The effects of exogenous testosterone on spatial memory in rats

Central European Journal of Biology

Volumn 5, Issue 4, 2010, Pages 466-471

  Hodosy, Július ^a   Páleš, Ján ^a   Ostatníková, Daniela ^a   Celec, Peter ^a  

^a Physics and Informatics   (Slovakia)

Author keywords

Androgens; Sex differences; Spatial abilities; Testosterone; Water maze

Indexed keywords

RATTUS;

EID: 77954027737     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-010-0037-x     Document Type: Article

References (37)

1. Saccuzzo D. P., Craig A. S., Johnson N. E., Larson G. E., Gender differences in dynamic spatial abilities, Pers. Individ. Differ., 1996, 21, 599-607.
2. Kaufman S. B., Sex differences in mental rotation and spatial visualization ability: Can they be accounted for by differences in working memory capacity?, Intelligence, 2007, 35, 211-223.
3. Hugdahl K., Thomsen T., Ersland L., Sex differences in visuo-spatial processing: An fMRI study of mental rotation, Neuropsychologia, 2006, 44, 1575-1583.
4. Koscik T., O'Leary D., Moser D. J., Andreasen N. C., Nopoulos P., Sex differences in parietal lobe morphology: Relationship to mental rotation performance, Brain Cogn., 2009, 69, 451-459.
5. Parsons T. D., Larson P., Kratz K., Thiebaux M., Bluestein B., Buckwalter J. G., et al., Sex differences in mental rotation and spatial rotation in a virtual environment, Neuropsychologia, 2004, 42, 555-562.
6. Vederhus L., Krekling S., Sex differences in visual spatial ability in 9-year-old children, Intelligence, 1996, 23, 33-43.
7. Kerns K. A., Berenbaum S. A., Sex differences in spatial ability in children, Behav. Genet., 1991, 21, 383-396.
8. Grimshaw G. M., Sitarenios G., Finegan J. A. K., Mental rotation at 7 years: relations with prenatal testosterone levels and spatial play experiences, Brain Cogn., 1995, 29, 85-100.
9. Gurzu C., Artenie V., Hritcu L., Ciobica A., Prenatal testosterone improves the spatial learning and memory by protein synthesis in different lobes of the brain in the male and female rat, Cent. Eur. J. Biol., 2008, 3, 39-47.
10. Williams C. L., Barnett A. M., Meck W. H., Organizational effects of early gonadal secretions on sexual differentiation in spatial memory, Behav. Neurosci., 1990, 104, 84-97.
11. McCormick C. M., Furey B. F., Child M., Sawyer M. J., Donohue S. M., Neonatal sex hormones have 'organizational' effects on the hypothalamic-pituitary-adrenal axis of male rats, Dev. Brain Res., 1998, 105, 295-307.
12. Roof R. L., Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats, Behav. Brain Res., 1993, 53, 1-10.
13. Kozaki T., Yasukouchi A., Sex Differences on Components of Mental Rotation at Different Menstrual Phases, Int. J. Neurosci., 2009, 119, 59-67.
14. Diamond M., Clinical implications of the organizational and activational effects of hormones, Horm. Behav., 2009, 55, 621-632.
15. Ulubaev A., Lee D. M., Purandare N., Pendleton N., Wu F. C. W., Activational effects of sex hormones on cognition in men, Clin. Endocrinol., 2009, 71, 607-623.
16. Barrett-Connor E., Goodman-Gruen D., Patay B., Endogenous sex hormones and cognitive function in older men, J. Clin. Endocrinol. Metab., 1999, 84, 3681-3685.
17. Thilers P. P., MacDonald S. W. S., Herlitz A., The association between endogenous free testosterone and cognitive performance: A population-based study in 35 to 90 year-old men and women, Psychoneuroendocrinology, 2006, 31, 565-576.
18. Janowsky J. S., Oviatt S. K., Orwoll E. S., Testosterone influences spatial cognition in older men, Behav. Neurosci., 1994, 108, 325-332.
