-
2
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23:1011-1027.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
4
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009; 27:740-745.
-
(2009)
J Clin Oncol
, vol.27
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
5
-
-
0042343801
-
A randomized trial of bevacizumab, an antivascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an antivascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349:427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
6
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002; 99:11393-11398.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
7
-
-
33751418762
-
A phase i dose-escalation study of weekly IMC-1121B, a fully human antivascular endothelial growth factor receptor 2 (VEGFR2) IgG1 monoclonal antibody (Mab), in patients (pts) with advanced cancer
-
[abstract #3032]
-
Camidge DR, Eckhardt SG, Diab S, et al. A phase I dose-escalation study of weekly IMC-1121B, a fully human antivascular endothelial growth factor receptor 2 (VEGFR2) IgG1 monoclonal antibody (Mab), in patients (pts) with advanced cancer [abstract #3032]. J Clin Oncol 2006; 24 (18 Suppl).
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 SUPPL.
-
-
Camidge, D.R.1
Eckhardt, S.G.2
Diab, S.3
-
8
-
-
69549147378
-
A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP Protocol C-08
-
[abstract #LBA4]
-
Wolmark N, Yothers G, O'Connell MJ, et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP Protocol C-08 [abstract #LBA4]. J Clin Oncol 2009; 27 (18 Suppl).
-
(2009)
J Clin Oncol
, vol.27
, Issue.18 SUPPL.
-
-
Wolmark, N.1
Yothers, G.2
O'Connell, M.J.3
-
9
-
-
66149147757
-
Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer
-
Allegra CJ, Yothers G, O'Connell MJ, et al. Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol 2009; 27:3385-3390.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3385-3390
-
-
Allegra, C.J.1
Yothers, G.2
O'Connell, M.J.3
-
10
-
-
60849123935
-
Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials
-
Sargent D, Sobrero A, Grothey A, et al. Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 2009; 27:872-877.
-
(2009)
J Clin Oncol
, vol.27
, pp. 872-877
-
-
Sargent, D.1
Sobrero, A.2
Grothey, A.3
-
11
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15:220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
12
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
13
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008; 26:2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
14
-
-
42949150908
-
Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer
-
Cassidy J, Clarke S, Diaz-Rubio E, et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol 2008; 26:2006-2012.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2006-2012
-
-
Cassidy, J.1
Clarke, S.2
Diaz-Rubio, E.3
-
15
-
-
49049105525
-
Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE Study
-
Hochster HS, Hart LL, Ramanathan RK, et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. J Clin Oncol 2008; 26:3523-3529.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3523-3529
-
-
Hochster, H.S.1
Hart, L.L.2
Ramanathan, R.K.3
-
16
-
-
36048960109
-
Randomized, controlled trial of irinotecan plus infusional, bolus, or oralfluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
-
Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oralfluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007; 25:4779-4786.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4779-4786
-
-
Fuchs, C.S.1
Marshall, J.2
Mitchell, E.3
-
17
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007; 25:1539-1544.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
18
-
-
56749169353
-
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
-
Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol 2008; 26:5326-5334.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5326-5334
-
-
Grothey, A.1
Sugrue, M.M.2
Purdie, D.M.3
-
19
-
-
62449211422
-
The safety of long-term bevacizumab use: Results from the BRiTE observational cohort study (OCS)
-
Purdie DM, Berlin JD, Flynn PJ, et al. The safety of long-term bevacizumab use: results from the BRiTE observational cohort study (OCS). J Clin Oncol 2008; 26 (20 Suppl).
-
(2008)
J Clin Oncol
, vol.26
, Issue.20 SUPPL.
-
-
Purdie, D.M.1
Berlin, J.D.2
Flynn, P.J.3
-
20
-
-
75649128589
-
Bevacizumab (Bev) beyond progression (BP) in combination with second-line chemotherapy (CT) after failure of a Bev containing first-line CT in patients (pts) with metastastic colorectal cancer (mCRC). Preliminary baseline and safety analysis from the AIO 0504/AGMT phase III study
-
[abstract #469]
-
Arnold D, Reinacher-Schick A, Muller L, et al. Bevacizumab (Bev) beyond progression (BP) in combination with second-line chemotherapy (CT) after failure of a Bev containing first-line CT in patients (pts) with metastastic colorectal cancer (mCRC). Preliminary baseline and safety analysis from the AIO 0504/AGMT phase III study [abstract #469]. Presented at 2008 Gastrointestinal Cancers Symposium; 2008.
-
(2008)
Presented at 2008 Gastrointestinal Cancers Symposium
-
-
Arnold, D.1
Reinacher-Schick, A.2
Muller, L.3
-
21
-
-
35648941728
-
Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
-
Saltz LB, Lenz HJ, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 2007; 25:4557-4561.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4557-4561
-
-
Saltz, L.B.1
Lenz, H.J.2
Kindler, H.L.3
-
22
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemother apy and bevacizumab alone for metastatic colorectal cancer
-
Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemother apy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27:672-680.
