The Galanin N-terminal fragment (1-15) interacts with neuropeptide Y in central cardiovascular control: Involvement of the NPY Y2 receptor subtype

Regulatory Peptides

Volumn 163, Issue 1-3, 2010, Pages 130-136

  Díaz Cabiale, Zaida ^a   Parrado, Concepción ^a   Narváez, Manuel ^a   Millón, Carmelo ^a   Puigcerver, Araceli ^a   Fuxe, Kjell ^b   Narváez, José A ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

NTS; Rat; Receptor autoradiography

Indexed keywords

GALANIN; GALANIN RECEPTOR; M 40; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CARDIOVASCULAR EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; RECEPTOR BINDING; SOLITARY TRACT NUCLEUS;

ANIMALS; CARDIOVASCULAR SYSTEM; GALANIN; MALE; NEUROPEPTIDE Y; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y;

RATTUS;

EID: 77953911371     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2010.04.014     Document Type: Article

References (38)

1. Tatemoto K., Rokaeus A., Jornvall H., McDonald T.J., Mutt V. Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett 1983, 164:124-128.
2. Jacobowitz D.M., Kresse A., Skofitsch G. Galanin in the brain: chemoarchitectonics and brain cartography-a historical review. Peptides 2004, 25:433-464.
3. Diaz-Cabiale Z., Parrado C., Vela C., Razani H., Covenas R., Fuxe K., Narvaez J.A. Role of galanin and galanin(1-15) on central cardiovascular control. Neuropeptides 2005, 39:185-190.
4. Walton K.M., Chin J.E., Duplantier A.J., Mather R.J. Galanin function in the central nervous system. Curr Opin Drug Discov Devel 2006, 9:560-570.
5. Lang R., Gundlach A.L., Kofler B. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther 2007, 115:177-207.
6. Narvaez J.A., Diaz Z., Aguirre J.A., Gonzalez-Baron S., Yanaihara N., Fuxe K., Hedlund P.B. Intracisternally injected galanin-(1-15) modulates the cardiovascular responses of galanin-(1-29) and the 5-HT1A receptor agonist 8-OH-DPAT. Eur J Pharmacol 1994, 257:257-265.
7. Harfstrand A., Fuxe K., Melander T., Hokfelt T., Agnati L.F. Evidence for a cardiovascular role of central galanin neurons: focus on interactions with alpha 2-adrenergic and neuropeptide Y mechanisms. J Cardiovasc Pharmacol 1987, 10(Suppl 12):S199-S204.
8. Diaz-Cabiale Z., Cordon M.P., Covenas R., Rivera A., Yanaihara N., Fuxe K., Gonzalez-Baron S., Narvaez J.A. Propranolol blocks the tachycardia induced by galanin (1-15) but not by galanin (1-29). Regul Pept 2002, 107:29-36.
9. Abbott S.B., Pilowsky P.M. Galanin microinjection into rostral ventrolateral medulla of the rat is hypotensive and attenuates sympathetic chemoreflex. Am J Physiol Regul Integr Comp Physiol 2009, 296:R1019-R1026.
10. Diaz-Cabiale Z., Narvaez J.A., Marcos P., Cordon M.P., Covenas R., Fuxe K., Gonzalez-Baron S. Galanin and NH2-terminal galanin fragments in central cardiovascular regulation. Ann N Y Acad Sci 1998, 863:421-424.
11. Diaz Z., Narvaez J.A., Hedlund P.B., Aguirre J.A., Gonzalez-Baron S., Fuxe K. Centrally infused galanin-(1-15) but not galanin-(1-29) reduces the baroreceptor reflex sensitivity in the rat. Brain Res 1996, 741:32-37.
12. Marcos P., Diaz-Cabiale Z., Cordon M.P., Covenas R., Yanaihara N., Fuxe K., Gonzalez-Baron S., Narvaez J.A. Central galanin and N-terminal galanin fragment induce c-Fos immunoreactivity in the medulla oblongata of the anesthetized rat. Peptides 2001, 22:1501-1509.
13. Díaz-Cabiale Z., Parrado C., Narvaéz M., Millón C., Puigcerver A., Fuxe K., Narvaéz J. Neurochemical modulation of central cardiovascular control. The integrative role of galanin 2010, Galanin: Birkhauser. T. Hokfelt (Ed.).
14. Hedlund P.B., Yanaihara N., Fuxe K. Evidence for specific N-terminal galanin fragment binding sites in the rat brain. Eur J Pharmacol 1992, 224:203-205.
15. Diaz-Cabiale Z., Narvaez J.A., Yanaihara N., Gonzalez-Baron S., Fuxe K. Galanin/alpha2-receptor interactions in central cardiovascular control. Neuropharmacology 2000, 39:1377-1385.
16. Diaz-Cabiale Z., Parrado C., Fuxe K., Agnati L., Narvaez J.A. Receptor-receptor interactions in central cardiovascular regulation. Focus on neuropeptide/alpha(2)-adrenoreceptor interactions in the nucleus tractus solitarius. J Neural Transm 2007, 114:115-125.
