The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15)

European Journal of Pharmacology

Volumn 399, Issue 2-3, 2000, Pages 197-203

  Narváez, José A ^a   Díaz Cabiale, Zaida ^d   Hedlund, Peter B ^b   Aguirre, José A ^a   Coveñas, Rafael ^c   González Barón, Salvador ^a   Fuxe, Kjell ^b  

^a Camp Teatinos S   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d NONE

Author keywords

Brain; Cardiovascular; Galanin; Galanin receptor; Galanin receptor antagonist; Galanin (1 15); Neuropeptide

Indexed keywords

GALANIN; GALANIN RECEPTOR; GALANIN[1-15]; HYPERTENSIVE FACTOR; M 40; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; PRESSORECEPTOR; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGY; CISTERNA MAGNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GALANIN; HEART RATE; MALE; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GALANIN; RECEPTORS, NEUROPEPTIDE; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 0343496988     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00383-6     Document Type: Article

References (46)

1. Bartfai T., Bedecs K., Land T., Langel U., Bertorelli R., Girotti P., Consolo S., Xu X.J., Wiesenfeld-Hallin Z., Nilsson S., Hökfelt T. M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord. Proc. Natl. Acad. Sci. U. S. A. 88:1991;10961-10965.
2. Bartfai B., Hökfelt T., Langel U. Galanin - a neuroendocrine peptide. Crit. Rev. Neurobiol. 7:1993;229-274.
3. Bartfai T., Langel U., Bedecs K., Andell S., Land T., Gregersen S., Ahre B., Girotti P., Consolo S., Corwin R., Crawley J.N., Xu X.J., Wiesenfeld-Hallin Z., Hökfelt T. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc. Natl. Acad. Sci. U. S. A. 90:1993;11287-11291.
4. Billecocq A., Hedlund P.B., Bolaños-Jiménez F., Fillion G. Characterization of galanin and 5-HT1A receptor coupling to adenyl-cyclase in discrete regions of the rat brain. Eur. J. Pharmacol. 269:1994;209-217.
5. Consolo S., Uboldi M.C., Caltavuturo C., Bartfai T. Galanin stimulates the N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in vivo in the ventral hippocampus. Neuroscience. 85:1998;819-826.
6. Corwin R.L., Robinson J.K., Crawley J.N. Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat. Eur. J. Neurosci. 5:1993;1528-1533.
7. Corwin R.L., Rowe P.M., Crawley J.N. Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats. Am. J. Physiol. 269:1995;R511-R518.
8. Crawley J.N. Biological actions of galanin. Regul. Pept. 59:1995;1-16.
9. Crawley J.N., Austin M.C., Fiske S.M., Martin S., Consolo S., Berthold M., Langel U., Fisone G., Bartfai T. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J. Neurosci. 10:1990;3695-3700.
10. Crawley J.N., Robinson J.K., Langel U., Bartfai T. Galanin receptor antagonists M40 and C7 block galanin-induced feeding. Brain Res. 600:1993;268-272.
11. 125I]galantide. J. Pharmacol. Exp. Ther. 275:1995;720-727.
12. Díaz Z., Narváez J.A., Hedlund P.B., Aguirre J.A., González-Barón S., Fuxe K. Centrally infused galanin-(1-15) but not galanin-(1-29) reduces the baroreceptor reflex sensitivity in the rat. Brain Res. 741:1996;32-37.
13. Fisone G., Berthold M., Bedecs K., Unden A., Bartfai T., Bertorelli R., Consolo S., Crawley J.N., Martin B., Nilsson S., Hökfelt T. N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor. Proc. Natl. Acad. Sci. U. S. A. 86:1989;9588-9591.
14. Fisone G., Langel U., Carlquist M., Bergman T., Consolo S., Hökfelt T., Undén A., Arnell S., Bartfai T. Galanin receptor and its ligands in the rat hippocampus. Eur. J. Pharmacol. 181:1989;269-276.
15. Girotti P., Bertorelli R., Fisone G., Land T., Langel U., Consolo S., Bartfai T. N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo. Brain Res. 216:1993;258-262.
16. Gustafson E.L., Smith K.E., Durkin M.M., Gerald C., Branchek T.A. Distribution of a rat galanin receptor mRNA in rat brain. NeuroReport. 7:1996;953-957.
17. 2-adrenergic and Neuropeptide Y mechanisms. J. Cardiovasc. Pharmacol. 10(Suppl. 12):1987;199-204.
18. 1A agonist act synergistically to produce vasodepressor responses in the rat. Eur. J. Pharmacol. 204:1991;87-95.
19. Hedlund P.B., Yanaihara N., Fuxe K. Evidence for specific N-terminal galanin fragment binding sites in the rat brain. Eur. J. Pharmacol. 224:1992;203-205.
20. Hedlund P.B., Finnman U.-B., Yanaihara N., Fuxe K. Galanin-(1-15), but not galanin-(1-29), modulates 5-HT1A receptors in the dorsal hippocampus of the rat brain: possible existence of galanin receptor subtypes. Brain Res. 634:1994;163-167.
