메뉴 건너뛰기




Volumn 76, Issue 9, 2010, Pages 923-927

Expression of 3HSD and P5R, genes respectively coding for δ5-3β-hydroxysteroid dehydrogenase and progesterone 5β reductase, in leaves and cell cultures of digitalis lanata EHRH

Author keywords

5.3 hydroxysteroiddehydrogenase; cardiac glycosides; Digitalis lanata; gene expression; Plantaginaceae; progesterone reductase

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; CARDENOLIDE; OXIDOREDUCTASE; PROGESTERONE 5BETA REDUCTASE; UNCLASSIFIED DRUG; DIGITALIS; PROGESTERONE 5 BETA REDUCTASE; PROGESTERONE 5 BETA-REDUCTASE;

EID: 77953851414     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250007     Document Type: Article
Times cited : (14)

References (30)
  • 4
    • 0031830211 scopus 로고    scopus 로고
    • Cardenolide biosynthesis in foxglove.
    • Kreis W, Hensel A, Stuhlemmer U. Cardenolide biosynthesis in foxglove. Planta Med 1998 64 491-499
    • (1998) Planta Med , vol.64 , pp. 491-499
    • Kreis, W.1    Hensel, A.2    Stuhlemmer, U.3
  • 5
    • 0025153490 scopus 로고
    • A stereospecific enzyme of the putative biosynthetic pathway of cardenolides. Characterization of a progesterone 5-reductase from leaves of Digitalis purpurea L.
    • Gärtner D E., Wendroth S, Seitz H U. A stereospecific enzyme of the putative biosynthetic pathway of cardenolides. Characterization of a progesterone 5-reductase from leaves of Digitalis purpurea L. FEBS Lett 1990 271 239-242
    • (1990) FEBS Lett , vol.271 , pp. 239-242
    • Gärtner, D.E.1    Wendroth, S.2    Seitz, H.U.3
  • 6
    • 0039819972 scopus 로고
    • 5-3-Hydroxysteroid dehydrogenase/5-4-ketosteroid isomerase (3-HSD), a possible enzyme of cardiac glycoside biosynthesis, in cell cultures and plants of Digitalis lanata EHRH.
    • Seidel S, Kreis W, Reinhard E. 5-3-Hydroxysteroid dehydrogenase/5-4- ketosteroid isomerase (3-HSD), a possible enzyme of cardiac glycoside biosynthesis, in cell cultures and plants of Digitalis lanata EHRH. Plant Cell Rep 1990 8 621-624
    • (1990) Plant Cell Rep , vol.8 , pp. 621-624
    • Seidel, S.1    Kreis, W.2    Reinhard, E.3
  • 7
    • 0039819973 scopus 로고    scopus 로고
    • Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata.
    • Stuhlemmer U, Kreis W. Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata. Plant Physiol Biochem 1996 34 85-91
    • (1996) Plant Physiol Biochem , vol.34 , pp. 85-91
    • Stuhlemmer, U.1    Kreis, W.2
  • 8
    • 0030798210 scopus 로고    scopus 로고
    • Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata
    • DOI 10.1016/S0031-9422(97)00315-4, PII S0031942297003154
    • Lindemann P, Luckner M. Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata. Phytochemistry 1997 46 507-513 (Pubitemid 27414932)
    • (1997) Phytochemistry , vol.46 , Issue.3 , pp. 507-513
    • Lindemann, P.1    Luckner, M.2
  • 9
    • 0001715956 scopus 로고
    • The production of secondary metabolites by plant cells cultivated in bioreactors.
    • Kreis W, Reinhard E. The production of secondary metabolites by plant cells cultivated in bioreactors. Planta Med 1989 55 409-416
    • (1989) Planta Med , vol.55 , pp. 409-416
    • Kreis, W.1    Reinhard, E.2
  • 10
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bioassays with tobacco tissue cultures.
    • Murashige T, Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 1962 15 473-479
    • (1962) Physiol Plant , vol.15 , pp. 473-479
    • Murashige, T.1    Skoog, F.2
  • 11
    • 0042988074 scopus 로고
    • A non-invasive method for the routine-estimation of fresh weight of cells grown in batch suspension cultures.
    • Blom T J. M., Kreis W, van Iren F, Libbenga K R. A non-invasive method for the routine-estimation of fresh weight of cells grown in batch suspension cultures. Plant Cell Rep 1992 11 146-149
    • (1992) Plant Cell Rep , vol.11 , pp. 146-149
    • Blom, T.J.M.1    Kreis, W.2    Van Iren, F.3    Libbenga, K.R.4
