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Volumn 16, Issue 2, 2010, Pages 162-166

W(h)ither metreleptin for lipodystrophy and the metabolic syndrome?

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; LEPTIN; METRELEPTIN; PLACEBO; UNCLASSIFIED DRUG; DRUG DERIVATIVE;

EID: 77953935732     PISSN: 1530891X     EISSN: None     Source Type: Journal    
DOI: 10.4158/EP10038.ED     Document Type: Editorial
Times cited : (8)

References (33)
  • 1
    • 79952437425 scopus 로고    scopus 로고
    • Lipodystrophy syndromes
    • Jameson JL, De Groot LJ, eds. 6th ed. Philadelphia, PA: Elsevier, Mosby, Saunders, In press
    • Gao C, Mantzoros CS. Lipodystrophy syndromes. In: Jameson JL, De Groot LJ, eds. Endocrinology. 6th ed. Philadelphia, PA: Elsevier, Mosby, Saunders, 2010. In press.
    • (2010) Endocrinology
    • Gao, C.1    Mantzoros, C.S.2
  • 2
    • 11344293751 scopus 로고    scopus 로고
    • Cardiovascular risk and body-fat abnormalities in HIV-infected adults
    • DOI 10.1056/NEJMra041811
    • Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med. 2005;352:48-62. (Pubitemid 40075680)
    • (2005) New England Journal of Medicine , vol.352 , Issue.1 , pp. 48-62
    • Grinspoon, S.1    Carr, A.2
  • 3
    • 0038030965 scopus 로고    scopus 로고
    • Clinical review 159 - Human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome: Clinical presentation, pathophysiology, and therapeutic strategies
    • DOI 10.1210/jc.2002-021704
    • Leow MK, Addy CL, Mantzoros CS. Clinical review 159: human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome; clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocrinol Metab. 2003;88:1961-1976. (Pubitemid 36549862)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.5 , pp. 1961-1976
    • Leow, M.K.S.1    Addy, C.L.2    Mantzoros, C.S.3
  • 4
    • 77953939677 scopus 로고    scopus 로고
    • Clinical classification and treatment of congenital and acquired lipodystrophy
    • Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract. 2010;16:310-323.
    • (2010) Endocr Pract , vol.16 , pp. 310-323
    • Chan, J.L.1    Oral, E.A.2
  • 5
    • 72449160044 scopus 로고    scopus 로고
    • Leptin therapy in lipodystrophy
    • Savage DB, O'Rahilly S. Leptin therapy in lipodystrophy. Diabetologia. 2010;53:7-9.
    • (2010) Diabetologia , vol.53 , pp. 7-9
    • Savage, D.B.1    O'Rahilly, S.2
  • 7
    • 53549134683 scopus 로고    scopus 로고
    • Identification of white adipocyte progenitor cells in vivo
    • Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell. 2008;135:240-249.
    • (2008) Cell , vol.135 , pp. 240-249
    • Rodeheffer, M.S.1    Birsoy, K.2    Friedman, J.M.3
  • 8
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 1999;401:73-76.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 10
    • 0037323424 scopus 로고    scopus 로고
    • Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy
    • DOI 10.1210/jc.2002-020795
    • Addy CL, Gavrila A, Tsiodras S, et al. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab. 2003;88:627-636. (Pubitemid 36207802)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.2 , pp. 627-636
    • Addy, C.L.1    Gavrila, A.2    Tsiodras, S.3    Brodovicz, K.4    Karchmer, A.W.5    Mantzoros, C.S.6
  • 12
    • 33745781499 scopus 로고    scopus 로고
    • Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
    • DOI 10.1210/jc.2005-1545
    • Lee JH, Chan JL, Sourlas E, Raptopoulos V, Mantzoros CS. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab. 2006;91:2605-2611. (Pubitemid 44024625)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.7 , pp. 2605-2611
    • Lee, J.H.1    Chan, J.L.2    Sourlas, E.3    Raptopoulos, V.4    Mantzoros, C.S.5
  • 13
    • 15044346225 scopus 로고    scopus 로고
    • Improvement in highly active antiretroviral therapy-induced metabolic syndrome by treatment with pioglitazone but not with fenofibrate: A 2 X 2 Factorial, randomized, double-blinded, placebo-controlled trial
    • DOI 10.1086/427697
    • Gavrila A, Hsu W, Tsiodras S, et al. Improvement in highly active antiretroviral therapy-induced metabolic syndrome by treatment with pioglitazone but not with fenofibrate: a 2 x 2 factorial, randomized, double-blinded, placebo-controlled trial. Clin Infect Dis. 2005;40:745-749. (Pubitemid 40381352)
    • (2005) Clinical Infectious Diseases , vol.40 , Issue.5 , pp. 745-749
    • Gavrila, A.1    Hsu, W.2    Tsiodras, S.3    Doweiko, J.4    Gautam, S.5    Martin, L.6    Moses, A.C.7    Karchmer, A.W.8    Mantzoros, C.S.9
  • 14
    • 65249122675 scopus 로고    scopus 로고
    • Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome?
    • Mantzoros CS. Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome? J Clin Endocrinol Metab. 2009;94:1089-1091.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1089-1091
    • Mantzoros, C.S.1
  • 15
    • 65249130126 scopus 로고    scopus 로고
    • The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
    • Mulligan K, Khatami H, Schwarz JM, et al. The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. J Clin Endocrinol Metab. 2009;94:1137-1144.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1137-1144
    • Mulligan, K.1    Khatami, H.2    Schwarz, J.M.3
  • 16
