Development of an in vitro modified skin absorption test for the investigation of the follicular penetration pathway of caffeine

Skin Pharmacology and Physiology

Volumn 23, Issue 6, 2010, Pages 320-327

  Trauer, S ^a,c   Lademann, J ^a   Knorr, F ^a   Richter, H ^a   Liebsch, M ^c   Rozycki, C ^d   Balizs, G ^d   Buttemeyer R ^b   Linscheid, M ^d   Patzelt, A ^a,b  

^a Center of Experimental and Applied Cutaneous Physiology   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Caffeine; Follicle closing technique; Franz diffusion cell; Hair follicle; Penetration

Indexed keywords

CAFFEINE;

ABDOMEN; ARTICLE; BREAST; DERMIS; DRUG DELIVERY SYSTEM; EPIDERMIS; FOLLICLE CLOSING TECHNIQUE; HAIR FOLLICLE; HISTOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; METHODOLOGY; PRIORITY JOURNAL; RISK ASSESSMENT; SKIN ABSORPTION; SKIN PENETRATION;

ABDOMEN; ABSORPTION; ADMINISTRATION, CUTANEOUS; ADULT; AGED; BREAST; CAFFEINE; DIFFUSION; EPIDERMIS; FEMALE; HAIR FOLLICLE; HUMANS; MIDDLE AGED; SKIN; SKIN ABSORPTION; TEMPERATURE;

EID: 77953925317     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000313514     Document Type: Article

References (36)

