Physiologically based pharmacokinetics of molecular imaging nanoparticles for mRNA detection determined in tumor-bearing mice

Oligonucleotides

Volumn 20, Issue 3, 2010, Pages 117-125

  Opitz, Armin W ^a   Wickstrom, Eric ^b   Thakur, Mathew L ^b   Wagner, Norman J ^a  

^a Institute University of Delaware Newark   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MOLECULAR IMAGING NANOPARTICLE; NANOPARTICLE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C; SOMATOMEDIN C DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; GENE TARGETING; PRIORITY JOURNAL; PROTEIN BINDING; TISSUE DISTRIBUTION; TUMOR XENOGRAFT; ANIMAL; EXPERIMENTAL NEOPLASM; GENETICS; MOUSE; PHARMACOKINETICS;

MUS;

ANIMALS; MICE; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; PHARMACOKINETICS; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 77954137157     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.2009.0216     Document Type: Article

References (55)

1. n-polydiamidopropanoyl-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents. Biopolymers 89, 1061-1076.
2. BARBEE, R.W., PERRY, B.D., RE, R.N., and MURGO, J.P. (1992). Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice. Am. J. Physiol. 263, R728-R733.
3. BARNETT, S.A., and WIDDOWSON, E.M. (1965). Organ-weights and body-composition in mice bred for many generations at\3 degrees Celsius. Proc. R. Soc. Lond. B. Biol. Sci. 162, 502-516.
4. BASILION, J.P., YEON, S., and BOTNAR, R. (2005). Curr. Top. Dev. Biol. 70, 1-33.
5. BASTIAN, S.E.P., WALTON, P.E., BALLARD, F.J., and BEL-FORD, D.A. (1999). Transport of IGF-I across epithelial cell monolayers. J. Endocrinol. 162, 361-369.
6. BASTIAN, S.E.P., WALTON, P.E., and BELFORD, D.A. (1997). Paracellular transport of insulin-like growth factor-I (IGF-I) across human umbilical vein endothelial cell monolayers. J. Cell. Physiol. 170, 290-298.
7. BAXTER, L.T., ZHU, H., MACKENSEN, D.G., and JAIN, R.K. (1994). Physiologically-based pharmacokinetic model for specific and nonspecific monoclonal-antibodies and fragments in normal-tissues and human tumor xenografts in nude-mice. Cancer Res. 54, 1517-1528.
8. BAXTER, R.C., and MARTIN, J.L. (1986). Radioimmunoassay of growth-hormone dependent insulin-like growth-factor binding-protein in human-plasma. J. Clin. Invest. 78, 1504-1512.
9. BLAKEY, G.E., NESTOROV, I.A., ARUNDEL, P.A., AARONS, L.J., and ROWLAND, M. (1997). Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat. J. Pharmacokinet. Biopharm. 25, 277-312.
10. BOROUJERDI, M.A., JONES, R.H., SONKSEN, P.H., and RUSSELL-JONES, D.L. (1997). Simulation of IGF-I pharmacokinetics after infusion of recombinant IGF-I in human subjects. Am. J. Physiol. Endocrinol. Metab. 36, E438-E447.
11. BOROUJERDI, M.A., SONKSEN, P.H., and JONES, R.H. (1994). A compartmental model for simulation of IGF-I kinetics and metabolism. Methods Inf. Med. 33, 514-521.
12. CALDER, W.A. (1984). Size, function, and life history. Harvard University Press, Cambridge, Massachusetts, pp. 13-25.
13. CHAKRABARTI, A., ZHANG, K., ARUVA, M.R., CARDI, C.A., OPITZ, A.W., WAGNER, N.J., THAKUR, M.L., and WICKSTROM, E. (2007). Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [Cu-64]DO3A-peptide nucleic acid-peptide nanoparticles. Cancer Biol. Ther. 6, 948-956.
14. CRISPENS, C.G. (1975a). Handbook on the laboratory mouse. Charles C. Thomas Publisher, Springfield, Illinois, pp. 95-123.
15. CRISPENS, C.G. (1975b). Handbook on the laboratory mouse. Charles C. Thomas Publisher, Springfield, Illinois, pp. 63-92.
16. DELAFONTAINE, P., SONG, Y.H., and LI, Y.X. (2004). Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 24, 435-444.
