Bone development of suckling piglets after prenatal, neonatal or perinatal treatment with dexamethasone

Journal of Animal Physiology and Animal Nutrition

Volumn 94, Issue 3, 2010, Pages 293-306

  Śliwa, Ewa ^a   Dobrowolski, P ^b   Piersiak, T ^b  

^a UNIVERSITY OF LIFE SCIENCES IN LUBLIN   (Poland)

^b MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

Author keywords

Bone mineral density; Catch up growth; Dexamethasone; Histomorphometry; Piglets

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; OSTEOCALCIN;

ANIMAL; ARTICLE; BLOOD; BONE DENSITY; BONE DEVELOPMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GROWTH, DEVELOPMENT AND AGING; MALE; NEWBORN; PREGNANCY; PRENATAL EXPOSURE; RANDOMIZED CONTROLLED TRIAL; SUCKLING; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; BONE DENSITY; BONE DEVELOPMENT; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; MALE; OSTEOCALCIN; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SWINE;

ANIMALIA; MAMMALIA;

EID: 77953792497     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2008.00909.x     Document Type: Article

References (74)

1. Aaron J E, Francis R M, Peacock M, Makins N B. Contrasting microanatomy of idiopathic and corticosteroid-induced osteoporosis. Clinical Orthopaedics and Related Research 1989, 243:294-305.
2. Adachi J, Ioannidid G. Osteoporosis After Steroid 2003, 7-14. Via Medica, Gdańsk, Poland
3. Calvert C A, Cornelius L M. The most cammon indications for using corticosteroid hormones in veterinary practice. Veterinary Medicine 1990, 85:826-845.
4. Carroll J A. Dexamethasone treatment at birth enhances neonatal growth in swine. Domestic Animal Endocrinology 2001, 21:97-109.
5. Cetin I, Foidart J M, Miozzo M, Raun T, Jansson T, Tsatsaris V, Reik W, Cross J, Hauguel-de-Mouzon S, Illsley N, Kingdom J, Huppertz B. Fetal growth restriction: a workshop report. Placenta 2004, 25:753-757.
6. Çetinkaya F, Tüfekçi B S, Kutluk G. A comparison of nebulized budesonide, intramuscular, and oral dexamethasone for treatment of croup. International Journal of Pediatric Otorhinolaryngology 2004, 68:435-456.
7. Clifton V L, Murphy V E. Maternal asthma as a model for examining fetal sex-specific effects on maternal physiology and placental mechanisms that regulate human fetal growth. Placenta 2004, 25:S45-S52.
8. Desai M, Gayle D, Babu J, Ross M G. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2005, 288:R91-R96.
9. Drake A J, Walker B R, Seckl J R. Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2005, 288:R34-R38.
10. Egerman R S, Franklin P, Andersen R N, Umstot E S, Carr T L, Sibai B. A comparison of the bioavailability of oral and intramuscular dexamethasone in women in late pregrancy. Obstetrics and Gynecology 1997, 89:276-280.
11. Feldman D M, Carbone J, Belden L, Borgida A F, Herson V. Betamethasone vs dexamethasone for the prevention of morbidity in very-low-birtheight neonates. American Journal of Obstetrics and Gynecology 2007, 197:284.e1-284.e4.
12. Ferretti J L, Capozza R F, Mondelo N, Montuori E, Zanchetta J R. Determination of femur structural properties by geometric and material variables as a function of body weight in rats. Evidence of sexual dimorphism. Bone 1993a, 14:256-270.
13. Ferretti J L, Capozza R F, Mondelo N, Zanchetta J R. Interrelationships between densitometric; geometric and mechanical properties of rat femora: inferences concerning mechanical regulation of bone modeling. Journal of Bone Mineral Research 1993b, 8:1389-1395.