21. Hollander M., Wolfe D.A. Nonparametric Statistical Methods. 1973;Wiley, New York, NY.
22. Kask K., Langel U., Bartfai T. Galanin - a neuropeptide with inhibitory actions. Cell. Mol. Neurobiol. 15:1995;653-673.
23. Kinney G.A., Emerson P.J., Miller R.J. Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus. J. Neurosci. 18:1998;3489-3500.
24. Lagny-Pourmir I., Lorinet A.M., Yanaihara N., Laburthe M. Structural requirements for galanin interactions with receptors from pancreatic beta cells and from brain tissue of the rat. Peptides. 10:1989;757-761.
25. Land T., Langel U., Löw M., Berthold M., Undén A., Bartfai T. Linear and cyclic N-terminal galanin fragments and analogues as ligands at the hypothalamic galanin receptor. Int. J. Pept. Protein Res. 38:1991;267-272.
26. +-ATPase and reverses its inhibition by ouabain. Regul. Pept. 62:1996;47-52.
27. Leibowitz S.F., Kim T. Impact of a galanin receptor antagonist on exogenous galanin and natural patterns of fat ingestion. Brain Res. 599:1992;148-152.
28. McDonald M.P., Crawley J.N. Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position task. Behav. Neurosci. 110:1996;1025-1032.
29. McDonald M.P., Willard L.B., Wenk G.L., Crawley J.N. Coadministration of galanin receptor antagonist M40 with a muscarinic M1 antagonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions. J. Neurosci. 18:1998;5078-5085.
30. Melander T., Hökfelt T., Rökaeus A. Distribution of galanin-like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 248:1986;475-517.
31. Melander T., Fuxe K., Härfstrand A., Eneroth P., Hökfelt T. Effects of intraventricular injections of galanin in the neuroendocrine functions in the male rat. Possible involvement of hypothalamic catecholamine neuronal systems. Acta Physiol. Scand. 131:1987;25-32.
32. 125I-galanin binding sites in the rat central nervous system. J. Chem. Neuroanat. 1:1988;213-233.
33. Merchentaler I. The hypophysiotropic galanin system of the rat brain. Neuroscience. 44:1991;643-654.
34. 1A receptor agonist 8-OH-DPAT. Eur. J. Pharmacol. 257:1994;257-265.
35. Narváez J.A., Cordón M.P., Díaz-Cabiale Z., Coveñas R., González-Barón S. Involvement of the autonomic nervous system on the cardiovascular effects of galanin peptides. J. Physiol. 509:1998;132P. London.
36. Ogren S.O., Hökfelt T., Kask K., Langel U., Bartfai T. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 51:1992;1-5.
37. Papas S., Bourque W. Galanin inhibits continuous and phasic firing in rat hypothalamic magnocellular neurosecretory cells. J. Neurosci. 17:1997;6048-6056.
38. Przewlocka B., Machelsa H., Rekowski P., Kupryszewski G., Pzrewloki R. Intracerebroventricular galanin and N-terminal galanin fragment enhance the morphine-induced analgesia in the rat. J. Neural Transm. 102:1995;229-235.
39. Skofitsch G., Jacobowitz D. Immunohistochemical mapping of galanin-like neurons in the rat central nervous system. Peptides. 6:1985;509-542.
40. 125I-galanin binding sites in the rat central nervous system. Peptides. 7:1986;1029-1042.
41. Tatemoto K., Rökaeus A., Jörnvall H., McDonald T.J., Mutt V. Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett. 164:1983;124-128.
42. Verge V.M.K., Xu X.J., Langel U., Hökfelt T., Wiesenfeld-Hallin Z., Bartfai T. Evidence for endogenous inhibition of autotomy by galanin in the rat after sciatic nerve section-demonstrated by chronic intrathecal infusion of a high affinity galanin receptor antagonist. Neurosci. Lett. 149:1993;193-197.
43. Wiesenfeld-Hallin Z., Xu X.J., Langel U., Bedecs K., Hökfelt T., Bartfai T. Galanin-mediated control of pain: enhanced role after nerve injury. Proc. Natl. Acad. Sci. U. S. A. 89:1992;3334-3337.
44. Wynick D., Smith D.M., Ghatei M., Akinsanya M., Bhogal R., Purkiss P., Byfield P., Yanaihara N., Bloom S.R. Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor. Proc. Natl. Acad. Sci. U. S. A. 90:1993;4231-4235.
45. Xu X.J., Wiesenfeld-Hallin Z., Langel U., Bedecs K., Bartfai T. New high affinity peptide antagonists to the spinal galanin receptor. Br. J. Pharmacol. 116:1995;2076-2080.
46. Yanaihara N., Mochizuki T., Iguchi K., Hoshino M., Nagashima T., Takatsuka N., Ishikawa J., Greeley G.H., Yanaihara C., Kuwahara A. Structure-function relationships of galanin. Hökfelt T., Bartfai T., Jacobowitz D., Ottoson D. Galanin: A New Multifunctional Peptide in the Neuroendocrine System. 1991;185-196 Macmillan, London.