1. Lotte C, Rougier A, Wilson DR, Maibach HI: In vivo relationship between transepidermal water loss and percutaneous penetration of some organic compounds in man: effect of anatomic site. Arch Dermatol Res 1987; 279: 351-356. (Pubitemid 17092171)
2. Daniels R: Galenic principles of modern skin care products. Skin Care Forum 2001; 25. http://www.scf-online.com/english/25-e/galenic-25-e.htm.
3. Moser K, Kriwet K, Naik A, Kalia YN, Guy RH: Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm 2001; 52:103-112.
4. Elias PM: Epidermal lipids, barrier function and desquamation. J Invest Dermatol 1983; 80: 44.
5. Elias PM: Epidermal lipids, membranes, and keratinization. Int J Dermatol 1981; 20:1-19.
6. Potts RO, Francoeur ML: The influence of stratum corneum morphology on water permeability. J Invest Dermatol 1991; 96:495-499.
7. Potts RO, Mak VH, Guy RH, Francoeur ML: Strategies to enhance permeability via stratum corneum lipid pathways. Adv Lipid Res 1991; 24:173-210.
8. Potts RO, Guy RH: Predicting skin permeability. Pharm Res 1992; 9: 663-669.
9. Potts RO, Guy RH: A predictive algorithm for skin permeability: the effects of molecular-size and hydrogen-bond activity. Pharm Res 1995; 12:1628-1633.
10. Lauer AC, Lieb LM, Ramachandran C, Flynn GL, Weiner ND: Transfollicular drug delivery. Pharm Res 1995; 12:179-186.
11. Lademann J, Richter H, Schaefer UF, Blume-Peytavi U, Teichmann A, Otberg N, Sterry W: Hair follicles: a long-term reservoir for drug delivery. Skin Pharmacol Physiol 2006; 19: 232-236.
12. Otberg N, Richter H, Schaefer H, Blume-Peytavi U, Sterry W, Lademann J: Variations of hair follicle size and distributionin different body sites. J Invest Dermatol 2004; 122: 14-19.
13. Otberg N, Patzelt A, Rasulev U, Hagemeister T, Linscheid M, Sinkgraven R, Sterry W, Lademann J: The role of hair follicles in the percutaneous absorption of caffeine. Br J Clin Pharmacol 2008; 65:488-492.
14. European Commission: Directive 86/609/EEC. 1986. http://ec.europa.eu/ food/fs/aw/aw-legislation/scientific/86-609-eec-en. pdf.
15. van de Sandt JJ, van Burgsteden JA, Cage S, Ca r m icha e l PL, Dick I, Kenyon S, Kor i nt h G, Larese F, Limasset JC, Maas WJ, Montomoli L, Nielsen JB, Payan JP, Robinson E, Sar-torelli P, Schaller KH, Wilkinson SC, Williams FM: In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study. Regul Toxicol Pharmacol 2004; 39: 271-281.
16. Franz TJ: Percutaneous absorption: on the relevance of in vitro data. J Invest Dermatol 1975; 64: 19 0-195
17. Organization for Economic Cooperation and Development: OECD Guidelines for Testing Chemicals. 428. Skin absorption: in vitro method. 2004. http://puck.sourceoecd. org/vl=2532293/cl=42/nw=1/rpsv/cgi-bin/fulltextew. plprpsv=/ij/oecdjournals/1607310x/v1n4/s28/p1.id x.
18. Schreiber S, Mahmoud A, Vuia A, Rübbelke MK, Schmidt E, Schaller M, Kandárová H, Haberland A, Schäfer UF, Bock U, Korting HC, Liebsch M, Schäfer-Korting M: Reconstructed epidermis versus human and animal skin in skin absorption studies. Toxicol In Vitro 2005; 19: 813-822.
19. Barry BW: Drug delivery routes in skin: a novel approach. Adv Drug Deliv Rev 2002; 54(suppl 1):S31-S40.
20. Teichmann A, Otberg N, Jacobi U, Sterry W, Lademann J: Follicular penetration: development of a method to block the follicles selectively against the penetration of topically applied substances. Skin Pharmacol Physiol 2006; 19: 216-223.
21. Dreher F, Fouchard F, Patouillet C, Andrian M, Simonnet JT, Benech-Kieffer F: Comparison of cutaneous bioavailability of cosmetic preparations containing caffeine or alpha-tocopherol applied on human skin models or human skin ex vivo at finite doses. Skin Pharmacol Appl Skin Physiol 2002; 15(suppl 1):4 0-58.
22. Organization for Economic Cooperation and Development: Guidance Document No 28. Paris, OECD 2004.
23. Williams FM: EDETOX: evaluations and predictions of dermal absorption of toxic chemicals. Int Arch Occup Environ Health 2004; 77:150-151.
24. El Maghraby GM, Williams AC, Barry BW: Skin hydration and possible shunt route penet ration in controlled estradioldelivery from ultradeformable and standard liposomes. J Pharm Pharmacol 2001; 53: 1311-132 2.
25. Jaeckle E, Schaefer UF, Loth H: Comparison of effects of different ointment bases on the penetration of ketoprofen through heat-separated human epidermis and artificial lipid barriers. J Pharm Sci 2003; 92: 1396-1406.
26. Kligman AM, Christophers E: Preparation of isolated sheets of human stratum corne-um. Arch Dermatol 1963; 88:702-705.
27. Rosado C, Cross SE, Pugh WJ, Roberts MS, Hadgraft J: Effect of vehicle pretreatment on the flux, retention, and diffusion of topically applied penetrants in vitro. Pharm Res 2003; 20:1502-1507.
28. Wagner H, Kostka KH, Lehr CM, Schaefer UF: Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents. J Control Release 2001; 75: 283-295.
29. Netzlaff F, Kaca M, Bock U, Haltner-Uko-madu E, Meiers P, Lehr CM, Schaefer UF: Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations. Eur J Pharm Biopharm 2007; 66:127-134.
30. Larsen RH, Nielsen F, Sørensen JA, Nielsen JB: Dermal penetration of fentanyl: inter-and intraindividual variations. Pharmacol Toxicol 2003; 93: 244-248.
31. Nielsen JB: Natural oils affect the human skin integrity and the percutaneous penetration of benzoic acid dose-dependently. Basic Clin Pharmacol Tox icol 2006; 98: 575-581.
32. Patzelt A, Richter H, Buettemeyer R, Huber HJ, Blume-Peytavi U, Sterry W, Lademann J: Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo. Eur J Pharm Biopharm 2008; 70:234-238.
33. Rougier A, Dupuis D, Lotte C, Roguet R, Wester RC, Maibach HI: Regional variation in percutaneous absorption in man: measurement by the stripping method. Arch Dermatol Res 1986; 278: 465-469.
34. Tokumura F, Yoshiura Y, Homma T, Nuka-tsuka H: Regional differences in adhesive tape stripping of human skin. Skin Res Technol 2006; 12:178-182.
35. Wilkinson SC, Maas WJ, Nielsen JB, Greaves LC, van de Sandt JJ, Williams FM: Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies. Int Arch Occup Environ Health 2006; 79: 405-413.
36. Dick IP, Scott RC: Pig ear skin as an in vitro model for human skin permeability. J Pharm Pharmacol 1992; 4 4: 6 4 0-6 45.