19. Cherrier M. M., Matsumoto A. M., Amory J. K., Asthana S., Bremner W., Peskind E. R., et al., Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment, Neurology, 2005, 64, 2063-2068.
20. Cherrier M. M., Matsumoto A. M., Amory J. K., Johnson M., Craft S., Peskind E. R., et al., Characterization of verbal and spatial memory changes from moderate to supraphysio logical increases in serum testosterone in healthy older men, Psychoneuroendocrinology, 2007, 32, 72-79.
21. Vaughan C., Goldstein F. C., Tenover J. L., Exogenous testosterone alone or with finasteride does not improve measurements of cognition in healthy older men with low serum testosterone, J. Androl., 2007, 28, 875-882.
22. Celec P., Ostatnikova D., Putz Z., Kudela M., The circalunar cycle of salivary testosterone and the visual-spatial performance, Bratisl. Lek. Listy, 2002, 103, 59-69.
23. Postma A., Meyer G., Tuiten A., van Honk J., Kessels R. P. C., Thijssen J., Effects of testosterone administration on selective aspects of object-location memory in healthy young women, Psychoneuroendocrinology, 2000, 25, 563-575.
24. Aleman A., Bronk E., Kessels R. P. C., Koppeschaar H. P. F., van Honk J., A single administration of testosterone improves visuospatial ability in young women, Psychoneuroendocrinology, 2004, 29, 612-617.
25. Hausmann M., Slabbekoorn D., van Goozen S. H. M., Cohen-Kettenis P. T., Gunturkun O., Sex hormones affect spatial abilities during the menstrual cycle, Behav. Neurosci., 2000, 114, 1245-1250.
26. Hasegawa N., Mochizuki M., Improved Effect of Pycnogenol (R) on Impaired Spatial Memory Function in Partial Androgen Deficiency Rat Model, Phytother. Res., 2009, 23, 840-843.
27. Sandstrom N. J., Kim J. H., Wasserman M. A., Testosterone modulates performance on a spatial working memory task in male rats, Horm. Behav., 2006, 50, 18-26.
28. Spritzer M. D., Gill M., Weinberg A., Galea L. A. M., Castration differentially affects spatial working and reference memory in male rats, Arch. Sex. Behav., 2008, 37, 19-29.
29. Moradpour F., Naghdi N., Fathollahi Y., Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats, Behav. Brain Res., 2006, 175, 223-232.
30. Hodosy J., Celec P., Ostatnikova D., Caganova M., Putz Z., Balaz P., et al., The effect of anastrozol on spatial memory in adult rats, Cent. Eur. J. Biol., 2009, 4, 186-189.
31. Osborne D. M., Edinger K., Frye C. A., Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats, Age, 2009, 31, 191-198.
32. Harooni H. E., Naghdi N., Sepehri H., Rohani A. H., Intra hippocampal injection of testosterone impaired acquisition, consolidation and retrieval of inhibitory avoidance learning and memory in adult male rats, Behav. Brain Res., 2008, 188, 71-77.
33. Naghdi N., Oryan S., Etemadi R., The study of spatial memory in adult male rats with injection of testosterone enanthate and flutamide into the basolateral nucleus of the amygdala in Morris water maze, Brain Res., 2003, 972, 1-8.
34. Naghdi N., Nafisy N., Majlessi N., The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water maze, Brain Res., 2001, 897, 44-51.
35. Naghdi N., Majlessi N., Bozorgmehr T., The effect of intrahippocampal injection of testosterone enanthate (an androgen receptor agonist) and anisomycin (protein synthesis inhibitor) on spatial learning and memory in adult, male rats, Behav. Brain Res., 2005, 156, 263-268.
36. Keene C. S., Bucci D. J., Damage to the retrosplenial cortex produces specific impairments in spatial working memory, Neurobiol. Learn. Mem., 2009, 91, 408-414.
37. Liu P., Bergin D. H., Differential effects of icv microinfusion of agmatine on spatial working and reference memory in the rat, Neuroscience, 2009, 159, 951-961.