Spectral properties and factors determining high quantum yield of thioflavin T incorporated in amyloid fibrils

Spectroscopy

Volumn 24, Issue 1-2, 2010, Pages 169-172

  Sulatskaya, A I ^a,b   Turoverov, K K ^a   Kuznetsova, I M ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

^b PETER THE GREAT ST PETERSBURG POLYTECHNIC UNIVERSITY   (Russian Federation)

Author keywords

Absorption; Amyloid fibrils; Dimers; Eximers; Fluorescence; Micelles; Quantum yield; Thioflavin T

Indexed keywords

DIMERS; GLYCOPROTEINS; MICELLES; QUANTUM YIELD;

AMYLOID FIBRIL; EXIMERS; FIBRIL FORMATION; FIBRIL STRUCTURE; FLUORESCENCE QUANTUM YIELD; MOLECULAR MECHANISM; MONOMERIC FORMS; SPECTRAL FACTORS; SPECTRAL PROPERTIES; THIOFLAVIN T;

FLUORESCENCE;

AMYLOID; ANILINE; BENZOTHIAZOLE; DIMER; MONOMER; THIOFLAVINE;

ABSORPTION SPECTROSCOPY; CONFERENCE PAPER; FLUORESCENCE; PROTEIN BINDING; QUANTUM YIELD;

EID: 77953803967     PISSN: 07124813     EISSN: None     Source Type: Journal    
DOI: 10.1155/2010/620781     Document Type: Conference Paper

References (12)

1. R.W. Carrell and B. Gooptu, Conformational changes and disease - serpins, prions and Alzheimer's, Curr. Opin. Struct. Biol. 8 (1998), 799-809.
2. C.M. Dobson, Protein folding and misfolding, Nature 18 (2003), 884-890.
3. C.M. Dobson, Experimental investigation of protein folding and misfolding, Methods 34 (2004), 4-14.
4. M. Groenning, L. Olsen, M. Weert, J.M. Flink, S. Frokjaer and F.S. Jorgensen, Study on the binding of thioflavin T to sheet-rich and non-sheet cavities, J. Struct. Biol. 158 (2007), 358-369.
5. R. Khurana, K. Coleman, C. Ionescu-Zanetti, S.A. Carter, V. Krishna, R.K. Grover, R. Roy and S. Singh, Mechanism of thioflavin-T binding to amyloid fibrils: localisation and implications, J. Struct. Biol. 151 (2005), 229-238.
6. E.H. Koo Lansbury and J.W. Kelly, Amyloid disease abnormal protein aggregation in neurodegeneration, Proc. Natl. Acad. Sci. USA 96 (1999), 9989-9990.
7. A.A. Maskevich, V.I. Stsiapura, V.A. Kuzmitsky, I.M. Kuznetsova, O.I. Povarova, V.N. Uversky and K.K. Turoverov, Spectral properties of thioflavin T in solvents with different dielectric properties and in a fibril-incorporated form, J. Proteome Res. 6 (2007), 1392-1401.
8. C.R. Raj and R. Ramaraj, α-cyclodextrin inducted intermolecular eximer formation of thioflavin T, Chem. Phys. Lett. 273 (1997), 285-290.
9. R. Schirra, Dye aggregation in freezing aqueous solutions, Chem. Phys. Lett. 119 (1985), 229-238.
10. K.K. Turoverov, A.G. Biktashev, A.V. Dorofeiuk and I.M. Kuznetsova, A complex of apparatus and programs for the measurement of spectral, polarization and kinetic characteristics of fluorescence in solution, Tsitologiia 40 (1998), 806-817.
11. K.K. Turoverov, I.M. Kuznetsova, A.A. Maskevich, V.I. Stepuro, V.A. Kuzmitsky and V.N. Uversky, Tht as an instrument for testing and investigation of amiloid and amiloid-like fibrils, Proc. of SPIE 6733 (2007), 1R-11R.
12. V.N. Uversky, A. Talapatra, J.R. Gillespie and A.L. Fink, Protein deposits as the molecular basis of amyloidosis, Med. Sci. Monit. 5 (1999), 1001-1012, 1238-1254.