Cardiac stem and progenitor cell identification: Different markers for the same cell?

Frontiers in Bioscience - Scholar

Volumn 2 S, Issue 2, 2010, Pages 641-652

  Ellison, Georgina M ^a   Galuppo, Valentina ^b   Vicinanza, Carla ^a,b   Aquila, Iolanda ^b   Waring, Cheryl D ^a   Leone, Angelo ^b   Indolfi, Ciro ^b   Torella, Daniele ^a,b  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

C kit; Cardiac Progenitor Cell; Cardiac Stem Cells; Epicardial Stem Cell; Isl 1; Myocardial Regeneration; Review; Sca 1; Side population

Indexed keywords

ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; BIOLOGICAL MARKER; HOMEODOMAIN PROTEIN; INSULIN GENE ENHANCER BINDING PROTEIN ISL 1; INSULIN GENE ENHANCER BINDING PROTEIN ISL-1; STEM CELL FACTOR RECEPTOR; TUMOR PROTEIN;

ADULT; CLASSIFICATION; CYTOLOGY; HEART; HEART MUSCLE CELL; HUMAN; METABOLISM; NEWBORN; PRENATAL DEVELOPMENT; REVIEW; STEM CELL;

ADULT; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; HEART; HOMEODOMAIN PROTEINS; HUMANS; INFANT, NEWBORN; MYOCYTES, CARDIAC; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; STEM CELLS;

EID: 77953930328     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Mariell Jessup, William T. Abraham, Donald E. Casey, Arthur M. Feldman, Gary S. Francis, Theodore G. Ganiats, Marvin A. Konstam, Donna M. Mancini, Peter S. Rahko, Marc A. Silver, Lynne Warner Stevenson and Clyde W. Yancy, writing on behalf of the 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult Writing Committee: 2009 Focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 119, 1977-2016 (2009)
2. Karl Swedberg, John Cleland, Henry Dargie, Helmut Drexler, Ferenc Follath, Michel Komajda, Luigi Tavazzi, Otto A. Smiseth, Antonello Gavazzi, Axel Haverich, Arno Hoes, Tiny Jaarsma, Jerzy Korewicki, Samuel Lévy, Cecilia Linde, José-Luis Lopez-Sendon, Markku S. Nieminen, Luc Piérard and Willem J. Remme: Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the Eur Heart J 26, 1115-1140 (2005)
3. Mariell Jessup and Susan Brozena: Heart failure. N. Engl. J. Med 348, 2007-2018 (2003)
4. Abdulaziz Al-khaldi and Robert C. Robbins: New directions in cardiac transplantation. Annu. Rev. Med 57, 455-471 (2006) (Pubitemid 43262001)
5. Bernardo Nadal-Ginard, Jan Kajstura, Annarosa Leri and Piero Anversa: Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ. Res 92, 139-150 (2003) (Pubitemid 36254270)
6. Stefanie Dimmeler, Andreas M. Zeiher and Michael D. Schneider: Unchain my heart: the scientific foundations of cardiac repair. J. Clin. Invest 115, 572-583 (2005) (Pubitemid 40322227)
7. Bernardo Nadal-Ginard, Daniele Torella and Georgina M. Ellison: Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's. Rev Esp Cardiol 59, 1175-1189 (2006) (Pubitemid 46139214)
8. Kai C. Wollert and Helmut Drexler: Clinical applications of stem cells for the heart. Circ. Res 96, 151-163 (2005) (Pubitemid 40209362)
9. Daniela Cesselli, Antonio P. Beltrami, Silvia Rigo, Natascha Bergamin, Federica D'Aurizio, Roberto Verardo, Silvano Piazza, Enio Klaric, Renato Fanin, Barbara Toffoletto, Stefania Marzinotto, Laura Mariuzzi, Nicoletta Finato, Maura Pandolfi, Annarosa Leri, Claudio Schneider, Carlo A. Beltrami and Piero Anversa: Multipotent progenitor cells are present in human peripheral blood. Circ Res 104, 1225-1234 (2009)
