Borage oil in the treatment of atopic dermatitis

Nutrition

Volumn 26, Issue 7-8, 2010, Pages 708-718

  Foster, Rachel H ^a   Hardy, Gil ^a,b   Alany, Raid G ^a,b  

^a THE UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; ARACHIDONIC ACID; BORAGE OIL; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; EMOLLIENT AGENT; ERUCIC ACID; GAMMA LINOLENIC ACID; IMMUNOMODULATING AGENT; LINOLEIC ACID; LINOLEOYL COENZYME A DESATURASE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PALMITIC ACID; PIMECROLIMUS; PRIMROSE OIL; SATURATED FATTY ACID; STEARIC ACID; TACROLIMUS;

ATOPIC DERMATITIS; CALORIC INTAKE; CHEMICAL COMPOSITION; CLINICAL TRIAL; DISEASE EXACERBATION; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; HIGH RISK PATIENT; HUMAN; MAINTENANCE THERAPY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN INFECTION; SLEEP DISORDER; SUPPLEMENTATION; TREATMENT OUTCOME;

BORAGO; DERMATITIS, ATOPIC; DIETARY SUPPLEMENTS; GAMMA-LINOLENIC ACID; HUMANS; PLANT OILS;

BORAGINACEAE; OENOTHERA;

EID: 77953804733     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.10.014     Document Type: Review

References (61)

