Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats

Behavioural Brain Research

Volumn 175, Issue 2, 2006, Pages 223-232

  Moradpour, Farshad ^a,b   Naghdi, Nasser ^a   Fathollahi, Yaghob ^b  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

Anastrozole; CA1 region; Estradiol valerat; Hippocampus; Testosterone enanthate

Indexed keywords

ANASTROZOLE; DIMETHYL SULFOXIDE; ESTRADIOL VALERATE; TESTOSTERONE ENANTATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CANNULATION; DOSE RESPONSE; DRUG EFFECT; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; MEMORY; MENTAL PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL DISCRIMINATION; TRAINING;

ANALYSIS OF VARIANCE; ANIMALS; AROMATASE INHIBITORS; DISCRIMINATION LEARNING; ESCAPE REACTION; ESTRADIOL; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICROINJECTIONS; NITRILES; RATS; RATS, WISTAR; REACTION TIME; SPATIAL BEHAVIOR; STATISTICS, NONPARAMETRIC; TESTOSTERONE; TRIAZOLES;

EID: 33750996740     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.08.037     Document Type: Article

References (68)

1. Adams M.M., Morrison J.H., and Gore A.C. N-methyl-d-aspartate receptor mRNA levels change during reproductive senescence in the hippocampus of female rats. Exp Neurol 170 (2001) 171-179
2. Ball M. the female sex cycle as a factor in learning in the rat. Am J Pysiol 78 (1926) 533-536
3. Balthazart J., and Foidart A. Brain aromatase and the control of male sexual behavior. J Steroid Biochem Mol Biol 44 (1993) 521-540
4. Balthazart J., Cornil C.A., Taziaux M., Charlier T.D., Bajllien M., and Ball G.F. Rapid changes in production and behavioral action of estrogen. Neuroscience 138 (2006) 783-791
5. Balthazart J., Baillien M., Charlier T., Cornil C., and Ball G. Multiple mechanisms control brain aromatase activity at the genomic and non-genomic level. J Steroid Biochem Mol Biol 86 (2003) 367-379
6. Balthazart J. Steroid metabolism and the activation of social behavior. In: Balthazart J. (Ed). advances in comparative and environmental physiology vol. 3 (1989), Springer-Verlag, Berlin 105-159
7. Berry B., Berry R., and Gallagher M. Spatial learning and memory at defined points of the estrous cycle: effects on performance of a hippocampal-dependent task. Behav Neurosc 111 2 (1997) 267-274
8. Beyer C. Estrogen and the developing mammalian brain. Anat Embryol 199 (1999) 379-390
9. Boon W.C., Diepstraten J., Burg J.v.d., Margaret E.E., Evan J., and Buuse M. Hippocampal NMDA receptor subunit expression and watermaze learning in estrogen deficient female mice. Mol Brain Res 140 (2005) 127-132
10. Choi J., and Silverman I. The relationship between testosterone and route-learning strategies in human. Brain Cogn 50 (2002) 116-120
11. Debonnel G., Bergeron R., and Montigny C. Potentiation by dehydro-epiandrosterone of the neuronal response to N-methyl-d-aspartate in ntheCA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors. J Endocrinol 150 Suppl. (1996) S33-S42
12. Diano S., Naftolin F., and Horvath T.L. Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study. Endocrinology 138 2 (1997) 778-789
13. Edinger K.L., Lee B., and Frye C.A. Mnemonic effects of testosterone and its 5alpha-reduced metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacol Biochem Behav 78 3 (2004) 559-568
14. Elissa JC, Janice MJ. Acute administration of estrogen and projestrone impairs the acquisition of the spatial Morris water maze in ovariectomized rats. Horm. Behav. 2000;38:234-42.
15. Flood J.F., Farr S.A., and Kaiser F.E. Age-related decrease of plasma testosterone in SAMP8 mice: replacement improves age-relatedimpairment of learning and memory. Physiol Behav 57 4 (1995) 669-673
16. Flood J.F., and Roberts E. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 118 (1988) 178-181
17. Frye C.A., and Sturgis J.D. Neurosteroids affect spatial/reference, working, and long-term memory of female rats. Neurobiol Learn Membr 64 (1995) 83-96
18. Furukuwa A., Yasumatsu N., Kimoto T., Enami T., Suzuki K., Tanabe N., et al. Hippocampal cytochorome P450 synthesize brain neurostroids which are paracrine neuromodulators of synaptic signal transduction. Biochim Biophys Acta 1619 (2003) 301-316