10. Bernardo Nadal-Ginard: Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis. Cell 15, 855-864 (1978)
11. Olaf Bergmann, Ratan D. Bhardwaj, Samuel Bernard, Sofia Zdunek, Fanie Barnabé-Heider, Stuart Walsh, Joel Zupicich, Kanar Alkass, Bruce A. Buchholz, Henrik Druid, Stefan Jovinge and Jonas Frisén: Evidence for Cardiomyocyte Renewal in Humans. Science 324, 98-102 (2009)
12. Georgina M. Ellison, Daniele Torella, Ioannis Karakikes and Bernardo Nadal-Ginard: Myocyte death and renewal: modern concepts of cardiac cellular homeostasis. Nat Clin Pract Cardiovasc Med 4 Suppl 1:S52-59 (2007) (Pubitemid 46151905)
13. Patrick C. H. Hsieh, Vincent F. M. Segers, Michael E. Davis, Catherine MacGillivray, Joseph Gannon, Jeffery D. Molkentin, Jeffrey Robbins and Richard T. Lee: Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 13, 970-974 (2007) (Pubitemid 47222045)
14. Antonio P. Beltrami, Laura Barlucchi, Daniele Torella, Mathue Baker, Federica Limana, Stefano Chimenti, Hideko Kasahara, Marcello Rota, Ezio Musso, Konrad Urbanek, Annarosa Leri, Jan Kajstura, Bernardo Nadal-Ginard and Piero Anversa: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114, 763-776 (2003) (Pubitemid 37186770)
15. Hidemasa Oh, Steven B. Bradfute, Teresa D. Gallardoe, Teruya Nakamura, Vinciane Gaussin, Yuji Mishinag, Jennifer Pocius, Lloyd H. Michael, Richard R. Behringeri, Daniel J. Garry, Mark L. Entman and Michael D. Schneider: Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl. Acad. Sci. U. S. A 100, 12313-12318 (2003) (Pubitemid 37271557)
16. Katsuhisa Matsuura, Toshio Nagai, Nobuhiro Nishigaki, Tomomi Oyama, Junichiro Nishi, Hiroshi Wada, Masanori Sano, Haruhiro Toko, Hiroshi Akazawa, Toshiaki Sato, Haruaki Nakaya, Hiroshi Kasanuki and Issei Komuro: Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J. Biol. Chem 279, 11384-11391 (2004) (Pubitemid 38401637)
17. Elisa Messina, Luciana De Angelis, Giacomo Frati, Stefania Morrone, Stefano Chimenti, Fabio Fiordaliso, Monica Salio, Massimo Battaglia, Michael V.G. Latronico, Marcello Coletta, Elisabetta Vivarelli, Luigi Frati, Giulio Cossu and Alessandro Giacomello: Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ. Res 95, 911-921 (2004) (Pubitemid 39435006)
18. Cindy M. Martin, Annette P. Meesona, Scott M. Robertson, Thomas J. Hawke, James A. Richardson, Susan Bates, Sean C. Goetsch, Teresa D. Gallardo and Daniel J. Garry: Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev. Biol 265, 262-275 (2004) (Pubitemid 38018836)
19. Otmar Pfister, Frédéric Mouquet, Mohit Jain, Ross Summer, Michiel Helmes, Alan Fine, Wilson S. Colucci and Ronglih Liao: CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ. Res 97, 52-61 (2005) (Pubitemid 40982322)
20. Yuichi Tomita, Keisuke Matsumura, Yoshio Wakamatsu, Yumi Matsuzaki, Isao Shibuya, Haruko Kawaguchi, Masaki Ieda, Sachiko Kanakubo, Takuya Shimazaki, Satoshi Ogawa, Noriko Osumi, Hideyuki Okano and Keiichi Fukuda: Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. J Cell Biol 170, 1135-1146 (2005) (Pubitemid 41362645)
21. Christopher S. Potten and Markus Loeffler: Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110, 1001-1020 (1990) (Pubitemid 120009472)
