M., Ennis F.A. Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species. J. Immunol. 1999, 162:7578-7583.
4. Grebe K.M., Yewdell J.W., Bennink J.R. Heterosubtypic immunity to influenza A virus: where do we stand?. Microbes Infect. 2008, 10:1024-1029.
5. Casorati G., De Libero G., Lanzavecchia A., Migone N. Molecular analysis of human gamma/delta+ clones from thymus and peripheral blood. J. Exp. Med. 1989, 170:1521-1535.
6. Qin G., Mao H., Zheng J., Sia S.F., Liu Y., Chan P.L., Lam K.T., Peiris J.S., Lau Y.L., Tu W. Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses. J. Infect. Dis. 2009, 200:858-865.
7. Correia D.V., d'Orey F., Cardoso B.A., Lanca T., Grosso A.R., deBarros A., Martins L.R., Barata J.T., Silva-Santos B. Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells. PLoS One 2009, 4:e5657.
8. Morita C.T., Jin C., Sarikonda G., Wang H. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev. 2007, 215:59-76.
9. Constant P., Davodeau F., Peyrat M.-A., Poquet Y., Puzo G., Bonneville M., Fournie J.-J. Stimulation of human gd T cells by nonpeptidic mycobacterial ligands. Science 1994, 264:267-270.
10. Morita C.T., Beckman E.M., Bukowski J.F., Tanaka Y., Band H., Bloom B.R., Golan D.E., Brenner M.B. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gd T cells. Immunity 1995, 3:495-507.
11. Tanaka Y., Sano S., Nieves E., DeLibero G., Rosa D., Modlin R.L., Brenner M.B., Bloom B.R., Morita C.T. Nonpeptide ligands for human gd T cells. Proc. Natl. Acad. Sci. USA 1994, 91:8175-8179.
12. Boullier S., Dadaglio G., Lafeuillade A., Debord T., Gougeon M.L. V delta 1 T cells expanded in the blood throughout HIV infection display a cytotoxic activity and are primed for TNF-alpha and IFN-gamma production but are not selected in lymph nodes. J. Immunol. 1997, 159:3629-3637.
13. Hacker G., Kromer S., Falk M., Heeg K., Wagner H., Pfeffer K. V delta 1+ subset of human gamma delta T cells responds to ligands expressed by EBV-infected Burkitt lymphoma cells and transformed B lymphocytes. J. Immunol. 1992, 149:3984-3989.
14. Maccario R., Revello M.G., Comoli P., Montagna D., Locatelli F., Gerna G. HLA-unrestricted killing of HSV-1-infected mononuclear cells. Involvement of either gamma/delta+ or alpha/beta+ human cytotoxic T lymphocytes. J. Immunol. 1993, 150:1437-1445.
15. Carding S.R., Allan W., Kyes S., Hayday A., Bottomly K., Doherty P.C. Late dominance of the inflammatory process in murine influenza by gamma/delta+ T cells. J. Exp. Med. 1990, 172:1225-1231.
16. Allan W., Carding S.R., Eichelberger M., Doherty P.C. Analyzing the distribution of cells expressing mRNA for T cell receptor gamma and delta chains in a virus-induced inflammatory process. Cell Immunol. 1992, 143:55-65.
17. Ponniah S., Doherty P.C., Eichelberger M. Selective responses of gd T-cell hybridomas to orthomyovirus-infected cells. J. Virol. 1996, 70:17-22.
18. Terajima M., Van Epps H.L., Li D., Leporati A.M., Juhlin S.E., Mustonen J., Vaheri A., Ennis F.A. Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus. Virus Res. 2002, 84:67-77.
19. Andrew E.M., Carding S.R. Murine gammadelta T cells in infections: beneficial or deleterious?. Microbes Infect. 2005, 7:529-536.
20. Billiau A., Matthys P. Interferon-gamma: a historical perspective. Cytokine Growth Factor Rev. 2009, 20:97-113.
21. Hu X., Ivashkiv L.B. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 2009, 31:539-550.
22. Zhou F. Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation. Int. Rev. Immunol. 2009, 28:239-260.
23. Lalvani A., Brookes R., Hambleton S., Britton W.J., Hill A.V., McMichael A.J. Rapid effector function in CD8+ memory T cells. J. Exp. Med. 1997, 186:859-865.
24. Chien Y.H., Konigshofer Y. Antigen recognition by gammadelta T cells. Immunol. Rev. 2007, 215:46-58.
25. Gober H.J., Kistowska M., Angman L., Jeno P., Mori L., De Libero G. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J. Exp. Med. 2003, 197:163-168.
26. Thompson K., Rogers M.J. Statins prevent bisphosphonate-induced gamma, delta-T-cell proliferation and activation in vitro. J. Bone Miner. Res. 2004, 19:278-288.
27. Thompson K., Rojas-Navea J., Rogers M.J. Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. Blood 2006, 107:651-654.
28. Li H., Deetz C.O., Zapata J.C., Cairo C., Hebbeler A.M., Propp N., Salvato M.S., Shao Y., Pauza C.D. Vaccinia virus inhibits T cell receptor-dependent responses by human gammadelta T cells. J. Infect. Dis. 2007, 195:37-45.
29. Selin L.K., Santolucito P.A., Pinto A.K., Szomolanyi-Tsuda E., Welsh R.M. Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells. J. Immunol. 2001, 166:6784-6794.