1. The Merck Manuals Online Medical Library for Healthcare Professionals. Available at: Accessed December 1, 2007. http://www.merck.com/mmpe/index.html.
2. Hoare C., Wan Li, Po A., Williams H. Systematic review of treatments of atopic eczema. Health Technol Assess 2000, 4(37):1-191. Available at:, Accessed February 1, 2008. http://www.ncchta.org/fullmono/mon437.pdf.
3. Primary Care Dermatology Society and British Association of Dermatologists. Guidelines for the management of atopic eczema (2005). Available at: Accessed February 11, 2008. http://www.bad.org.uk/healthcare/guidelines/PCDSBAD-Eczema.pdf.
4. Hanifin J.M., Cooper K.D., Ho V.C., Kang S., Krafchik B.R., Margolis D.J., et al. Guidelines of care for atopic dermatitis. J Am Acad Dermatol 2004, 50(3):391-404.
5. Leung D.Y., Jain N., Leo H.L. New concepts in the pathogenesis of atopic dermatitis. Curr Opin Immunol 2003, 15(6):634-638.
6. Horrobin D.F. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr 2000, 71(suppl 1):367S-372S.
7. Manku M.S., Horrobin D.F., Morse N., Kyte V., Jenkins K., Wright S., et al. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. Prostaglandins Leukot Med 1982, 9:615-628.
8. Wright S. Essential fatty acids and the skin. Br J Dermatol 1991, 125(6):503-515.
9. Horrobin D.F. Nutritional and medical importance of gamma-linolenic acid. Prog Lipid Res 1992, 31(2):163-194.
10. Ziboh V.A., Miller C.C., Cho Y. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. Am J Clin Nutr 2000, 71(suppl 1):361S-366S.
11. Bibel D.J., Miller S.J., Brown B.E., Pandey B.B., Elias P.M., Shinefield H.R., et al. Antimicrobial activity of stratum corneum lipids from normal and essential fatty acid-deficient mice. J Invest Dermatol 1989, 92(4):632-638.
12. Galli E., Picardo M., Chini L., Passi S., Moschese V., Terminali O., et al. Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease?. Br J Dermatol 1994, 130:752-756.
13. Barre D.E. Potential of evening primrose, borage, black currant, and fungal oils in human health. Ann Nutr Metab 2001, 45(2):47-57.
14. Gunstone F.D. Gamma linolenic acid-occurrence and physical and chemical properties. Prog Lipid Res 1992, 31(2):145-161.
15. Van Gool C.J., Zeegers M.P., Thijs C. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. Br J Dermatol 2004, 150(4):728-740.
16. Connor W.E. Importance of n3 fatty acids in health and disease. Am J Clin Nutr 2000, 71(suppl):171S-175S.
17. Landi G. Oral administration of borago oil in atopic dermatitis. J Appl Cosmetology 1993, 11(4):115-120.
18. van Gool C.J., Thijs C., Henquet C.J., et al. Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis-a randomized controlled trial in infants at high familial risk. Am J Clin Nutr 2003, 77(4):943-951.
19. Morse N.L., Clough P.M. A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries?. Curr Pharm Biotechnol 2006, 7(6):503-524.
20. Morse P.F., Horrobin D.F., Manku M.S., et al. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. Br J Dermatol 1989, 121:75-90.
21. Elias P.M., Brown B.E., Ziboh V.A. The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function. J Invest Dermatol 1980, 74(4):230-233.
22. Hansen H.S., Jensen B. Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and α-linolate. Biochim Biophys Acta 1985, 834:357-363.
23. Tollesson A., Frithz A. Transepidermal water loss and water content in the stratum corneum in infantile seborrhoeic dermatitis. Acta Derm Venereol 1993, 73(1):18-20.
24. Kanehara S., Ohtani T., Uede K., Furukawa F. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. J Dermatol 2007, 34(12):811-815.
25. Brosche T., Platt D. Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people. Arch Gerontol Geriatr 2000, 30(2):139-150.
26. Miller C.C., Tang W., Ziboh V.A., Fletcher M.P. Dietary supplementation with ethyl ester concentrates of fish oil (n-3) and borage oil (n-6) polyunsaturated fatty acids induces epidermal generation of local putative anti-inflammatory metabolites. J Invest Dermatol 1991, 96(1):98-103.
27. Miller C.C., Ziboh V.A. Gammalinolenic acid-enriched diet alters cutaneous eicosanoids. Biochem Biophys Res Commun 1988, 154(3):967-974.
28. Ziboh V.A., Fletcher M.P. Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4. Am J Clin Nutr 1992, 55(1):39-45.
29. Don M., Melli P., Braida F., Comici A., Barbi F., Spano C., et al. Efficacy of essential fatty acids in the treatment of atopic dermatitis and correlations of their changes with clinical response. Ital J Pediatr 2003, 29(6):427-432.
30. Wright S., Bolton C. Breast milk fatty acids in mothers of children with atopic eczema. Br J Nutr 1989, 62(3):693-697.
31. Businco L., Ioppi M., Morse N.L., Nisini R., Wright S. Breast milk from mothers of children with newly developed atopic eczema has low levels of long chain polyunsaturated fatty acids. J Allergy Clin Immunol 1993, 91(6):1134-1139.
32. Manku M.S., Horrobin D.F., Morse N.L., Wright S., Burton J.L. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. Br J Dermatol 1984, 110(6):643-648.