22. Daniele Torella, Georgina M. Ellison, Bernardo Nadal-Ginard and Ciro Indolfi: Cardiac stem and progenitor cell biology for regenerative medicine. Trends Cardiovasc Med 15, 229-236 (2005) (Pubitemid 41338011)
23. Federico Quaini, Konrad Urbanek, Antonio P. Beltrami, Nicoletta Finato, Carlo A. Beltrami, Bernardo Nadal-Ginard, Jan Kajstura, Annarosa Leri, and Piero Anversa: Chimerism of the transplanted heart. N Engl J Med 346, 5-15 (2002) (Pubitemid 34438914)
24. Karl-Ludwig Laugwitz, Alessandra Moretti, Jason Lam, Peter Gruber, Yinhong Chen, Sarah Woodard, Li-Zhu Lin, Chen-Leng Cai, Min Min Lu, Michael Reth, Oleksandr Platoshyn, Jason X.-J. Yuan, Sylvia Evans and Kenneth R. Chien: Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433, 647-653 (2005) (Pubitemid 40282999)
25. Cai Chen-Leng Cai, Xingqun Liang, Yunqing Shi, Po-Hsien Chu, Samuel L Pfaff, Ju Chen and Sylvia Evans: Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 5, 877-889 (2003) (Pubitemid 37527688)
26. Alexandra Capela and Sally Temple: LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron 35, 865-875 (2002)
27. Daniele Torella, Georgina M. Ellison, Ioannis Karakikes and Bernardo Nadal-Ginard: Growth-factor-mediated cardiac stem cell activation in myocardial regeneration. Nat Clin Pract Cardiovasc Med 4 Suppl 1, S46-51 (2007) (Pubitemid 46164270)
28. Georgina M. Ellison, Daniele Torella, Claudia Perez-Martinez, Amando Perez, Saranya Purushothaman, Carla Vicinanza, Valentina Galuppo, Valter Agosti, Ciro Indolfi, Felippe Fernandez and Bernardo Nadal-Ginard: In situ activation of endogenous cardiac stem cells by intra-coronary administration of IGF-1 and HGF induces myocardial survival and regeneration in the infarcted pig myocardium. Eur Heart J Abstract Suppl 30, 536 (2009)
29. Shinka Miyamoto, Nanako Kawaguchi, Georgina M. Ellison, Rumiko Matsuoka, Toshiharu Shin'oka and Hiromi Kurosawa: Characterization of Long-Term Cultured c-kitpos Cardiac Stem Cells (CSCs) Derived from Adult Rat Hearts. Stem Cells Dev Jul 6. [Epub ahead of print] (2009)
30. Yvonne N. Tallini, Kai Su Greene, Michael Cravena, Alyson Spealmana, Martin Breitbach, James Smith, Patricia J. Fisher, Michele Steffey, Michael Hesse, Robert M. Doran, Ashley Woods, Babu Singh, Andrew Yen, Bernd K. Fleischmann and Michael I. Kotlikoff: c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci U S A 106, 1808-1813 (2009)
31. Jenna Fransioli, Brandi Bailey, Natalie A. Gude, Christopher T. Cottage, John A. Muraski, Gregory Emmanuel, Weitao Wu, Roberto Alvarez, Marta Rubio, Sergio Ottolenghi, Erik Schaefer and Mark A. Sussman: Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 26, 1315-1324 (2008)
32. Daniele Torella, Georgina M. Ellison, Ioannis Karakikes and Bernardo Nadal-Ginard B: Resident cardiac stem cells. Cell Mol Life Sci 64, 661-673 (2007)
33. Hajime Kubo, Naser Jaleel, Asangi Kumarapeli, Remus M. Berretta, George Bratinov, Xiaoyin Shan, Hongmei Wang, Steven R. Houser and Kenneth B. Margulies: Increased cardiac myocyte progenitors in failing human hearts. Circulation 118, 649-657 (2008)
34. Konrad Urbanek, Federico Quaini, Giordano Tasca, Daniele Torella, Clotilde Castaldo, Bernardo Nadal-Ginard, Annarosa Leri, Jan Kajstura, Eugenio Quaini, Piero Anversa: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A 100, 10440-10445 (2003) (Pubitemid 37071897)
