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Volumn 70, Issue 12, 2010, Pages 4809-4819

Gene expression: Protein interaction systems network modeling identifies transformation-associated molecules and pathways in ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PROTEIN P53;

EID: 77953766711     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0447     Document Type: Article
Times cited : (39)

References (43)
  • 1
    • 67349248619 scopus 로고    scopus 로고
    • Molecular classification of solid tumours towards pathway-driven therapeutics
    • Swanton C, Caldas C. Molecular classification of solid tumours: towards pathway-driven therapeutics. Br J Cancer 2009;100:1517-22.
    • (2009) Br J Cancer , vol.100 , pp. 1517-1522
    • Swanton, C.1    Caldas, C.2
  • 2
    • 60849097255 scopus 로고    scopus 로고
    • Gene expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene expression signatures in breast cancer. N Engl J Med 2009;360:790-800.
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 3
    • 58149489177 scopus 로고    scopus 로고
    • Ovarian carcinoma subtypes are different diseases: Implications for biomarker studies
    • Kobel M, Kalloger SE, Boyd N, et al. Ovarian carcinoma subtypes are different diseases: implications for biomarker studies. PLoS Med 2008;5:e232.
    • (2008) PLoS Med , vol.5
    • Kobel, M.1    Kalloger, S.E.2    Boyd, N.3
  • 4
    • 61449231569 scopus 로고    scopus 로고
    • Ovarian cancer: A clinical challenge that needs some basic answers
    • Lawrenson K, Gayther SA. Ovarian cancer: a clinical challenge that needs some basic answers. PLoS Med 2009;6:e25.
    • (2009) PLoS Med , vol.6
    • Lawrenson, K.1    Gayther, S.A.2
  • 5
    • 17144403478 scopus 로고    scopus 로고
    • Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
    • Bapat SA, Mali AM, Koppikar CB, et al. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res 2005;65:3025-9.
    • (2005) Cancer Res , vol.65 , pp. 3025-3029
    • Bapat, S.A.1    Mali, A.M.2    Koppikar, C.B.3
  • 6
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Available from
    • McLendon R, Friedman A, Bigner D. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-8. Available from: http://cancergenome.nih.gov.
    • (2008) Nature , vol.455 , pp. 1061-1068
    • McLendon, R.1    Friedman, A.2    Bigner, D.3
  • 7
    • 54349101605 scopus 로고    scopus 로고
    • Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
    • Available from
    • Kilpinen S, Autio R, Ojala K, et al. Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biol 2008;9:R139. Available from: http://www.genesapiens.org.
    • (2008) Genome Biol , vol.9
    • Kilpinen, S.1    Autio, R.2    Ojala, K.3
  • 8
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild AH, Yao G, Chang JT, et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006;439:353-7.
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1    Yao, G.2    Chang, J.T.3
  • 9
    • 33947305781 scopus 로고    scopus 로고
    • ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
    • Available from
    • Margolin AA, Nemenman I, Basso K, et al. ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics 2006;7 Suppl 1:S7. Available from: http://gforge.nci.nih.gov/frs/ ?group-id=78.
    • (2006) BMC Bioinformatics , vol.7 , Issue.SUPPL. 1
    • Margolin, A.A.1    Nemenman, I.2    Basso, K.3
  • 10
    • 58149271021 scopus 로고    scopus 로고
    • Integrated network analysis platform for protein-protein interactions
    • Wu J, Vallenius T, Ovaska K, et al. Integrated network analysis platform for protein-protein interactions. Nat Methods 2009;6:75-7.
    • (2009) Nat Methods , vol.6 , pp. 75-77
    • Wu, J.1    Vallenius, T.2    Ovaska, K.3
  • 11
    • 70349859809 scopus 로고    scopus 로고
    • Snail and Slug mediate radio- And chemo-resistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • Kurrey NK, Jalgaonkar SP, Joglekar AV, et al. Snail and Slug mediate radio- and chemo-resistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009;27:2059-68.
