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Volumn 51, Issue 6, 2010, Pages 959-966

Molecular imaging of changes in the prevalence of vascular endothelial growth factor receptor in sunitinib-treated murine mammary tumors

Author keywords

99mTcscVEGF; Imaging; SPECT; Sunitinib; Vegf receptors

Indexed keywords

BEVACIZUMAB; CD31 ANTIGEN; RADIOPHARMACEUTICAL AGENT; SINGLE CHAIN VASCULAR ENDOTHELIAL GROWTH FACTOR TC 99M; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2; DIAGNOSTIC AGENT; INDOLE DERIVATIVE; PYRROLE DERIVATIVE; TECHNETIUM; VASCULOTROPIN A;

EID: 77953953880     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.072199     Document Type: Article
Times cited : (27)

References (40)
  • 1
    • 33746548452 scopus 로고    scopus 로고
    • Predicting benefit from antiangiogenic agents in malignancy
    • Jubb AM, Oates AJ, Holden S, Koeppen H. Predicting benefit from antiangiogenic agents in malignancy. Nat Rev Cancer. 2006;6:626-635.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 626-635
    • Jubb, A.M.1    Oates, A.J.2    Holden, S.3    Koeppen, H.4
  • 2
    • 10944242667 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Creating a unique "window" of opportunity
    • Lin MI, Sessa WC. Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell. 2004;6:529-531.
    • (2004) Cancer Cell. , vol.6 , pp. 529-531
    • Lin, M.I.1    Sessa, W.C.2
  • 4
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008;8:579-591.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 5
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to antiangiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to antiangiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 6
    • 69349097400 scopus 로고    scopus 로고
    • Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy
    • Ebos JML, Lee CR, Kerbel RS. Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy. Clin Cancer Res. 2009;15:5020-5025.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5020-5025
    • Ebos, J.M.L.1    Lee, C.R.2    Kerbel, R.S.3
  • 7
    • 64049108890 scopus 로고    scopus 로고
    • Resistance to EGF-R (erbB-1) and VEGF-R modulating agents
    • Dempke WC, Heinemann V. Resistance to EGF-R (erbB-1) and VEGF-R modulating agents. Eur J Cancer. 2009;45:1117-1128.
    • (2009) Eur. J. Cancer , vol.45 , pp. 1117-1128
    • Dempke, W.C.1    Heinemann, V.2
  • 8
    • 46949084994 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: Tools or decorations?
    • Sessa C, Guibal A, Del Conte G, Ruegg C. Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations? Nat Clin Pract Oncol. 2008;5:378-391.
    • (2008) Nat. Clin. Pract. Oncol. , vol.5 , pp. 378-391
    • Sessa, C.1    Guibal, A.2    Del Conte, G.3    Ruegg, C.4
  • 9
    • 34147191481 scopus 로고    scopus 로고
    • Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF based probes
    • Backer MV, Levashova Z, Patel V, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF based probes. Nat Med. 2007;13:504-509.
    • (2007) Nat. Med. , vol.13 , pp. 504-509
    • Backer, M.V.1    Levashova, Z.2    Patel, V.3
  • 11
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003;9:327-337.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 12
    • 65249120736 scopus 로고    scopus 로고
    • SPECT and PET imaging of EGF receptor with site-specifically labeled EGF and dimeric EGF
    • Levashova Z, Backer MV, Horng G, et al. SPECT and PET imaging of EGF receptor with site-specifically labeled EGF and dimeric EGF. Bioconjug Chem. 2009;20:742-749.
    • (2009) Bioconjug Chem. , vol.20 , pp. 742-749
    • Levashova, Z.1    Backer, M.V.2    Horng, G.3
  • 13
    • 33746936677 scopus 로고    scopus 로고
    • Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells
    • Ewan LC, Jopling HM, Jia H, et al. Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells. Traffic. 2006;7:1270-1282.
    • (2006) Traffic , vol.7 , pp. 1270-1282
    • Ewan, L.C.1    Jopling, H.M.2    Jia, H.3
  • 14
    • 0033602091 scopus 로고    scopus 로고
    • Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