35. Konrad Urbanek, Daniele Torella, Farooq Sheikh, Antonella De Angelis, Daria Nurzynska, Furio Silvestri, C. Alberto Beltrami, Rossana Bussani, Antonio P. Beltrami, Federico Quaini, Roberto Bolli, Annarosa Leri, Jan Kajstura and Piero Anversa: Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A 102, 8692-8697 (2005) (Pubitemid 40862797)
36. Claudia Bearzi, Marcello Rota, Toru Hosoda, Jochen Tillmanns, Angelo Nascimbene, Antonella De Angelis, Saori Yasuzawa-Amano, Irina Trofimova, Robert W. Siggins, Nicole LeCapitaine, Stefano Cascapera, Antonio P. Beltrami, David A. D'Alessandro, Elias Zias, Federico Quaini, Konrad Urbanek, Robert E. Michler, Roberto Bolli, Jan Kajstura, Annarosa Leri and Piero Anversa: Human cardiac stem cells. Proc Natl Acad Sci U S A 104, 14068-14073 (2007) (Pubitemid 350003336)
37. Cristina Chimenti, Jan Kajstura, Daniele Torella, Konrad Urbanek, Hubert Heleniak, Claudia Colussi, Franca Di Meglio, Bernardo Nadal-Ginard, Andrea Frustaci, Annarosa Leri, Attilio Maseri and Piero Anversa: Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res 93, 604-613 (2003) (Pubitemid 37222156)
38. Daniele Torella, Georgina M. Ellison, Ioannis Karakikes, Valentina Galuppo, Daniela De Serio, Francesco Onorati, Pasquale Mastroroberto, Attilio Renzulli, Ciro Indolfi and Bernardo Nadal-Ginard: Biological properties and regenerative potential, In vitro and in vivo, of human cardiac stem cells isolated from each of the four chambers of the adult human heart. Circulation 114 II, 87 (2006)
39. Katsuhisa Matsuura, Atsushi Honda, Toshio Nagai, Noritoshi Fukushima, Koji Iwanaga, Masakuni Tokunaga, Tatsuya Shimizu, Teruo Okano, Hiroshi Kasanuki, Nobuhisa Hagiwara and Issei Komuro: Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest 119, 2204-2217 (2009)
40. Anke M. Smits, Patrick van Vliet, Corina H. Metz, Tom Korfage, Joost P. G. Sluijter, Pieter A. Doevendans and Marie-José Goumans: Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an In vitro model for studying human cardiac physiology and pathophysiology. Nat Protoc 4, 232-243 (2009)
41. Anke M. Smits, Linda W. van Laake, Krista den Ouden, Chantal Schreurs, Károly Szuhai, Cees J. van Echteld, Christine L. Mummery, Pieter A. Doevendans and Marie-José Goumans: Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium. Cardiovasc Res 83, 527-535 (2009)
42. Tomomi Oyama, Toshio Nagai, Hiroshi Wada, Atsuhiko T. Naito, Katsuhisa Matsuura, Koji Iwanaga, Toshinao Takahashi, Motohiro Goto, Yoko Mikami, Noritaka Yasuda, Hiroshi Akazawa, Akiyoshi Uezumi, Shin'ichi Takeda and Issei Komuro: Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes In vitro and in vivo. J Cell Biol 176, 329-341 (2007) (Pubitemid 46184884)
43. Cindy M. Martin, Anwarul Ferdous, Teresa Gallardo, Caroline Humphries, Hesham Sadek, Arianna Caprioli, Joseph A. Garcia, Luke I. Szweda, Mary G. Garry and Daniel J. Garry: Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ Res 102, 1075-1081 (2008) (Pubitemid 351667861)
