Expression profiles of adult T-cell leukemialymphoma and associations with clinical responses to zidovudine and interferon α

Leukemia and Lymphoma

Volumn 51, Issue 7, 2010, Pages 1200-1216

  Alizadeh, Ash A ^a   Bohen, Sean P ^a   Lossos, Chen ^b   Martinez Climent, Jose A ^c   Ramos, Juan Carlos ^b   Cubedo Gil, Elena ^b   Harrington Jr , William J ^b   Lossos, Izidore S ^b,d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotherapeutic approaches; lymphoid leukemia; prognostication; transcription factor changes

Indexed keywords

ALPHA INTERFERON; MESSENGER RNA; PROTEOCHONDROITIN SULFATE; RIBOSOME PROTEIN; ZIDOVUDINE;

ANTIGEN PRESENTATION; ARTICLE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG MEGADOSE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LEUKEMIA CELL LINE; MAINTENANCE THERAPY; MALE; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; T CELL LEUKEMIA; TREATMENT RESPONSE;

ADULT; ANTI-HIV AGENTS; COMPARATIVE GENOMIC HYBRIDIZATION; DRUG THERAPY, COMBINATION; GENE EXPRESSION PROFILING; HUMANS; INTERFERON-ALPHA; LEUKEMIA-LYMPHOMA, ADULT T-CELL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; ZIDOVUDINE;

EID: 77954092980     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428191003728628     Document Type: Article

References (50)