14. Ferretti J L, Gaffuri O, Capozza R, Cointry G, Bozzini C, Olivera M, Zanchetta J R, Bozzini C E. Dexamethasone effects on mechanical; geometric and densitometric properties of rat femur diaphyses as described by peripheral quantitative computerized tomography; bending tests. Bone 1995a, 16:119-124.
15. Ferretti J L, Capozza R F, Cointry G R, Delgado C J, Zanchetta J R. Monophasic dose- response curves of betamethasone on geometric and mechanical properties of femur diaphyses in growing rats. Bone 1995b, 16:103-108.
16. Finer N N, Craft A, Vaucher E Y, Clark R H, Sola A. Postnatal steroids: short-term gain and long-term pain? Journal of Pediatrics 2000, 137:9-13.
17. Freemont A J. Bone. Current Orthopaedics 1998, 12:181-192.
18. Guinn D A. Repeat courses of antenatal corticosteroids: The controversy continues. American Journal of Obstetrics and Gynecology 2004, 190:585-587.
19. Hanania N A. Dose-related decrease in bone density among asthmatic patients treated with inhaled corticosteroids. The Journal of Allergy and Clinical Immunology 1995, 96:571-579.
20. Holemans K, Leona A, André F. Fetal growth; long-term consequences in animal models of growth retardation. European Journal of Obstetrics and Gynecology and Reproductive Biology 1998, 81:149-156.
21. Holemans K, Aerts L, Van Assche F A. Fetal growth restriction and consequences for the offspring in animal models. Journal of the Society for Gynecologic Investigation 2003, 10:392-399.
22. Huang T S, Yang R S, Tsai T W, Liu S H. Growth hormone cannot enhance the recovery of dexamethasone-induced osteopenia after withdrawal in young female wistar rats. Tohoku Journal of Experimental Medicine 2004, 204:257-266.
23. Ikeda S, Morishita Y, Tsutsumi H, Ito M, Shiraishi A, Arita S, Akahoshi S, Narusawa K, Nakamura T. Reductions in bone turnover; minerals and structure associated with mechanical properties of lumbar vertebra; femur in glucocorticoid-treated growing minipigs. Bone 2003, 33:779-787.
24. Jobe A H, Soll R F. Choice and dose of corticosteroid for antenatal treatments. American Journal of Obstetrics and Gynecology 2004, 190:878-881.
25. Kanitz E, Otten W, Tuchscherer M, Manteuffel G. Effects of prenatal stress on corticosteroid receptors and monoamine concentrations in limbic areas of suckling piglets (Sus scrofa) at different ages. Journal of Veterinary Medicine. A Physiology, Pathology, Clinical Medicine 2003, 50:132-139.
26. Kuna P. Anti-inflammatory drugs- effective and safe in the treatment of bronchial asthma. Terapia 2002, 1:119-122.
27. Lane S J, Vaja S, Swaminathan R, Lee T H. Effects of prednisolone on bone turnover in patients with corticosteroid resistant asthma. Clinical and Experimental Allergy 1996, 26:1197-1201.
28. Leenhouwers J I, Knol E F, van der Lende T. Differences in late prenatal development as an explanation for genetic differences in piglets survival. Livestock Production Science 2002, 78:57-62.
29. Levitt N S, Lindsay R S, Holmes M C, Seckl J R. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 1996, 64:412-418.
30. Levy-Marchal C, Jaquet D, Czernichow P. Long-term metabolic consequences of being born small for gestational age. Seminars in Neonatology 2004, 9:67-74.
31. Loew D, Schuster O, Graul E H. Dose-dependent pharmacokinetics of dexamethasone. European Journal of Clinical Pharmacology 1986, 30:225-230.
32. Lugo R A, Nahata M C, Menke J A, McClead R E. Pharmacokinetics of dexamethasone in premature neonates. European Journal of Clinical Pharmacology 1996, 49:447-483.
33. McDonald T J, Franko K L, Brown J M, Jenkins S L, Nathanielsz P W, Nijland M J. Betamethasone in the last week of pregnancy causes fetal growth retardation but not adult hypertension in rats. Journal of the Society for Gynecologic Investigation 2003, 10:399-473.
