The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion

European Journal of Immunology

Volumn 40, Issue 7, 2010, Pages 1884-1889

  Lax, Siân ^a   Hardie, Debbie L ^a   Wilson, Amy ^a   Douglas, Mike R ^a   Anderson, Graham ^a   Huso, David ^b   Isacke, Clare M ^c   Buckley, Christopher D ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

CD248; Endosialin; Fibroblast; Lymphoid tissue; Stromal cells

Indexed keywords

(4 HYDROXY 3 NITROPHENYL)ACETYL CHICKEN IMMUNOGLOBULIN; ENDOSIALIN; IMMUNOGLOBULIN; UNCLASSIFIED DRUG; 4-HYDROXY-5-NITROPHENYL ACETIC ACID; BIOLOGICAL MARKER; CD248 PROTEIN, HUMAN; HAPTEN; LEUKOCYTE ANTIGEN; NITROPHENOL; PHENYLACETIC ACID DERIVATIVE; TUMOR ANTIGEN; TUMOR ENDOTHELIAL MARKER 1, MOUSE; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; FIBROBLAST; IMMUNE RESPONSE; IMMUNIZATION; LYMPH NODE; MOUSE; NONHUMAN; PERICYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; T LYMPHOCYTE; ANIMAL; CELL COMMUNICATION; CELL LINE; CELL MOTION; CHICKEN; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, NEOPLASM; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CELL COMMUNICATION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CHICKENS; FIBROBLASTS; GAMMA-GLOBULINS; HAPTENS; HUMANS; IMMUNIZATION; LYMPH NODES; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; NITROPHENOLS; PERICYTES; PHENYLACETATES; STROMAL CELLS; T-LYMPHOCYTES;

EID: 77954103111     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939877     Document Type: Article

References (22)

1. Tobler, N. E. and Detmar, M., Tumor and lymph node lymphangiogenesis - impact on cancer metastasis. J. Leukoc. Biol. 2006. 80: 691-696.
2. Conway, E. M., Van deWouwer,M., Pollefeyt, S., Jurk, K., Van Aken, H., De Vriese, A., Weitz, J. I. et al., The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor κB and mitogen-activated protein kinase pathways. J. Exp. Med. 2002. 196: 565-577.
3. Norsworthy, P. J., Fossati-Jimack, L., Cortes-Hernandez, J., Taylor, P. R., Bygrave, A. E., Thompson, R. D., Nourshargh, S. et al., Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J. Immunol. 2004. 172: 3406-3414. (Pubitemid 38337919)
4. MacFadyen, J. R., Haworth, O., Roberston, D., Hardie, D., Webster, M.-T., Morris, H. R., Panico, M. et al., Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett. 2005. 579: 2569-2575.
5. MacFadyen, J., Savage, K., Wienke, D. and Isacke, C. M., Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene Expr. Patterns 2007. 7: 363-369.
6. Simonavicius, N., Robertson, D., Bax, D. A., Jones, C., Huijbers, I. J. and Isacke, C. M., Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod. Pathol. 2008. 21: 308-315.
7. Christian, S., Winkler, R., Helfrich, I., Boos, A. M., Besemfelder, E., Schadendorf, D. and Augustin, H. G., Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am. J. Pathol. 2008. 172: 486-494.
8. Nanda, A., Karim, B., Peng, Z., Liu, G., Qiu, W., Gan, C., Vogelstein, B. et al., Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc. Natl. Acad. Sci. USA 2006. 103: 3351-3356.
9. Ohradanova, A., Gradin, K., Barathova, M., Zatovicova, M., Holotnakova, T., Kopacek, J., Parkkila, S. et al., Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2. Br. J. Cancer 2008. 99: 1348-1356.
10. Lax, S., Hou, T.-Z., Jenkinson, E., Salmon, M., MacFadyen, J. R., Isacke, C. M., Anderson, G. et al., CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett. 2007. 581: 3550-3556.
11. Toellner, K.-M., Luther, S. A., Sze, D. M. Y., Choy, R. K. W., Taylor, D. R., MacLennan, I. C. M. and Acha-Orbea, H., T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 1998. 187: 1193-1204.
12. Hawsawi, N. M., Ghebeh, H., Hendrayani, S.-F., Tulbah, A., Al-Eid, M., Al-Tweigeri, T., Ajarim, D. et al., Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res. 2008. 68: 2717-2725.
13. Katakai, T., Hara, T., Sugai, M., Gonda, H. and Shimizu, A., Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J. Exp. Med. 2004. 200: 783-795.
14. Katakai, T., Suto, H., Sugai, M., Gonda, H., Togawa, A., Suematsu, S., Ebisuno, Y. et al., Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J. Immunol. 2008. 181: 6189-6200.
15. Bekiaris, V., Withers, D., Glanville, S. H., McConnell, F. M., Parnell, S. M., Kim, M.-Y., Gaspal, F. M. C. et al., Role of CD30 in B/T segregation in the spleen. J. Immunol. 2007. 179: 7535-7543.
16. Chambers, S. M., Boles, N. C., Lin, K.-Y. K., Tierney, M. P., Bowman, T. V., Bradfute, S. B., Chen, A. J. et al., Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell 2007. 1: 578-591.
17. Kim, W. J., Mohan, R. R., Mohan, R. R. and Wilson, S. E., Effect of PDGF, IL-1alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea. Invest. Ophthalmol. Vis. Sci. 1999. 40: 1364-1372.
18. Tomkowicz, B., Rybinski, K., Foley, B., Ebel, W., Kline, B., Routhier, E., Sass, P. et al., Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. Proc. Natl. Acad. Sci. USA 2007. 104: 17965-17970.
19. Bagley, R. G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S., Ishida, I. et al., Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. Int. J. Oncol. 2009. 34: 619-627.
20. Wang, C.-H., Cherng, W.-J., Yang, N.-I., Kuo, L.-T., Hsu, C.-M., Yeh, H.-I., Lan, Y.-J. et al., Late-outgrowth endothelial cells attenuate intimal hyperplasia contributed by mesenchymal stem cells after vascular injury. Arterioscler. Thromb. Vasc. Biol. 2008. 28: 54-60.
21. Buettner, M., Pabst, R. and Bode, U., Stromal cell heterogeneity in lymphoid organs. Trends Immunol. 2010. 31: 80-86.
22. Dhanjal, T. S., Pendaries, C., Ross, E. A., Larson, M. K., Protty, M. B., Buckley, C. D. and Watson, S. P., A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 2007. 109: 4237-4244.