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Volumn 163, Issue 1-3, 2010, Pages 96-101

Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes

Author keywords

Alpha cell; Diabetes; Glucagon; Glucagon like peptide 2 (GLP 2); Glucose dependent insulinotropic polypeptide (GIP); Incretin effect; Type 1 diabetes mellitus

Indexed keywords

ARGININE; C PEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; INSULIN; SODIUM CHLORIDE;

EID: 77953914489     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2010.05.004     Document Type: Article
Times cited : (20)

References (32)
  • 1
    • 33846856711 scopus 로고    scopus 로고
    • Alpha-cells of the endocrine pancreas: 35years of research but the enigma remains
    • Gromada J., Franklin I., Wollheim C.B. Alpha-cells of the endocrine pancreas: 35years of research but the enigma remains. Endocr Rev 2007, 28(1):84-116.
    • (2007) Endocr Rev , vol.28 , Issue.1 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 2
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion
    • Muller W.A., Faloona G.R., Aguilar-Parada E., Unger R.H. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 1970, 283(3):109-115.
    • (1970) N Engl J Med , vol.283 , Issue.3 , pp. 109-115
    • Muller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 3
  • 4
    • 0023109225 scopus 로고
    • Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus
    • Reaven G.M., Chen Y.D., Golay A., Swislocki A.L., Jaspan J.B. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987, 64(1):106-110.
    • (1987) J Clin Endocrinol Metab , vol.64 , Issue.1 , pp. 106-110
    • Reaven, G.M.1    Chen, Y.D.2    Golay, A.3    Swislocki, A.L.4    Jaspan, J.B.5
  • 5
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P., Vella A., Basu A., Basu R., Schwenk W.F., Rizza R.A. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 2000, 85(11):4053-4059.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.11 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 6
    • 0018194884 scopus 로고
    • Abnormal alpha cell function in human diabetes: the response to oral protein
    • Raskin P., Aydin I., Yamamoto T., Unger R.H. Abnormal alpha cell function in human diabetes: the response to oral protein. Am J Med 1978, 64(6):988-997.
    • (1978) Am J Med , vol.64 , Issue.6 , pp. 988-997
    • Raskin, P.1    Aydin, I.2    Yamamoto, T.3    Unger, R.H.4
  • 7
    • 0022544334 scopus 로고
    • Effect of composition of mixed meals-low- versus high-carbohydrate content-on insulin, glucagon, and somatostatin release in healthy humans and in patients with NIDDM
    • Gutniak M., Grill V., Efendic S. Effect of composition of mixed meals-low- versus high-carbohydrate content-on insulin, glucagon, and somatostatin release in healthy humans and in patients with NIDDM. Diab Care 1986, 9(3):244-249.
    • (1986) Diab Care , vol.9 , Issue.3 , pp. 244-249
    • Gutniak, M.1    Grill, V.2    Efendic, S.3
  • 8
    • 23944516266 scopus 로고    scopus 로고
    • Impact of glucagon response on postprandial hyperglycemia in men with impaired glucose tolerance and type 2 diabetes mellitus
    • Henkel E., Menschikowski M., Koehler C., Leonhardt W., Hanefeld M. Impact of glucagon response on postprandial hyperglycemia in men with impaired glucose tolerance and type 2 diabetes mellitus. Metabolism 2005, 54(9):1168-1173.
    • (2005) Metabolism , vol.54 , Issue.9 , pp. 1168-1173
    • Henkel, E.1    Menschikowski, M.2    Koehler, C.3    Leonhardt, W.4    Hanefeld, M.5
  • 9
    • 12244284000 scopus 로고    scopus 로고
    • Beta- and alpha-cell dysfunction in type 2 diabetes
    • Del Prato S., Marchetti P. Beta- and alpha-cell dysfunction in type 2 diabetes. Horm Metab Res 2004, 36(11-12):775-781.
    • (2004) Horm Metab Res , vol.36 , Issue.11-12 , pp. 775-781
    • Del Prato, S.1    Marchetti, P.2
  • 10
    • 23044517378 scopus 로고    scopus 로고
    • Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon?
