Increasing anthraquinone production by overexpression of 1-deoxy-d-xylulose-5-phosphate synthase in transgenic cell suspension cultures of Morinda citrifolia

Biotechnology Letters

Volumn 32, Issue 7, 2010, Pages 997-1003

  Quevedo, Carla ^a   Perassolo, María ^a   Alechine, Eugenia ^a   Corach, Daniel ^a   Giulietti, Ana María ^a   Talou, Julián Rodriguez ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

1 deoxy d xylulose 5 phosphate synthase; Anthraquinones; Morinda citrifolia

Indexed keywords

1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE; AGROBACTERIUM TUMEFACIENS STRAIN; CATHARANTHUS ROSEUS; CELL LINES; CELL SUSPENSION CULTURES; CONTROL-CELL; D-XYLULOSE 5-PHOSPHATE; IN-CONTROL; KEY ENZYMES; METABOLIC PATHWAYS; MORINDA CITRIFOLIA; OVER-EXPRESSION; PHENYLALANINE AMMONIA-LYASE; SYNTHASES; TOTAL PHENOLICS; TRANSGENIC CELLS; TRANSGENIC LINES;

AGRICULTURAL PRODUCTS; AMINO ACIDS; KETONES; PHENOLS; PLANTS (BOTANY);

CELL CULTURE;

ANTHRAQUINONE DERIVATIVE; DEOXYXYLULOSE 5 PHOSPHATE SYNTHASE; DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE; MESSENGER RNA; PHENOL DERIVATIVE; PHENYLALANINE AMMONIA LYASE; PLANT RNA; TRANSFERASE; VEGETABLE PROTEIN;

ARTICLE; CATHARANTHUS; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE VECTOR; GENETICS; METABOLISM; MORINDA; RHIZOBIUM RADIOBACTER; TRANSGENIC PLANT;

ANTHRAQUINONES; CATHARANTHUS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC VECTORS; MORINDA; PHENOLS; PHENYLALANINE AMMONIA-LYASE; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; RHIZOBIUM RADIOBACTER; RNA, MESSENGER; RNA, PLANT; TRANSFERASES;

AGROBACTERIUM TUMEFACIENS; CATHARANTHUS ROSEUS; MORINDA CITRIFOLIA;

EID: 77953873349     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-010-0250-8     Document Type: Article

References (26)

