Mouse models of human bladder cancer as a tool for drug discovery

Current Protocols in Pharmacology

Volumn , Issue SUPPL. 49, 2010, Pages

  Seager, Catherine ^a   Puzio Kuter, Anna M ^a   Cordon Cardo, Carlos ^a   McKiernan, James ^a   Abate Shen, Cory ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

bladder cancer; GEM mouse models; mTOR inhibition; orthotopic models; preclinical studies

Indexed keywords

CRE RECOMBINASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; RAPAMYCIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLADDER CANCER; CANCER DIAGNOSIS; CANCER INVASION; CLINICAL EVALUATION; DRUG DEVELOPMENT; DRUG SCREENING; DYSURIA; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC RECOMBINATION; HEMATURIA; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LOW BACK PAIN; MOUSE; MUTATION; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PHENOTYPE; POLYURIA; PRIORITY JOURNAL; REPORTER GENE; REVIEW; TUMOR CELL; TUMOR GENE; TUMOR GROWTH; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; FEMALE; GENETIC ENGINEERING; GENETIC VECTORS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SPECIMEN HANDLING; URINARY BLADDER NEOPLASMS;

EID: 77953828247     PISSN: 19348282     EISSN: 19348290     Source Type: Journal    
DOI: 10.1002/0471141755.ph1414s49     Document Type: Review

References (28)

1. Ahlering, T.E., Dubeau, L., and, Jones, P.A., 1987. A new in vivo model to study invasion and metastasis of human bladder carcinoma. Cancer Res. 15: 6660 6665.
2. Branda, C.S., and, Dymecki, S.M., 2004. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev. Cell 6: 7-28.
3. Chin, J., Kadhim, S., Garcia, B., Kim, Y.S., and, Karlik, S., 1991. Magnetic resonance imaging for detecting and treatment monitoring of orthotopic murine bladder tumor implants. J. Urol. 145: 1297-1301.
4. Chong, L., Ruping, Y., Jiancheng, B., Guohong, Y., Yougang, F., Jiansong, W., Xiang, G., Jie, H., and, Shusheng, X., 2006. Characterization of a novel transplantable orthotopic murine xenograft model of a human bladder transitional cell tumor (BIU-87). Cancer Biol. Ther. 4: 394 398.
5. Cordon-Cardo, C., 2008. Molecular alterations associated with bladder cancer initiation and progression. Scand. J. Urol. Nephrol. Suppl. 42: 154-165.
6. Dalbagni, G., Presti, J., Reuter, V., Fair, W.R., and, Cordon-Cardo, C., 1993. Genetic alterations in bladder cancer. Lancet 342: 469-471.
7. Dinney, C.P., McConkey, D.J., Millikan, R.E., Wu, X., Bar-Eli, M., Adam, L., Kamat, A.M., Siefker-Radtke, A.O., Tuziak, T., Sabichi, A.L., Grossman, H.B., Benedict, W.F., and, Czerniak, B., 2004. Focus on bladder cancer. Cancer Cell 6: 111-116.
8. Donovan, J., and, Brown, P., 2006. Euthanasia. Curr. Protoc. Immunol. 73: 1.8.1-1.8.4.
9. Eble, J., Sauter, G., Epstein, J., and, Sesterhenn, I., 2004. Tumors of the Urinary SystemPathology and Genetics. IARC Press, Lyon, France.
10. Fomchenko, E.I., and, Holland, E.C., 2006. Mouse models of brain tumors and their applications in preclinical trials. Clin. Cancer Res. 12: 5288-5297.
11. Hadaschik, B.A., Black, P.C., Sea, J.C., Metwalli, A.R., Fazli, L., Dinney, C.P., Gleave, M.E., and, So, A.I., 2007. A validated mouse model for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging. BJU Int. 100: 1377-1384.
12. Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R.C., Ghafoor, A., Feuer, E.J., and, Thun, M.J., 2005. Cancer statistics, 2005. CA Cancer J. Clin. 55: 10-30.
13. Jonkers, J., Meuwissen, R., van der Gulden, H., Peterse, H., van der Valk, M., and, Berns, A., 2001. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat. Genet. 29: 418-425.
14. Kinkade, C.W., Castillo-Martin, M., Puzio-Kuter, A., Yan, J., Foster, T.H., Gao, H., Sun, Y., Ouyang, X., Gerald, W.L., Cordon-Cardo, C., and, Abate-Shen, C., 2008. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J. Clin. Invest. 118: 3051-3064.
15. Knowles, M.A., 2008. Bladder cancer subtypes defined by genomic alterations. Scand. J. Urol. Nephrol. Suppl. 2008 Sep;(218): 116-130.
16. Lesche, R., Groszer, M., Gao, J., Wang, Y., Messing, A., Sun, H., Liu, X., and, Wu, H., 2002. Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32: 148-149.
17. Mitra, A.P., and, Cote, R.J., 2009. Molecular Pathogenesis and Diagnostics of Bladder Cancer. Annu. Rev. Pathol. 4: 251-285.
18. Olive, K.P., and, Tuveson, D.A., 2006. A "mouse hospital" for preclinical testing of novel cancer therapeutics. Clin. Cancer Res. 12: 5277-5287.
19. Ouyang, X., Jessen, W.J., Al-Ahmadie, H., Serio, A.M., Lin, Y., Shih, W.J., Reuter, V.E., Scardino, P.T., Shen, M.M., Aronow, B.J., Vickers, A.J., Gerald, W.L., and, Abate-Shen, C., 2008. Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer. Cancer Res. 68: 2132-2144.
20. Phelan, M.C., 2006. Techniques for mammalian cell tissue culture. Curr. Protoc. Mol. Biol. 74: A.3F.1-A.3F.18.
21. Puzio-Kuter, A.M., Castillo-Martin, M., Kinkade, C.W., Wang, X., Shen, T.H., Matos, T., Shen, M.M., Cordon-Cardo, C., and, Abate-Shen, C., 2009. Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 23: 675-680.
22. Rangarajan, A., and, Weinberg, R.A., 2003. Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice. Nat. Rev. Cancer 3: 952-959.
23. Seager, C.M., Puzio-Kuter, A.M., Trushar Patel, T., Jain, S., Carlos Cordon-Cardo, C., McKiernan, J., and, Abate-Shen, C., 2009. Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer. Cancer Prev. Res. 2: 1008-1014.
24. Singh, M., and, Johnson, L., 2006. Using genetically engineered mouse models of cancer to aid drug development: An industry perspective. Clin. Cancer Res. 12: 5312-5328.
25. Soriano, P., 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21: 70-71.
26. St. Clair, M.B., Sowers, A.L., Davis, J.A., and, Rhodes, L.L., 1999. Urinary bladder catheterization of female mice and rats. Contemp. Top. Lab. Anim. Sci. 38: 78-79.
27. Watanabe, T., Shinohara, N., Sazawa, A., Harabayashi, T., Ogiso, Y., Koyanagi, T., Takiguchi, M., Hashimoto, A., Kuzumaki, N., Yamashita, M., Tanaka, M., Grossman, H.B., and, Benedict, W.F., 2000. An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies. Cancer Gene Ther. 7: 1575-1580.
28. Wu, X.R., 2005. Urothelial tumorigenesis: A tale of divergent pathways. Nat. Rev. Cancer 5: 713-725.