Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 135, Issue 1, 2003, Pages 9-15

  Wakimoto, Koji ^a   Fujimura, Hisako ^a   Iwamoto, Takahiro ^b   Oka, Toru ^c   Kobayashi, Kinji ^a   Kita, Satomi ^b   Kudoh, Sumiyo ^c   Kuro o, Makoto ^d   Nabeshima, Yo Ichi ^e   Shigekawa, Munekazu ^b   Imai, Yuji ^a   Komuro, Issei ^f  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

^f CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Embryo; Heart; Heartbeat; Mitochondria; Mouse; Myofibril; Na+ Ca2+ exchanger; NCX

Indexed keywords

CALCIUM; CONTRACTILE PROTEIN; SODIUM; TRANSCRIPTION FACTOR; SLC8A2 PROTEIN, MOUSE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGER 1; SODIUM-CALCIUM EXCHANGER 1;

ARTICLE; DISORIENTATION; EMBRYO; GENETIC SELECTION; HEART BEAT; HEART MUSCLE CELL; HETEROZYGOSITY; HOMEOSTASIS; MITOCHONDRION SWELLING; MOUSE; MOUSE STRAIN; MUSCLE FIBRIL; MYELOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRASTRUCTURE; WILD TYPE; ANIMAL; BRAIN; CELL CULTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HEART; KIDNEY; METABOLISM; MITOCHONDRION; MOUSE MUTANT; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; EMBRYO; GENE EXPRESSION REGULATION; HEART; KIDNEY; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MYOCYTES, CARDIAC; MYOFIBRILS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM-CALCIUM EXCHANGER;

EID: 0037683719     PISSN: 10964959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-4959(03)00057-5     Document Type: Article

References (28)

1. Bridge J.H., Smolley J.R., Spitzer K.W. The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science. 248:1990;376-378.
2. 2+ exchanger is essential for embryonic heart development in mice. Mol. Cells. 10:2000;712-722.
3. Decker M.L., Janes D.M., Barclay M.M., Harger L., Decker R.S. Regulation of adult cardiocyte growth: effects of active and passive mechanical loading. Am. J. Physiol. 272:1997;H2902-2918.
4. Griffiths E.J., Halestrap A.P. Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. J. Mol. Cell Cardiol. 25:1993;1461-1469.
5. 2+ trigger site. Arch. Biochem. Biophys. 195:1979;460-467.
6. Horackova M., Morash B., Byczko Z. Altered transarcolemmal Ca transport modifies the myofibrillar ultrastructure and protein metabolism in cultured adult ventricular cardiomyocytes. Mol. Cell Biochem. 204:2000;21-33.
7. 2+ exchanger isoforms NCX1 and NCX3 does not require their direct phosphorylation. Biochemistry. 37:1998;17230-17238.
8. Koushik S.V., Wang J., Rogers R., Moskophidis D., Lambert N.A., Creazzo T.L., et al. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 15:2001;1209-1211.
9. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3:1997;614-620.
10. Lemanski L.F. Role of tropomyosin in actin filament formation in embryonic salamander heart cells. J. Cell Biol. 82:1979;227-238.
11. Lemanski L.F., Paulson D.H., Hill C.S. Normal anterior endoderm corrects the heart defect in cardiac mutant salamanders. Science. 204:1979;860-862. Ambystoma mexicanum.
12. Lemanski L.F., Meng F., Lemanski S.L., Dawson N., Zhang C., Foster D., et al. Creation of chimeric mutant axolotls: a model to study early embryonic heart development in Mexican axolotls. Anat. Embryol. 203:2001;335-342. Berl.
13. 2+ exchanger. J. Biol. Chem. 269:1994;17434-17439.
14. Mahony L. Regulation of intracellular calcium concentration in the developing heart. Cardiovasc. Res. 31:1996;E61-E67.
15. Marchetti P., Castedo M., Susin S.A., Zamzami N., Hirsh T., Macho A., et al. Mitochondrial permeability transition is a central coordinating event of apoptosis. J. Exp. Med. 184:1996;1155-1160.
16. 2+ exchanger. Science. 250:1990;562-565.
17. 2+ exchanger, NCX3. J. Biol. Chem. 271:1996;24914-24921.
18. Rugh R. The Mouse - Its Reproduction and Development. 1990;Oxford University Press.
19. Samarel A.M., Engelmann G.L. Contractile activity modulates myosin heavy chain-beta expression in neonatal rat heart cells. Am. J. Physiol. 261:1991;H1067-H1077.
20. Samarel A.M., Spragia M.L., Maloney V., Kamal S.A., Engelmann G.L. Contractile arrest accelerates myosin heavy chain degradation in neonatal rat heart cells. Am. J. Physiol. 263:1992;C642-C652.
21. Schlüter K.-D., Millar B.C., McDermott B.J., Piper H.M. Regulation of protein synthesis and degradation in adult ventricular cardiomyocytes. Am. J. Physiol. 269:1995;C1347-C1355.
22. Sharp W.W., Terracio L., Borg T.K., Samarel A.M. Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells. Circ. Res. 73:1993;172-183.
23. Simpson D.G., Decker M.L., Clark R.S., Decker R.S. Contractile activity and cell-cell contact regulate myofibrillar organization in cultured cardiac myocytes. J. Cell Biol. 123:1993;323-336.
24. Simpson D.G., Sharp W.W., Borg T.K., Price R.L., Terracio P.L., Samarel A.M. Mechanical regulation of cardiac myocyte protein turnover and myofibrillar structure. Am. J. Physiol. 270:1996;C1075-C1087.
25. Uchino H., Elmer E., Uchino K., Lindvall O., Siesjo B.K. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat. Acta. Physiol. Scand. 155:1995;469-471.
26. 2+ exchanger gene leads to cardiomyocytes apoptosis and defects in heartbeat. J. Biol. Chem. 275:2000;36991-36998.
27. Zajdel R.W., Dube D.K., Lemanski L.F. The cardiac mutant Mexican axolotl is a unique animal model for evaluation of cardiac myofibrillogenesis. Exp. Cell Res. 248:1999;557-566.
28. Zajdel R.W., McLean M.D., Isitmangil G., Lemanski L.F., Wieczorek D.F., Dube D.K. Alteration of cardiac myofibrillogenesis by liposome-mediated delivery of exogenous proteins and nucleic acids into whole embryonic hearts. Anat. Embryol. 201:2000;217-228. Berl.