1. Bo-Ra K, Soo-Un K, Yung-Jin C (2005) Differential expression of three 1-deoxy-d-xylulose-5-phosphate synthase genes in rice. Biotechnol Lett 27: 997-1001.
2. Bradford MM (1976) A rapid and sensitive method for quantization of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
3. Eichinger D, Bacher A, Zenk MH, Eisenreich W (1999) Quantitative assessment of metabolic flux by 13C NMR analysis biosynthesis of anthraquinones in Rubia tinctorum. J Am Chem Soc 121: 7469-7475.
4. Enfissi EM, Fraser PD, Lois LM, Boronat A, Schuch W, Bramley PM (2005) Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. Plant Biotechnol J 3: 17-27.
5. Estevez JM, Cantero A, Reindl A, Reichler S, León P (2001) 1-Deoxy-d-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants. J Biol Chem 276: 22901-22909.
6. Gonzáles-García S, Moreira MT, Artal G, Maldonado L, Feijoo G (2010) Environmental impact assessment of non-wood based pulp production by soda-anthraquinone pulping process. J Clean Prod 18: 137-145.
7. Han YS, van der Heijden R, Verpoorte R (2001) Biosynthesis of anthraquinone in cell cultures of the Rubiaceae. Plant Cell Tiss Organ Cult 67: 201-220.
8. Han YS, Roytrakul S, Verberne M, van Der Heijden R, Linthorst Huub JM, Verpoorte R (2003) Cloning of a cDNA encoding 1-deoxy-d-xylulose 5-phosphate synthase from Morinda citrifolia and analysis of its expression in relation to anthraquinone accumulation. Plant Sci 164(6): 911-917.
9. Khemvong S, Suvachittanont W (2005) Molecular cloning and expression of a cDNA encoding 1-deoxy-d-xylulose-5-phosphate synthase from oil palm Elaeis guinensis Jacq. Plant Sci 109: 571-578.
10. Moreno PRH, van der Heijden R, Verpoorte R (2004) Elicitor-mediated induction of isochorismate synthase and accumulation of 2, 3-dihydroxy benzoic acid in Catharanthus roseus cells suspension and shoot cultures. Plant Cell Rep 14: 188-191.
11. Muñoz-Bertomeu J, Arrillaga I, Ros R, Segura J (2006) Up-Regulation of 1-deoxy-d-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike Lavender. Plant Physiol 142: 890-900.
12. Nordin H, Lajis J, Mooi LY, Abdullah A, Sukari MA, Ali AM (2003) Antitumor promoting and antioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica. Asia Pacific Mol Biol Biotechnol 11(1): 3-7.
13. Nuñez Montoya SC, Comini LR, Sarmiento M, Becerra C, Albesa I, Arguello GA, Cabrera JL (2002) Natural anthraquinones probed as Type I and Type II photosensitizer: single oxygen and superoxide anion production. J Photochem Photobiol B Biol 78: 77-83.
14. Perassolo M, Quevedo C, Busto V, Ianone F, Giulietti AM, Rodriguez Talou J (2007) Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures. Enzyme Microb Technol 41: 181-185.
15. Querol J, Besumbes O, Lois LM, Boronat A, Imperial S (2001) A fluorometric assay for the determination of 1-deoxy-d-xylulose 5-phosphate synthase activity. Anal Biochem 296(1): 101-105.
16. Rodriguez Talou J, Verberne MC, Budi Muljono RA, van Tgelen LJP, Gonzalvez-Bernal B, Linthorst HJM, Wullens GJ, Bol JF, Verpoorte R (2001a) Isochorismate synthase transgenic expression in Catharanthus roseus cell suspensions. Plant Physiol Biochem 39: 595-602.
17. Rodriguez Talou J, Verberne M, Gonsalvez-Bernal B, Linthorst H, Bol J, Verpoorte R (2001b) Metabolic engineering in the anthraquinones biosynthetic pathway of Rubiaceae. In: Proceedings of the thirds Mercosur congress on process system engineering, pp 1879-1884.
18. Schnablová R, Synkov H, Vičánková A, Burketová L, Eder J, Cvikrová M (2006) Transgenic ipt tobacco overproducing cytokinins overaccumulates phenolic compounds during in vitro growth. Plant Physiol Biochem 44: 526-534.
19. Schulte U, El-Shagi H, Zenk MH (1984) Optimization of 19 Rubiaceae species in cell culture for the production of anthraquinone. Plant Cell Rep 3: 51-54.
20. Shetty P, Atallah MT, Shetty K (2003) Stimulation of total phenolics, l-DOPA and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analogue in germinating fava beans (Vicia faba). Process Biochem 38: 1707-1717.
21. Singh K, Raizada J, Bhardwaj P, Ghawana S, Rani A, Singh H, Kaul K, Kumar S (2004) 26S rRNA-based internal control gene primer pair reverse transcription-polymerase chain reaction-based quantitative expression studies in diverse plant species. Anal Biochem 335: 330-333.
22. Sittie AA, Lemmich E, Olsen CE, Hviid L, Kharazmi A, Nkrumah FK, Christensen SB (1999) Structure-activity studies: in vitro antileishmanial and antimalarial activities of antrhaquinones from Morinda lucida. Plant Med 65: 259-261.
23. van der Fits CTE (2000) Transcriptional regulation of stress-induced plant secondary metabolism. PhD thesis, Leiden University, The Netherlands.
24. Vasconsuelo A, Picotto G, Rodriguez Talou J, Boland R (2003) Involvement of the PLC/PKC pathway in chitosan-induced anthraxquinone production by Rubia tinctorum L. cell cultures. Plant Sci 165: 429-436.
25. Wang MY, West BJ, Jensen CJ, Nowicki SC, Palu A, Anderson G (2002) Morinda citrifolia (Noni): a literature review and recent advances in Noni research. A Pharmacol Sin 23(12): 1127-1141.
26. Zucker M (1969) Induction of phenylalanine ammonia-lyase in Xanthium leaf disks photosynthetic requirement and effect of day length. Plant Physiol 44: 912-922.