34. McIwraith C W. Developmental orthopedic disease: problems of limbs in young horses. Journal of Equine Veterinary Science 2004, 24:457-479.
35. Michel C, Cabanac M. Effects of dexamethasone on the body weight set point of rats. Physiology and Behavior 1999, 68:145-150.
36. Miller E. The role of glucocorticoids treatment in veterinary practice. Waltham Focus 1999, 9:26-31.
37. Miller S C, Bowman B M, Jee W S. Available animal models of osteopenia - small large. Bone 1995, 17:117S-123S.
38. Miner J N. Designer glucocorticoids. Biochemical Pharmacology 2002, 64:355-361.
39. Namgung R, Tsang R C. Bone in the pregnant mother and newborn at birth. Clinica Chimica Acta 2003, 333:1-11.
40. Newnham J P, Moss T J. Antenatal glucocorticoids and growth: single versus multiple doses in animal and human studies. Seminars in Neonatology 2001, 6:285-292.
41. O'Regan D, Kenyon C J, Seckl J R, Holmes M C. Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology. American Journal of Physiology-Endocrinology and Metabolism 2004, 287:E863-E870.
42. Orzechowski A, Ostaszewski P, Brodnicka A, Wilczak J, Balasińska B, Jank M, Grzełkowska K, Ploszaj T, Olczak J, Mrówczyńska A. Excess of glucocorticoids impairs whole-body antioxidant status in young rats Relation to the effect of dexamethasone in soleus muscle and spleen. Hormone and Metabolic Research 2000, 32:174-180.
43. Oughen O, Wright E M, Jones J, Alaghband-Zadeh J, Nicolaides K H, Johnson M R. Fetal bone metabolism in normal and rhesus isoimmunised pregnancies. British Journal of Obstetrics and Gynaecology 2001, 108:986-992.
44. Owen D, Andrews M H, Matthews S G. Maternal adversity; glucocorticoids and programming of neuroendocrine function; behaviour. Neuroscience and Biobehavioral Reviews 2005, 29:209-226.
45. Pearce G, Tabensky D A, Delmas P D, Baker H W, Seeman E. Corticosteroid-induced bone loss in men. The Journal of Clinical Endocrinology and Metabolism 1998, 83:801-806.
46. Prummel M F, Wiersinga W M, Lips P, Sanders G T, Sauerwein H P. The course of biochemical parameters of bone turnover during treatment with corticosteroids. The Journal of Clinical Endocrinology and Metabolism 1991, 72:382-386.
47. Raff H. Neonatal dexamethasone therapy: short- and long-term consequences. Trends in Endocrinology and Metabolism 2004, 15:352-353.
48. Reid I R. Relationships among body mass; its components and bone. Bone 2002, 31:547-555.
49. Rocha D, Plastow G. Commercial pigs: an untapped resource for human obesity reasarch? Drug Discovery Today 2006, 11:475-477.
50. Ryan S. Bone mineralization in preterm infants. Nutrition 1998, 10:745-747.
51. Sayer A A, Cooper C. Fetal programming of body composition and musculo skeletal. development. Early Human Development 2005, 81:735-744.
52. Seaman-Bridges J S, Carroll J A, Safranski T J, Berg E P. Short- and long-term influence of prenatal dexamethasone treatment on swine growth. Domestic Animal Endocrinology 2003, 24:193-208.
53. Shen C N, Seckl J R, Slack J M, Tosh D. Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas. The Biochemical Journal 2003, 375:41-50.
54. Sizonenko S V, Borradori-Tolsa C, Vauthay D M, Lodygensky G, Lazeyras F, Hüppi P S. Impact of intrauterine growth restriction and glucocorticoids on brain development: Insight using advanced magnetic resonance imaging. Molecular and Cellular Endocrinology 2006, 254-255:163-171.
55. Śliwa E, Dobrowolski P. Perinatal programming of skeletal system. Journal of Pre-Clinical and Clinical Research 2007c, 1:112-118.
56. Śliwa E, Kowalik S, Tatara M R, Studziński T. Effect of maternal administration of dexamethasone during last weeks of pregnancy on foetal skeletal system in pigs. Bulletin of the Veterinary Institute in Pulawy 2004, 48:449-452.