    • (2009) Stem Cells , vol.27 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3
  • 12
    • 37649022627 scopus 로고    scopus 로고
    • Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes
    • Yasui DH, Peddada S, Bieda MC, et al. Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. PNAS 2007;104:19416-21.
    • (2007) PNAS , vol.104 , pp. 19416-19421
    • Yasui, D.H.1    Peddada, S.2    Bieda, M.C.3
  • 14
    • 33749871179 scopus 로고    scopus 로고
    • Nuclear-mitochondrial genomic profiling reveals a pattern of evolution in epithelial ovarian tumor stem cells
    • DOI 10.1038/sj.onc.1209649, PII 1209649
    • Wani AA, Sharma N, Shouche YS, et al. Nuclear-mitochondrial genomic profiling reveals a pattern of evolution in epithelial ovarian tumor stem cells. Oncogene 2006;25:6336-44. (Pubitemid 44564749)
    • (2006) Oncogene , vol.25 , Issue.47 , pp. 6336-6344
    • Wani, A.A.1    Sharma, N.2    Shouche, Y.S.3    Bapat, S.A.4
  • 15
    • 65249184461 scopus 로고    scopus 로고
    • CD133-expressing stem cells associated with ovarian metastases establish an endothelial hierarchy and contribute to tumor vasculature
    • Kusumbe AP, Mali AM, Bapat SA. CD133-expressing stem cells associated with ovarian metastases establish an endothelial hierarchy and contribute to tumor vasculature. Stem Cells 2009;27:498-508.
    • (2009) Stem Cells , vol.27 , pp. 498-508
    • Kusumbe, A.P.1    Mali, A.M.2    Bapat, S.A.3
  • 16
    • 73649107330 scopus 로고    scopus 로고
    • Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy
    • Kusumbe AP, Bapat SA. Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy. Cancer Res 2009;69:9245-53.
    • (2009) Cancer Res , vol.69 , pp. 9245-9253
    • Kusumbe, A.P.1    Bapat, S.A.2
  • 17
    • 33748485372 scopus 로고    scopus 로고
    • Chromosomal losses of regions on 5q and lack of high-level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma
    • Staebler A, Karberg B, Behm J, et al. Chromosomal losses of regions on 5q and lack of high-level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma. Genes Chromosomes Cancer 2006;45:905-17.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 905-917
    • Staebler, A.1    Karberg, B.2    Behm, J.3
  • 18
    • 50249140088 scopus 로고    scopus 로고
    • Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target
    • Fejzo MS, Dering J, Ginther C, et al. Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target. Genes Chromosomes Cancer 2008;47:873-83.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 873-883
    • Fejzo, M.S.1    Dering, J.2    Ginther, C.3
  • 19
    • 0035757413 scopus 로고    scopus 로고
    • Analyses by comparative genomic hybridization of genes relating with cisplatin-resistance in ovarian cancer
    • Takano M, Kudo K, Goto T, et al. Analyses by comparative genomic hybridization of genes relating with cisplatin-resistance in ovarian cancer. Hum Cell 2001;14:267-71.
    • (2001) Hum Cell , vol.14 , pp. 267-271
    • Takano, M.1    Kudo, K.2    Goto, T.3
  • 20
    • 48249143703 scopus 로고    scopus 로고
    • Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression
    • Scotto L, Narayan G, Nandula SV, et al. Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression. Genes Chromosomes Cancer 2008;47:755-65.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 755-765
    • Scotto, L.1    Narayan, G.2    Nandula, S.V.3
  • 21
    • 46849098205 scopus 로고    scopus 로고
    • Multiple loci with different cancer specificities within the 8q24 gene desert
    • Ghoussaini M, Song H, Koessler T, et al. Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst 2008;100:962-6.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 962-966
    • Ghoussaini, M.1    Song, H.2    Koessler, T.3
  • 22
    • 68149180901 scopus 로고    scopus 로고
    • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
    • Pomerantz MM, Ahmadiyeh N, Jia L, et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet 2009;41:882-4.
