Gabexate mesilate, a synthetic protease inhibitor, attenuates endotoxin-induced pulmonary vascular injury by inhibiting tumor necrosis factor production by monocytes

Critical Care Medicine

Volumn 24, Issue 6, 1996, Pages 1047-1053

  Murakami, Kazunori ^a   Okajima, Kenji ^a   Uchiba, Mitsuhiro ^a   Okabe, Hiroaki ^a   Takatsuki, Kiyoshi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute lung injury; Adult respiratory distress syndrome; Disseminated intravascular coagulation; Endotoxin; Gabexate mesilate; Heparin; Leukocytes; Protease inhibitor; Sepsis; Tumor necrosis factor

Indexed keywords

ALBUMIN I 125; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10; ELASTASE; ENDOTOXIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GABEXATE MESILATE; HEPARIN; PROTEINASE INHIBITOR; SIVELESTAT; SUPEROXIDE; THROMBIN; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE AGGREGATION; LEUKOPENIA; LUNG BLOOD VESSEL; LUNG INJURY; MALE; MICROSCOPY; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS;

ANIMALS; CAPILLARY PERMEABILITY; ESCHERICHIA COLI; GABEXATE; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, WISTAR; RESPIRATORY DISTRESS SYNDROME, ADULT; SERINE PROTEINASE INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029973005     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199606000-00027     Document Type: Article

References (44)

