Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene

British Journal of Pharmacology

Volumn 160, Issue 6, 2010, Pages 1443-1452

  Bilkei Gorzo, A ^a   Berner, J ^b   Zimmermann, J ^b   Wickstrom R ^b   Racz, I ^a   Zimmer, A ^a  

^a UNIVERSITY OF BONN   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

analgesia; conditioned place preference; knockout; morphine; naloxone; respiration; sensitization; substance P; withdrawal

Indexed keywords

MORPHINE; NALOXONE; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; NEUROKININ A; SUBSTANCE P; TACHYKININ;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; GASTROINTESTINAL MOTILITY; GENE; HOT PLATE TEST; KNOCKOUT MOUSE; MALE; MORPHINE ADDICTION; MORPHINE TOLERANCE; MOUSE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PLACE PREFERENCE; PRIORITY JOURNAL; RESPIRATION DEPRESSION; TAC1 GENE; TAIL FLICK TEST; WITHDRAWAL SYNDROME; ADDICTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; GENETICS; METABOLISM; PAIN; PAIN MEASUREMENT; RESPIRATORY FAILURE;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ADDICTIVE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NEUROKININ A; PAIN; PAIN MEASUREMENT; RESPIRATORY INSUFFICIENCY; SUBSTANCE P; TACHYKININS;

EID: 77954040630     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00757.x     Document Type: Article

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