메뉴 건너뛰기




Volumn 10, Issue , 2010, Pages

Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACRIDINE; CAMPTOTHECIN; MESSENGER RNA PRECURSOR; PEPTIDE NUCLEIC ACID; PROTEIN MDM2; PROTEIN P53; MDM2 PROTEIN, HUMAN; MESSENGER RNA; MUTAGENIC AGENT; RNA PRECURSOR;

EID: 77954047794     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-342     Document Type: Article
Times cited : (25)

References (31)
  • 1
    • 1942453441 scopus 로고    scopus 로고
    • Modification of alternative splicing by antisense therapeutics
    • 10.1089/154545704322988067, 15104897
    • Kole R, Vacek M, Williams T. Modification of alternative splicing by antisense therapeutics. Oligonucleotides 2004, 14:65-74. 10.1089/154545704322988067, 15104897.
    • (2004) Oligonucleotides , vol.14 , pp. 65-74
    • Kole, R.1    Vacek, M.2    Williams, T.3
  • 2
    • 11844256373 scopus 로고    scopus 로고
    • Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
    • 10.1073/pnas.0406700102, 544058, 15608067
    • Lu QL, Rabinowitz A, Chen YC, Yokota T, Yin H, Alter J, Jadoon A, Bou-Gharios G, Partridge T. Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. Proc Natl Acad Sci USA 2005, 102:198-203. 10.1073/pnas.0406700102, 544058, 15608067.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 198-203
    • Lu, Q.L.1    Rabinowitz, A.2    Chen, Y.C.3    Yokota, T.4    Yin, H.5    Alter, J.6    Jadoon, A.7    Bou-Gharios, G.8    Partridge, T.9
  • 3
    • 0036765860 scopus 로고    scopus 로고
    • Restoration of human beta-globin gene expression in murine and human IVS2-654 thalassemic erythroid cells by free uptake of antisense oligonucleotides
    • 10.1124/mol.62.3.545, 12181431
    • Suwanmanee T, Sierakowska H, Lacerra G, Svasti S, Kirby S, Walsh CE, Fucharoen S, Kole R. Restoration of human beta-globin gene expression in murine and human IVS2-654 thalassemic erythroid cells by free uptake of antisense oligonucleotides. Mol Pharmacol 2002, 62:545-553. 10.1124/mol.62.3.545, 12181431.
    • (2002) Mol Pharmacol , vol.62 , pp. 545-553
    • Suwanmanee, T.1    Sierakowska, H.2    Lacerra, G.3    Svasti, S.4    Kirby, S.5    Walsh, C.E.6    Fucharoen, S.7    Kole, R.8
  • 5
    • 0043133425 scopus 로고    scopus 로고
    • Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle
    • 10.1093/hmg/ddg196, 12874101
    • Gebski BL, Mann CJ, Fletcher S, Wilton SD. Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle. Hum Mol Genet 2003, 12:1801-1811. 10.1093/hmg/ddg196, 12874101.
    • (2003) Hum Mol Genet , vol.12 , pp. 1801-1811
    • Gebski, B.L.1    Mann, C.J.2    Fletcher, S.3    Wilton, S.D.4
  • 6
    • 0035800055 scopus 로고    scopus 로고
    • Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain
    • 10.1021/bi010263l, 11425312
    • Karras JG, Maier MA, Lu T, Watt A, Manoharan M. Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain. Biochemistry 2001, 40:7853-7859. 10.1021/bi010263l, 11425312.
    • (2001) Biochemistry , vol.40 , pp. 7853-7859
    • Karras, J.G.1    Maier, M.A.2    Lu, T.3    Watt, A.4    Manoharan, M.5
  • 8
  • 9
    • 0030582315 scopus 로고    scopus 로고
    • Induction of exon skipping of the dystrophin transcript in lymphoblastoid cells by transfecting an antisense oligodeoxynucleotide complementary to an exon recognition sequence
    • 10.1006/bbrc.1996.1375, 8806654
    • Pramono ZA, Takeshima Y, Alimsardjono H, Ishii A, Takeda S, Matsuo M. Induction of exon skipping of the dystrophin transcript in lymphoblastoid cells by transfecting an antisense oligodeoxynucleotide complementary to an exon recognition sequence. Biochem Biophys Res Commun 1996, 226:445-449. 10.1006/bbrc.1996.1375, 8806654.
