The embryonic vertebrate heart tube is a dynamic suction pump

Science

Volumn 312, Issue 5774, 2006, Pages 751-753

  Forouhar, Arian S ^a   Liebling, Michael ^a   Hickerson, Anna ^a   Nasiraei Moghaddam, Abbas ^a   Tsai, Huai Jen ^c   Hove, Jay R ^d   Fraser, Scott E ^a   Dickinson, Mary E ^a,e   Gharib, Morteza ^a,b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d UNIVERSITY OF CINCINNATI   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; CELLS; DIMENSIONAL STABILITY; ELASTIC WAVES; LASER THEORY; MICROSCOPIC EXAMINATION;

EMBRYONIC VERTEBRATE; HEART TUBE; PERISTALTIC PUMP;

BIOLOGICAL ORGANS;

BLOOD; CARDIOVASCULAR SYSTEM; EMBRYONIC DEVELOPMENT; FISH; FOUR-DIMENSIONAL MODELING; LASER METHOD; SCANNING ELECTRON MICROSCOPY; SUCTION; VERTEBRATE; VISUALIZATION;

ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD PUMP; CELL MOTION; CONFOCAL LASER MICROSCOPY; ELASTICITY; EMBRYO; EMBRYONIC STRUCTURES; HEART; HEART DEVELOPMENT; HEART FUNCTION; HEART TUBE; IMAGING; NONHUMAN; PERISTALSIS; PERISTALTIC PUMP; PRIORITY JOURNAL; ZEBRA FISH;

ANIMALS; BIOMECHANICS; CARDIAC OUTPUT; HEART; MICROSCOPY, CONFOCAL; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; PRESSURE; ZEBRAFISH;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 33646458083     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123775     Document Type: Article

References (12)

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12. We thank J. Dabiri, M. Milano, J. Vermot, and J. Pierce for comments on the paper; S. Megason and L. Trinh for help with zebrafish and imaging techniques; and S. Lin for providing the Tg(gata1:GFP) zebrafish line. This work was supported by American Heart Association grant 03665071Y (J.R.H.), NIH grant 5R01HL078694 (S.E.F., M.E.D., and M.L.), and Swiss National Science Foundation grants PBEL2-104418 and PA002-111433 (M.L).