17. Diaz-Cabiale Z., Parrado C., Rivera A., de la Calle A., Agnati L., Fuxe K., Narvaez J.A. Galanin-neuropeptide Y (NPY) interactions in central cardiovascular control: involvement of the NPY Y receptor subtype. Eur J Neurosci 2006, 24:499-508.
18. Diaz-Cabiale Z., Parrado C., Vela C., Covenas R., Yanaihara N., Fuxe K., Gonzalez-Baron S., Narvaez J.A. Intracisternal galanin/angiotensin II interactions in central cardiovascular control. Regul Pept 2005, 127:133-140.
19. Dumont Y., Fournier A., St-Pierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain. J Neurosci 1993, 13:73-86.
20. Fuxe K., Aguirre J.A., Agnati L.F., von Euler G., Hedlund P., Covenas R., Zoli M., Bjelke B., Eneroth P. Neuropeptide Y and central cardiovascular regulation. Focus on its role as a cotransmitter in cardiovascular adrenergic neurons. Ann N Y Acad Sci 1990, 611:111-132.
21. Barraco R.A., Ergene E., Dunbar J.C., el-Ridi M.R. Cardiorespiratory response patterns elicited by microinjections of neuropeptide Y in the nucleus tractus solitarius. Brain Res Bull 1990, 24:465-485.
22. Yang S.N., Narvaez J.A., Bjelke B., Agnati L.F., Fuxe K. Microinjections of subpicomolar amounts of NPY(13-36) into the nucleus tractus solitarius of the rat counteract the vasodepressor responses of NPY(1-36) and of a NPY Y1 receptor agonist. Brain Res 1993, 621:126-132.
23. Aguirre J.A., Fuxe K., Agnati L.F., von Euler G. Centrally injected neuropeptide Y (13-36) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y (1-36) in the awake male rat. Neurosci Lett 1990, 118:5-8.
24. 34]NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline. Neurosci Lett 1994, 171:27-31.
25. Narvaez J.A., Aguirre J.A., Fuxe K. Subpicomolar amounts of NPY(13-36) injected into the nucleus tractus solitarius of the rat counteract the cardiovascular responses to L-glutamate. Neurosci Lett 1993, 151:182-186.
26. Agnati L.F., Ferre S., Lluis C., Franco R., Fuxe K. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev 2003, 55:509-550.
27. AbdAlla S., Abdel-Baset A., Lother H., el Massiery A., Quitterer U. Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension. J Mol Neurosci 2005, 26:185-192.
28. Fior D.R., Hedlund P.B., Fuxe K. Autoradiographic evidence for a bradykinin/angiotensin II receptor-receptor interaction in the rat brain. Neurosci Lett 1993, 163:58-62.
29. Gehlert D.R., Schober D.A., Morin M., Berglund M.M. Co-expression of neuropeptide Y Y1 and Y5 receptors results in heterodimerization and altered functional properties. Biochem Pharmacol 2007, 74:1652-1664.
30. Borroto-Escuela D.O., Narvaez M., Marcellino D., Parrado C., Narvaez J.A., Tarakanov A.O., Agnati L.F., Diaz-Cabiale Z., Fuxe K. Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization. Biochem Biophys Res Commun 2010, 393:767-772.
31. Lu X., Lundstrom L., Langel U., Bartfai T. Galanin receptor ligands. Neuropeptides 2005, 39:143-146.
32. Narvaez J.A., Diaz-Cabiale Z., Hedlund P.B., Aguirre J.A., Covenas R., Gonzalez-Baron S., Fuxe K. The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15). Eur J Pharmacol 2000, 399:197-203.
33. Crawley J.N., Robinson J.K., Langel U., Bartfai T. Galanin receptor antagonists M40 and C7 block galanin-induced feeding. Brain Res 1993, 600:268-272.
34. Rada P., Avena N.M., Leibowitz S.F., Hoebel B.G. Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist. Alcohol 2004, 33:91-97.
35. Waters S.M., Krause J.E. Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues. Neuroscience 2000, 95:265-271.
36. Branchek T., Smith K.E., Walker M.W. Molecular biology and pharmacology of galanin receptors. Ann N Y Acad Sci 1998, 863:94-107.
37. O'Donnell D., Ahmad S., Wahlestedt C., Walker P. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. J Comp Neurol 1999, 409:469-481.
38. Fuxe K., Marcellino D., Rivera A., Diaz-Cabiale Z., Filip M., Gago B., Roberts D.C., Langel U., Genedani S., Ferraro L., de la Calle A., Narvaez J., Tanganelli S., Woods A., Agnati L.F. Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology. Brain Res Rev 2008, 58:415-452.