Liver metastases. Pathogenesis and oncogenesis;Lebermetastasen. Pathogenese und Onkogenese

Chirurg

Volumn 81, Issue 6, 2010, Pages 551-556

  Wellner, U F ^a   Keck, T ^a   Brabletz, T ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Cancer stem cells; Epithelial mesenchymal transition; Metastasis; Migrating cancer stem cells

Indexed keywords

BETA CATENIN; CADHERIN;

ADENOMA; ANIMAL; ARTICLE; BREAST TUMOR; CANCER INVASION; CANCER STEM CELL; CELL MOTION; CELL TRANSFORMATION; COLORECTAL TUMOR; EPITHELIUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER TUMOR; MESENCHYMAL STEM CELL; METASTASIS; MOUSE; NUCLEOTIDE SEQUENCE; PANCREAS TUMOR; PATHOLOGY; PROGNOSIS; SIGNAL TRANSDUCTION;

ADENOMA; ANIMALS; BETA CATENIN; BREAST NEOPLASMS; CADHERINS; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; EPITHELIUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MESENCHYMAL STEM CELLS; MICE; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PROGNOSIS; SIGNAL TRANSDUCTION;

EID: 77954082926     PISSN: 00094722     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00104-009-1868-8     Document Type: Article

References (28)

1. Brabletz T, Jung A, Hermann K et al (1998) Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 194: 701-704.
2. Brabletz T, Jung A, Reu S et al (2001) Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A 98: 10356-10361.
3. Brabletz T, Jung A, Spaderna S et al (2005) Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev 5: 744-749.
4. Clarke MF, Dick JE, Dirks PB et al (2006) Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66: 9339-9344.
5. Elenbaas B, Spirio L, Koerner F et al (2001) Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 15: 50-65.
6. Friedl P, Wolf K (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev 3: 362-374.
7. Hermann PC, Huber SL, Herrler T et al (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1: 313-323.
8. Hess KR, Varadhachary GR, Taylor SH et al (2006) Metastatic patterns in adenocarcinoma. Cancer 106: 1624-1633.
9. Holzel D, Eckel R, Engel J (2009) Colorectal cancer metastasis. Frequency, prognosis, and consequences. Chirurg 80: 331-340.
10. Hurt EM, Farrar WL (2008) Cancer stem cells: the seeds of metastasis? Mol Interv 8: 140-142.
11. Jones S, Chen WD, Parmigiani G et al (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 105: 4283-4288.
12. Kelly PN, Dakic A, Adams JM et al (2007) Tumor growth need not be driven by rare cancer stem cells. Science (New York, N. Y) 317: 337.
13. Kirchner T, Brabletz T (2000) Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol 157: 1113-1121.
14. Lawson JC, Blatch GL, Edkins AL (2009) Cancer stem cells in breast cancer and metastasis. Breast Cancer Res Treat 118: 241-254.
15. Mani SA, Guo W, Liao MJ et al (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
16. Morel AP, Lievre M, Thomas C et al (2008) Generation of breast cancer stem cells through epithelial-mesenchymal transition. PloS one 3: e2888.
17. Nguyen DX, Bos PD, Massague J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev 9: 274-284.
18. Quintana E, Shackleton M, Sabel MS et al (2008) Efficient tumour formation by single human melanoma cells. Nature 456: 593-598.
19. Schneider G, Schmid RM (2003) Genetic alterations in pancreatic carcinoma. Mol Cancer 2: 15.
20. Spaderna S, Schmalhofer O, Hlubek F et al (2006) A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 131: 830-840.
21. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev 2: 442-454.
22. Ueno H, Mochizuki H, Hashiguchi Y et al (2004) Predictors of extrahepatic recurrence after resection of colorectal liver metastases. Br J Surg 91: 327-333.
23. Ueno H, Mochizuki H, Hatsuse K et al (2000) Indicators for treatment strategies of colorectal liver metastases. Ann Surg 231: 59-66.
24. Vogelstein B, Fearon ER, Hamilton SR et al (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532.
25. Wellner U, Schubert J, Burk UC et al (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11: 1487-1495.
26. Yu SC, Bian XW (2009) Enrichment of cancer stem cells based on heterogeneity of invasiveness. Stem Cell Rev 5: 66-71.
27. Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437.
28. Zlobec I, Lugli A (2008) Prognostic and predictive factors in colorectal cancer. J Clin Pathol 61: 561-569.