A Burkholderia pseudomallei ΔpurM mutant is avirulent in immunocompetent and immunodeficient animals: Candidate strain for exclusion from select-agent lists

Infection and Immunity

Volumn 78, Issue 7, 2010, Pages 3136-3143

  Propst, Katie L ^a   Mima, Takehiko ^a   Choi, Kyoung Hee ^b   Dow, Steven W ^a   Schweizer, Herbert P ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b Wonkwang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOSYNTHESIS; BURKHOLDERIA PSEUDOMALLEI; FEMALE; GENE DELETION; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; INFECTION SENSITIVITY; MELIOIDOSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYRIAN HAMSTER; ANIMAL; BACTERIAL GENE; BAGG ALBINO MOUSE; GENETICS; HAMSTER; IMMUNOLOGY; LIVER; LUNG; MICROBIOLOGY; MOUSE MUTANT; MUTAGENESIS; PATHOGENICITY; PHYSIOLOGY; SPLEEN;

ANIMALS; BURKHOLDERIA PSEUDOMALLEI; CRICETINAE; FEMALE; GENE DELETION; GENES, BACTERIAL; LIVER; LUNG; MELIOIDOSIS; MESOCRICETUS; MICE; MICE, INBRED BALB C; MICE, SCID; MUTAGENESIS; SPLEEN;

EID: 77953939501     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01313-09     Document Type: Article

References (41)