1. Matsuoka M, Jeang KT. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 2007;7:270-280.
2. Franchini G, Nicot C, Johnson JM. Seizing of T cells by human T-cell leukemia/lymphoma virus type 1. Adv Cancer Res 2003;89:69-132. (Pubitemid 41184280)
3. Mitra-Kaushik S, Harding J, Hess J, Schreiber R, Ratner L. Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma. Blood 2004;104:3305-3311.
4. Felber BK, Paskalis H, Kleinman-Ewing C, Wong-Staal F, Pavlakis GN. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 1985;229:675-679.
5. Sodroski JG, Rosen CA, Haseltine WA. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 1984;225:381-385.
6. Twizere JC, Springael JY, Boxus M, et al. Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood 2007;109:1051-1060.
7. Takeda S, Maeda M, Morikawa S, et al. Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int J Cancer 2004;109:559-567.
8. Furukawa Y, Kubota R, Tara M, Izumo S, Osame M. Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood 2001;97:987-993.
9. ShimoyamaM. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-1987). Br J Haematol 1991;79:428-437.
10. Waldmann TA, Goldman CK, Bongiovanni KF, et al. Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2. Blood 1988;72: 1805-1816.
11. Nasr R, Rosenwald A, El-Sabban ME, et al. Arsenic/ interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells. Blood 2003;101:4576-4582.
12. Ramos JC, Ruiz P Jr, Ratner L, et al. IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood 2007;109:3060-3068.
13. Ishida T, Iida S, Akatsuka Y, et al. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma. Clin Cancer Res 2004;10:7529-7539.
14. Matutes E, Taylor GP, Cavenagh J, et al. Interferon alpha and zidovudine therapy in adult T-cell leukaemia lymphoma: response and outcome in 15 patients. Br J Haematol 2001;113:779-784.
15. White JD, Wharfe G, Stewart DM, et al. The combination of zidovudine and interferon alpha-2B in the treatment of adult T-cell leukemia/lymphoma. Leuk Lymphoma 2001;40:287-294.
16. Gill PS, Harrington W Jr , Kaplan MH, et al. Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. N Engl J Med 1995;332: 1744-1748.
17. Hermine O, Bouscary D, Gessain A, et al. Brief report: treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon alfa. N Engl J Med 1995;332: 1749-1751.
18. Natkunam Y, Zhao S, Mason DY, et al. The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. Blood 2007;109:1636-1642.
19. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000;403:503-511.
20. Tusher V, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-5121.
21. Saeed AI, Bhagabati NK, Braisted JC, et al. TM4 microarray software suite. Methods Enzymol 2006;411:134-193.
22. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005;102:15545-15550.
23. Shaffer A, Wright G, Yang L, et al. A library of gene expression signatures to illuminate normal and pathological lymphoid biology. Immunol Rev 2006;210:67-85.
24. Gentles A, Alizadeh A, Lee S, et al. A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood 2009;114:3158-3166.
25. Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA, et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 2007;109:271-280.
26. Rubio-Moscardo F, Blesa D, Mestre C, et al. Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood 2005;106:3214-3222.
27. Pise-Masison CA, Radonovich M, Mahieux R, et al. Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes. Cancer Res 2002;62:3562-3571.
28. de La Fuente C, Deng L, Santiago F, Arce L, Wang L, Kashanchi F. Gene expression array of HTLV type 1- infected T cells: up-regulation of transcription factors and cell cycle genes. AIDS Res Hum Retroviruses 2000;16: 1695-1700.
29. Harhaj EW, Good L, Xiao G, Sun SC. Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene 1999;18:1341-1349.
30. Pise-Masison CA, Radonovich M, Dohoney K, et al. Gene expression profiling of ATL patients: compilation of diseaserelated genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. Blood 2009;113:4016-4026.
31. Inoue J, Seiki M, Taniguchi T, Tsuru S, Yoshida M. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J 1986;5:2883-2888.
32. Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell 1994;78:45-57.
33. Yamada Y, Warren AJ, Dobson C, Forster A, Pannell R, Rabbitts TH. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci USA 1998;95:3890-3895.
34. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci USA 1991;88:4367-4371.
35. Dong WF, Billia F, Atkins HL, Iscove NN, Minden MD. Expression of rhombotin 2 in normal and leukaemic haemopoietic cells. Br J Haematol 1996;93:280-286.
36. Creighton CJ, Bromberg-White JL, Misek DE, et al. Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation. Mol Cancer Res 2005;3:119-129.
37. Mauri P, Scarpa A, Nascimbeni AC, et al. Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identi- fication of novel cancer markers. FASEB J 2005;19:1125-1127.
38. Chung EJ, Hwang SG, Nguyen P, et al. Regulation of leukemic cell adhesion, proliferation, and survival by betacatenin. Blood 2002;100:982-990.
39. Nakayama K, Kamihira S. Survivin an important determinant for prognosis in adult T-cell leukemia: a novel biomarker in practical hemato-oncology. Leuk Lymphoma 2002;43:2249-2255.
40. Imai T, Hieshima K, Haskell C, et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 1997;91:521-530.
41. Andre F, Cabioglu N, Assi H, et al. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Ann Oncol 2006;17:945-951.
42. Shulby SA, Dolloff NG, Stearns ME, Meucci O, Fatatis A. CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res 2004;64:4693-4698.
43. Buonamici S, Trimarchi T, Ruocco MG, et al. CCR7 signalling as an essential regulator of CNS infiltration in Tcell leukaemia. Nature 2009;459:1000-1004.
44. Tsukasaki K, Tanosaki S, DeVos S, et al. Identifying progression- associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays. Int J Cancer 2004;109:875-881.
45. Hanai S, Nitta T, Shoda M, et al. Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia. Cancer Sci 2004;95:306-310.
46. Ozawa T, Itoyama T, Sadamori N, et al. Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci. J Hum Genet 2004;49:154-165.
47. Tsukasaki K, Krebs J, Nagai K, et al. Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course. Blood 2001;97:3875-3881.
48. Tsukasaki K. Genetic instability of adult T-cell leukemia/ lymphoma by comparative genomic hybridization analysis. J Clin Immunol 2002;22:57-63.
49. Martinez-Climent JA, Alizadeh AA, Segraves R, et al. Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations. Blood 2003;101: 3109-3117.
50. Feng X, Ratner L. Human T-cell leukemia virus type 1 blunts signaling by interferon alpha. Virology 2008;374:210-216.