Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men

Psychoneuroendocrinology

Volumn 32, Issue 1, 2007, Pages 72-79

  Cherrier, M M ^a,b   Matsumoto, A M ^a,b   Amory, J K ^a   Johnson, M ^a,b   Craft, S ^a,b   Peskind, E R ^a,b   Raskind, M A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Education and Clinical Center   (United States)

Author keywords

Aging; Cognition; Dose response; Estradiol; Human; Testosterone

Indexed keywords

PLACEBO; SODIUM CHLORIDE; TESTOSTERONE; TESTOSTERONE ENANTATE;

AGED; AGING; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFECT; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLITE; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PERFORMANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPATIAL MEMORY; TESTOSTERONE BLOOD LEVEL; VERBAL MEMORY;

AGED; AGED, 80 AND OVER; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ESTRADIOL; HUMANS; MALE; MEMORY; MIDDLE AGED; PLACEBOS; TESTOSTERONE; VERBAL BEHAVIOR;

EID: 33845665357     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2006.10.008     Document Type: Article

References (33)

1. Alexander G.M., Swerdloff R.S., Wang C., Davidson T., McDonald V., Steiner B., and Hines M. Androgen-behavior correlations in hypogonadal men and eugonadal men. II. Cognitive abilities. Horm. Behav. 33 2 (1998) 85-94
2. Barrett-Connor E., Goodman-Gruen D., and Patay B. Endogenous sex hormones and cognitive function in older men. J. Clin. Endocrinol. Metab. 84 10 (1999) 3681-3685
3. Basaria S., and Dobs A.S. Risks versus benefits of testosterone therapy in elderly men. Drugs Aging 15 2 (1999) 131-142
4. Bhasin S., Woodhouse L., Casaburi R., Singh A.B., Bhasin D., Berman N., Chen X., Yarasheski K.E., Magliano L., Dzekov C., Dzekov J., Bross R., Phillips J., Sinha-Hikim I., Shen R., and Storer T.W. Testosterone dose-response relationships in healthy young men. Am. J. Physiol. Endocrinol. Metab. 281 6 (2001) E1172-E1181
5. Cherrier M.M., Asthana S., Baker L.D., Plymate S., Matsumoto A., Peskind E., Raskind M.A., Brodkin K., Bremner W., Petrova A., Latendresse S., and Craft S. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology 57 (2001) 80-88
6. Cherrier M.M., Anawalt B.D., Herbst J.K., Amory J.K., Craft S., Matsumoto A., and Bremner W.J. Cognitive effects of short term manipulation of serum sex steroids in healthy young men. J Clin. Endocrinol. Metab. 87 (2002) 3090-3096
7. Cherrier M.M., Craft S., and Matsumoto A.H. Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report. J. Androl. 24 4 (2003) 568-576
8. Cherrier M.M., Matsumoto A.M., Amory J.K., Ahmed S., Bremner W., Peskind E.R., Raskind M.A., Johnson M., and Craft S. The role of aromatization in testosterone supplementation: effects on cognition in older men. Neurology 64 (2005) 290-296
9. Folstein M.F., Folstein S.E., and McHugh P.R. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975) 189-198
10. Gouchie C., and Kimura D. The relationship between testosterone levels and cognitive ability patterns. Psychoneuroendocrinology 16 4 (1991) 323-334
11. Gray P.B., Singh A.B., Woodhouse L.J., Storer T.W., Casaburi R., Dzekov J., Dzekov C., Sinha-Hikim I., and Bhasin S. Dose-dependent effects of testosterone on sexual function, mood and visuospatial cognition in older men. J. Clin. Endocrinol. Metab. 90 7 (2005) 3838-3846
12. Hampson E., and Moffat S.D. Is testosterone related to spatial cognition and hand preference in humans?. Brain and Cognition 26 (1994) 255-266
