Utility of the recovery electrocardiogram after exercise: a novel indicator for the diagnosis and genotyping of long QT syndrome?

Heart Rhythm

Volumn 7, Issue 7, 2010, Pages 906-911

  Chattha, Ishvinder S ^a   Sy, Raymond W ^a   Yee, Raymond ^a   Gula, Lorne J ^a   Skanes, Allan C ^a   Klein, George J ^a   Bennett, Matthew T ^a   Krahn, Andrew D ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Diagnosis; Exercise stress test; Genetic; Inherited cardiac arrhythmia; Mutation; QT interval

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BICYCLE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; EXERCISE; FEMALE; GENOTYPE; HUMAN; LONG QT SYNDROME; MALE; PRIORITY JOURNAL; SEX;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ADULT; AGED; CHILD; ELECTROCARDIOGRAPHY; EXERCISE; EXERCISE TEST; FEMALE; GENOTYPE; HUMANS; LONG QT SYNDROME; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 77953871781     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2010.03.006     Document Type: Article

References (28)

1. Vohra J. The long QT syndrome. Heart Lung Circ 16 (2007) S5-S12
2. Napolitano C., Priori S.G., Schwartz P.J., et al. Genetic testing in the long QT syndrome-development and validation of an efficient approach to genotyping in clinical practice. JAMA 294 (2005) 2975-2980
3. Schwartz P.J., Priori S.G., Spazzolini C., et al. Genotype-phenotype correlation in the long-QT syndrome-gene-specific triggers for life-threatening arrhythmias. Circulation 103 (2001) 89-95
4. Choi G., Kopplin L.J., Tester D.J., Will M.L., Haglund C.M., and Ackerman M.J. Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes. Circulation 110 (2004) 2119-2124
5. Ackerman M.J., Tester D.J., and Porter C.J. Swimming is a gene-specific arrhythmogenic trigger for inherited long QT syndrome. J Am Coll Cardiol 35 (2000) 160A
6. Bai R., Napolitano C., Bloise R., Monteforte N., and Priori S.G. Yield of genetic screening in inherited cardiac channelopathies: how to prioritize access to genetic testing. Circ Arrhythm Electrophysiol 2 (2009) 6-15
7. Takenaka K., Tomohiko A., and Shimizu W. Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome. ACC Curr J Rev 12 3 (2005) 81
8. Walker B.D., Krahn A.D., Klein G.J., Skanes A.C., and Yee R. Burst bicycle exercise facilitates diagnosis of latent long QT syndrome. Am Heart J 150 (2005) 1059-1063
9. Swan H., Viitasalo M., Piippo K., Laitinen P., Kontula K., and Toivonen L. Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol 34 (1999) 823-829
10. Schwartz P.J., Priori S.G., Locati E.H., et al. Long QT syndrome patients with mutations on the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate: implications for gene-specific therapy. Circulation 93 (1996) 1602
11. Shimizu W., Noda T., Takaki H., et al. Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome. Heart Rhythm 1 (2004) 276-283
12. Ackerman M.J., Khositseth A., Tester D.J., Hejlik J.B., Shen W.K., and Porter C.B.J. Epinephrine-induced QT interval prolongation: a gene-specific paradoxical response in congenital long QT syndrome. Mayo Clinic Proc 77 (2002) 413-421
13. Vyas H., Hejlik J., and Ackerman M.J. Epinephrine QT stress testing in the evaluation of congenital long-QT syndrome-diagnostic accuracy of the paradoxical QT response. Circulation 113 (2006) 1385-1392
14. Schwartz P.J. The congenital long QT syndromes from genotype to phenotype: clinical implications. J Int Med 259 1 (2006) 30-47
15. Lepeschkin E., and Surawicz B. The measurement of the Q-T interval of the electrocardiogram. Circulation 6 (1952) 378-388
16. Anderson M.E., Al-Khatib S.M., Roden D.M., and Califf R.M. Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. Am Heart J 144 (2002) 769-781
17. Bazett H. An analysis of the time-relations of electrocardiograms. Heart 7 (1920) 353-370
18. Chauhan V.S., Krahn A.D., Walker B.D., Klein G.J., Skanes A.C., and Yee R. Sex differences in QTc interval and QT dispersion: dynamics during exercise and recovery in healthy subjects. Am Heart J 144 (2002) 858-864
19. Krahn A.D., Yee R., Chauhan V., et al. Beta blockers normalize QT hysteresis in long QT syndrome. Am Heart J 143 (2002) 528-534
20. Lahiri M.K., Kannankeril P.J., and Goldberger J.J. Assessment of autonomic function in cardiovascular disease. J Am Coll Cardiol 51 (2008) 1275-1333
21. Moss A.J., Zareba W., Benhorin J., et al. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation 92 (1995) 2929-2934
22. Zhang L., Timothy K.W., Vincent G.M., et al. Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome-ECG findings identify genotypes. Circulation 102 (2000) 2849-2855
23. Kanters J.K., Fanoe S., Larsen L.A., Thomsen P.E.B., Toft E., and Christiansen M. T wave morphology analysis distinguishes between KvLQT1 and HERG mutations in long QT syndrome. Heart Rhythm 1 (2004) 285-292
24. Khositseth A., Hejlik J., Shen W.K., and Ackerman M.J. Epinephrine-induced T-wave notching in congenital long QT syndrome. Heart Rhythm 2 (2005) 141-146
25. Struijk J.J., Kanters J.K., Andersen M.P., et al. Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology. Med Biol Eng Comput 44 (2006) 543-549
26. Vaglio M., Couderc J.P., McNitt S., Xia X., Moss A.J., and Zareba W. A quantitative assessment of T-wave morphology in LQT1, LQT2, and healthy individuals based on Hotter recording technology. Heart Rhythm 5 (2008) 11-18
27. Hodges M. Rate correction of the QT interval. Card Electrophysiol 3 (2009) 360-363
28. McLaughlin N.B., Campbell R.W., and Murray A. Comparison of automatic QT measurement techniques in the normal 12 lead electrocardiogram. Br Med J 74 (1995) 84-89