The dopamine-D2-receptor agonist ropinirole dose-dependently blocks the Ca2+-triggered permeability transition of mitochondria

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1797, Issue 6-7, 2010, Pages 1245-1250

  Parvez, Suhel ^a   Winkler Stuck, Kirstin ^a   Hertel, Silvia ^a   Schönfeld, Peter ^a   Siemen, Detlef ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Mitochondria; Neuroprotection; Parkinson's disease; Permeability transition; Ropinirole

Indexed keywords

ANTIMYCIN A1; CALCIUM ION; CYTOCHROME C; DOPAMINE 2 RECEPTOR STIMULATING AGENT; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATE; PRAMIPEXOLE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; ROPINIROLE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME RELEASE; INHIBITION KINETICS; LIVER MITOCHONDRION; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; NEUROPROTECTION; NONHUMAN; OXIDATION; PATCH CLAMP; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ANIMALS; BRAIN; CALCIUM; CYTOCHROMES C; INDOLES; MITOCHONDRIA; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NAD; OXIDATIVE PHOSPHORYLATION; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2;

RATTUS;

EID: 77953812541     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2010.02.001     Document Type: Article

References (29)

1. Goetz C.G. Dopaminergic agonists in the treatment of Parkinson's disease. Neurology 1990, 40:54-57.
2. Clarke C.E., Guttman M. Dopamine agonist monotherapy in Parkinson's disease. Lancet 2002, 360:1767-1769.
3. Carter A.J., Muller R.E. Pramipexole, a dopamine D2 autoreceptor agonist, decreases the extracellular concentration of dopamine in vivo. Eur. J. Pharmacol. 1991, 200:65-72.
4. Iida M., Miyazaki I., Tanaka K., Kabuto H., Iwata-Ichikawa E., Ogawa N. Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res. 1999, 838:51-59.
5. van Loo G., Saelens X., van Gurp M., MacFarlane M., Martin S.J., Vandenabeele P. The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ. 2002, 9:1031-1042.
6. Halestrap A.P., McStay G.P., Clarke S.J. The permeability transition pore complex: another view. Biochimie 2002, 84:153-166.
7. Broekemeier K.M., Dempsey M.E., Pfeiffer D.R. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J Biol. Chem 1989, 264:7826-7830.
8. Bernardi P., Vassanelli S., Veronese P., Colonna R., Szabo I., Zoratti M. Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. J. Biol. Chem. 1992, 267:2934-2939.
9. Kinnally K.W., Antonenko Y.N., Zorov D.B. Modulation of inner mitochondrial membrane channel activity. J. Bioenerg. Biomembr. 1992, 24:99-110.
10. Zoratti M., Szabo I. The mitochondrial permeability transition. Biochim. Biophys. Acta 1995, 1241:139-176.
11. Cheng Y., Debska-Vielhaber G., Siemen D. Interaction of mitochondrial potassium channels with the permeability transition pore. FEBS Lett. Dec 27. 2009, Electronic publication ahead of print.
12. Bernardi P., Krauskopf A., Basso E., Petronilli V., Blachly-Dyson E., Di Lisa F., Forte M.A. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 2006, 273:2077-2099.
13. Loupatatzis C., Seitz G., Schönfeld P., Lang F., Siemen D. Single-channel currents of the permeability transition pore from the inner mitochondrial membrane of rat liver and of a human hepatoma cell line. Cell Physiol. Biochem. 2002, 12:269-278.
14. Basso E., Petronilli V., Forte M.A., Bernardi P. Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J. Biol. Chem. 2008, 283:26307-26311.
15. Di Lisa F., Canton M., Menabò R., Dodoni G., Bernardi P. Mitochondria and reperfusion injury. The role of permeability transition. Basic Res. Cardiol. 2003, 98:235-241.
16. Cassarino D.S., Fall C.P., Smith T.S., Bennett P.P. Pramipexole reduces reactive oxygen species production in vivo and in vitro and inhibits the mitochondrial permeability transition produced by the Parkinsonian neurotoxin methylpyridinium ion. J. Neurochem. 1998, 71:295-301.
17. Sayeed I., Parvez S., Winkler-Stuck K., Seitz G., Trieu I., Wallesch C.-W., Schönfeld P., Siemen D. Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole. FASEB J. 2006, 20:556-558.
18. Liu Y., Fiskum G., Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 2002, 80:780-787.
19. Åkerman K.E.O., Wikström M.K.F. Safranine as a probe of the mitochondrial membrane potential. FEBS Lett. 1976, 68:191-197.
20. Brooks S.P., Storey K.P. Bound and determined: a computer program for making buffers of defined ion concentrations. Anal. Biochem. 1992, 201:119-126.
21. Andrabi S.A., Sayeed I., Siemen D., Wolf G., Horn T.F. Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J. 2004, 18:869-871.
22. Fontaine E., Eriksson O., Ichas F., Bernardi P. Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex I. J. Biol. Chem. 1998, 273:12662-12668.
23. Green D.R., Kroemer G. Pharmacological manipulation of cell death: clinical applications in sight?. J. Clin. Invest. 2005, 115:2610-2617.
24. Luzardo-Alvarez A., Delgado-Charro M.B., Blanco-Mendez J. Iontophoretic delivery of ropinirole hydrochloride: effect of current density and vehicle formulation. Pharm. Res. 2001, 18:1714-1720.
25. Hunter D.R., Haworth R.A., Southard J.H. Relationship between configuration, function and permeability in calcium-treated mitochondria. J. Biol. Chem 1976, 251:5069-5077.
26. Di Lisa F., Bernardi P. A CaPful of mechanisms regulating the mitochondrial permeability transition. J. Mol. Cell. Cardiol. 2009, 46:775-780.
27. Nicholls D.G., Ferguson S.J. Bioenergetics 3 2002, Academic Press, London.
28. Nicolli A., Petronilli V., Bernardi P. Modulation of the mitochondrial cyclosporine A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation. Biochemistry 1993, 32:4461-4465.
29. Hubble J., Koller W.C., Atchison P., Taylor A.C., Citerone D.R., Zussman B.D., Friedman C.J., Hawker N. Linear pharmacokinetic behavior of ropinirole. J. Clin. Pharmacol. 2000, 40:641-646.