Design, synthesis, and immunosuppressive activity of new deoxybenzoin derivatives

ChemMedChem

Volumn 5, Issue 7, 2010, Pages 1117-1122

  Li, Huan Qiu ^a   Luo, Yin ^a   Song, Ran ^a   Li, Zi Lin ^a   Yan, Tao ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Cytotoxicity; Deoxybenzoins; Immunosuppression; Oximes

Indexed keywords

2 (4 BROMOPHENYL) 1 (3,4 DIHYDROXYPHENYL)ETHANONE OXIME; BETA ACTIN; CASPASE 3; CD28 ANTIGEN; CD3 ANTIGEN; CYCLOSPORIN A; DEOXYBENZOIN DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; 2-(4-BROMOPHENYL)-1-(3,4-DIHYDROXYPHENYL)ETHANONE OXIME; BENZOIN; DEOXYBENZOIN; OXIME;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FLOW CYTOMETRY; LYMPH NODE CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CONFORMATION; CYTOLOGY; LYMPH NODE; SYNTHESIS; TOXICITY; X RAY CRYSTALLOGRAPHY;

ANIMALS; APOPTOSIS; BENZOIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FLOW CYTOMETRY; IMMUNOSUPPRESSIVE AGENTS; LYMPH NODES; MICE; MOLECULAR CONFORMATION; OXIMES;

EID: 77954119432     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000107     Document Type: Article

References (27)

1. H. Hackstein, A. W. Thomson, Nat. Rev. Immunol. 2004, 4, 24.
2. B. D. Kahan, Nat. Rev. Immunol. 2003, 3, 831.
3. F. J. Dumont, Curr. Opin. Invest. Drugs. 2001, 2, 357.
4. C. Mignat, Drug Saf. 1997, 16, 267.
5. J. L. Ader, L. Rostaing, Curr. Opin. Nephrol. Hypertens. 1998, 7, 539.
6. M. Hojo, T. Morimoto, M. Maluccio, T. Asano, K. Morimoto, M. Lagman, T. Shimbo, M. Suthanthiran, Nature 1999, 397, 530.
7. D. Sheikh-Hamad, V. Nadkarni, Y. J. Choi, L. D. Truong, C. Wideman, R. Hodjati, K. H. Gabbay, J. Am. Soc. Nephrol. 2001, 12, 2732.
8. L. W. Miller, Am. J. Transplant. 2002, 2, 807.
9. J. M. Smith, T. L. Nemeth, R. A. McDonald, Pediatr. Clin. North Am. 2003, 50, 1283.
10. Z. M. Shao, J. Wu, Z. Z. Shen, S. H. Barsky, Cancer Res. 1998, 58, 4851.
11. L. Sun, N. Tran, F. Tang, J. Med. Chem. 1998, 41, 2588.
12. K. Niwa, M. Hashimoto, S. Morishita, Y. Yokoyama, H. Mori, T. Tamaya, Jpn. J. Cancer Res. 1999, 90, 726.
13. P. Fiedor, L. Kozerski, J. C. Dobrowolski, R. Kawecki, K. Biniecki, J. Pachecka, W. Rowinski, A. P. Mazurek, Transpl. Proc. 1998, 2, 537.
14. R. Sanduja, A. J. Weinheimer, M. Alam, J. Chem. Res. Synop. 1985, 56.
15. K. Wähälä, T. A. Hase, J. Chem. Soc. Perkin Trans. 1 1991, 1, 3005.
16. H. Q. Li, J. Y. Xue, L. Shi, S. Y. Gui, H. L. Zhu, Eur. J. Med. Chem. 2008, 43, 662.
17. N. Fokialakis, G. Lambrinidis, D. J. Mitsiou, N. Aligiannis, S. Mitakou, A. L. Skaltsounis, H. Pratsinis, E. Mikros, M. N. Alexis, Chem. Biol. 2004, 11, 397.
18. H. Q. Li, L. Shi, Q. S. Li, P. C. Lv, Y. Luo, J. Zhao, H.-L. Zhu, Bioorg. Med. Chem. 2009, 17, 6264.
19. T. Shinohara, A. Takeda, J. Toda, T. Sano, Chem. Pharm. Bull. 1998, 46, 430.
20. S. Levine, R. Sowinski, J. Immunol. 1978, 2, 602.
21. L. A. Saghatforoush, F. Chalabian, A. Aminkhani, G. Karimnezhad, S. Ershad, Eur. J. Med. Chem. 2009, 11, 4490.
22. X. H. Sun, Y. Bai, Y. F. Liu, B. Chen, Y. Q. Jia, Z. F. Zeng, Chin. J. Chem. 2009, 7, 1397.
23. H. Nawaz, Z. Akhter, S. Yameen, H. M. Siddiqi, B. Mirza, A. Rifat, J. Organomet. Chem. 2009, 694, 2198
24. Z. P. Xiao, D. H. Shi, H. Q. Li, L. N. Zhang, C. Xu, H. L. Zhu, Bioorg. Med. Chem. 2007, 15, 3703.
25. C. Fátima, S. M. Raul, C. Mnica, K. U. Miren, S. Xavier, T. Imanol, D. Esther, J. Org. Chem. 2005, 70, 3178.
26. F. J. Oliver, G. Rubia, V. Rolli, M. C. Ruiz-Ruiz, G. de Murcia, J. M. Murcia, J. Biol. Chem. 1998, 273, 33533.
27. M. Vasudevan, K. K. Gunnam, M. Parle, J. Ethnopharmacol. 2007, 109, 264.