-
1
-
-
1942453441
-
Modification of alternative splicing by antisense therapeutics
-
10.1089/154545704322988067, 15104897
-
Kole R, Vacek M, Williams T. Modification of alternative splicing by antisense therapeutics. Oligonucleotides 2004, 14:65-74. 10.1089/154545704322988067, 15104897.
-
(2004)
Oligonucleotides
, vol.14
, pp. 65-74
-
-
Kole, R.1
Vacek, M.2
Williams, T.3
-
2
-
-
11844256373
-
Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
-
10.1073/pnas.0406700102, 544058, 15608067
-
Lu QL, Rabinowitz A, Chen YC, Yokota T, Yin H, Alter J, Jadoon A, Bou-Gharios G, Partridge T. Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. Proc Natl Acad Sci USA 2005, 102:198-203. 10.1073/pnas.0406700102, 544058, 15608067.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 198-203
-
-
Lu, Q.L.1
Rabinowitz, A.2
Chen, Y.C.3
Yokota, T.4
Yin, H.5
Alter, J.6
Jadoon, A.7
Bou-Gharios, G.8
Partridge, T.9
-
3
-
-
0036765860
-
Restoration of human beta-globin gene expression in murine and human IVS2-654 thalassemic erythroid cells by free uptake of antisense oligonucleotides
-
10.1124/mol.62.3.545, 12181431
-
Suwanmanee T, Sierakowska H, Lacerra G, Svasti S, Kirby S, Walsh CE, Fucharoen S, Kole R. Restoration of human beta-globin gene expression in murine and human IVS2-654 thalassemic erythroid cells by free uptake of antisense oligonucleotides. Mol Pharmacol 2002, 62:545-553. 10.1124/mol.62.3.545, 12181431.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 545-553
-
-
Suwanmanee, T.1
Sierakowska, H.2
Lacerra, G.3
Svasti, S.4
Kirby, S.5
Walsh, C.E.6
Fucharoen, S.7
Kole, R.8
-
4
-
-
0033062736
-
Antisense morpholino oligonucleotide analog induces missplicing of C-myc mRNA
-
Giles RV, Spiller DG, Clark RE, Tidd DM. Antisense morpholino oligonucleotide analog induces missplicing of C-myc mRNA. Antisense Nucleic Acid Drug Dev 1999, 9:213-220.
-
(1999)
Antisense Nucleic Acid Drug Dev
, vol.9
, pp. 213-220
-
-
Giles, R.V.1
Spiller, D.G.2
Clark, R.E.3
Tidd, D.M.4
-
5
-
-
0043133425
-
Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle
-
10.1093/hmg/ddg196, 12874101
-
Gebski BL, Mann CJ, Fletcher S, Wilton SD. Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle. Hum Mol Genet 2003, 12:1801-1811. 10.1093/hmg/ddg196, 12874101.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 1801-1811
-
-
Gebski, B.L.1
Mann, C.J.2
Fletcher, S.3
Wilton, S.D.4
-
6
-
-
0035800055
-
Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain
-
10.1021/bi010263l, 11425312
-
Karras JG, Maier MA, Lu T, Watt A, Manoharan M. Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain. Biochemistry 2001, 40:7853-7859. 10.1021/bi010263l, 11425312.