1. Parrillo JE: Pathogenic mechanisms of septic shock. N Engl J Med 1993; 328: 1471-1477
2. St. John RC, Dorinsky PM: Immunologic therapy for ARDS, septic shock and multiple organ failure. Chest 1993; 103:932-943
3. Bone RC, Balk R, Slotman G, et al: Adult respiratory distress syndrome. Chest 1992; 101:320-326
4. 1-proteinase inhibitor complex in patients with disseminated intravascular coagulation: Pathophysiologic implications. Am J Hematol 1994; 47:82-88
5. Taenaka N, Shimada Y, Hirata T, et al: Gabexate mesilate (FOY) therapy of disseminated intravascular coagulation due to sepsis. Crit Care Med 1983; 9:735-738
6. Yoshikawa T, Furukawa Y, Murakami M, et al: Protective effect of gabexate mesilate against experimental disseminated intravascular coagulation in rats. Haemostasis 1983; 13:262-267
7. Heflin AC, Brigham KI: Prevention by granulocyte depletion of increased vascular permeability of sheep following endotoxemia. J Clin Invest 1981; 68: 1253-1260
8. Horn RG: Evidence for participation of granulocytes in the pathogenesis of the generalized Shwartzman reaction: A review. J Infect Dis 1973; 128:134-143
9. Kawabata K, Suzuki M, Sugitani M, et al: ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun 1991; 177:814-820
10. Bajaj SP, Rapaport SI, Prodanos CA: A simplified procedure for purification of human prothrombin, factor IX and factor X. Prep Biochem 1981; 11:397-412
11. Morita T, Jackson CM: Localization of the structural difference between bovine blood coagulation factor X1 and X2 to tyrosine 18 in the activation peptide. J Biol Chem 1986; 261:4008-4014
12. Mulligan MS, Polley MJ, Bayer RJ, et al: Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140). J Clin Invest 1992; 90: 1600-1607
13. Chang SW, Ohara N, Kuo G, et al: Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor. Am J Physiol 1989; 257: L232-L239
14. Okajima K, Koga S, Okabe H, et al: Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia. Acta Haematol 1989; 81:15-18
15. Zhang X, Ellis EF: Superoxide dismutase reduces permeability and edema induced by hypertension in rats. Am J Physiol 1990; 259:H497-H503
16. Wallace JL, Keenan CM, Granger DN: Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990; 259:G462-G467
17. Watabe S, Sendo F, Kimura S, et al: Activation of cytotoxic polymorphonuclear leukocytes by in vivo administration of a streptococcal preparation, OK-432. J Natl Cancer Inst 1984; 72: 1365-1370
18. Leculier C, Couprie N, Adeleine P, et al: The effect of high molecular weight- and low molecular weight-heparins on superoxide ion production and degranulation by human polymorphonuclear leukocytes. Thromb Res 1993; 69:519-531
19. Tanaka H, Shimazu T, Sugimoto H, et al: A sensitive and specific assay for granulocyte elastase in inflammatory tissue fluid using L-pyroglutamyl-L-prolyl-L-valine-p-nitroanilide. Clin Chim Acta 1990; 187:173-180
20. 2) and hydroxyl radical production by human polymorphonuclear leukocytes. Hepatogastroenterology 1992; 39: 59-61
21. Russel-Smith NC, Flower RJ, Cardinal DC: Measuring platelet and leukocyte aggregation/adhesion responses in very small volumes of whole blood. J Pharmacol Methods 1981; 6:315-333
22. Ford TC, Rickwood D: Formation of isotonic Nycodenz gradients for cell separations. Anal Biochem 1982; 124: 293-298
23. Glauser FL, Fairman RP: The uncertain role of the neutrophil in increased permeability pulmonary edema. Chest 1985; 88:601-607
24. Damerau B, Wustefeld H, Fricke D, et al: Influence of the anti-inflammatory serine protease inhibitor gabexate mesilate (Foy) on aggregation, locomotion and adhesion of polymorphonuclear leukocytes. Agents Actions 1984; 15: 594-599
25. Klebanoff SJ, Vadas MA, Harlan JH, et al: Stimulation of neutrophils by tumor necrosis factor. J Immunol 1986; 136: 4220-4225
26. Mulligan MS, Varani J, Dame MK, et al: Role of endothelial-leukocyte adhesion molecule-1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest 1991; 88:1396-1406
27. Okajima K, Yang WP, Okabe H, et al: Role of leukocytes in the activation of intravascular coagulation in patients with septicemia. Am J Hematol 1991; 36:265-271
28. Ohno H, Kambayashi J, Chang SW, et al: FOY: (Ethyl p-(6-guanidino-hexanoyloxy) benzoate) methane-sulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulofibrinolytic system in comparison with heparin or aprotinin. Thromb Res 1981; 24:445-452
29. Dentener MA, Bazil V, Eckhardt JU, et al: Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-α, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J Immunol 1993; 150:2885-2891
30. Winn R, Maunder R, Chi E, et al: Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats. J Appl Physiol 1987; 62:116-121
31. Brigham KL, Meyrick B: Endotoxin and lung injury. Am Rev Respir Dis 1986; 133:913-927
32. Meyrick BO, Ryan US, Brigham KL: Direct effects of E. coli endotoxin on structure and permeability of pulmonary endothelial monolayer of intimai explants. Am J Pathol 1986; 122:140-151
33. Colman RW: Contact systems in infectious disease. Rev Infect Dis 1989; 11:S689-S699
34. Basadre JO, Singh H, Herndon DN, et al: Effect of antibody-mediated neutropenia on the cardiopulmonary response to endotoxemia. J Surg Res 1988; 45: 266-275
35. Pober JS, Cotran RS: The role of endothelial cells in inflammation. Transplantation 1990; 50:537-544
36. Bone RC, Francis PB, Pierce AK: Intravascular coagulation associated with the adult respiratory distress syndrome. Am J Med 1976; 61:585-589
37. Kaplan JE, Malik AB: Thrombin-induced intravascular coagulation: Role in vascular injury. Semin Thromb Hemost 1987; 13:398-415
38. Garcia JGN, Sifilinger-Brinboim A, Bizios R, et al: Thrombin-induced increase in albumin permeability across the endothelium. J Cell Physiol 1986; 128:96-104
39. Gaynor E, Bouveier C, Spaet TH: Vascular lesions: Possible pathogenetic basis of the generalized Shwartzman reaction. Science 1970; 170:986-988
40. Taylor FB Jr, Chan ACK, Peer GT, et al: DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood 1991; 78: 364-368
41. Rinaldo JE, Dauber JH, Christman J, et al: Neutrophil alveolitis following endotoxemia. Enhancement by previous exposure to hypoxia. Am Rev Respir Dis 1984; 133:1065-1071
42. Meyrick B, Berry LC Jr, Christman BW: Response of cultured human pulmonary artery endothelial cells to endotoxin. Am J Physiol 1995; 268:L239-L244
43. Emerson TE, Fournel MA, Redens TB, et al: Efficacy of antithrombin III supplementation in animal model of fulminant Escherichia coli endotoxemia or bacteremia. Am J Med 1989; 87:3B-27S-3B-33S
44. Traber DL, Adams T Jr, Sziebert L, et al: Effect of a proteolytic enzyme inhibitor on the cardiopulmonary response to endotoxin. Resuscitation 1986; 14: 91-104