  • 12
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
    • Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 72 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 13
    • 30344460658 scopus 로고    scopus 로고
    • Molecular cloning and heterologous expression of progesterone 5-reductase (P5 R) from Digitalis lanata EHRH.
    • Herl V, Fischer G, Müller-Uri F, Kreis W. Molecular cloning and heterologous expression of progesterone 5-reductase (P5 R) from Digitalis lanata EHRH. Phytochemistry 2006 67 225-231
    • (2006) Phytochemistry , vol.67 , pp. 225-231
    • Herl, V.1    Fischer, G.2    Müller-Uri, F.3    Kreis, W.4
  • 15
    • 0345469129 scopus 로고
    • Paper chromatography of cardiac glycosides and aglycones from Digitalis purpurea.
    • Jensen K B. Paper chromatography of cardiac glycosides and aglycones from Digitalis purpurea. Acta Pharmacol Toxicol 1953 9 99-108
    • (1953) Acta Pharmacol Toxicol , vol.9 , pp. 99-108
    • Jensen, K.B.1
  • 16
    • 0006801177 scopus 로고
    • Bijdrage tot het chemisch anderzoek van Digitalispreparaten.
    • Kedde D L. Bijdrage tot het chemisch anderzoek van Digitalispreparaten. Pharm Weekbl 1947 82 741-757
    • (1947) Pharm Weekbl , vol.82 , pp. 741-757
    • Kedde, D.L.1
  • 18
    • 34447540345 scopus 로고    scopus 로고
    • Cloning, heterologous expression and characterization of 5-3-hydroxsteroid dehydrogenase/5-4-ketosteroid isomerase from Digitalis lanata EHRH.
    • Herl V, Frankenstein J, Meitinger N, Müller-Uri F, Kreis W. Cloning, heterologous expression and characterization of 5-3-hydroxsteroid dehydrogenase/5-4-ketosteroid isomerase from Digitalis lanata EHRH. Planta Med 2007 73 704-710
    • (2007) Planta Med , vol.73 , pp. 704-710
    • Herl, V.1    Frankenstein, J.2    Meitinger, N.3    Müller-Uri, F.4    Kreis, W.5
  • 19
    • 71049156278 scopus 로고    scopus 로고
    • Norcholanic acids as substrates for recombinant 3-hydroxysteroid dehydrogenase and progesterone 5-reductase, enzymes of the 5-cardenolide biosynthesis.
    • Schebitz P, Nothdurft L, Hensel A, Müller-Uri F, Kreis W. Norcholanic acids as substrates for recombinant 3-hydroxysteroid dehydrogenase and progesterone 5-reductase, enzymes of the 5-cardenolide biosynthesis. Tetrahedron Lett 2010 51 367-370
    • (2010) Tetrahedron Lett , vol.51 , pp. 367-370
    • Schebitz, P.1    Nothdurft, L.2    Hensel, A.3    Müller-Uri, F.4    Kreis, W.5
  • 20
    • 0032589562 scopus 로고    scopus 로고
    • 5-3-Hydroxsteroid dehydrogenase from Digitalis lanata EHRH. a multifunctional enzyme in steroid metabolism?
    • Finsterbusch A, Lindemann P, Grimm R, Eckerskorn C, Luckner M. 5-3-Hydroxsteroid dehydrogenase from Digitalis lanata EHRH. a multifunctional enzyme in steroid metabolism? Planta 1999 209 478-486
    • (1999) Planta , vol.209 , pp. 478-486
    • Finsterbusch, A.1    Lindemann, P.2    Grimm, R.3    Eckerskorn, C.4    Luckner, M.5
  • 21
    • 84990768001 scopus 로고
    • Enzyme activities in cardenolide-accumulating, mixotrophic shoot cultures of Digitalis purpurea L.
    • Gärtner D E., Seitz H U. Enzyme activities in cardenolide- accumulating, mixotrophic shoot cultures of Digitalis purpurea L. J Plant Physiol 1993 141 269-275
    • (1993) J Plant Physiol , vol.141 , pp. 269-275
    • Gärtner, D.E.1    Seitz, H.U.2
  • 22
    • 33750387646 scopus 로고    scopus 로고
    • Molecular cloning and expression of progesterone 5β-reductase (5β-POR) from Isoplexis canariensis
    • DOI 10.1055/s-2006-946698
    • Herl V, Fischer G, Bötsch R, Müller-Uri F, Kreis W. Molecular cloning and expression of progesterone 5-reductase (P5 R) from Isoplexis canariensis. Planta Med 2006 72 1163-1165 (Pubitemid 44638918)
    • (2006) Planta Medica , vol.72 , Issue.12 , pp. 1163-1165
    • Herl, V.1    Fischer, G.2    Botsch, R.3    Muller-Uri, F.4    Kreis, W.5
  • 23
    • 62949202356 scopus 로고    scopus 로고