1. Alcantara, R. B., R. D. Read, M. W. Valderas, T. D. Brown, and R. M. Roop II. 2004. Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model. Infect. Immun. 72:4911-4917.
2. Athan, E., A. M. Allworth, C. Engler, I. Bastian, and A. C. Cheng. 2005. Melioidosis in tsunami survivors. Emerg. Infect. Dis. 11:1638-1639.
3. Atkins, T., R. Prior, K. Mack, P. Russell, M. Nelson, J. Prior, J. Ellis, P. C. Oyston, G. Dougan, and R. W. Titball. 2002. Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis. J. Med. Microbiol. 51:539-547.
4. Atkins, T., R. G. Prior, K. Mack, P. Russell, M. Nelson, P. C. Oyston, G. Dougan, and R. W. Titball. 2002. A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect. Immun. 70:5290-5294.
5. Breitbach, K., J. Kohler, and I. Steinmetz. 2008. Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle. Trans. R. Soc. Trop. Med. Hyg. 102(Suppl. 1):S89-S94.
6. Cersini, A., M. C. Martino, I. Martini, G. Rossi, and M. L. Bernardini. 2003. Analysis of virulence and inflammatory potential of Shigella flexneri purine biosynthesis mutants. Infect. Immun. 71:7002-7013.
7. Cheng, A. C., and B. J. Currie. 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin. Microbiol. Rev. 18:383-416.
8. Chierakul, W., W. Winothai, C. Wattanawaitunechai, V. Wuthiekanun, T. Rugtaengan, J. Rattanalertnavee, P. Jitpratoom, W. Chaowagul, P. Singhasivanon, N. J. White, N. P. Day, and S. J. Peacock. 2005. Melioidosis in 6 tsunami survivors in southern Thailand. Clin. Infect. Dis. 41:982-990.
9. Choi, K.-H., T. Mima, Y. Casart, D. Rholl, A. Kumar, I. R. Beacham, and H. P. Schweizer. 2008. Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei. Appl. Environ. Microbiol. 74:1064-1075.
10. Ciervo, A., R. Mattei, and A. Cassone. 2006. Melioidosis in an Italian tourist injured by the tsunami in Thailand. J. Chemother. 18:443-444. (Pubitemid 44450031)
11. Currie, B. J. 2003. Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions. Eur. Respir. J. 22:542-550.
12. Currie, B. J., D. A. B. Dance, and A. C. Cheng. 2008. The global distribution of Burkholderia pseudomallei and melioidosis: an update. Trans. R. Soc. Trop. Med. Hyg. 102(Suppl. 1):S1-S4.
13. Dance, D. A. B. 2005. Melioidosis and glanders as possible biological weapons, p. 99-145. In W. Fong and K. Alibek (ed.), Bioterrorism and infectious agents. A new dilemma for the 21st century. Springer Science and Business Media, New York, NY.
14. DeShazer, D., P. Brett, R. Carlyon, and D. Woods. 1997. Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterization of the flagellin structural gene. J. Bacteriol. 179:2116-2125.
15. Essex-Lopresti, A. E., J. A. Boddey, R. Thomas, M. P. Smith, M. G. Hartley, T. Atkins, N. F. Brown, C. H. Tsang, I. R. Peak, J. Hill, I. R. Beacham, and R. W. Titball. 2005. A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo. Infect. Immun. 73:1260-1264.
16. Goodyear, A., A. Jones, R. Troyer, H. Bielefeldt-Ohmann, and S. Dow. 2010. Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. J. Immunol. 184:1445-1454.
17. Goodyear, A., L. Kellihan, H. Bielefeldt-Ohmann, R. Troyer, K. Propst, and S. Dow. 2009. Protection from pneumonic infection with Burkholderia species by inhalational immunotherapy. Infect. Immun. 77:1579-1588.
18. Holden, M. T. G., R. W. Titball, S. J. Peacock, A. M. Cerdeno-Tarraga, T. P. Atkins, L. C. Crossman, T. L. Pitt, C. Churcher, K. L. Mungall, S. D. Bentley, M. Sebaihia, N. R. Thomson, N. Bason, I. R. Beacham, K. Brooks, K. A. Brown, N. F. Brown, G. L. Challis, I. Cherevach, T. Chillingworth, A. Cronin, B. Crossett, P. Davis, D. DeShazer, T. Feltwell, A. Fraser, Z. Hance, H. Hauser, S. Holroyd, K. Jagels, K. E. Keith, M. Maddison, S. Moule, C. Price, M. A. Quail, E. Rabbinowitsch, K. Rutherford, M. Sanders, M. Simmonds, S. Songsivilai, K. Stevens, S. Tumapa, M. Vesaratchavest, S. Whitehead, C. Yeats, B. G. Barrell, P. C. F. Oyston, and J. Parkhill. 2004. Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc. Natl. Acad. Sci. U. S. A. 101:14240-14245.
19. Jackson, M., S. W. Phalen, M. Lagranderie, D. Ensergueix, P. Chavarot, G. Marchal, D. N. McMurray, B. Gicquel, and C. Guilhot. 1999. Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine. Infect. Immun. 67:2867-2873.
20. Kite-Powell, A., J. R. Livengood, J. Suarez, R. Hopkins, T. A. Clark, and D. Chertow. 2006. Imported melioidosis - South Florida, 2005. MMWR Morb. Mortal. Wkly. Rep. 55:873-876.
