Rapid and label-free screening of enzyme inhibitors using segmented flow electrospray ionization mass spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 21, Issue 7, 2010, Pages 1107-1113

  Pei, Jian ^a   Li, Qiang ^a   Kennedy, Robert T ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ANALYTICAL TOOL; DISCRETE SAMPLE; DOSE-RESPONSE CURVES; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; EMITTER TIPS; ENZYME ASSAYS; ENZYME INHIBITORS; FLOW INJECTION ANALYSIS; HIGH-THROUGHPUT; HIGH-THROUGHPUT SCREENING; LABEL FREE; NANOLITER PLUGS; RAPID SCAN; SAMPLE ANALYSIS; SAMPLE INTRODUCTION; SEGMENTED FLOW;

ENZYMES; IONIZATION; LABELS; MASS SPECTROMETRY; PARTICLE DETECTORS; PLATINUM; THROUGHPUT;

ELECTROSPRAY IONIZATION;

CHOLINESTERASE INHIBITOR; ENZYME INHIBITOR;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; COLORIMETRY; CONTROLLED STUDY; DOSE RESPONSE; ELECTROSPRAY MASS SPECTROMETRY; FLOW INJECTION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROLYSIS; REPRODUCIBILITY; SENSITIVITY ANALYSIS;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDROPHONIUM; LINEAR MODELS; MALATHION; NEOSTIGMINE; PHYSOSTIGMINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77953913640     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2010.02.013     Document Type: Article

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