    • 61449175863 scopus 로고    scopus 로고
    • r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: Observational and interventional studies in humans
    • Brennan AM, Lee JH, Tsiodras S, et al. r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans. Eur J Endocrinol. 2009;160:173-176.
    • (2009) Eur J Endocrinol , vol.160 , pp. 173-176
    • Brennan, A.M.1    Lee, J.H.2    Tsiodras, S.3
  • 17
    • 63749088446 scopus 로고    scopus 로고
    • GH/GHRH axis in HIV lipodystrophy
    • Stanley TL, Grinspoon SK. GH/GHRH axis in HIV lipodystrophy. Pituitary. 2009;12:143-152.
    • (2009) Pituitary , vol.12 , pp. 143-152
    • Stanley, T.L.1    Grinspoon, S.K.2
  • 19
    • 33947283865 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy
    • DOI 10.1016/j.metabol.2006.11.010, PII S0026049506004355
    • Park JY, Javor ED, Cochran EK, DePaoli AM, Gorden P. Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy. Metabolism. 2007;56:508-516. (Pubitemid 46427848)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 508-516
    • Park, J.Y.1    Javor, E.D.2    Cochran, E.K.3    DePaoli, A.M.4    Gorden, P.5
  • 20
    • 77953954942 scopus 로고    scopus 로고
    • Rationale for leptin-replacement therapy for severe lipodystrophy
    • Oral EA, Chan JL. Rationale for leptin-replacement therapy for severe lipodystrophy. Endocr Pract. 2010;16:324-333.
    • (2010) Endocr Pract , vol.16 , pp. 324-333
    • Oral, E.A.1    Chan, J.L.2
  • 23
    • 33744946045 scopus 로고    scopus 로고
    • Leptin receptor expression and signaling in lymphocytes: Kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
    • Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006;176:7745-7752. (Pubitemid 43849075)
    • (2006) Journal of Immunology , vol.176 , Issue.12 , pp. 7745-7752
    • Papathanassoglou, E.1    El-Haschimi, K.2    Li, X.C.3    Matarese, G.4    Strom, T.5    Mantzoros, C.6
  • 24
    • 34347253938 scopus 로고    scopus 로고
    • Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: Variation of concentration-dependent parameters according to assay
    • DOI 10.1210/jc.2006-2864
    • Chan JL, Wong SL, Orlova C, Raciti P, Mantzoros CS. Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay. J Clin Endocrinol Metab. 2007;92:2307-2311. (Pubitemid 46997138)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.6 , pp. 2307-2311
    • Chan, J.L.1    Wong, S.L.2    Orlova, C.3    Raciti, P.4    Mantzoros, C.S.5
  • 26
    • 0020418338 scopus 로고
    • Development of IgE antibodies to human (recombinant DNA), porcine, and bovine insulins in diabetic subjects
    • Fireman P, Fineberg SE, Galloway JA. Development of IgE antibodies to human (recombinant DNA), porcine, and bovine insulins in diabetic subjects. Diabetes Care. 1982;5(suppl 2):119-125. (Pubitemid 13251457)
    • (1982) Diabetes Care , vol.5 , Issue.SUPPL. 2 , pp. 119-125
    • Fireman, P.1    Fineberg, S.E.2    Galloway, J.A.3
  • 27
    • 0027397680 scopus 로고
    • Five-year follow-up of growth hormone antibodies in growth hormone deficient children treated with recombinant human growth hormone
    • Massa G, Vanderschueren-Lodeweyckx M, Bouillon R. Five-year follow-up of growth hormone antibodies in growth hormone deficient children treated with recombinant human growth hormone. Clin Endocrinol (Oxf). 1993;38:137-142. (Pubitemid 23042721)
    • (1993) Clinical Endocrinology , vol.38 , Issue.2 , pp. 137-142
    • Massa, G.1    Vanderschueren-Lodeweyckx, M.2    Bouillon, R.3
  • 28
    • 74949143243 scopus 로고    scopus 로고
    • Narrative review: The role of leptin in human physiology; emerging clinical applications
    • Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology; emerging clinical applications. Ann Intern Med. 2010;152:93-100.
    • (2010) Ann Intern Med , vol.152 , pp. 93-100
    • Kelesidis, T.1    Kelesidis, I.2    Chou, S.3    Mantzoros, C.S.4
  • 30
    • 33745106645 scopus 로고    scopus 로고
    • Drug Insight: The role of leptin in human physiology and pathophysiology - Emerging clinical applications
    • DOI 10.1038/ncpendmet0196, PII N0196
    • Brennan AM, Mantzoros CS. Drug insight: the role of leptin in human physiology and pathophysiology - emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006;2:318-327. (Pubitemid 43885911)
    • (2006) Nature Clinical Practice Endocrinology and Metabolism , vol.2 , Issue.6 , pp. 318-327
    • Brennan, A.M.1    Mantzoros, C.S.2
  • 31
    • 0037651108 scopus 로고    scopus 로고
    • The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    • DOI 10.1172/JCI200317490
    • Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest. 2003;111:1409-1421. (Pubitemid 36554712)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.9 , pp. 1409-1421
    • Chan, J.L.1    Heist, K.2    DePaoli, A.M.3    Veldhuis, J.D.4    Mantzoros, C.S.5
  • 32
    • 21844471790 scopus 로고    scopus 로고
    • Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    • DOI 10.1016/S0140-6736(05)66830-4, PII S0140673605668304
    • Chan JL, Mantzoros CS. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet. 2005;366:74-85. (Pubitemid 40956533)
    • (2005) Lancet , vol.366 , Issue.9479 , pp. 74-85
    • Chan, J.L.1    Mantzoros, C.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.