    • Dougher M, Terman BI. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene. 1999;18:1619-1627.
    • (1999) Oncogene , vol.18 , pp. 1619-1627
    • Dougher, M.1    Terman, B.I.2
  • 15
    • 34247102347 scopus 로고    scopus 로고
    • VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing
    • Santos SC, Miguel C, Domingues I, et al. VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing. Exp Cell Res. 2007;313:1561-1574.
    • (2007) Exp. Cell. Res. , vol.313 , pp. 1561-1574
    • Santos, S.C.1    Miguel, C.2    Domingues, I.3
  • 16
    • 33646562554 scopus 로고    scopus 로고
    • Structure-function studies of two synthetic antivascular endothelial growth factor Fabs and comparison with the Avastin Fab
    • Fuh G, Wu P, Liang WC, et al. Structure-function studies of two synthetic antivascular endothelial growth factor Fabs and comparison with the Avastin Fab. J Biol Chem. 2006;281:6625-6631.
    • (2006) J. Biol. Chem. , vol.281 , pp. 6625-6631
    • Fuh, G.1    Wu, P.2    Liang, W.C.3
  • 17
    • 57349179851 scopus 로고    scopus 로고
    • Pazopnib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy
    • Sloan B, Scheinfeld NS. Pazopnib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy. Curr Opin Investig Drugs. 2008;9:1324-1335.
    • (2008) Curr. Opin. Investig Drugs , vol.9 , pp. 1324-1335
    • Sloan, B.1    Scheinfeld, N.S.2
  • 18
    • 71549138874 scopus 로고    scopus 로고
    • Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib: A molecular imaging study
    • Blankenberg FG, Levashova L, Sarkar SK, Pizzonia J, Backer MV, Backer JB. Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib: a molecular imaging study. Transl Oncol. 2010;3:56-64.
    • (2010) Transl Oncol. , vol.3 , pp. 56-64
    • Blankenberg, F.G.1    Levashova, L.2    Sarkar, S.K.3    Pizzonia, J.4    Backer, M.V.5    Backer, J.B.6
  • 19
    • 33645735004 scopus 로고    scopus 로고
    • Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia
    • Franco M, Man S, Chen L, et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res. 2006;66:3639-3648.
    • (2006) Cancer Res. , vol.66 , pp. 3639-3648
    • Franco, M.1    Man, S.2    Chen, L.3
  • 20
    • 52049113198 scopus 로고    scopus 로고
    • Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic treatment
    • Palmowski M, Huppert J, Hauff P, et al. Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic treatment. Cancer Res. 2008;68:7042-7049.
    • (2008) Cancer Res. , vol.68 , pp. 7042-7049
    • Palmowski, M.1    Huppert, J.2    Hauff, P.3
  • 21
    • 33847118123 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
    • Chang YS, Adnane J, Trail PA, et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol. 2007;59:561-574.
    • (2007) Cancer Chemother. Pharmacol. , vol.59 , pp. 561-574
    • Chang, Y.S.1    Adnane, J.2    Trail, P.A.3
  • 22
    • 49549123352 scopus 로고    scopus 로고
    • Vertical VEGF targeting: A combination of ligand blockade with receptor tyrosine kinase inhibition
    • Bozec A, Gros FX, Penault-Llorca F, et al. Vertical VEGF targeting: a combination of ligand blockade with receptor tyrosine kinase inhibition. Eur J Cancer. 2008;44:1922-1930.
    • (2008) Eur. J. Cancer , vol.44 , pp. 1922-1930
    • Bozec, A.1    Gros, F.X.2    Penault-Llorca, F.3
  • 23
    • 37849049198 scopus 로고    scopus 로고
    • Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis
    • Selvakumaran M, Yao KS, Feldman MD, O'Dwyer PJ. Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis. Biochem Pharmacol. 2008;75:627-668.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 627-668
    • Selvakumaran, M.1    Yao, K.S.2    Feldman, M.D.3    O'Dwyer, P.J.4
  • 24
    • 34548101663 scopus 로고    scopus 로고
    • Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts
    • Smith NR, James NH, Oakley I, et al. Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts. Mol Cancer Ther. 2007;6:2198-2208.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2198-2208
    • Smith, N.R.1    James, N.H.2    Oakley, I.3
  • 25
    • 44849093414 scopus 로고    scopus 로고
    • A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities
    • Christensen JG. A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities. Ann Oncol. 2007;18(suppl 10):x3-x10.
    • (2007) Ann. Oncol. , vol.18 , Issue.10 SUPPL.
    • Christensen, J.G.1
  • 26
    • 0030806273 scopus 로고    scopus 로고
    • Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
    • Benjamin LE, Keshet E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA. 1997;94:8761-8766.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8761-8766
    • Benjamin, L.E.1    Keshet, E.2
  • 27
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso MR, Davis R, Norberg SM. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest. 2006;116:2610-2621.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2610-2621
    • Mancuso, M.R.1    Davis, R.2    Norberg, S.M.3
  • 28
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein HJ, Elias AD, Rugo HS, et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol. 2008;26:1810-1816.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3
  • 29
    • 65049087191 scopus 로고    scopus 로고
    • Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis
    • Johannsen M, Flörcken A, Bex A, et al. Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis. Eur Urol. 2009;55:1430-1438.
    • (2009) Eur. Urol. , vol.55 , pp. 1430-1438
    • Johannsen, M.1    Flörcken, A.2    Bex, A.3
  • 30
    • 64149106522 scopus 로고    scopus 로고
    • Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
    • Reynolds AR, Hart IR, Watson AR, et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med. 2009;15:392-400.
    • (2009) Nat. Med. , vol.15 , pp. 392-400
    • Reynolds, A.R.1    Hart, I.R.2    Watson, A.R.3
  • 31
    • 11244266064 scopus 로고    scopus 로고
    • Regulation of endothelial cell death and its role in angiogenesis and vascular regression
    • Sakamaki K. Regulation of endothelial cell death and its role in angiogenesis and vascular regression. Curr Neurovasc Res. 2004;1:305-315.
    • (2004) Curr. Neurovasc Res. , vol.1 , pp. 305-315
    • Sakamaki, K.1
  • 33
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009;15:220-231.
    • (2009) Cancer Cell. , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 35
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenesis basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenesis basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423-436.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 36
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005;8:299-309.
    • (2005) Cancer Cell. , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 37
    • 68049139572 scopus 로고    scopus 로고
    • Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells
    • Xiong YQ, Sun HC, Zhang W, et al. Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin Cancer Res. 2009;15:4838-4846.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4838-4846
    • Xiong, Y.Q.1    Sun, H.C.2    Zhang, W.3
  • 38
    • 68049120464 scopus 로고    scopus 로고
    • Tumor endothelial cells join the resistance
    • Dudley AC, Klagsbrun M. Tumor endothelial cells join the resistance. Clin Cancer Res. 2009;15:4787-4789.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4787-4789
    • Dudley, A.C.1    Klagsbrun, M.2
  • 39
    • 70349327818 scopus 로고    scopus 로고
    • Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor model
    • Loveless ME, Whisenant JG, Wilson K, et al. Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor model. Mol Imaging. 2009;8:187-198.
    • (2009) Mol. Imaging , vol.8 , pp. 187-198
    • Loveless, M.E.1    Whisenant, J.G.2    Wilson, K.3
  • 40
    • 57849086172 scopus 로고    scopus 로고
    • Validation of novel imaging methodologies for use as cancer clinical trial end-points
    • Sargent DJ, Rubinstein L, Schwartz L, et al. Validation of novel imaging methodologies for use as cancer clinical trial end-points. Eur J Cancer. 2009;45:290-299.
    • (2009) Eur. J. Cancer , vol.45 , pp. 290-299
    • Sargent, D.J.1    Rubinstein, L.2    Schwartz, L.3


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