    • (2009) Nat Genet , vol.41 , pp. 882-884
    • Pomerantz, M.M.1    Ahmadiyeh, N.2    Jia, L.3
  • 23
    • 45849102747 scopus 로고    scopus 로고
    • Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma
    • Li Y, Meng G, Guo QN. Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. Exp Mol Pathol 2008;84:234-9.
    • (2008) Exp Mol Pathol , vol.84 , pp. 234-239
    • Li, Y.1    Meng, G.2    Guo, Q.N.3
  • 24
    • 33745338458 scopus 로고    scopus 로고
    • The DNA-binding domain of yeast Hsf1 regulates both DNA-binding and transcriptional activities
    • DOI 10.1016/j.bbrc.2006.06.057, PII S0006291X06013623
    • Yamamoto A, Sakurai H. The DNA-binding domain of yeast Hsf1 regulates both DNA-binding and transcriptional activities. Biochem Biophys Res Commun 2006;346:1324-9. (Pubitemid 43946838)
    • (2006) Biochemical and Biophysical Research Communications , vol.346 , Issue.4 , pp. 1324-1329
    • Yamamoto, A.1    Sakurai, H.2
  • 25
    • 67650078254 scopus 로고    scopus 로고
    • Copy number gain and oncogenic activity of YWHAZ/14-3-3ζ in head and neck squamous cell carcinoma
    • Lin M, Morrison CD, Jones S, et al. Copy number gain and oncogenic activity of YWHAZ/14-3-3ζ in head and neck squamous cell carcinoma. Int J Cancer 2009;125:603-11.
    • (2009) Int J Cancer , vol.125 , pp. 603-611
    • Lin, M.1    Morrison, C.D.2    Jones, S.3
  • 26
    • 37549018422 scopus 로고    scopus 로고
    • Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas
    • Ishikawa N, Takano A, Yasui W, et al. Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res 2007;67:11601-11.
    • (2007) Cancer Res , vol.67 , pp. 11601-11611
    • Ishikawa, N.1    Takano, A.2    Yasui, W.3
  • 29
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JE, McGarvey KM, Yu X, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007;39:237-42.
    • (2007) Nat Genet , vol.39 , pp. 237-242
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3
  • 30
    • 74949130404 scopus 로고    scopus 로고
    • Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer
    • Lee PS, Teaberry VS, Bland AE, et al. Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. Int J Cancer 2009;26:1378-89.
    • (2009) Int J Cancer , vol.26 , pp. 1378-1389
    • Lee, P.S.1    Teaberry, V.S.2    Bland, A.E.3
  • 31
    • 65249155369 scopus 로고    scopus 로고
    • Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome
    • Berchuck A, Iversen ES, Luo J, et al. Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome. Clin Cancer Res 2009;15:2448-55.
    • (2009) Clin Cancer Res , vol.15 , pp. 2448-2455
    • Berchuck, A.1    Iversen, E.S.2    Luo, J.3
  • 32
    • 16644397923 scopus 로고    scopus 로고
    • Loss of imprinting of PEG1/ MEST in lung cancer cell lines
    • Nakanishi H, Suda T, Katoh M, et al. Loss of imprinting of PEG1/ MEST in lung cancer cell lines. Oncol Rep 2004;12:1273-8.
    • (2004) Oncol Rep , vol.12 , pp. 1273-1278
    • Nakanishi, H.1    Suda, T.2    Katoh, M.3
  • 33
    • 33745728174 scopus 로고    scopus 로고
    • Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney
    • Dekel B, Metsuianim S, Schmidt-Ott KM, et al. Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney. Cancer Res 2006;66:6040-9.
