Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile

European Journal of Pharmacology

Volumn 578, Issue 2-3, 2008, Pages 270-278

  Shi, Rong qian ^a   Lee, Jong Kook ^a   Hayashi, Yoshitaka ^a   Takeuchi, Yoko ^a   Kambe, Fukushi ^a   Futaki, Sugiko ^a   Seo, Hisao ^a   Murata, Yoshiharu ^a   Kodama, Itsuo ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Amiodarone; DNA microarray analysis; ECG; Gene expression profile; Thyroid hormone

Indexed keywords

AMIODARONE; LIOTHYRONINE; MESSENGER RNA; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA MICROARRAY; DOWN REGULATION; ELECTROCARDIOGRAM; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HEART; HEART LEFT VENTRICLE; HEART MUSCLE; HYPOPHYSIS; HYPOTHYROIDISM; LIVER; LONG TERM CARE; MALE; MICROARRAY ANALYSIS; MUTATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QT INTERVAL; RAT; STATISTICAL SIGNIFICANCE; UPREGULATION; WISTAR RAT;

AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOTTING, NORTHERN; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; GENE EXPRESSION PROFILING; HEART; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; HYPOTHYROIDISM; LIVER; MALE; METHIMAZOLE; MYOCARDIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PITUITARY GLAND; RATS; RATS, WISTAR; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 37349004736     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.09.039     Document Type: Article

References (43)

1. Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D., Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., and Yawo H. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 274 (1999) 17159-17163
2. Amiodarone Trials Meta-Analysis Investigators. Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials. Lancet 350 (1997) 1417-1424
3. Anderson K.P., Walker R., Dustman T., Lux R.L., Ershler P.R., Kates R.E., and Urie P.M. Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo. Circulation 79 (1989) 948-958
4. Bakker O., van Beeren H.C., and Wiersinga W.M. Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein. Endocrinology 134 (1994) 1665-1670
5. Barry D.M., and Nerbonne J.M. Myocardial potassium channels: electrophysiological and molecular diversity. Annu. Rev. Physiol. 58 (1996) 363-394
6. Bernal J. The significance of thyroid hormone transporters in the brain. Endocrinology 146 (2005) 1698-1700
7. Bosch R.F., Li G.R., Gaspo R., and Nattel S. Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 289 (1999) 156-165
8. Eisen M.B., Spellman P.T., Brown P.O., and Botstein D. Cluster analysis and display of genome-wide expression patterns. PNAS 95 (1998) 14863-14868
9. Forrest D., and Vennstrom B. Functions of thyroid hormone receptors in mice. Thyroid 10 (2000) 41-52
10. Franklyn J.A., Davis J.R., Gammage M.D., Littler W.A., Ramsden D.B., and Sheppard M.C. Amiodarone and thyroid hormone action. Clin. Endocrinol. (Oxf) 22 (1985) 257-264 JID - 0346653
11. Friesema E.C.H., Jansen J., Milici C., and Visser T.J. Thyroid hormone transporters. Vitam. Horm. 70 (2005) 137-167
12. Gauthier K., Chassande O., Plateroti M., Roux J.P., Legrand C., Pain B., Rousset B., Weiss R., Trouillas J., and Samarut J. Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J. 18 (1999) 623-631
13. Goldberger J., Helmy I., Katzung B., and Scheinman M. Use-dependent properties of flecainide acetate in accessory atrioventricular pathways. Am. J. Cardiol. 73 (1994) 43-49
14. Gotzsche L.B. Beta-adrenergic receptors, voltage-operated Ca(2+)-channels, nuclear triiodothyronine receptors and triiodothyronine concentration in pig myocardium after long-term low-dose amiodarone treatment. Acta Endocrinol. (Copenh) 129 (1993) 337-347
15. Gotzsche L.B., and Orskov H. Cardiac triiodothyronine nuclear receptor binding capacities in amiodarone-treated, hypo- and hyperthyroid rats. Eur. J. Endocrinol. 130 (1994) 281-290
16. Greenberg M.L., Lerman B.B., Shipe J.R., Kaiser D.L., and DiMarco J.P. Relation between amiodarone and desethylamiodarone plasma concentrations and electrophysiologic effects, efficacy and toxicity. J. Am. Coll. Cardiol. 9 (1987) 1148-1155
17. + channel activities of cultured rat cardiomyocytes. J. Mol. Cell. Cardiol. 29 (1997) 617-627
18. Kennedy R.L., Griffiths H., and Gray T.A. Amiodarone and the thyroid. Clin. Chem. 35 (1989) 1882-1887
19. Kodama I., Kamiya K., and Toyama J. Cellular electropharmacology of amiodarone. Cardiovasc. Res. 35 (1997) 13-29
20. Lambert C., Cardinal R., Vermeulen M., Lamontagne D., Nadeau R., Paradis P., and Rouleau J.L. Lack of relation between the ventricular refractory period prolongation by amiodarone and the thyroid state in rats. J. Pharmacol. Exp. Ther. 242 (1987) 320-325
21. Latham K.R., Sellitti D.F., and Goldstein R.E. Interaction of amiodarone and desethylamiodarone with solubilized nuclear thyroid hormone receptors. J. Am. Coll. Cardiol. 9 (1987) 872-876
22. Lazar M.A. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr. Rev. 14 (1993) 184-193
23. Le Bouter S., Demolombe S., Chambellan A., Bellocq C., Aimond F., Toumaniantz G., Lande G., Siavoshian S., Baro I., Pond A.L., Nerbonne J.M., Leger J.J., Escande D., and Charpentier F. Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology. Circ. Res. 92 (2003) 234-242
24. Le Bouter S., El Harchi A., Marionneau C., Bellocq C., Chambellan A., van Veen T., Boixel C., Gavillet B., Abriel H., Le Quang K., Chevalier J.C., Lande G., Leger J.J., Charpentier F., Escande D., and Demolombe S. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation 110 (2004) 3028-3035
25. Mitchell G.F., Jeron A., and Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am. J. Physiol. 274 (1998) H747-H751
26. Nattel S., and Singh B.N. Evolution, mechanisms, and classification of antiarrhythmic drugs: focus on class III actions. Am. J. Cardiol. 84 (1999) 11R-19R
27. Norman M.F., and Lavin T.N. Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells. J. Clin. Invest. 83 (1989) 306-313
28. Polikar R., Goy J.J., Schlapfer J., Lemarchand-Beraud T., Biollaz J., Magnenat P., and Nicod P. Effect of oral triiodothyronine during amiodarone treatment for ventricular premature complexes. Am. J. Cardiol. 58 (1986) 987-991
29. Sager P.T., Uppal P., Follmer C., Antimisiaris M., Pruitt C., and Singh B.N. Frequency-dependent electrophysiologic effects of amiodarone in humans. Circulation 88 (1993) 1063-1071
30. Sap J., Munoz A., Damm K., Goldberg Y., Ghysdael J., Leutz A., Beug H., and Vennstrom B. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324 (1986) 635-640
31. Schroder-van der Elst J.P., and van der Heide D. Thyroxine, 3,5,3′-triiodothyronine, and 3,3′,5′-triiodothyronine concentrations in several tissues of the rat: effects of amiodarone and desethylamiodarone on thyroid hormone metabolism [corrected]. Endocrinology 127 (1990) 1656-1664
32. Singh B.N. Antiarrhythmic drugs: a reorientation in light of recent developments in the control of disorders of rhythm. Am. J. Cardiol. 81 (1998) 3D-13D
33. Singh B.N., and Nademanee K. Amiodarone and thyroid function: clinical implications during antiarrhythmic therapy. Am. Heart J. 106 (1983) 857-869
34. Singh B.N., Venkatesh N., Nademanee K., Josephson M.A., and Kannan R. The historical development, cellular electrophysiology and pharmacology of amiodarone. Prog. Cardiovasc. Dis. 31 (1989) 249-280
35. Sun W., Sarma J.S., and Singh B.N. Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: comparison with amiodarone. Circulation 100 (1999) 2276-2281
36. Takeuchi Y., Murata Y., Sadow P., Hayashi Y., Seo H., Xu J., O'Malley B.W., Weiss R.E., and Refetoff S. Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo. Endocrinology 143 (2002) 1346-1352
37. van Beeren H.C., Bakker O., and Wiersinga W.M. Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein. Mol. Cell. Endocrinol. 112 (1995) 15-19
38. van Beeren H.C., Bakker O., and Wiersinga W.M. Structure-function relationship of the inhibition of the 3,5,3′-triiodothyronine binding to the alpha1- and beta1-thyroid hormone receptor by amiodarone analogs. Endocrinology 137 (1996) 2807-2814
39. Varro A., Takacs J., Nemeth M., Hala O., Virag L., Iost N., Balati B., Agoston M., Vereckei A., Pastor G., Delbruyere M., Gautier P., Nisato D., and Papp J.G. Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone. Br. J. Pharmacol. 133 (2001) 625-634
40. Weinberger C., Thompson C.C., Ong E.S., Lebo R., Gruol D.J., and Evans R.M. The c-erb-A gene encodes a thyroid hormone receptor. Nature 324 (1986) 641-646
41. Weiss R.E., Murata Y., Cua K., Hayashi Y., Seo H., and Refetoff S. Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice. Endocrinology 139 (1998) 4945-4952
42. White P., and Dauncey M.J. Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development. J. Mol. Endocrinol. 23 (1999) 241-254
43. + current in rat ventricle. Am. J. Physiol. 276 (1999) H1599-H1607