17. EBLING, W.F., WADA, D.R., and STANSKI, D.R. (1994). From piecewise to full physiological pharmacokinetic modeling\applied to thiopental disposition in the rat. J. Pharmacokinet. Biopharm. 22, 259-292.
18. EVERETT, N.B., SIMMONS, B., and LASHER, E.P. (1956). Distribution of blood (Fe-59) and plasma (I-131) volumes of rats determined by liquid nitrogen freezing. Circ. Res. 4, 419-424.
19. FARIA, A.C.S., VELDHUIS, J.D., THORNER, M.O., and VANCE, M.L. (1989). Half-time of endogenous growth-hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin. J. Clin. Endocrinol. Metab. 68, 535-541.
20. FORSTEN-WILLIAMS, K., CASSINO, T.R., DELO, L.J., BELLIS, A.D., ROBINSON, A.S., and RYAN, T.E. (2007). Enhanced insulin-like growth factor-I (IGF-I) cell association at reduced pH is dependent on IGF binding protein-3 (IGFBP-3) interaction. J. Cell. Physiol. 210, 298-308.
21. GEARHART, J.M., JEPSON, G.W., CLEWELL, H.J., ANDERSEN, M.E., and CONOLLY, R.B. (1990). Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. Toxicol. Appl. Pharmacol. 106, 295-310.
22. GERLOWSKI, L.E., and JAIN, R.K. (1983). Physiologically based pharmacokinetic modeling\principles and applications. J. Pharm. Sci. 72, 1103-1127.
23. 3IGF-I. Am. J. Physiol. Endocrinol. Metab. 271, E649-E657.
24. GJEDDE, S.B., and GJEDDE, A. (1980). Organ blood-flow rates and cardiac-output of the BALB=c mouse. Comp. Biochem. Physiol. A. Physiol. 67, 671-674.
25. HILMAS, D.E., and GILLETTE, E.L. (1974). Morphometric analyses of microvasculature of tumors during growth and after X-irradiation. Cancer 33, 103-110.
26. JAIN, R.K. (1988). Determinants of tumor blood-flow\a review. Cancer Res. 48, 2641-2658.
27. JEMAL, A., SIEGEL, R., WARD, E., MURRAY, T., XU, J.Q., and THUN, M.J. (2007). Cancer statistics, 2007. CA. Cancer J. Clin. 57, 43-66.
28. JUUL, A. (2003). Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm. IGF Res. 13, 113-170.
29. KALLINOWSKI, F., SCHLENGER, K.H., RUNKEL, S., KLOES, M., STOHRER, M., OKUNIEFF, P., and VAUPEL, P. (1989). Blood-flow, metabolism, cellular microenvironment, and growth-rate of human-tumor xenografts. Cancer Res. 49, 3759-3764.
30. KOBER, F., ILTIS, I., COZZONE, P.J., and BERNARD, M. (2004). Cine-MRI assessment of cardiac function in mice anesthetized with ketamine=xylazine and isoflurane. Magn. Reson. Mater. Phys. Biol. Med. 17, 157-161.
31. LINDSTEDT, S.L., and SCHAEFFER, P.J. (2002). Use of allom-etry in predicting anatomical and physiological parameters of mammals. Lab. Anim. 36, 1-19.
32. MARNINGAS, P.A., DEGUZZMAN, L.R., HOLLENBACH, S.J., VOLK, K.A., and BELLAMY, R.F. (1986). Regional blood flow during hypothermic arrest. Ann. Emerg. Med. 15, 390-396.
33. MELGAR, S., KARLSSON, A., and MICHAELSSON, E.M. (2005). Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL=6 but not in BALB=c mice: correlation between symptoms and inflammation. Am. J. Physiol.-Gastrointest. Liver Physiol. 288, G1328-G1338.
34. MIZUNO, N., KATO, Y., IWAMOTO, M., URAE, A., AMA-MOTO, T., NIWA, T., and SUGIYAMA, Y. (2001). Kinetic analysis of the disposition of insulin-like growth factor 1 in healthy volunteers. Pharm. Res. 18, 1203-1209.
35. OPITZ, A.W. (2008). Structural and functional investigations of a molecular imaging nanoparticle for magnetic resonance imaging of oncogene expression in the pancreas, Ph.D., Chemical Engineering, University of Delaware: Newark, 457 p.
36. PAYE, J.M.D., and FORSTEN-WILLIAMS, K. (2006). Regulation of insulin-like growth factor-I (IGF-I) delivery by IGF binding proteins and receptors. Ann. Biomed. Eng. 34, 618-632.
37. PENG, B., ANDREWS, J., NESTOROV, I., BRENNAN, B., NICKLIN, P., and ROWLAND, M. (2001). Tissue distribution and physiologically based pharmacokinetics of antisense phosphorothioate oligonucleotide ISIS 1082 in rat. Antisense Nucleic Acid Drug Dev. 11, 15-27.
