Effect of humidity on constant output and breath enhanced nebulizer designs when tested in the EN 13544-1 EC standard

Aerosol Science and Technology

Volumn 37, Issue 3, 2003, Pages 282-292

  Nerbrink, Ola ^a,b,c   Pagels, J ^d   Pieron, C A ^e   Dennis, J H ^e  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NOVO NORDISK A S   (Denmark)

^c ASTRAZENECA R AND D   (Sweden)

^d LUND INSTITUTE OF TECHNOLOGY   (Sweden)

^e UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC HUMIDITY; BREATH CONTROLLED DEVICES; PATIENT MONITORING;

NEBULIZERS;

ATMOSPHERIC AEROSOLS;

AEROSOL; INHALATION CHAMBER; MEDICAL APPLICATION;

AEROSOL; AMBIENT AIR; AQUEOUS SOLUTION; ARTICLE; BREATH ANALYSIS; HUMIDITY; MOISTURE; NEBULIZER; PARTICLE SIZE; PRIORITY JOURNAL;

EID: 0037366969     PISSN: 02786826     EISSN: None     Source Type: Journal    
DOI: 10.1080/02786820300948     Document Type: Article

References (20)

1. Clark, A. R. (1995). The Use of Laser Diffraction for the Evaluation of the Aerosol Clouds Generated by Medical Nebulizers, Int. J. Pharm. 115:69-78.
2. Dennis, J. H., Stenton, S. C., Beach, J. R., Avery, A. J., Walters, E. H., and Hendrick, D. J. (1990). Jet and Ultrasonic Nebuliser Output: Use of a New Method for Direct Measurement of Aerosol Output, Thorax. 45:728-732.
3. Dennis, J. H., and Nerbrink, O. (2001). New Nebulizer Technology, in Drug Delivery to the Lung, Vol. 162, H. Bisgaard, C. O'Callahan, and G. Smaldone, eds., Marcel Dekker Inc., New York.
4. Ferron, G. A., and Soderholm, S. C. (1990). Estimation of the Times for Evaporation of Pure Water Droplets and for Stabilization of Salt Solution, J. Aerosol Sci. 21:415-429.
5. Ferron, G. A., Roth, C., Busch, B., and Karg, E. (1997). Estimation of the Size Distribution of Aerosols Produced by Jet Nebulisers as a Function of Time, J. Aerosol Sci. 28:805-820.
6. Finlay, W. H. (1998). Estimating the Type of Hygroscopic Behaviour Exhibited by Aqueous Aerosols, J. Aerosol Med. 11(4):221-229.
7. Hinds, W. C. (1982). Aerosol Technology. John Wiley & Sons, Hoboken, New Jersey.
8. Ho, K. K. L., Kellaway, I. W., and Tredree, R. (1986). Particle Size Analysis of Nebulized Aerosols Using Fraunhofer Laser Diffraction and Inertial Compaction Methods, J. of Parm. Pharmacol. 38(suppl):26.
9. Knoch, M., Wunderlich, E., Roth, C., and Gebhardt, J. (1994). Output Characterization of Medical Nebulisers, J. Aerosol Sci. 25:S439-440.
10. Kwong, W. T., Ho, S. L., and Coates, A. L. (2000). Comparison of Nebulized Particle Size Distribution with Malvern Laser Diffraction Analyzer Versus Andersen Cascade Impactor and Low-flow Marple Personal Cascade Impactor, J. Aerosol Med. 13(4):303-314.
11. Nerbrink, O., Hansson, H. C., and Dahlbäck, M. (1994). Why Do Medical Nebulisers Vary in Output Characteristics, J. Aerosol Med. 7:259-276.
12. Newman, S. P., Pellow, P. G. D., and Clark, S. W. (1986). Droplet Size Distributions of Nebulised Aerosols Used for Inhalation Therapy, Clin. Phys. Physiol. Meas. 7:139-146.
13. Mercer, T. T. (1965). Output Characteristics of Several Commercial Nebulizers, Ann. Allergy 23:314-326.
14. Phipps, P. R., and Gonda, I. (1990). Droplets Produced by Medical Nebulisers Some Factors Affecting Their Size and Solute Concentration, Chest. 97:1327-1332.
15. Prokop, R. M., Finlay, W. H., Stapleton, K. W., and Zuberbuhler, P. (1995). The Effect of Ambient Relative Humidity on Regional Doses Delivered by a Jet Nebulizer, J. Aerosol Med. 8(4):363-371.
16. Roth, C., and Gebhardt, J. (1996). Inertial Classification of Droplets Produced by Medical Nebulisers, Part. Part. Syst. Charact. 13:192-195.
17. Smaldone, G. C., Cruz-Rivera, M., and Nikander, K. (1998). In Vitro Determination of Inhaled Mass and Particle Distribution for Budesonide Nebulizing Suspension, J. Aerosol Med. 11:113-125.
18. Smye, S. W., Jollie, M. I., and Littelwood, J. M. (1991). A Mathematical Model of Some Aspects of Jet Nebulizer Performance, Clin. Phys. Pysiol. Meas. 12:289-300.
19. Stapleton, K. W., and Finlay, H. W. (1995). Determining Solution Concentration Within Aerosol Droplets Output by Jet Nebulizers, J. Aerosol Sci. 26(1):137-145.
20. Stapleton, K. W., and Finlay, H. W. (1998). Errors in Characterizing Nebulized Particle Size Distributions with Cascade Impactors, J. Aerosol Med. 11:80-83.