21. Limmathurotsakul, D., W. Chaowagul, W. Chierakul, K. Stepniewska, B. Maharjan, V. Wuthiekanun, N. J. White, N. P. Day, and S. J. Peacock. 2006. Risk factors for recurrent melioidosis in northeast Thailand. Clin. Infect. Dis. 43:979-986.
22. Lopez, C. M., D. A. Rholl, L. A. Trunck, and H. P. Schweizer. 2009. Versatile dual-technology system for markerless allele replacement in Burkholderia pseudomallei. Appl. Environ. Microbiol. 75:6496-6503.
23. Miller, J. H. 1992. A short course in bacterial genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
24. Peacock, S. J., H. P. Schweizer, D. A. B. Dance, T. L. Smith, J. E. Gee, V. Wuthiekanun, D. DeShazer, I. Steinmetz, P. Tan, and B. J. Currie. 2008. Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei. Emerg. Infect. Dis. 14:e2. http://www.cdc.gov/eid/content/14/7/e2.htm.
25. Pechous, R., J. Celli, R. Penoske, S. F. Hayes, D. W. Frank, and T. C. Zahrt. 2006. Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain. Infect. Immun. 74:4452-4461.
26. Pilatz, S., K. Breitbach, N. Hein, B. Fehlhaber, J. Schulze, B. Brenneke, L. Eberl, and I. Steinmetz. 2006. Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence. Infect. Immun. 74:3576-3586.
27. Reckseidler, S. L., D. DeShazer, P. A. Sokol, and D. E. Woods. 2001. Detection of bacterial virulence genes by subtractive hybridization: identification of capsular polysaccharide of Burkholderia pseudomallei as a major virulence determinant. Infect. Immun. 69:34-44.
28. Reckseidler-Zenteno, S. L., R. DeVinney, and D. E. Woods. 2005. The capsular polysaccharide of Burkholderia pseudomallei contributes to survival in serum by reducing complement factor C3b deposition. Infect. Immun. 73:1106-1115.
29. Rowland, C. A., G. Lertmemongkolchai, A. Bancroft, A. Haque, M. S. Lever, K. F. Griffin, M. C. Jackson, M. Nelson, A. O'Garra, R. Grencis, G. J. Bancroft, and R. A. Lukaszewski. 2006. Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei. Infect. Immun. 74:5333-5340.
30. Santanirand, P., V. S. Harley, D. A. Dance, B. S. Drasar, and G. J. Bancroft. 1999. Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei. Infect. Immun. 67:3593-3600.
31. Schlech, W. F., III, J. B. Turchik, R. E. Westlake, Jr., G. C. Klein, J. D. Band, and R. E. Weaver. 1981. Laboratory-acquired infection with Pseudomonas pseudomallei (melioidosis). N. Engl. J. Med. 305:1133-1135.
32. Schutzer, S. E., L. R. Schlater, C. M. Ronning, D. DeShazer, B. J. Luft, J. J. Dunn, J. Ravel, C. M. Fraser-Liggett, and W. C. Nierman. 2008. Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from select agent lists. PLoS One 3:e2058.
33. Schweizer, H. P., and S. J. Peacock. 2008. What antibiotic selection markers should be used for the select agents Burkholderia pseudomallei and Burkholderia mallei? Emerg. Infect. Dis. 14:1689-1692.
34. Sheehan, B. J., J. T. Bosse, A. J. Beddek, A. N. Rycroft, J. S. Kroll, and P. R. Langford. 2003. Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host. Infect. Immun. 71:3960-3970.
35. Srilunchang, T., T. Proungvitaya, S. Wongratanacheewin, R. Strugnell, and P. Homchampa. 2009. Construction and characterization of an unmarked aroC deletion mutant of Burkholderia pseudomallei strain A2. Southeast Asian J. Trop. Med. Public Health 40:123-130.
36. Stevens, M. P., A. Haque, T. Atkins, J. Hill, M. W. Wood, A. Easton, M. Nelson, C. Underwood-Fowler, R. W. Titball, G. J. Bancroft, and E. E. Galyov. 2004. Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis. Microbiology 150:2669-2676.
37. Svensson, E., C. Welinder-Olsson, B. A. Claesson, and M. Studahl. 2006. Cutaneous melioidosis in a Swedish tourist after the tsunami in 2004. Scand. J. Infect. Dis. 38:71-74.
38. Thongdee, M., L. A. Gallagher, M. Schell, T. Dharakul, S. Songsivilai, and C. Manoil. 2008. Targeted mutagenesis of Burkholderia thailandensis and Burkholderia pseudomallei through natural transformation of PCR fragments. Appl. Environ. Microbiol. 74:2985-2999.
39. Tuanyok, A., M. Tom, J. Dunbar, and D. E. Woods. 2006. Genome-wide expression analysis of Burkholderia pseudomallei infection in a hamster model of acute melioidosis. Infect. Immun. 74:5465-5476.
40. Wiersinga, W. J., T. van der Poll, N. J. White, N. P. Day, and S. J. Peacock. 2006. Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat. Rev. Microbiol. 4:272-282.
41. Wuthiekanun, V., and S. J. Peacock. 2006. Management of melioidosis. Expert Rev. Anti Infect. Ther. 4:445-455.