33. Wright S., Sanders T.A. Adipose tissue essential fatty acid composition in patients with atopic eczema. Eur J Clin Nutr 1991, 45(10):501-505.
34. Lindskov R., Holmer G. Polyunsaturated fatty acids in plasma, red blood cells and mononuclear cell phospholipids of patients with atopic dermatitis. Allergy 1992, 47:517-521.
35. Oliwiecki S., Burton J.L., Elles K., et al. Levels of essential and other fatty acids in plasma and cell phospholipids from normal controls and patients with atopic eczema. Acta Derm Venereol 1991, 71:224-228.
36. Shimasaki H. PUFA content and effect of dietary intake of gamma-linolenic acid-rich oil on profiles of n-6, n-3 metabolites in plasma of children with atopic eczema. J Clin Biochem Nutr 1995, 19(3):183-192.
37. Strannegård I.L., Svennerholm L., Strannegård O. Essential fatty acids in serum lecithin of children with atopic dermatitis and in umbilical cord serum of infants with high or low IgE levels. Int Arch Allergy Appl Immunol 1987, 82(3-4):422-423.
38. Sakai K., Ueno K., Ogawa Y., Okuyama H. Fatty acid composition of plasma lipids in young atopic patients. Chem Pharm Bull 1986, 34:2944-2949.
39. Chapkin R.S., Ziboh V.A., Marcelo C.L., et al. Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation. J Lipid Res 1986, 27(9):945-954.
40. Henz B.M., Jablonska S., van de Kerkhof P.C., Stingl G., Blaszczyk M., Vandervalk P.G.M., et al. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol 1999, 140(4):685-688. [see comment].
41. Buslau M., Thaci D. Atopische dermatitis: Borretschol zur systemischen therapie. (German) Zeitschrift Dermatol 1996, 182(3):131-136. [Atopic dermatitis: Borage oil for systemic therapy].
42. Miller C.C., Ziboh V.A., Wong T., Fletcher M.P. Dietary supplementation with oils rich in (n-3) and (n-6) fatty acids influences in vivo levels of epidermal lipoxygenase products in guinea pigs. J Nutr 1990, 120(1):36-44.
43. James M.J., Gibson R.A., Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000, 71(suppl):343S-348S.
44. Fletcher M.P., Ziboh V.A. Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. Inflammation 1990, 14(5):585-597.
45. Scher J.U., Pillinger M.H. The anti-inflammatory effects of prostaglandins. J Invest Med 2009, 57(6):703-708.
46. Lacey R.W., Lord V.L. Sensitivity of staphylococci to fatty acids: novel inactivation of linolenic acid by serum. J Med Microbiol 1981, 14(1):41-49.
47. Andreassi M., Forleo P., Di Lorio A., et al. Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. J Int Med Res 1997, 25(5):266-274.
48. Valsecchi R., Di Lnadro A., Pansera B., et al. Gammalinolenic acid in the treatment of atopic dermatitis. J Eur Acad Dermatol Venereol 1996, 7(1):77-79. [letter].
49. Kiehl R., Ionescu G., Manuel P., et al. Klinische, immun- und lipidmodulatorische effekte einer behandlung mit ungesattigten fettsauren bei atopischer dermatitis [Clinical, immuno- and lipid modulating effects of unsaturated fatty acids in patients with atopic eczema] (German). Z Hautkr 1994, 69(1):42-48.
50. Takwale A., Tan E., Agarwal S., Barclay G., et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003, 327(7428):1385-1388.
51. Bahmer F.A., Schafer J. Die Behandlung der atopischen Dermatitis mit Borretschsamen-Ol (Glandol)-eine zeitreihenanalytische Studie [Treatment of atopic dermatitis with borage seed oil (Glandol) -a time series analytic study] (German). Kinderarztl Prax 1992, 60(7):199-202.
52. Melnik B.C., Bahmer F.A. Die behandlung des atopischen ekzems mit glandol(tm) und epoleum(tm) -eine vergleichende studie. [Treatment of atopic dermatitis with Glandol™ and Epoleum™-a comparative study] (German). Aktuelle Derm 1995, 21(7):215-219.
53. Borrek S., Hidebrandt A., Forster J. Gammalinolensaure-reiche Borretschsamenol-Kapseln bei Kindern mit Atopischer Dermatitis. Eine placebo-kontrollierte Doppelblind-Studie [Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study] (German). Klin Padiatr 1997, 209(3):100-104.
54. Borelli S., Bresser H., Belsan I. Externe therapie mit gamma-linolensaure-ergebnis einer doppelblindstudie [External therapy with gamma-linolenic acid-results of a double-blind study] (German). Z Hautkr 1994, 69(8):523-524.
55. Tollesson A., Frithz A. Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. Br J Dermatol 1993, 129(1):95.
56. Eritsland J. Safety considerations of polyunsaturated fatty acids. Am J Clin Nutr 2000, 71(suppl):197S-201.
57. Williams H.C. Evening primrose oil for atopic dermatitis: time to say goodnight. BMJ 2003, 327:1358-1359.
58. Charman C.R., Morris A.D., Williams H.C. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol 2000, 142(5):931-936.
59. Richmond C. Obituaries: David Horrobin. BMJ 2003, 326:885.
60. Barrett S. Primrose oil and eczema: how research was promoted and suppressed. Available at: Accessed March 1, 2008. http://www.quackwatch.org/01QuackeryRelatedTopics/DSH/epo.html.
61. Roland I., de Leval X., Evrard B., Pirotte B., Dogné J.M., Delattre L., et al. Modulation of the arachidonic cascade with omega3 fatty acids or analogues: potential therapeutic benefits. Mini Rev Med Chem 2004, 4(6):659-668.