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
23
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360:563-572.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
24
-
-
70349782389
-
An overview of small-molecule inhibitors of VEGFR signaling
-
Ivy SP, Wick JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009; 6:569-579.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 569-579
-
-
Ivy, S.P.1
Wick, J.Y.2
Kaufman, B.M.3
-
25
-
-
0032490124
-
Kirsten ras mutations in patients with colorectal cancer: The multicenter 'RASCAL' study
-
Andreyev HJ, Norman AR, Cunningham D, et al. Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J Natl Cancer Inst 1998; 90:675-684.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 675-684
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
-
26
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
27
-
-
0036332684
-
Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer
-
Cassano A, Bagala C, Battelli C, et al. Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer. Anticancer Res 2002; 22:2179-2184.
-
(2002)
Anticancer Res
, vol.22
, pp. 2179-2184
-
-
Cassano, A.1
Bagala, C.2
Battelli, C.3
-
28
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356:125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
29
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
30
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitortargeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitortargeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003; 9:327-337.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
31
-
-
36048992408
-
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
-
Saltz LB, Rosen LS, Marshall JL, et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007; 25:4793-4799.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4793-4799
-
-
Saltz, L.B.1
Rosen, L.S.2
Marshall, J.L.3
-
32
-
-
67649651712
-
Phase i study to evaluate the safety and efficacy of sunitinib in combination with FOLFIRI in treatment-näive metastatic colorectal cancer (mCRC)
-
[abstract #3563]
-
Starling N, Vazquez F, Cunningham D, et al. Phase I study to evaluate the safety and efficacy of sunitinib in combination with FOLFIRI in treatment-näive metastatic colorectal cancer (mCRC) [abstract #3563]. J Clin Oncol 2008; 26 (Suppl).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Starling, N.1
Vazquez, F.2
Cunningham, D.3
-
33
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008; 7:3129-3140.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
-
34
-
-
49249113484
-
Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
-
Azad NS, Posadas EM, Kwitkowski VE, et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008; 26:3709-3714.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3709-3714
-
-
Azad, N.S.1
Posadas, E.M.2
Kwitkowski, V.E.3
-
35
-
-
77951907727
-
A phase i study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors
-
Sharma S, Abhyankar V, Burgess RE, et al. A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors. Ann Oncol 2010; 21:297-304.
-
(2010)
Ann Oncol
, vol.21
, pp. 297-304
-
-
Sharma, S.1
Abhyankar, V.2
Burgess, R.E.3
-
36
-
-
63149168979
-
Phase i study of cediranib in combination with oxaliplatin and infusional 5-Fluorouracil in patients with advanced color-ectal cancer
-
Chen E, Jonker D, Gauthier I, et al. Phase I study of cediranib in combination with oxaliplatin and infusional 5-Fluorouracil in patients with advanced color-ectal cancer. Clin Cancer Res 2009; 15:1481-1486.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1481-1486
-
-
Chen, E.1
Jonker, D.2
Gauthier, I.3
-
37
-
-
63449117507
-
A phase II, double-blind, randomized multicenter study of cediranib with FOLFOX versus bevacizu-mab with FOLFOX in patients with previously treated metastatic colorectal cancer (mCRC): Final PFS results
-
[abstract #4028]
-
Cunningham D, Wong RP, D'haens G, et al. A phase II, double-blind, randomized multicenter study of cediranib with FOLFOX versus bevacizu-mab with FOLFOX in patients with previously treated metastatic colorectal cancer (mCRC): final PFS results [abstract #4028]. J Clin Oncol 2008; 26 (Suppl).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Cunningham, D.1
Wong, R.P.2
D'Haens, G.3
-
38
-
-
77953911437
-
Phase i study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced refractory colorectal carcinoma (CRC)
-
[abstract #3560]
-
Strumberg D, Scheulen ME, Frost A, et al. Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced refractory colorectal carcinoma (CRC) [abstract #3560]. J Clin Oncol 2009; 27 (15 Suppl).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Strumberg, D.1
Scheulen, M.E.2
Frost, A.3
-
39
-
-
59349086005
-
A phase i study of brivanib alaninate (BMS-582664),anoral dual inhibitorof VEGFR and FGFR tyrosine kinases, in combination with full dose cetuximab (BC) in patients (pts) with advanced gastrointestinal malignancies (AGM) who failed prior therapy
-
[abstract #4111]
-
Garrett CR, Siu LL, Giaccone G, et al. A phase I study of brivanib alaninate (BMS-582664),anoral dual inhibitorof VEGFR and FGFR tyrosine kinases, in combination with full dose cetuximab (BC) in patients (pts) with advanced gastrointestinal malignancies (AGM) who failed prior therapy [abstract #4111]. J Clin Oncol 2008; 26 (Suppl).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Garrett, C.R.1
Siu, L.L.2
Giaccone, G.3
-
40
-
-
77953916721
-
Correlation between K-ras status and efficacy results from a phase I/II study of brivanib alaninate in combination with cetuximab in patients (pts) with advanced or metastatic colorectal cancer (CRC)
-
[abstract #375].
-
Ayers M, Awad M, Malone D, et al. Correlation between K-ras status and efficacy results from a phase I/II study of brivanib alaninate in combination with cetuximab in patients (pts) with advanced or metastatic colorectal cancer (CRC) [abstract #375]. 2009 Gastrointestinal Cancers Symposium.
-
(2009)
Gastrointestinal Cancers Symposium
-
-
Ayers, M.1
Awad, M.2
Malone, D.3
|