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Volumn 16, Issue 25, 2010, Pages 7372-7375

Copper-mediated reductive amination of aryl halides with trimethylsilyl azide

Author keywords

Amination; Azides; Copper; Cross coupling; Reduction

Indexed keywords

ARYL AMINES; ARYL AZIDES; ARYL HALIDES; CHEMICAL EQUATIONS; CROSS-COUPLED; CROSS-COUPLING; CROSS-COUPLINGS; GOOD YIELD; REDUCTIVE AMINATION; TRIETHYLAMINES; TRIMETHYLSILYL AZIDE;

EID: 77954036948     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200903511     Document Type: Article
Times cited : (30)

References (44)
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    • note
    • 2 in DMA, the mixture turned pale blue. The color change was, presumably, due to the enhanced solubility of copper species caused by the formation of a complex with 2-aminoethanol. The dissolved copper species aids the increase in the reaction efficiency.
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    • note
    • Use of copper plate for the reaction of 4-bromobiphenyl was not effective (36%). Therefore, the morphological properties of the copper metal appear to be important for a smooth reaction.
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    • note
    • No formation of the regioisomers of aminobenzenes was observed, suggesting that the reaction does not proceed via hydroamination of a benzyne intermediate, which might be generated by the removal of hydrogen halide with base in heated polar aprotic solvents.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.