Endocrine disruptors and fertility: NR0B2, a new therapeutic target?;Perturbateurs endocriniens et fertilité NR0B2 nouvelle cible thérapeutique?

Medecine/Sciences

Volumn 26, Issue 4, 2010, Pages 359-361

  Decourteix, Mélanie ^a,b   Volle, David H ^a,b  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; ESTROGEN RECEPTOR; G9A PROTEIN, MOUSE; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2; RETINOIC ACID RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MALE; MALE INFERTILITY; METABOLISM; METHYLATION; MOUSE; MOUSE MUTANT; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS;

ANIMALS; ANIMALS, NEWBORN; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTORS; FEMALE; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; INFERTILITY, MALE; MALE; METHYLATION; MICE; MICE, KNOCKOUT; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS; TRANSCRIPTION, GENETIC;

EID: 77953932834     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2010264359     Document Type: Article

References (12)

1. Toppari J. Environmental endocrine disrupters. Sex Dev 2008; 2: 260-7.
2. Iguchi T, Watanabe H, Katsu Y. Developmental effects of estrogenic agents on mice, fish, and frogs: a minireview. Horm Behav 2001; 40: 248-51. (Pubitemid 32846359)
3. Greschik H, Flaig R, Renaud JP, Moras D. Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. J Biol Chem 2004; 279: 33639-46. (Pubitemid 39063013)
4. Greschik H, Wurtz JM, Sanglier S, et al. Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Mol Cell 2002; 9: 303-13. (Pubitemid 34195556)
5. Cederroth CR, Schaad O, Descombes P, et al. Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. Endocrinology 2007; 148: 5507-19. (Pubitemid 350012657)
6. Nam K, Marshall P, Wolf RM, Cornell W. Simulation of the different biological activities of diethylstilbestrol (DES) on estrogen receptor alpha and estrogen-related receptor gamma. Biopolymers 2003; 68: 130-8. (Pubitemid 36098313)
7. Lai K, Harnish DC, Evans MJ. Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner. J Biol Chem 2003; 278: 36418-29. (Pubitemid 37139971)
8. Johansson L, Thomsen JS, Damdimopoulos AE, et al. The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta. J Biol Chem 1999; 274: 345-53. (Pubitemid 29035068)
9. Volle DH, Duggavathi R, Magnier BC, et al. The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. Genes Dev 2007; 21: 303-15.
10. Volle DH, Decourtreix M, Garo E, et al. The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. J Clin Invest 2009; 119: 3752-64.
11. Volle DH, Mouzat K, Duggavathi R, et al. Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility. Mol Endocrinol 2007; 21: 1014-27. (Pubitemid 46984755)
12. Tachibana M, Nozaki M, Takeda N, Shinkai Y. Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J 2007; 26: 3346-59. (Pubitemid 47123532)