HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland

Oncogene

Volumn 29, Issue 25, 2010, Pages 3639-3649

  Ogba, N ^a   Doughman, Y Q ^a   Chaplin, L J ^a   Hu, Y ^a   Gargesha, M ^b   Watanabe, M ^a   Montano, M M ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b Case Western Reserve University   (United States)

Author keywords

angiogenesis; HEXIM1; HIF 1 ; mammary tumors; P TEFb; VEGF

Indexed keywords

ESTROGEN RECEPTOR ALPHA; HEXAMETHYLENE BISACETAMIDE INDUCIBLE PROTEIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; BREAST TUMOR; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOXIA; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR VASCULARIZATION; WILD TYPE;

ANIMALS; CARCINOGENS; CELL HYPOXIA; CELL LINE, TUMOR; EPITHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MUTATION; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; RNA-BINDING PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS;

EID: 77954087427     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.110     Document Type: Article

References (33)

1. Bogin L, Degani H. (2002). Hormonal regulation of VEGF in orthotopic MCF7 human breast cancer. Cancer Res 62: 1948-1951.
2. Bos R, van Diest PJ, van der Groep P, Shvarts A, Greijer AE, van der Wall E. (2004). Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related. Breast Cancer Res 6: R450-R459.
3. Buteau-Lozano H, Ancelin M, Lardeux B, Milanini J, Perrot-Applanat M. (2002). Transcriptional regulation of vascular endothelial growth factor by estradiol and tamoxifen in breast cancer cells: a complex interplay between estrogen receptors alpha and beta. Cancer Res 62: 4977-4984.
4. Cho J, Kim D, Lee S, Lee Y. (2005). Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1 alpha in MCF-7 human breast cancer cells. Mol Endocrinol 19: 1191-1199.
5. Deroo BJ, Korach KS. (2006). Estrogen receptors and human disease. J Clin Invest 116: 561-570.
6. Ellis LM, Hicklin DJ. (2008). VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8: 579-591.
7. Ferrara N, Gerber HP, LeCouter J. (2003). The biology of VEGF and its receptors. Nat Med 9: 669-676.
8. Garvin S, Nilsson UW, Dabrosin C. (2005). Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells. Br J Cancer 93: 1005-1010.
9. Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W et al. (2006). Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Endocrinology 147: 3285-3295.
10. Hyder SM. (2006). Sex-steroid regulation of vascular endothelial growth factor in breast cancer. Endocr Relat Cancer 13: 667-687.
11. Kawai H, Li H, Chun P, Avraham S, Avraham HK. (2002). Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. Oncogene 21: 7730-7739.
12. Kazi AA, Jones JM, Koos RD. (2005). Chromatin immunoprecipita-tion analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter. Mol Endocrinol 19: 2006-2019.
13. Kazi AA, Koos RD. (2007). Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Endocrinology 148: 2363-2374.
14. Kazi AA, Molitoris KH, Koos RD. (2009). Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus. Biol Reprod 81: 378-387.
15. Kimbro KS, Simons JW. (2006). Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 13: 739-749.
16. Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM et al. (2000). Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 74: 311-317.
17. Li B, Kittrell FS, Medina D, Rosen JM. (1995). Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein. Mol Carcinog 14: 75-83.
18. Liao D, Corle C, Seagroves TN, Johnson RS. (2007). Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563-572.
19. Lydon JP, Ge G, Kittrell FS, Medina D, O'Malley BW. (1999). Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res 59: 4276-4284.
20. Maity A, Sall W, Koch CJ, Oprysko PR, Evans SM. (2001). Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia. Breast Cancer Res Treat 67: 51-60.
21. Molitoris KH, Kazi AA, Koos RD. (2009). Inhibition of oxygen-induced hypoxia-inducible factor-1alpha degradation unmasks estradiol induction of vascular endothelial growth factor expression in ECC-1 cancer cells in vitro. Endocrinology 150: 5405-5414.
22. Montano MM, Doughman YQ, Deng H, Chaplin L, Yang J, Wang N et al. (2008). Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res 102: 415-422.
23. Ogba N, Chaplin LJ, Doughman YQ, Fujinaga K, Montano MM. (2008). HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Res 68: 7015-7024.
24. Rossiter H, Barresi C, Ghannadan M, Gruber F, Mildner M, Fodinger D et al. (2007). Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J 21: 3994-4004.
25. Rugo HS. (2004). Bevacizumab in the treatment of breast cancer: rationale and current data. Oncologist 9(Suppl 1): 43-49.
26. Seifeddine R, Dreiem A, Tomkiewicz C, Fulchignoni-Lataud MC, Brito I, Danan JL et al. (2007). Hypoxia and estrogen co-operate to regulate gene expression in T-47D human breast cancer cells. J Steroid Biochem Mol Biol 104: 169-179.
27. Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K et al. (2005). HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Proc Natl Acad Sci USA 102: 8555-8560.
28. Sims 3rd RJ, Belotserkovskaya R, Reinberg D. (2004). Elongation by RNA polymerase II: the short and long of it. Genes Dev 18: 2437-2468.
29. Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M et al. (2004). Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene 23: 1052-1063.
30. Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM. (2005). The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene 24: 5576-5588.
31. Wittmann BM, Wang N, Montano MM. (2003). Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. Cancer Res 63: 5151-5158.
32. Woodfin A, Voisin MB, Nourshargh S. (2007). PECAM-1: a multifunctional molecule in inflammation and vascular biology. Arter-ioscler Thromb Vasc Biol 27: 2514-2523.
33. Zhou Q, Yik JH. (2006). The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol Mol Biol Rev 70: 646-659.