19. Galea L.A.M., Kavaliers M., Ossenkopp K.P., and Hampson E. Gonadal hormone levels and spatial learning performance in the Morris water maze in male and female meadow voles, Microtus pennsylvanicus. Horm Behav 29 (1995) 106-125
20. Gelea L.A.M., Wide J.K., Paine T.A., Holmes M.M., Floresco S.B., and Ormerod B.K. High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have no effects on working memory. Behav Brain Res 126 (2001) 115-126
21. Goudsmit C., and Kimura D. The relationship between testosterone levels and cognitive ability patterns. Psychoneuroendocrinology 16 (1991) 323-334
22. Goudsmit E., Van De Poll N.E., and Swaab D.F. Testosterone fails to reverse spatial memory decline in aged rats and impairs retention in young and middle-aged animals. Behav Neural Biol 53 (1990) 6-20
23. Hampson E., and Kimura D. Sex differences and hormonal influences on cognitive function in humans. In: Becker J.B. (Ed). Behavioral endocrinology (1992), MIT Press, Cambridge, MA 357-398
24. Hampson E. Spatial cognition in humans: possible modulation by androgens and estrogens. J Psychol Neurosci 20 (1995) 397-404
25. Handa R.J., Hejna G.M., and Lorens S.A. Androgen inhibits neuro-transmitter turnover in the medical prefrontal cortex of the rat following exposure to a novel environment. Brain Res 751 (1997) 131-138
26. Hiltunen M., Iivonen S., and Soininen H. Aromatase enzyme and Alzheimer's disease. Miner Endocrinol 31 1 (2006) 61-73
27. Hojo Y., Hattori T.-A., Enami T., Furukawa A., Suzuki K., Ishii H.-T., et al. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochoromes P45017β and P450 aromatase localized in neuros. PANS 101 (2004) 865-870
28. Jahr C.E. Drooling and stuttering, or do synapses whisper?. Trends Neurosci 26 (2003) 7-9
29. Janowsky J.S., Oviatt S.K., and Orwoll E.S. Testosterone influences spatial cognition in older men. Behav Neurosci 108 2 (1994) 325-332
30. Jarvik L.F. Human intelligence: sex differences. Acta Genet Med Gemellol 34 (1998) 183-198
31. Joseph R., Hess S., and Birecree E. Effect of hormone manipulations and exploration on sex differences in maze learning. Behav Biol 24 (1978) 364-377
32. Juraska J.M., Henderson V., and Muller J. Differential rearing experience, gender, and radial maze performance. Dev Psyhobiol 17 (1984) 209-215
33. Kerr J.E., Allore R.J., Beck S.E., and Handa R.J. Distribution and hormonal regulation of androgen receptor (AR) and AR messenger RNA in the rat hippocampus. Endocrinology 136 (1995) 3213-3221
34. Kerr J.E., Beck S.E., and Handa R.J. Androgens selectively modulate c-fos messenger RNA induction in the rat hippocampus following novelty. Neuroscience 74 3 (1996) 757-766
35. Kransoff A., and Weston L.M. Puberal status and sex differences: actively and maze behavior in rats. Dev Psychobiol 9 (1976) 261-269
36. Kritzer M.F., McLaughlin P.J., Smirlis T., and Robinson J.K. Gonadectomy impairs T-maze acquisition in adult male rats. Horm Behav 39 2 (2001) 167-174
37. Lapchak P.A., Araujo D.M., Quirion R., and Beaudet A. Chronic estradiol treatment alters central cholinergic function in the female rat: effect on choline acetyltransferase activity, acetylcholine conthe tent, and nicotinic autoreceptor function. Brain Res 525 (1990) 249-255
38. Lephart E.D. A review of brain aromatase cytochrome P450. Brain Res Rev 22 (1996) 1-26
39. Liisa A.M., Tiffany T.-Y., Jesse A., and Alasdair M. High level of estradiol impair spatial performance in the Morris water maze and increase "depressive-like" behaviors in the female meadow vole. Physiol Behav 77 (2002) 217-225
40. Maxwell J.W., Caroake J.W., and Biddle A.P. Sex differences in the comprehension of spatial orientation. J Psychol 91 (1975) 127-131
41. Mccarthy M.M. Functional significance of steroid modulation of GABAergic neurotransmission: analysis at the behavioral, cellular, and molecular levels. Horm Behav 29 (1995) 131-140
42. Mukai H., Takata N., Ishii H.-t., Tanabe N., Hojo Y., Furukawa, et al. Hippocampal synthesis of estrogens and androgens which are paracrine modulators of plasticity. Synaptocrinology 138 3 (2006) 746-757
43. Naftolin F., and Maclusky N.J. Aromatization hypothesis revisited. In: Serio M., Motta M., Zanisi M., and Martini L. (Eds). Sexual differentiation: basic and clinical aspects (1984), Raven Press, New York 79-91