    • (1996) Biochem Biophys Res Commun , vol.226 , pp. 445-449
    • Pramono, Z.A.1    Takeshima, Y.2    Alimsardjono, H.3    Ishii, A.4    Takeda, S.5    Matsuo, M.6
  • 11
    • 0003826861 scopus 로고    scopus 로고
    • Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides
    • 10.1038/15079, 10545916
    • Taylor JK, Zhang QQ, Wyatt JR, Dean NM. Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides. Nat Biotechnol 1999, 17:1097-1100. 10.1038/15079, 10545916.
    • (1999) Nat Biotechnol , vol.17 , pp. 1097-1100
    • Taylor, J.K.1    Zhang, Q.Q.2    Wyatt, J.R.3    Dean, N.M.4
  • 12
    • 0037130279 scopus 로고    scopus 로고
    • Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression
    • Mercatante DR, Kole R. Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression. Biochim Biophys Acta 2002, 1587:126-132.
    • (2002) Biochim Biophys Acta , vol.1587 , pp. 126-132
    • Mercatante, D.R.1    Kole, R.2
  • 13
    • 0034065833 scopus 로고    scopus 로고
    • Modification of alternative splicing pathways as a potential approach to chemotherapy
    • 10.1016/S0163-7258(99)00067-4, 10739878
    • Mercatante D, Kole R. Modification of alternative splicing pathways as a potential approach to chemotherapy. Pharmacol Ther 2000, 85:237-243. 10.1016/S0163-7258(99)00067-4, 10739878.
    • (2000) Pharmacol Ther , vol.85 , pp. 237-243
    • Mercatante, D.1    Kole, R.2
  • 14
    • 0032145989 scopus 로고    scopus 로고
    • The MDM2 gene amplification database
    • 10.1093/nar/26.15.3453, 147746, 9671804
    • Momand J, Jung D, Wilczynski S, Niland J. The MDM2 gene amplification database. Nucleic Acids Res 1998, 26:3453-3459. 10.1093/nar/26.15.3453, 147746, 9671804.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3453-3459
    • Momand, J.1    Jung, D.2    Wilczynski, S.3    Niland, J.4
  • 15
    • 0035186743 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms
    • Wang H, Nan L, Yu D, Agrawal S, Zhang R. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin Cancer Res 2001, 7:3613-3624.
    • (2001) Clin Cancer Res , vol.7 , pp. 3613-3624
    • Wang, H.1    Nan, L.2    Yu, D.3    Agrawal, S.4    Zhang, R.5
  • 16
    • 0034576957 scopus 로고    scopus 로고
    • A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer
    • 10.1002/1097-0215(20001201)88:5<804::AID-IJC19>3.0.CO;2-Z, 11072252
    • Tortora G, Caputo R, Damiano V, Bianco R, Chen J, Agrawal S, Bianco AR, Ciardiello F. A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. Int J Cancer 2000, 88:804-809. 10.1002/1097-0215(20001201)88:5<804::AID-IJC19>3.0.CO;2-Z, 11072252.
    • (2000) Int J Cancer , vol.88 , pp. 804-809
    • Tortora, G.1    Caputo, R.2    Damiano, V.3    Bianco, R.4    Chen, J.5    Agrawal, S.6    Bianco, A.R.7    Ciardiello, F.8
  • 17
    • 0842347354 scopus 로고    scopus 로고
    • MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides
    • Bartel F, Harris LC, Wurl P, Taubert H. MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides. Mol Cancer Res 2004, 2:29-35.
    • (2004) Mol Cancer Res , vol.2 , pp. 29-35
    • Bartel, F.1    Harris, L.C.2    Wurl, P.3    Taubert, H.4
  • 18
    • 0032975130 scopus 로고    scopus 로고
    • Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression
    • 2230374, 10072445
    • Chen L, Lu W, Agrawal S, Zhou W, Zhang R, Chen J. Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. Mol Med 1999, 5:21-34. 2230374, 10072445.
