Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 16, 2010, Pages 1090-1101

  Cleave, Jayda ^a   Willson, Philip J ^a   Town, Jennifer ^b   Gordon, John R ^b,c  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c ROYAL UNIVERSITY HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DUST EXPOSURE; INFLAMMATION; LONG TERM EXPOSURE; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PIG FARMING; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY AIRFLOW; RESPIRATORY TRACT INJURY;

ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; DUST; ENZYME-LINKED IMMUNOSORBENT ASSAY; HOUSING, ANIMAL; INFLAMMATION; INHALATION EXPOSURE; INTERLEUKIN-1BETA; INTERLEUKIN-6; METHACHOLINE CHLORIDE; MICE; PLETHYSMOGRAPHY; RESPIRATORY SYSTEM; RISK ASSESSMENT; SWINE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MUS; SUIDAE;

EID: 77953973999     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2010.482916     Document Type: Article

References (40)

1. Baggiolini, M. 1998. Chemokines and leukocyte traffic. Nature 392:565-568.
2. Charavaryamath, C., Janardhan, K. S., Townsend, H. G., Willson, P., and Singh, B. 2005. Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness. Respir. Res. 6:50.
3. Charavaryamath, C., Juneau, V., Suri, S. S., Janardhan, K. S., Townsend, H., and Singh, B. 2008. Role of Toll-like receptor 4 in lung inflammation following exposure to swine barn air. Exp. Lung Res. 34:19-35.
4. Chénard, L., Senthilselvan, A., Grover, V. K., Kirychuk, S. P., Lawson, J. A., Hurst, T. S., and Dosman, J. A. 2007. Lung function and farm size predict healthy worker effect in swine farmers. Chest 131:245-254.
5. Colditz, I. G., and Movat, H. Z. 1984. Desensitization of acute inflammatory lesions to chemotaxins and endotoxin. J. Immunol. 133:2163-2168.
6. Cook, D. N., Wang, S., Wang, Y., Howles, G. P., Whitehead, G. S., Berman, K. G., Church, T. D., Frank, B., Gaspard, R., Yu, Y., Paigen, B. J., Quachenbush, J., and Schwartz, D. A. 2003. Identification of novel genes mediating inate immunity. Fifth International Symposium, Future of Rural Peoples: Rural Economy, Healthy People, Environment, Rural Communities, October 19-23, 2003, Saskatoon, Saskatchewan, Canada.
7. Cybulsky, M. I., McComb, D. J., and Movat, H. Z. 1988. Neutrophil leukocyte emigration induced by endotoxin. Mediator roles of IL-1 and TNF. J. Immunol. 140:3144-3149.
8. Doerschuk, C. M., Burns, A. R., Kumasaka, T., Shoberg, D. S., Wiebke, J. L., and Smith, K. M. 1996. Adhesion molecules in bacterial pneumonia. In Adhesion molecules and the lung, eds. P. A. Ward and J. C. Fantone, in Lung biology in health and disease, exec. ed. C. Lenfant, vol.89, pp. 311-320. CRC Press: Boca Raton, FL.
9. Dosman, J. A., Fukushima, Y., Senthilselvan, A., Kirychuk, S. P., Lawson, J. A., Pahwa, P., Cormier, Y., Hurst, T., Barber, E. M., and Rhodes, C. S. 2006. Respiratory response to endotoxin and dust predicts evidence of inflammatory response in volunteers in a swine barn. Am. J. Ind. Med. 49:761-766.
10. Dosman, J. A., Senthilselvan, A., Kirychuk, S. P., Lemay, S., Barber, E. M., Willson, P., Cormier, Y., and Hurst, T. S. 2000. Positive human health effects of wearing a respirator in a swine barn. Chest 118:852-860.
11. Doyle, N. A., Bhagwan, S. D., Meek, B. B., Kutkoski, G. J., Steeber, D. A., Tedder T. F., and Doerschuk, C. M. 1997. Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice. J. Clin. Invest. 99:526-533
12. Gordon, J. R., Li, F., Nayyar, A., Xiang, J., and Zhang, X. 2005. CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma. J. Immunol. 175:1516-1522.
13. Larsson, K., Eklund, A., Malmberg, P., and Belin, L. 1992. Alterations in bronchoalveolar lavage fluid but not in lung function and bronchial responsiveness in swine confinement workers. Chest 101:767-774.
14. Larsson, K., Malmberg, P., and Eklund, A. 1994. Acute exposure to swine dust causes airway inflammation and bronchial hyperresponsiveness. Am. J. Ind. Med. 25:57-58.
15. Mackiewicz, B. 1998. Study on exposure of pig farm workers to bioaerosols, immunologic reactivity and health effects. Ann. Agric. Environ. Med. 5:169-175.
16. Mayeux, P. R. 1997. Pathobiology of lipopolysaccharide. J. Toxicol. Environ. Health 51: 415-435.
17. Michel, O., Nagy, A., Schroeven, M., Duchateau, J., Neve, J., Fondu, P., and Sergysels, R. 1997. Dose-response relationship to inhaled endotoxin in normal subjects. Am. J. Crit. Care Med. 156:1157-1164.
18. Mueller-Anneling, L. J., O'Neill, M. E., and Thorne, P. S. 2006. Biomonitoring for assessment of organic dust-induced lung inflammation. Eur. Respir. J. 27:1096-1102.