13. Haren M.T., Wittert G.A., Chapman I.M., Coates P., and Morley J.E. Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status. Maturitas 50 2 (2005) 124-133
14. Hogervorst E., Bandelow S., and Moffat S.D. Increasing testosterone levels and effects on cognitive functions in elderly men and women: a review. Current Drug Targets- CNS & Neurological Disorders 4 (2005) 531-540
15. Janowsky J.S., Oviatt S.K., and Orwoll E.S. Testosterone influences spatial cognition in older men. Behav. Neurosci. 108 2 (1994) 325-332
16. Janowsky J.S., Chavez B., and Orowoll E. Sex steroids modify working memory. J. Cogn. Neurosci. 12 3 (2000) 407-414
17. Kenny A.M., Bellantonio S., Gruman C.A., Acosta R.D., and Prestwood K.M. Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels. J. Gerontol. A Biol. Sci. Med. Sci. 57 5 (2002) M321-M325
18. Kenny A.M., Fabregas G., Song C., Biskup B., and Bellantonio S. Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss. J. Gerontol. A Biol. Sci. Med. Sci. 59 1 (2004) 75-78
19. Lezak M.D. Neuropsychologcial Assessment. third ed (1995), Oxford University Press, Oxford
20. Liverman C.T., and Blazer D.G. Testosterone and Aging: Clinical Research Directions. Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy (2004), National Academies Press
21. Matsumoto A.M. Andropause: clinical implications of the decline in serum testosterone levels with aging in men. J. Gerontol. A Biol. Sci. Med. Sci. 57 2 (2002) M76-M99
22. Mattis S. Dementia Rating Scale (1988), Psychological Assessment Resources, Inc.
23. Moffat S.D., and Hampson E. A curvilinear relationship between testosterone and spatial cognition in humans: possible influence of hand preference. Psychoneuroendocrinology 21 3 (1996) 323-337
24. Moffat S.D., Zonderman A.B., Metter E.J., Blackman M.R., Harman S.M., and Resnick S.M. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J. Clin. Endocrinol. Metab. 87 11 (2002) 5001-5007
25. Moscovitch M. Cognitive resources and dual-task interference effects on retrieval in normal people: The role of the frontal lobes and medial temporal cortex. Neuropsychology 8 (1994) 524-534
26. Muller M., Aleman A., Grobbee D.E., de Haan E.H., and van der Schouw Y.T. Endogenous sex hormone levels and cognitive function in aging men. Neurology 64 (2005) 866-871
27. O'Connor D.B., Archer J., Hair W.M., and Wu F.C. Activational effects of testosterone on cognitive function in men. Neuropsychologia 39 13 (2001) 1385-1394
28. Shute V.J., Pellegrino J.W., Hubert L., and Reynolds R.W. The relationship between androgen levels and human spatial abilities. Bull. Psychonom. Soc. 21 (1983) 465-468
29. Sih R., Morley J.E., Kaiser F.E., Perry H.M., Patrick P., and Ross C. Testosterone replacement in older hypogonadal men: A 12 month randomized controlled trial. J. Clin. Endocrinol. Metab. 82 6 (1997) 1661-1667
30. Swerdloff R.S., and Wang C. Androgens and aging men. Exp. Gerontol. 28 (1993) 435-446
31. Tiernan K., Schenk K., Shimonova M., Schollaert D., Swadberg D., Boorkman P., and Cherrier M.M. An examination of the validity and reliability of a novel route test in healthy older adults and AD patients. Clin. Neuropsychol. 8 1 (2004) 39-42
32. Wolf O., Pruet R., Hellhammer D.H., Kudielka B.M., Schurmeyer T.H., and Kirschbaum C. Testosterone and cognition in elderly men: a single testosterone injection blocks the practice effect in verbal fluency, but has no effect on spatial or verbal memory. Biol. Psychiatry 47 (2000) 650-654
33. Yaffe K., Lui L.Y., Zmuda J., and Cauley J. Sex hormones and cognitive function in older men. J. Am. Geriatr. Soc. 50 4 (2002) 707-712