Cisplatin induces duplex 3′ overhangs and 5′ blunt ends in epididymal epithelium in a Bax-dependent manner without any protection from l-ascorbic acid

European Journal of Pharmacology

Volumn 641, Issue 2-3, 2010, Pages 238-245

  Narayana, Kilarkaje ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Anticancer drug; Bax; Bcl 2; DNA strand break; In situ oligo ligation; Oxidative stress; P53; Reproductive toxicity

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASCORBIC ACID; CISPLAT; CISPLATIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOPLASM; DOUBLE STRANDED DNA BREAK; EPIDIDYMIS DISEASE; GENE EXPRESSION; GENE LOCATION; GENETIC MARKER; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUCLEIC ACID ANALYSIS; ORGAN WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; WEIGHT REDUCTION;

3' FLANKING REGION; 5' FLANKING REGION; ANIMALS; ASCORBIC ACID; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL MARKERS; CISPLATIN; DEOXYGUANOSINE; DNA BREAKS, DOUBLE-STRANDED; EPIDIDYMIS; MALE; MICE; MICE, INBRED BALB C; ORGAN SIZE; OXIDATIVE STRESS; RANDOM ALLOCATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77954084201     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.032     Document Type: Article

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