    • Raju B., Cryer P.E. Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon?. Am J Physiol Endocrinol Metab 2005, 289(2):E181-E186.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , Issue.2
    • Raju, B.1    Cryer, P.E.2
  • 11
    • 34250854205 scopus 로고    scopus 로고
    • The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    • Dunning B.E., Gerich J.E. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007, 28(3):253-283.
    • (2007) Endocr Rev , vol.28 , Issue.3 , pp. 253-283
    • Dunning, B.E.1    Gerich, J.E.2
  • 12
    • 0022467301 scopus 로고
    • Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues
    • Firth R.G., Bell P.M., Marsh H.M., Hansen I., Rizza R.A. Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. J Clin Invest 1986, 77(5):1525-1532.
    • (1986) J Clin Invest , vol.77 , Issue.5 , pp. 1525-1532
    • Firth, R.G.1    Bell, P.M.2    Marsh, H.M.3    Hansen, I.4    Rizza, R.A.5
  • 13
    • 0016850888 scopus 로고
    • Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus
    • Gerich J.E., Lorenzi M., Karam J.H., Schneider V., Forsham P.H. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA 1975, 234(2):155-159.
    • (1975) JAMA , vol.234 , Issue.2 , pp. 155-159
    • Gerich, J.E.1    Lorenzi, M.2    Karam, J.H.3    Schneider, V.4    Forsham, P.H.5
  • 14
    • 33847682160 scopus 로고    scopus 로고
    • Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
    • Knop F.K., Vilsboll T., Madsbad S., Holst J.J., Krarup T. Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus. Diabetologia 2007, 50(4):797-805.
    • (2007) Diabetologia , vol.50 , Issue.4 , pp. 797-805
    • Knop, F.K.1    Vilsboll, T.2    Madsbad, S.3    Holst, J.J.4    Krarup, T.5
  • 15
    • 48449093468 scopus 로고    scopus 로고
    • Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    • Muscelli E., Mari A., Casolaro A., Camastra S., Seghieri G., Gastaldelli A., et al. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008, 57(5):1340-1348.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1340-1348
    • Muscelli, E.1    Mari, A.2    Casolaro, A.3    Camastra, S.4    Seghieri, G.5    Gastaldelli, A.6
  • 16
    • 33847634679 scopus 로고    scopus 로고
    • Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects
    • Meier J.J., Deacon C.F., Schmidt W.E., Holst J.J., Nauck M.A. Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects. Diabetologia 2007, 50(4):806-813.
    • (2007) Diabetologia , vol.50 , Issue.4 , pp. 806-813
    • Meier, J.J.1    Deacon, C.F.2    Schmidt, W.E.3    Holst, J.J.4    Nauck, M.A.5
  • 17
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
    • Creutzfeldt W.O., Kleine N., Willms B., Orskov C., Holst J.J., Nauck M.A. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diab Care 1996, 19(6):580-586.
    • (1996) Diab Care , vol.19 , Issue.6 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Orskov, C.4    Holst, J.J.5    Nauck, M.A.6
  • 18
    • 0038574573 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
    • Meier J.J., Gallwitz B., Siepmann N., Holst J.J., Deacon C.F., Schmidt W.E., et al. Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. Diabetologia 2003, 46(6):798-801.
    • (2003) Diabetologia , vol.46 , Issue.6 , pp. 798-801
    • Meier, J.J.1    Gallwitz, B.2    Siepmann, N.3    Holst, J.J.4    Deacon, C.F.5    Schmidt, W.E.6
  • 19
    • 0018138396 scopus 로고
    • Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secretion from the perfused rat pancreas
    • Pederson R.A., Brown J.C. Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secretion from the perfused rat pancreas. Endocrinology 1978, 103(2):610-615.
    • (1978) Endocrinology , vol.103 , Issue.2 , pp. 610-615
    • Pederson, R.A.1    Brown, J.C.2
  • 20
    • 0242383351 scopus 로고    scopus 로고
    • The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