-
(2001)
Biochemistry
, vol.40
, pp. 7853-7859
-
-
Karras, J.G.1
Maier, M.A.2
Lu, T.3
Watt, A.4
Manoharan, M.5
-
7
-
-
2542610648
-
Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing
-
10.1093/nar/gkh584, 419592, 15148357
-
Siwkowski AM, Malik L, Esau CC, Maier MA, Wancewicz EV, Albertshofer K, Monia BP, Bennett CF, Eldrup AB. Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing. Nucleic Acids Res 2004, 32:2695-2706. 10.1093/nar/gkh584, 419592, 15148357.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 2695-2706
-
-
Siwkowski, A.M.1
Malik, L.2
Esau, C.C.3
Maier, M.A.4
Wancewicz, E.V.5
Albertshofer, K.6
Monia, B.P.7
Bennett, C.F.8
Eldrup, A.B.9
-
8
-
-
0035878539
-
Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells
-
10.1093/hmg/10.15.1547, 11468272
-
van Deutekom JC, Bremmer-Bout M, Janson AA, Ginjaar IB, Baas F, den Dunnen JT, van Ommen GJ. Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells. Hum Mol Genet 2001, 10:1547-1554. 10.1093/hmg/10.15.1547, 11468272.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1547-1554
-
-
van Deutekom, J.C.1
Bremmer-Bout, M.2
Janson, A.A.3
Ginjaar, I.B.4
Baas, F.5
den Dunnen, J.T.6
van Ommen, G.J.7
-
9
-
-
0030582315
-
Induction of exon skipping of the dystrophin transcript in lymphoblastoid cells by transfecting an antisense oligodeoxynucleotide complementary to an exon recognition sequence
-
10.1006/bbrc.1996.1375, 8806654
-
Pramono ZA, Takeshima Y, Alimsardjono H, Ishii A, Takeda S, Matsuo M. Induction of exon skipping of the dystrophin transcript in lymphoblastoid cells by transfecting an antisense oligodeoxynucleotide complementary to an exon recognition sequence. Biochem Biophys Res Commun 1996, 226:445-449. 10.1006/bbrc.1996.1375, 8806654.
-
(1996)
Biochem Biophys Res Commun
, vol.226
, pp. 445-449
-
-
Pramono, Z.A.1
Takeshima, Y.2
Alimsardjono, H.3
Ishii, A.4
Takeda, S.5
Matsuo, M.6
-
10
-
-
0035793047
-
Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse
-
10.1073/pnas.011408598, 14541, 11120883
-
Mann CJ, Honeyman K, Cheng AJ, Ly T, Lloyd F, Fletcher S, Morgan JE, Partridge TA, Wilton SD. Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse. Proc Natl Acad Sci USA 2001, 98:42-47. 10.1073/pnas.011408598, 14541, 11120883.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 42-47
-
-
Mann, C.J.1
Honeyman, K.2
Cheng, A.J.3
Ly, T.4
Lloyd, F.5
Fletcher, S.6
Morgan, J.E.7
Partridge, T.A.8
Wilton, S.D.9
-
11
-
-
0003826861
-
Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides
-
10.1038/15079, 10545916
-
Taylor JK, Zhang QQ, Wyatt JR, Dean NM. Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides. Nat Biotechnol 1999, 17:1097-1100. 10.1038/15079, 10545916.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 1097-1100
-
-
Taylor, J.K.1
Zhang, Q.Q.2
Wyatt, J.R.3
Dean, N.M.4
-
12
-
-
0037130279
-
Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression
-
Mercatante DR, Kole R. Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression. Biochim Biophys Acta 2002, 1587:126-132.
-
(2002)
Biochim Biophys Acta
, vol.1587
, pp. 126-132
-
-
Mercatante, D.R.1
Kole, R.2
-
13
-
-
0034065833
-
Modification of alternative splicing pathways as a potential approach to chemotherapy
-
10.1016/S0163-7258(99)00067-4, 10739878
-
Mercatante D, Kole R. Modification of alternative splicing pathways as a potential approach to chemotherapy. Pharmacol Ther 2000, 85:237-243. 10.1016/S0163-7258(99)00067-4, 10739878.
-
(2000)
Pharmacol Ther
, vol.85
, pp. 237-243
-
-
Mercatante, D.1
Kole, R.2
-
14
-
-
0032145989
-
The MDM2 gene amplification database
-
10.1093/nar/26.15.3453, 147746, 9671804
-
Momand J, Jung D, Wilczynski S, Niland J. The MDM2 gene amplification database. Nucleic Acids Res 1998, 26:3453-3459. 10.1093/nar/26.15.3453, 147746, 9671804.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 3453-3459
-
-
Momand, J.1
Jung, D.2
Wilczynski, S.3
Niland, J.4
-
15
-
-
0035186743
-
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms
-
Wang H, Nan L, Yu D, Agrawal S, Zhang R. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin Cancer Res 2001, 7:3613-3624.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3613-3624
-
-
Wang, H.1
Nan, L.2
Yu, D.3
Agrawal, S.4
Zhang, R.5
-
16
-
-
0034576957
-
A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer
-
10.1002/1097-0215(20001201)88:5<804::AID-IJC19>3.0.CO;2-Z, 11072252
-
Tortora G, Caputo R, Damiano V, Bianco R, Chen J, Agrawal S, Bianco AR, Ciardiello F. A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. Int J Cancer 2000, 88:804-809. 10.1002/1097-0215(20001201)88:5<804::AID-IJC19>3.0.CO;2-Z, 11072252.