44. Alessandra Moretti, Leslie Caron, Atsushi Nakano, Jason T. Lam, Alexandra Bernshausen, Yinhong Chen, Yibing Qyang, Lei Bu, Mika Sasaki, Silvia Martin-Puig, Yunfu Sun, Sylvia M. Evans, Karl-Ludwig Laugwitz and Kenneth R. Chien: Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127, 1151-1165 (2006) (Pubitemid 44895618)
45. Yunfu Suna, Xingqun Liangb, Nader Najafia, Margaret Cassa, Lizhu Lina, Cheng-Leng Caia, Ju Chenb and Sylvia M. Evans: Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol 304, 286-296 (2007) (Pubitemid 46399697)
46. Lei Bu, Xin Jiang, Silvia Martin-Puig, Leslie Caron, Shenjun Zhu, Ying Shao, Drucilla J. Roberts, Paul L. Huang, Ibrahim J. Domian and Kenneth R. Chien: Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature 460, 113-117 (2009)
47. Michael S. Parmacek and Johnathan A. Epstein: Pursuing cardiac progenitors: regeneration redux. Cell 120, 295-298 (2005) (Pubitemid 40222424)
48. Yibing Qyang, Silvia Martin-Puig, Murali Chiravuri, Shuibing Chen, Huansheng Xu, Lei Bu, Xin Jiang, Lizhu Lin, Anne Granger, Alessandra Moretti, Leslie Caron, Xu Wu, Jonathan Clarke, Makoto M. Taketo, Karl-Ludwig Laugwitz, Randall T. Moon, Peter Gruber, Sylvia M. Evans, Sheng Ding and Kenneth R. Chien: The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell 1, 165-179 (2007) (Pubitemid 47224618)
49. Francesca Rochais, Karim Mesbah and Robert G. Kelly: Signaling pathways controlling second heart field development. Circ Res 104, 933-942 (2009)
50. Margaret E. Buckingham, Sigolène M. Meilhac and Stéphane Zaffran: Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6, 826-835 (2005)
51. Robert G. Kelly, Nigel A. Brown and Margaret E. Buckingham: The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell 1, 435-440 (2001) (Pubitemid 33586092)
52. Sigolène M. Meilhac, Milan Esner, Robert G Kelly, Jean-François Nicolas and Margaret E Buckingham: The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev Cell 6, 685-698 (2004) (Pubitemid 38579352)
53. Robert G. Kelly and Margaret E. Buckingham: The anterior heart-forming field: voyage to the arterial pole of the heart. Trends Genet 18, 210-216 (2002) (Pubitemid 34273742)
54. Brian L. Black: Transcriptional pathways in second heart field development. Semin Cell Dev Biol 18, 67-76 (2007) (Pubitemid 46343797)
55. Owen W. J. Prall, Mary K. Menon, Mark J. Solloway, Yusuke Watanabe, Stéphane Zaffran, Fanny Bajolle, Christine Biben, Jim J. McBride, Bronwyn R. Robertson, Hervé Chaulet, Fiona A. Stennard, Natalie Wise, Daniel Schaft, Orit Wolstein, Milena B. Furtado, Hidetaka Shiratori, Kenneth R. Chien, Hiroshi Hamada, Brian L. Black, Yumiko Saga, Elizabeth J. Robertson, Margaret E. Buckingham and Richard P. Harvey: An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128, 947-959 (2007) (Pubitemid 46341418)
56. Takashi Mikawa and Donald A. Fischman: Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels. Proc Natl Acad Sci U S A 89, 9504-9508 (1992)
57. Takashi Mikawa and Robert G. Gourdie: Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol 174, 221-232 (1996) (Pubitemid 26132683)
58. Adriana C. Gittenberger-de Groot, Mark-Paul F.M. Vrancken Peeters, Monica M.T. Mentink, Robert G. Gourdie and Robert E. Poelmann: Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circ Res 82, 1043-1052 (1998) (Pubitemid 28253329)