57. Śliwa E, Kowalik S, Tatara M R, Majcher P, Krupski W, Studziński T. Effects of dexamethasone on physical properties and mineral density of long bones in piglets. Bulletin of the Veterinary Institute in Pulawy 2005a, 49:97-100.
58. Śliwa E, Wawrzyniak-Gacek A, Tatara M R, Kowalik S, Łuszczewska-Sierakowska I, Krupski W, Majcher P, Pierzynowski S G, Studziński T. The influence of dexamethasone and alpha-ketoglutarate on the development of skeletal system in pigs. Medycyna Weterynaryjna 2005b, 61:526-531.
59. Śliwa E, Tatara M R, Kowalik S, Krupski W, Majcher P, Piersiak T, Studziński T. Influence of dexamethasone on the growth and mineralization of the skeletal system in pigs during prenatal life. Medycyna Weterynaryjna 2005c, 61:1145-1148.
60. Śliwa E, Tatara M R, Nowakowski H, Pierzynowski S G, Studziński T. Effect of maternal dexamethasone and alpha-ketoglutarate administration on skeletal. development during the last three weeks of prenatal life in pigs. The of Journal Maternal-Fetal and Neonatal Medicine 2006, 19:489-493.
61. Śliwa E, Tatara M R, Studziński T. Sex-dependent effect of dexamethasone administered prenatally on femur development in piglets. Eesti arst 2007a, 8:571-572.
62. Śliwa E, Dobrowolski P, Tatara M R, Pierzynowski S G. Alpha-ketoglutarate partially protects newborns from metabolic changes evoked by chronic maternal exposure to glucocorticoids. Journal of Pre-Clinical and Clinical Research 2007b, 1:55-59.
63. Smink J J, Buchholz I M, Hamers N, Tilburg C M, Christis C, Sakkers J B, Meer K, Buul-Offers S C, Koedam J A. Short-term glucocorticoid treatment of piglets causes changes in growth plate morphology and angiogenesis. Osteoarthritis and Cartilage 2003, 11:864-871.
64. Smith N H, Ozanne S E. Intrauterine origins of metabolic disease. Review of Gynecology and Perinatal Practice 2006, 6:211-217.
65. Smith G N, Kingdom J C, Penning D H, Metthews S G. Antenatal corticosteroids: is more better? Lancet 2000, 355:251-252.
66. So K-w, Ng P-c. Treatment and prevention of neonatal osteopenia. Current Paediatrics 2005, 15:106-113.
67. Stellon A J, Webb A, Compston J E. Bone histomorphometry and structure in corticosteroid treated chronic active hepatitis. Gut 1988, 29:378-384.
68. Tan K S, Thomson N C. Asthma in pregnancy. The American of Journal Medicine 2000, 109:727-733.
69. Tsen L C. Dexamethasone was effective in preventing nausea and vomiting after surgical termination of pregnancy. Obstetrics and Gynecology 2002, 4:136-137.
70. Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. The Journal of Biological Chemistry 1995, 270:15958-15961.
71. Ward W, Atkinson S, Donovan S, Paes B. Bone metabolism, circulating IGF-1 and IFGBPs in dexamethasone-treated preterm infants. Early Human Development 1999, 56:127-141.
72. Weiler H A, Paes B, Shah J K, Atkinson S A. Longitudinal assessment of growth and bone mineral accretion in prematurely born infants treated for chronic lung disease with dexamethasone. Early Human Development 1997, 47:271-286.
73. Welberg L A, Seckl J R, Holmes M C. Inhibition of 11beta-hydroxysteroid dehydrogenase; the foeto-placental barrier to maternal glucocorticoids; permanently programs amygdale GR mRNA expression and anxiety-like behavior in the offspring. The European Journal of Neuroscience 2000, 12:1047-1054.
74. Welberg L A, Seckl J R, Holmes M C. Prenatal glucocorticoid programming of brain corticosteroid receptors; corticotrophin-releasing hormone: possible implications for behavior. Neuroscience 2001, 104:71-79.