    • Vilsboll T., Knop F.K., Krarup T., Johansen A., Madsbad S., Larsen S., et al. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. J Clin Endocrinol Metab 2003, 88(10):4897-4903.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.10 , pp. 4897-4903
    • Vilsboll, T.1    Knop, F.K.2    Krarup, T.3    Johansen, A.4    Madsbad, S.5    Larsen, S.6
  • 21
    • 34548475076 scopus 로고    scopus 로고
    • The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas
    • de Heer J., Pedersen J., Orskov C., Holst J.J. The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas. Diabetologia 2007, 50(10):2135-2142.
    • (2007) Diabetologia , vol.50 , Issue.10 , pp. 2135-2142
    • de Heer, J.1    Pedersen, J.2    Orskov, C.3    Holst, J.J.4
  • 22
    • 30044441999 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans
    • Meier J.J., Nauck M.A., Pott A., Heinze K., Goetze O., Bulut K., et al. Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans. Gastroenterology 2006, 130(1):44-54.
    • (2006) Gastroenterology , vol.130 , Issue.1 , pp. 44-54
    • Meier, J.J.1    Nauck, M.A.2    Pott, A.3    Heinze, K.4    Goetze, O.5    Bulut, K.6
  • 23
    • 0021211623 scopus 로고
    • The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antisera
    • Krarup T., Holst J.J. The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antisera. Regul Pept 1984, 9(1-2):35-46.
    • (1984) Regul Pept , vol.9 , Issue.1-2 , pp. 35-46
    • Krarup, T.1    Holst, J.J.2
  • 24
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon C.F., Nauck M.A., Meier J., Hucking K., Holst J.J. Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 2000, 85(10):3575-3581.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.10 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.3    Hucking, K.4    Holst, J.J.5
  • 25
  • 26
    • 0026027919 scopus 로고
    • Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine
    • Orskov C., Jeppesen J., Madsbad S., Holst J.J. Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest 1991, 87(2):415-423.
    • (1991) J Clin Invest , vol.87 , Issue.2 , pp. 415-423
    • Orskov, C.1    Jeppesen, J.2    Madsbad, S.3    Holst, J.J.4
  • 27
    • 0020048507 scopus 로고
    • Glucagon immunoreactivity in plasma from normal and dystrophic mice
    • Ahren B., Lundquist I. Glucagon immunoreactivity in plasma from normal and dystrophic mice. Diabetologia 1982, 22(4):258-263.
    • (1982) Diabetologia , vol.22 , Issue.4 , pp. 258-263
    • Ahren, B.1    Lundquist, I.2
  • 29
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon C.F., Nauck M.A., Meier J., Hucking K., Holst J.J. Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 2000, 85(10):3575-3581.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.10 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.3    Hucking, K.4    Holst, J.J.5
  • 30
    • 33846010109 scopus 로고    scopus 로고
    • Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution
    • Knop F.K., Vilsboll T., Larsen S., Hojberg P.V., Volund A., Madsbad S., et al. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. Am J Physiol Endocrinol Metab 2007, 292(1):E324-E330.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.1
    • Knop, F.K.1    Vilsboll, T.2    Larsen, S.3    Hojberg, P.V.4    Volund, A.5    Madsbad, S.6
  • 31
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck M.A., Heimesaat M.M., Orskov C., Holst J.J., Ebert R., Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993, 91(1):301-307.
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 32
    • 0242499995 scopus 로고    scopus 로고
    • No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects
    • Sorensen L.B., Flint A., Raben A., Hartmann B., Holst J.J., Astrup A. No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. Int J Obes Relat Metab Disord 2003, 27(4):450-456.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.4 , pp. 450-456
    • Sorensen, L.B.1    Flint, A.2    Raben, A.3    Hartmann, B.4    Holst, J.J.5    Astrup, A.6


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