    • (2006) Cancer Res , vol.66 , pp. 6040-6049
    • Dekel, B.1    Metsuianim, S.2    Schmidt-Ott, K.M.3
  • 34
    • 61449089633 scopus 로고    scopus 로고
    • Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker
    • Sadr-Nabavi A, Ramser J, Volkmann J, et al. Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. Int J Cancer 2009;124:1727-35.
    • (2009) Int J Cancer , vol.124 , pp. 1727-1735
    • Sadr-Nabavi, A.1    Ramser, J.2    Volkmann, J.3
  • 35
    • 33745315497 scopus 로고    scopus 로고
    • Promoter array studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells
    • Wang Y, Hayakawa J, Long F, et al. "Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells. Ann N Y Acad Sci 2005;1058:162-85.
    • (2005) Ann N Y Acad Sci , vol.1058 , pp. 162-185
    • Wang, Y.1    Hayakawa, J.2    Long, F.3
  • 36
    • 27744570398 scopus 로고    scopus 로고
    • Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy
    • DOI 10.1038/sj.onc.1208883, PII 1208883
    • Frigola J, Munoz M, Clark SJ, et al. Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. Oncogene 2005;24:7320-6. (Pubitemid 41622236)
    • (2005) Oncogene , vol.24 , Issue.49 , pp. 7320-7326
    • Frigola, J.1    Muoz, M.2    Clark, S.J.3    Moreno, V.4    Capella, G.5    Peinado, M.A.6
  • 37
    • 57149110826 scopus 로고    scopus 로고
    • The Human Protein Atlas-a tool for pathology
    • Available from
    • Pontén F, Jirström K, Uhlen M. The Human Protein Atlas-a tool for pathology. J Pathol 2008;216:387-93. Available from: http://www. proteinatlas.org.
    • (2008) J Pathol , vol.216 , pp. 387-393
    • Pontén, F.1    Jirström, K.2    Uhlen, M.3
  • 38
    • 0035890422 scopus 로고    scopus 로고
    • Loss of DNA mismatch repair imparts defective cdc2 signaling and G([2]) arrest responses without altering survival after ionizing radiation
    • Yan T, Schupp JE, Hwang HS, et al. Loss of DNA mismatch repair imparts defective cdc2 signaling and G([2]) arrest responses without altering survival after ionizing radiation. Cancer Res 2001;61:8290-7.
    • (2001) Cancer Res , vol.61 , pp. 8290-8297
    • Yan, T.1    Schupp, J.E.2    Hwang, H.S.3
  • 39
    • 65249189337 scopus 로고    scopus 로고
    • Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma
    • Kulkarni AA, Kingsbury SR, Tudzarova S, et al. Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res 2009;15:2417-25.
    • (2009) Clin Cancer Res , vol.15 , pp. 2417-2425
    • Kulkarni, A.A.1    Kingsbury, S.R.2    Tudzarova, S.3
  • 40
    • 38048999928 scopus 로고    scopus 로고
    • Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor β resistant cells
    • Biswas S, Trobridge P, Romero-Gallo J, et al. Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor β resistant cells. Genes Chromosomes Cancer 2008;47:95-106.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 95-106
    • Biswas, S.1    Trobridge, P.2    Romero-Gallo, J.3
  • 41
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 42
    • 0036885134 scopus 로고    scopus 로고
    • CAS (cellular apoptosis susceptibility) gene expression in ovarian carcinoma: Correlation with 20q13.2 copy number and cyclin D1, p53, and Rb protein expression
    • Peiró G, Diebold J, Löhrs U. CAS (cellular apoptosis susceptibility) gene expression in ovarian carcinoma: Correlation with 20q13.2 copy number and cyclin D1, p53, and Rb protein expression. Am J Clin Pathol 2002;118:922-9.
    • (2002) Am J Clin Pathol , vol.118 , pp. 922-929
    • Peiró, G.1    Diebold, J.2    Löhrs, U.3


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