59. José-María Pérez-Pomares, Rita Carmona, Mauricio González-Iriarte, Gerardo Atencia, Andy Wessels and Ramón Muñoz-Chápuli: Origin of coronary endothelial cells from epicardial mesothelium in avian embryos. Int J Dev Biol 46, 1005-1013 (2002)
60. Federica Limana, Antonella Zacheo, David Mocini, Antonella Mangoni, Giovanna Borsellino, Adamo Diamantini, Roberta De Mori, Luca Battistini, Elisa Vigna, Massimo Santini, Vincenzo Loiaconi, Giulio Pompilio, Antonia Germani and Maurizio C. Capogrossi: Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ Res 101, 1255-1265 (2007) (Pubitemid 350294642)
61. Nicola Smart, Catherine A. Risebro, Athalie A. D. Melville, Kelvin Moses, Robert J. Schwartz, Kenneth R. Chien and Paul R. Riley: Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445, 177-1782 (2007)
62. José M. Pérez-Pomares, Juan M. González-Rosa and Ramón Muñoz-Chápuli: Building the vertebrate heart - an evolutionary approach to cardiac development. Int J Dev Biol Jan 23. [Epub ahead of print] (2009)
63. Jordan A. Kreidberg, Hannu Sariola, Janet M. Loring, Masahiro Maeda, Jerry Pelletier, David Housman and Rudolf Jaenisch: WT-1 is required for early kidney development. Cell 74, 679-691 (1993) (Pubitemid 23259748)
64. Adrian W. Moore, Lesley McInnes, Jordan Kreidberg, Nicholas D. Hastie and Andreas Schedl: YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126, 1845-1857 (1999) (Pubitemid 29240319)
65. Kay-Dietrich Wagner, Nicole Wagner, Anja Bondke, Benno Nafz, Bert Flemming, Heinz Theres and Holger Scholz: The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction. FASEB J 16, 1117-1119 (2002)
66. Bin Zhou, Qing Ma, Satish Rajagopal, Sean M. Wu, Ibrahim Domian, José Rivera-Feliciano, Dawei Jiang, Alexander von Gise, Sadakatsu Ikeda, Kenneth R. Chien and William T. Pu: Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454, 109-113 (2008) (Pubitemid 351931979)
67. Chen-Leng Cai, Jody C. Martin, Yunfu Sun, Li Cui, Lianchun Wang, Kunfu Ouyang, Lei Yang, Lei Bu, Xingqun Liang, Xiaoxue Zhang, William B. Stallcup, Christopher P. Denton, Andrew McCulloch, Ju Chen and Sylvia M. Evans: A myocardial lineage derives from Tbx18 epicardial cells. Nature 454, 104-108 (2008) (Pubitemid 351931969)
68. Daniele Torella, Ciro Indolfi, David F. Goldspink, Georgina M. Ellison: Cardiac stem cell-based myocardial regeneration: towards a translational approach. Cardiovasc Hematol Agents Med Chem 6, 53-59 (2008) (Pubitemid 351247876)
69. Steven J. Kattman, Tara L. Huber and Gordon M. Keller: Multipotent Flk-1+ Cardiovascular Progenitor CellsGive Rise to the Cardiomyocyte, Endothelial, and Vascular Smooth Muscle Lineages. Dev Cell 11, 723-732 (2006) (Pubitemid 44644969)
70. Sean M. Wu, Yuko Fujiwara, Susan M. Cibulsky, David E. Clapham, Ching-ling Lien, Thomas M. Schultheiss and Stuart H. Orkin: Developmental Origin of a Bipotential Myocardial and Smooth Muscle Cell Precursor in the Mammalian Heart. Cell 127, 1137-1150 (2006) (Pubitemid 44914005)
71. Harald C. Ott, Thomas S. Matthiesen, Johannes Brechtken, Suzanne Grindle, Saik-Kia Goh, Wendy Nelson and Doris A. Taylor: The adult human heart as a source for stem cells: repair strategies with embryonic-like progenitor cells. Nat Clin Pract Cardiovasc Med 4 Suppl 1, S27-39 (2007) (Pubitemid 46151903)