19. O'Sullivan, S., Dahlen, S.E., Larsson, K., Larsson, B.M., Malmberg, P., Kumlin, M., and Palmberg, L. 1998. Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine. Thorax 53:1041-1046.
20. Park, H., Jung, K., Kang, K., Nahm, D., Cho, S., and Kim, Y. 1999. Enhanced basophil histamine release and neutrophil chemotactic activity predispose grain dust-induced airway obstruction. Clin. Exp. Allergy 29:543-549.
21. Pedersen, B., Iversen, M., Bungaard Larsen, B., and Dahl, R. 1996. Pig farmers have signs of bronchial inflammation and increased numbers of lymphocytes and neutrophils in BAL fluid. Eur. Respir. J. 9:524-530.
22. Poole, J. A.,Wyatt, T. A., Oldenburg, P. J., Elliott, M. K., West, W. W., Sisson, J. H., Von Essen, S. G., and Romberger, D. J. 2009. Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L1085-L1095.
23. Romberger, D. J., Bodlak, V., Von Essen, S. G., Mathisen, T., and Wyatt, T. A. 2002. Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation. J. Appl. Physiol. 93: 289-296.
24. Salem, H., and Katz, S. A., eds. 2006. Inhalation toxicology, 2nd ed. Boca Raton, FL: CRC Press.
25. Schneider, A. M., Li, F., Zhang, X., and Gordon, J. R. 2001. Induction of pulmonary allergenspecific IgA responses or airway hyperresponsiveness in the absence of allergic lung disease following sensitization with limiting doses of ovalbumin-alum. Cell. Immunol. 212:101-109.
26. Senthilselvan, A., Dosman, J. A., Kirychuk, S. P., Barber, E. M., Rhodes, C. S., Zhang, Y., and Hurst, T. S. 1997. Accelerated lung function decline in swine confinement workers. Chest 111:1733-1741.
27. Senthilselvan, A., Dosman, J. A., Chénard, L., Burch, L. H., Predicala, B. Z., Sorowski, R., Schneberger, D., Hurst, T., Kirychuk, S., Gerdts, V., Cormier, Y., Rennie, D. C., and Schwartz, D. A. 2009. Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility. J. Allergy Clin. Immunol. 123:1034-1040.
28. Sundblad, B.-M., Palmberg, L., and Larsson, K. 2002. Bronchial responsiveness to eucapnic hyperventilation and methacholine following exposure to organic dust. Chest 122:363-368.
29. Sundblad, B.-M., von Scheele, I., Palmberg, L., Olsson, M., and Larsson, K. 2009. Repeated exposure to organic material alters inflammatory and physiological airway responses. Eur. Respir. J. 34:80-88.
30. Thorn, J., and Rylander, R. 1998. Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique. Thorax 53:1047-1052.
31. Ulich, T. R., Watson, L. R., Yin, S. M., Guo, K. Z., Wang, P., Thang, H., and del Castillo, J. 1991. The intratracheal administration of endotoxin and cytokines. I. Characterization of LPS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1-, and TNF-induced inflammatory infiltrate. Am. J. Pathol. 138:1485-1496.
32. Van Zee, K. J., Fischer, E., Hawes, A. S., Hebert, C. A., Terrell, T. G., Baker, J. B., Lowry, S. F., and Moldawer, L. L. 1992. Effects of intravenous IL-8 administration in nonhuman primates. J. Immunol. 148:1746-1752.
33. Vijayaraghavan, R., Scaper, M., Thompson, R., Stock, M. F., Boylstein, L. A., Lou, J. E., and Alarie, Y. 1994. Computer assisted recognition of the effects of airborne chemicals acting at different areas of the respiratory tract in mice. Arch. Toxicol. 68:490-499.
34. Wang, Z., Larsson, K., Palmberg, L., Malmberg, P., Larsson, P., and Larsson, L. 1997. Inhalation of swine dust induces cytokine release in the upper and lower airways. Eur. Respir. J. 10:381-387.
35. Wang, Z., Malmberg, P., Larsson, P., Larsson, B. M., and Larsson, K. 1996. Time course of interleukin-6 and tumor necrosis factoralpha increase in serum following inhalation of swine dust. Am. J. Respir. Crit. Care Med. 153:147-152.
36. Wyatt, T. A., Sisson, J. H., Von Essen, S. G., Poole, J. A., and Romberger, D. J. 2008. Exposure to hog barn dust alters airway epithelial ciliary beating. Eur. Respir. J. 31:1249-1255.
37. Zeece, M. G. 1999. Identification of an IgEbinding region in soybean acidic glycinin G1. Food Agric. Immunol. 11:83-90.
38. Zejda, J. E., Hurst, T. S., Rhodes, C. S., Barber, E. M., McDuffie, H. H., and Dosman, J. A. 1993. Respiratory health of swine producers. Focus on young workers. Chest 103: 702-709.
39. Zhao, X., Town, J. R., Li, F., Zhang, X., Cockcroft, D. W., and Gordon, J. R. 2009. ELR-CXC chemokine receptor antagonism targets inflammatory responses at multiple levels. J. Immunol. 182:3213-3222.
40. Zhou, C., Hurst, T. S., Cockcroft, D. W., and Dosman, J. A. 1991. Increased airways responsiveness in swine farmers. Chest 99:941-944.