44. Naftolin F. Metabolism of steroids in the brain. In: James V.H.T. (Ed). Excerpta medica international congress series (1976), Excerpta Medica, Amsterdam 29-33
45. Naghdi N., Mohaddess G., Khamnei S., and Arjomand M. No significant differences between intact and testosterone depleted or administrated male rats in spatial learning and memory. Iran J Pharmaceut Res 1 (2005) 29-32
46. Naghdi N., Nafisy N., and Majlessi N. The effects of intra-hippocampal testosterone and flutamide on spatial localization in Morris water maze. Brain Res 897 (2001) 44-51
47. Naghdi N., Oryan S., and Etemadi R. The study of spatial memory in adult male rats with injection of testosterone enanthate and flutamide into the basolateral nucleus of the amygdale in Morris water maze. Brain Res 972 (2003) 1-8
48. Orchinik M., and McEwen B. Novel and classical actions of neuroactine steroids. Res Biochem Inc 4 1 (1993) 1-7
49. Packard M.G. Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats. Neuroreport 8 14 (1997) 3009-3013
50. Packard M.G., Kohlmaier J.R., and Alexander G.M. Post-training intrahippocampal estradiol injections enhance spatial memory in male rats: interaction with cholinergic systems. Behav Neurosci 110 3 (1996) 626-632
51. Packard M.G. Post-training estrogen and memory modulation. Horm Behav 34 (1998) 126-139
52. Packard M.G. Post-training intrahippocampal estradiol injections enhance spatial memory in male rats: interaction with cholinergic systems. Behav Neurosci 110 3 (1996) 626-632
53. Paech K., Webb P., Kuiper G.G.J.M., Nilsson S., Gustafsson J.A., Kushner P.J., et al. Differential ligand activation,of estrogen receptors ERα and ERβ at AP1 sites. Science 277 (1997) 1508-1510
54. Pereyra F.V., Arancibia S.R., Castio A.L.Del., and Rivas S.S. Modulation of short-term and long-term memory by steroid sexual hormones. Life Sci 56 914 (1995) 225-260
55. Poucet B., Save E., and Lenck-Santini P.-P. Sensory and memory properties of hippocampal place cells. Rev Neurosci 11 (2000) 95-111
56. Rhodes M.E., Pui-Kai L.I., and Burke A.M. Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition. Brain Res 773 (1997) 28-32
57. Rhodes M.E., Pui-Kai L.I., Flood J.F., and Johnson D.A. Enhancement of hippocampal acetylcholine release by the neurosteroid dehydro-epiandrosterone sulfate: an in vivo microdialysis study. Brain Res 733 (1996) 284-286
58. Riedel G., Micheau J., Lam A.G., Roloff E., Martin S.J., Bridge H., et al. Reversible neural inactivation reveals hippocampal participation in several memory processes. Nat Neurosci 2 (1999) 898-905
59. Rubinow D.R., and Schmidt P.J. Androgens, brain, and behavior. Am J Psych 153 (1996) 947-958
60. Russell D.R., Daniel S., Aaron M.J., Ilia N.K., Janice E.T., and Bruce S.M. Dihydrotestosterone increases hippocampal N-methyl-d-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats. Endocrinology 146 4 (2005) 2091-2097
61. Simpson E.R., Mahendroo M.S., Means G.D., Kilgore M.W., Hinshelwood M.M., Graham-lorence S., et al. Aromatase cytochorome P450, the enzyme responsible fir estrogen biosynthesis. Endocr Rev 15 (1994) 342-355
62. Sternbach H. Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psych 155 (1998) 203-218
63. Vazquez-Pereyra F., Rivas-Arancibia S., and Castillo A.L.D. Modulation of short-term and long-term memory by steroid sexual hormones. Life Sci 56 (1995) 255-260
64. Warren S.G., and Juraska J.M. Spatial and non-spatial learning across the rat estrous cycle. Behav Neurosci 111 (1997) 259-266
65. Williams C.L., Barnett A.M., and Meck W.H. Organizational effects of early gonadal secretion on sexual differentiation in spatial memory. Behav Neurosci 104 (1990) 84-97
66. Wolf O.T., and Kirschbaum C. Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Horm Behav 41 (2002) 259-266
67. Zamani M.R., Levy W.B., and Desmond N.L. Estradiol increased delayed, N-methyl-d-aspartate receptor-mediated excitation in the hippocampal CA1 region. Physiol Behav 77 (2002) 217-225
68. Zamani M.R., Desmond N.L., and Levy W.B. Estradiol modulates longterm synaptic depression in female rat hippocampus. J Neurophysiol 84 (2000) 1800-1808