38. PLATA, E.J., and MURPHY, W.H. (1972). Growth and hema-tologic properties of BALB=Wm strain of inbred mice. Lab. Anim. Sci. 22, 712-720.
39. QUICK, D.J., and SHULER, M.L. (1999). Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences. Biotechnol. Prog. 15, 540-555.
40. RACZKA, E., QUINTANA, A., POGGI, A., and DONATI, M.B. (1983). Distribution of cardiac-output during development of 2 metastasizing murine tumors. Eur. J. Cancer Clin. Oncol. 19, 1021-1029.
41. SARA, V.R., and HALL, K. (1990). Insulin-like growth-factors and their binding-proteins. Physiol. Rev. 70, 591-614.
42. SARIN, S.K., SABBA, C., and GROSZMANN, R.J. (1990). Splanchnic and systemic hemodynamics in mice using a radioactive microsphere technique. Am. J. Physiol. 258, G365-G369.
43. SCHMITTMANN, G., and ROHR, U.D. (2000). Comparison of the permeability surface product (PS) of the blood capillary wall in skeletal muscle tissue of various species and in vitro porous membranes using hydrophilic drugs. J. Pharm. Sci. 89, 115-127.
44. STOTT, W.T., DRYZGA, M.D., and RAMSEY, J.C. (1983). Blood-flow distribution in the mouse. J. Appl. Toxicol. 3, 310-312.
45. TEN HOVE, T., VAN DEN BLINK, B., PRONK, I., DRILLEN-BURG, P., PEPPELENBOSCH, M.P., and VAN DEVENTER, S.J.H. (2002). Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut 50, 507-512.
46. TIAN, X., ARUVA, M.R., QIN, W.Y., ZHU, W.Z., DUFFY, K.T., SAUTER, E.R., THAKUR, M.L., and WICKSTROM, E. (2004). External imagingofCCND1 cancer gene activityinexperimental human breast cancer xenografts with Tc-99m-peptide- peptide nucleic acid-peptide chimeras. J. Nucl. Med. 45, 2070-2082.
47. TIAN, X., ARUVA, M.R., QIN, W.Y., ZHU, W.Z., SAUTER, E.R., THAKUR, M.L., and WICKSTROM, E. (2005a). Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [Tc-99m] peptide-peptide nucleic acid-peptide chimera. Bioconjug. Chem. 16, 70-79.
48. TIAN, X., ARUVA, M.R., RAO, P.S., QIN, W.Y., READ, P., SAUTER, E.R., THAKUR, M.L., and WICKSTROM, E. (2003). Therapeutic oligonucleotides. Ann. N. Y. Acad. Sci. 1002, 165-188.
49. TIAN, X., ARUVA, M.R., ZHANG, K., SHANTHLY, N., CARDI, C.A., THAKUR, M.L., and WICKSTROM, E. (2007). PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu]Chelator-peptide nucleic acid-IGF1 analog radio-hybridization probes. J. Nucl. Med. 48, 1699-1707.
50. TIAN, X., CHAKRABARTI, A., AMIRKHANOV, N.V., ARUVA, M.R., ZHANG, K.J., MATHEW, B., CARDI, C., QIN, W.Y., SAUTER, E.R., THAKUR, M.L., and WICKSTROM, E. (2005b). Tumor progression and therapeutic resistance. Ann. N. Y. Acad. Sci. 1059, 106-144.
51. TSAI, P.P., PACHOWSKY, U., STELZER, H.D., and HACK-BARTH, H. (2002). Impact of environmental enrichment in mice. 1: Effect of housing conditions on body weight, organ weights and hematology in different strains. Lab. Anim. 36, 411-419.
52. WICKSTROM, E., THAKUR, M.L., and SAUTER, E.R. (2004). Receptor-specific targeting with complementary peptide nucleic acids conjugated to peptide analogs and radionuclides. Lett. Pept. Sci. 10, 191-214.
53. WISH, L., FURTH, J., and STOREY, R.H. (1950). Direct determinations of plasma, cell, and organ-blood volumes in normal and hypervolemic mice. Proc. Soc. Exp. Biol. Med. 74, 644-648.
54. XU, L., EISEMAN, J.L., EGORIN, M.J., and D'ARGENIO, D.Z. (2003). Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)17-demethoxy-geldanamycin and its active metabolite in tumor-bearing mice. J. Pharmacokinet. Pharmacodyn. 30, 185-219.
55. YUAN, F., LEUNIG, M., BERK, D.A., and JAIN, R.K. (1993). Microvascular permeability of albumin, vascular surface-area, and vascular volume measured in human adenocarcinoma Ls174t using dorsal chamber in SCID mice. Microvasc. Res. 45, 269-289.