-
(2000)
Int J Cancer
, vol.88
, pp. 804-809
-
-
Tortora, G.1
Caputo, R.2
Damiano, V.3
Bianco, R.4
Chen, J.5
Agrawal, S.6
Bianco, A.R.7
Ciardiello, F.8
-
17
-
-
0842347354
-
MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides
-
Bartel F, Harris LC, Wurl P, Taubert H. MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides. Mol Cancer Res 2004, 2:29-35.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 29-35
-
-
Bartel, F.1
Harris, L.C.2
Wurl, P.3
Taubert, H.4
-
18
-
-
0032975130
-
Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression
-
2230374, 10072445
-
Chen L, Lu W, Agrawal S, Zhou W, Zhang R, Chen J. Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. Mol Med 1999, 5:21-34. 2230374, 10072445.
-
(1999)
Mol Med
, vol.5
, pp. 21-34
-
-
Chen, L.1
Lu, W.2
Agrawal, S.3
Zhou, W.4
Zhang, R.5
Chen, J.6
-
19
-
-
0031939875
-
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
-
10.1073/pnas.95.1.195, 18173, 9419352
-
Chen L, Agrawal S, Zhou W, Zhang R, Chen J. Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage. Proc Natl Acad Sci USA 1998, 95:195-200. 10.1073/pnas.95.1.195, 18173, 9419352.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 195-200
-
-
Chen, L.1
Agrawal, S.2
Zhou, W.3
Zhang, R.4
Chen, J.5
-
20
-
-
4544379668
-
Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates
-
10.1093/nar/gkh820, 519114, 15371552
-
Shiraishi T, Nielsen PE. Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates. Nucleic Acids Res 2004, 32:4893-4902. 10.1093/nar/gkh820, 519114, 15371552.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 4893-4902
-
-
Shiraishi, T.1
Nielsen, P.E.2
-
21
-
-
0036655060
-
Alternative and aberrant splicing of MDM2 mRNA in human cancer
-
10.1016/S1535-6108(02)00091-0, 12150820
-
Bartel F, Taubert H, Harris LC. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2002, 2:9-15. 10.1016/S1535-6108(02)00091-0, 12150820.
-
(2002)
Cancer Cell
, vol.2
, pp. 9-15
-
-
Bartel, F.1
Taubert, H.2
Harris, L.C.3
-
22
-
-
0034009499
-
P76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53
-
10.1074/jbc.275.8.5733, 10681559
-
Perry ME, Mendrysa SM, Saucedo LJ, Tannous P, Holubar M. p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53. J Biol Chem 2000, 275:5733-5738. 10.1074/jbc.275.8.5733, 10681559.
-
(2000)
J Biol Chem
, vol.275
, pp. 5733-5738
-
-
Perry, M.E.1
Mendrysa, S.M.2
Saucedo, L.J.3
Tannous, P.4
Holubar, M.5
-
23
-
-
1042274013
-
Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma
-
10.1002/1097-0215(20010520)95:3<168::AID-IJC1029>3.0.CO;2-A, 11307150
-
Bartel F, Meye A, Wurl P, Kappler M, Bache M, Lautenschlager C, Grunbaum U, Schmidt H, Taubert H. Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. Int J Cancer 2001, 95:168-175. 10.1002/1097-0215(20010520)95:3<168::AID-IJC1029>3.0.CO;2-A, 11307150.
-
(2001)
Int J Cancer
, vol.95
, pp. 168-175
-
-
Bartel, F.1
Meye, A.2
Wurl, P.3
Kappler, M.4
Bache, M.5
Lautenschlager, C.6
Grunbaum, U.7
Schmidt, H.8
Taubert, H.9
-
24
-
-
0141706686
-
Tumor promotion by Mdm2 splice variants unable to bind p53
-
Fridman JS, Hernando E, Hemann MT, de Stanchina E, Cordon-Cardo C, Lowe SW. Tumor promotion by Mdm2 splice variants unable to bind p53. Cancer Res 2003, 63:5703-5706.