    • (1999) Mol Med , vol.5 , pp. 21-34
    • Chen, L.1    Lu, W.2    Agrawal, S.3    Zhou, W.4    Zhang, R.5    Chen, J.6
  • 19
    • 0031939875 scopus 로고    scopus 로고
    • Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
    • 10.1073/pnas.95.1.195, 18173, 9419352
    • Chen L, Agrawal S, Zhou W, Zhang R, Chen J. Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage. Proc Natl Acad Sci USA 1998, 95:195-200. 10.1073/pnas.95.1.195, 18173, 9419352.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 195-200
    • Chen, L.1    Agrawal, S.2    Zhou, W.3    Zhang, R.4    Chen, J.5
  • 20
    • 4544379668 scopus 로고    scopus 로고
    • Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates
    • 10.1093/nar/gkh820, 519114, 15371552
    • Shiraishi T, Nielsen PE. Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates. Nucleic Acids Res 2004, 32:4893-4902. 10.1093/nar/gkh820, 519114, 15371552.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4893-4902
    • Shiraishi, T.1    Nielsen, P.E.2
  • 21
    • 0036655060 scopus 로고    scopus 로고
    • Alternative and aberrant splicing of MDM2 mRNA in human cancer
    • 10.1016/S1535-6108(02)00091-0, 12150820
    • Bartel F, Taubert H, Harris LC. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2002, 2:9-15. 10.1016/S1535-6108(02)00091-0, 12150820.
    • (2002) Cancer Cell , vol.2 , pp. 9-15
    • Bartel, F.1    Taubert, H.2    Harris, L.C.3
  • 22
    • 0034009499 scopus 로고    scopus 로고
    • P76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53
    • 10.1074/jbc.275.8.5733, 10681559
    • Perry ME, Mendrysa SM, Saucedo LJ, Tannous P, Holubar M. p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53. J Biol Chem 2000, 275:5733-5738. 10.1074/jbc.275.8.5733, 10681559.
    • (2000) J Biol Chem , vol.275 , pp. 5733-5738
    • Perry, M.E.1    Mendrysa, S.M.2    Saucedo, L.J.3    Tannous, P.4    Holubar, M.5
  • 23
    • 1042274013 scopus 로고    scopus 로고
    • Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma
    • 10.1002/1097-0215(20010520)95:3<168::AID-IJC1029>3.0.CO;2-A, 11307150
    • Bartel F, Meye A, Wurl P, Kappler M, Bache M, Lautenschlager C, Grunbaum U, Schmidt H, Taubert H. Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. Int J Cancer 2001, 95:168-175. 10.1002/1097-0215(20010520)95:3<168::AID-IJC1029>3.0.CO;2-A, 11307150.
    • (2001) Int J Cancer , vol.95 , pp. 168-175
    • Bartel, F.1    Meye, A.2    Wurl, P.3    Kappler, M.4    Bache, M.5    Lautenschlager, C.6    Grunbaum, U.7    Schmidt, H.8    Taubert, H.9
  • 28
    • 50249188836 scopus 로고    scopus 로고
    • Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain
    • 10.1021/bc800068h, 18646838
    • Koppelhus U, Shiraishi T, Zachar V, Pankratova S, Nielsen PE. Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain. Bioconjug Chem 2008, 19:1526-1534. 10.1021/bc800068h, 18646838.
    • (2008) Bioconjug Chem , vol.19 , pp. 1526-1534
    • Koppelhus, U.1    Shiraishi, T.2    Zachar, V.3    Pankratova, S.4    Nielsen, P.E.5
  • 29
    • 34548178892 scopus 로고    scopus 로고
    • Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption
    • 10.1038/nprot.2006.92, 17406290
    • Shiraishi T, Nielsen PE. Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption. Nat Protoc 2006, 1:633-636. 10.1038/nprot.2006.92, 17406290.
    • (2006) Nat Protoc , vol.1 , pp. 633-636
    • Shiraishi, T.1    Nielsen, P.E.2
  • 30
    • 33748433244 scopus 로고    scopus 로고
    • Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery
    • 10.1016/j.coph.2006.04.004, 16860608
    • Mae M, Langel U. Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol 2006, 6:509-514. 10.1016/j.coph.2006.04.004, 16860608.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 509-514
    • Mae, M.1    Langel, U.2
  • 31
    • 56649113066 scopus 로고    scopus 로고
    • Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle
    • 10.1093/nar/gkn671, 2582604, 18842625
    • Ivanova GD, Arzumanov A, Abes R, Yin H, Wood MJ, Lebleu B, Gait MJ. Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle. Nucleic Acids Res 2008, 36:6418-6428. 10.1093/nar/gkn671, 2582604, 18842625.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6418-6428
    • Ivanova, G.D.1    Arzumanov, A.2    Abes, R.3    Yin, H.4    Wood, M.J.5    Lebleu, B.6    Gait, M.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.