Improved sensitivity for two-photon frequency-domain lifetime measurement

Optics Express

Volumn 18, Issue 13, 2010, Pages 13631-13639

  Estrada, Arnold D ^a   Dunn, Andrew K ^a  

^a The University of Texas at Austin   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADSORBATES; DEMODULATION; FREQUENCY DOMAIN ANALYSIS; LIGHT EMISSION; MATHEMATICAL MODELS; MODULATION; OPTICAL VARIABLES MEASUREMENT; PHASE SHIFT; PHOSPHORESCENCE; TWO PHOTON PROCESSES;

AMPLITUDE DEMODULATION; BACKGROUND CONDITIONS; FREQUENCY COMPONENTS; LIFETIME MEASUREMENTS; MEASUREMENT SENSITIVITY; MODULATION FREQUENCIES; PHOSPHORESCENCE LIFETIME; SECOND HARMONICS; SINUSOIDAL MODULATION; TWO PHOTON; TWO-PHOTON ABSORPTIONS; TWO-PHOTON EXCITATIONS;

PHOTONS;

ARTICLE; ENERGY TRANSFER; EQUIPMENT DESIGN; FLUORESCENCE; INSTRUMENTATION; LUMINESCENCE; METHODOLOGY; NONLINEAR SYSTEM; OPTICS; PHOTON;

ENERGY TRANSFER; EQUIPMENT DESIGN; FLUORESCENCE; LUMINESCENCE; LUMINESCENT MEASUREMENTS; NONLINEAR DYNAMICS; OPTICS AND PHOTONICS; PHOTONS;

EID: 77953857770     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.18.013631     Document Type: Article

References (21)

1. R. M. Clegg, O. Holub, and C. Gohlke, "Fluorescence lifetime-resolved imaging: measuring lifetimes in an image," Methods Enzymol. 360, 509-542 (2003).
2. E. B. van Munster, and T. W. J. Gadella, "Fluorescence lifetime imaging microscopy (FLlM.)," Adv. Biochem, Eng. Biotechnol. 95, 143-175 (2005).
3. M. Y. Berezin, and S. Achilefu, "Fluorescence lifetime measurements and biological imaging," Chem. Rev. 110(5), 2641-2684 (2010).
4. H. M., R. Gonçalves, C. D. Maule, P. A., S. Jorge, and J. C. G. Esteves da Silva, "Fiber optic lifetime pH sensing based on ruthenium(II) complexes with dicarboxybipyridine," Anal. Chim, Acta 626(1), 62-70 (2008).
5. J. M. Vanderkooi, and D. F. Wilson, "A. new method for measuring oxygen concentration in biological systems," Adv. Exp. Med. Biol. 200, 189-193 (1986).
6. W. Zhong, P. Urayama, and M.-A. Mycek, "Imaging fluorescence lifetime modulation of a ruthenium- based dye in living cells: the potential for oxygen sensing," J. Phys. D Appl. Phys. 36(14), 1689-1695 (2003).
7. R. D. Shonat, and A. C. Kight, "Oxygen tension, imaging in the mouse retina," Ann. Biomed. Eng. 31(9), 1084-1096 (2003).
8. A. D. Estrada, A. Ponticorvo, T. N. Ford, and A. K. Dunn, "Microvascular oxygen quantification using twophoton microscopy," Opt. Lett. 33(10), 1038-1040 (2008).
9. E. G. Mik, T. G. van Leeuwen, N. J. Raat, and C. Ince, "Quantitative determination of localized tissue oxygen concentration in vivo by two-photon excitation phosphorescence lifetime measurements," J. Appl. Physiol. 97(5), 1962-1969 (2004).
10. J. R., Lakowicz, "Principles of Fluorescence Spectroscopy," in Principles of Fluorescence Spectroscopy, 3 ed. (Springer Science + Business Media, LLC, New York, NY, 2006), pp. 171,192-194.
11. D. Jameson, E. Gratton, and R. Hall, "The measurement and analysis of heterogeneous emissions by multifrequency phase and modulation fluorometry," Applied Spectroscopy .. (1984).
12. J. Alcala, E. Gratton, and D. Jameson, "A multifrequency phase fluorometer using the harmonic content of a mode-locked laser," Instrum. Sci. Technol. 14(3), 225-250 (1985).
13. E. Gratton, S. Breusegein, J. Sutin, Q. Ruan, and N. Barry, "Fluorescence lifetime imaging for the two-photon microscope: time-domain and frequency-domain methods," J. Biomed. Opt. 8(3), 381-390 (2003).
14. P. T. C. So, T. French, W. M. Yu, K. M. Berland, C. Y. Dong, and E. Gratton, "Time-resolved fluorescence microscopy using two-photon excitation," Bioimaging 3(2), 49-63 (1995).
15. A. Esposito, H. C. Gerritsen, and F. S. Wouters, "Optimizing frequency-domain fluorescence lifetime sensing for high-throughput applications: photon economy and acquisition speed," J. Opt. Soc. Am. A 24(10), 3261-3273 (2007).
16. R. Freeman, D. Gilliland, and F. Lytle, "Second harmonic detection of sinusoidally modulated two-photon excited fluorescence," Anal. Chem. 62(20), 2216-2219 (1990).
17. P. Tian, and W. S. Warren, "Ultrafast measurement of two-photon absorption, by loss modulation," Opt. Lett. 27(18), 1634-1636 (2002).
18. J. Van Houten and R. Watts, "Temperature dependence of the photophysical and photochemical properties of the tris (2, 2'-bipyridyl) ruthenium (II) ion in aqueous solution," J. Am. Chein. Soc (1976).
19. R. P. Briñas, T. Troxler, R. M., Hochstrasser, and S. A. Vinogradov, "Phosphorescent oxygen sensor with dendritic protection, and two-photon absorbing antenna," J. Am. Chem. Soc. 127(33), 11851-11862 (2005).
20. I. Dunphy, S. A. Vinogradov, and D. F. Wilson, "Oxyphor R2 and G2: phosphors for measuring oxygen by oxygen-dependent quenching of phosphorescence," Anal. Biochem. 310(2), 191-198 (2002).
21. L. W. Lo, C. J. Koch, and D. F. Wilson, "Calibration of oxygen-dependent quenching of the phosphorescence of Pd-meso-tetra (4-carboxyphenyl) porphine: a phosphor with general application for measuring oxygen concentration in biological systems," Anal. Biochem. 236(1), 153-160 (1996).