-
(2003)
Cancer Res
, vol.63
, pp. 5703-5706
-
-
Fridman, J.S.1
Hernando, E.2
Hemann, M.T.3
de Stanchina, E.4
Cordon-Cardo, C.5
Lowe, S.W.6
-
25
-
-
0035477551
-
Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs
-
60237, 11574678
-
Sazani P, Kang SH, Maier MA, Wei C, Dillman J, Summerton J, Manoharan M, Kole R. Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs. Nucleic Acids Res 2001, 29:3965-3974. 60237, 11574678.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 3965-3974
-
-
Sazani, P.1
Kang, S.H.2
Maier, M.A.3
Wei, C.4
Dillman, J.5
Summerton, J.6
Manoharan, M.7
Kole, R.8
-
26
-
-
0036903132
-
Systemically delivered antisense oligomers upregulate gene expression in mouse tissues
-
10.1038/nbt759, 12426578
-
Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, Bortner D, Kole R. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat Biotechnol 2002, 20:1228-1233. 10.1038/nbt759, 12426578.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 1228-1233
-
-
Sazani, P.1
Gemignani, F.2
Kang, S.H.3
Maier, M.A.4
Manoharan, M.5
Persmark, M.6
Bortner, D.7
Kole, R.8
-
27
-
-
0029295025
-
Solid-phase synthesis of peptide nucleic acids
-
10.1002/psc.310010304, 9222994
-
Christensen L, Fitzpatrick R, Gildea B, Petersen KH, Hansen HF, Koch T, Egholm M, Buchardt O, Nielsen PE, Coull J, et al. Solid-phase synthesis of peptide nucleic acids. J Pept Sci 1995, 1:175-183. 10.1002/psc.310010304, 9222994.
-
(1995)
J Pept Sci
, vol.1
, pp. 175-183
-
-
Christensen, L.1
Fitzpatrick, R.2
Gildea, B.3
Petersen, K.H.4
Hansen, H.F.5
Koch, T.6
Egholm, M.7
Buchardt, O.8
Nielsen, P.E.9
Coull, J.10
-
28
-
-
50249188836
-
Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain
-
10.1021/bc800068h, 18646838
-
Koppelhus U, Shiraishi T, Zachar V, Pankratova S, Nielsen PE. Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain. Bioconjug Chem 2008, 19:1526-1534. 10.1021/bc800068h, 18646838.
-
(2008)
Bioconjug Chem
, vol.19
, pp. 1526-1534
-
-
Koppelhus, U.1
Shiraishi, T.2
Zachar, V.3
Pankratova, S.4
Nielsen, P.E.5
-
29
-
-
34548178892
-
Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption
-
10.1038/nprot.2006.92, 17406290
-
Shiraishi T, Nielsen PE. Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption. Nat Protoc 2006, 1:633-636. 10.1038/nprot.2006.92, 17406290.
-
(2006)
Nat Protoc
, vol.1
, pp. 633-636
-
-
Shiraishi, T.1
Nielsen, P.E.2
-
30
-
-
33748433244
-
Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery
-
10.1016/j.coph.2006.04.004, 16860608
-
Mae M, Langel U. Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol 2006, 6:509-514. 10.1016/j.coph.2006.04.004, 16860608.
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 509-514
-
-
Mae, M.1
Langel, U.2
-
31
-
-
56649113066
-
Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle
-
10.1093/nar/gkn671, 2582604, 18842625
-
Ivanova GD, Arzumanov A, Abes R, Yin H, Wood MJ, Lebleu B, Gait MJ. Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle. Nucleic Acids Res 2008, 36:6418-6428. 10.1093/nar/gkn671, 2582604, 18842625.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 6418-6428
-
-
Ivanova, G.D.1
Arzumanov, A.2
Abes, R.3
Yin, H.4
Wood, M.J.5
Lebleu, B.6
Gait, M.J.7
|