    • The VEP 1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-4,5-steroid 5-reductase activity in Arabidopsis thaliana L.
    • Herl V, Fischer G, Reva V A., Stiebritz M, Muller Y A., Müller-Uri F, Kreis W. The VEP 1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-4,5-steroid 5-reductase activity in Arabidopsis thaliana L. Biochimie 2009 91 517-525
    • (2009) Biochimie , vol.91 , pp. 517-525
    • Herl, V.1    Fischer, G.2    Reva, V.A.3    Stiebritz, M.4    Muller, Y.A.5    Müller-Uri, F.6    Kreis, W.7
  • 25
    • 74549116751 scopus 로고    scopus 로고
    • Digitalis purpurea P5 R2, encoding steroid 5-reductase, is a novel defense-related gene involved in cardenolide biosynthesis.
    • Perez-Bermudez P, Moya Garcia A A., Tunon I, Gavidia I. Digitalis purpurea P5 R2, encoding steroid 5-reductase, is a novel defense-related gene involved in cardenolide biosynthesis. New Phytol 2010 185 687-700
    • (2010) New Phytol , vol.185 , pp. 687-700
    • Perez-Bermudez, P.1    Moya Garcia, A.A.2    Tunon, I.3    Gavidia, I.4
  • 26
    • 41849085212 scopus 로고    scopus 로고
    • Using progesterone 5-reductase, a gene encoding a key enzyme in the cardenolide biosynthesis, to infer the phylogeny of the genus Digitalis.
    • Herl V, Albach D C., Müller-Uri F, Bräuchler C, Heubl G, Kreis W. Using progesterone 5-reductase, a gene encoding a key enzyme in the cardenolide biosynthesis, to infer the phylogeny of the genus Digitalis. Plant Syst Evol 2008 271 65-78
    • (2008) Plant Syst Evol , vol.271 , pp. 65-78
    • Herl, V.1    Albach, D.C.2    Müller-Uri, F.3    Bräuchler, C.4    Heubl, G.5    Kreis, W.6
  • 27
    • 3242742852 scopus 로고    scopus 로고
    • Seasonal cardenolide production and Dop5βr gene expression in natural populations of Digitalis obscura
    • DOI 10.1016/j.phytochem.2004.05.004, PII S0031942204002183
    • Roca-Perez L, Boluda R, Gavidia I, Perez-Bermudez P. Seasonal cardenolide production and Dop 5 r gene expression in natural populations of Digitalis obscura. Phytochemistry 2004 65 1869-1878 (Pubitemid 38981676)
    • (2004) Phytochemistry , vol.65 , Issue.13 , pp. 1869-1878
    • Roca-Perez, L.1    Boluda, R.2    Gavidia, I.3    Perez-Bermudez, P.4
  • 28
    • 0036219927 scopus 로고    scopus 로고
    • Involvement of the VEP1 gene in vascular strand development in Arabidopsis thaliana.
    • Jun J H., Ha C M., Nam H G. Involvement of the VEP1 gene in vascular strand development in Arabidopsis thaliana. Plant Cell Physiol 2002 43 323-330
    • (2002) Plant Cell Physiol , vol.43 , pp. 323-330
    • Jun, J.H.1    Ha, C.M.2    Nam, H.G.3
  • 29
    • 47749101233 scopus 로고    scopus 로고
    • The crystal structure of progesterone 5-reductase from Digitalis lanata defines a novel class of short-chain dehydrogenases/reductases.
    • Thorn A, Egerer-Sieber C, Jäger C M., Herl V, Müller-Uri F, Kreis W, Muller Y. The crystal structure of progesterone 5-reductase from Digitalis lanata defines a novel class of short-chain dehydrogenases/reductases. J Biol Chem 2008 283 17260-17269
    • (2008) J Biol Chem , vol.283 , pp. 17260-17269
    • Thorn, A.1    Egerer-Sieber, C.2    Jäger, C.M.3    Herl, V.4    Müller-Uri, F.5    Kreis, W.6    Muller, Y.7
  • 30
    • 72149111396 scopus 로고    scopus 로고
    • Recombinant 4,5-steroid 5-reductases as biocatalysts for the reduction of activated C=C-double bonds in monocyclic and acyclic molecules.
    • Burda E, Krausser M, Fischer G, Hummel W, Müller-Uri F, Kreis W, Gröger H. Recombinant 4,5-steroid 5-reductases as biocatalysts for the reduction of activated C=C-double bonds in monocyclic and acyclic molecules. Adv Synth Catal 2009 351 2787-2790
    • (2009) Adv Synth Catal , vol.351 , pp. 2787-2790
    • Burda, E.1    Krausser, M.2    Fischer, G.3    Hummel, W.4    Müller-Uri, F.5    Kreis, W.6    Gröger, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.