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Volumn 8, Issue 2, 2010, Pages 124-138

Drug and medical device interactions: Stent thrombosis and personalizing clopidogrel therapy

Author keywords

Acute coronary syndromes; Antiplatelet therapy; Cytochrome P450 2C19; Loss of function polymorphism; Major adverse cardiovascular events; Stent

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; CYTOCHROME P450 2C19;

EID: 77953763296     PISSN: 18756921     EISSN: 18756913     Source Type: Journal    
DOI: 10.2174/187569210791383929     Document Type: Article
Times cited : (3)

References (117)
  • 1
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001; 358(9281): 527-33.
    • (2001) Lancet , vol.358 , Issue.9281 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3
  • 2
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002; 288: 2411-20.
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 3
    • 0037005777 scopus 로고    scopus 로고
    • Meta-analysis of randomized and registry comparison of ticlopidine with clopidogrel after stenting
    • Bhatt DL, Bertrand ME, Berger PB, et al. Meta-analysis of randomized and registry comparison of ticlopidine with clopidogrel after stenting. J Am Coll Cardiol 2002; 39(1): 9-14.
    • (2002) J Am Coll Cardiol , vol.39 , Issue.1 , pp. 9-14
    • Bhatt, D.L.1    Bertrand, M.E.2    Berger, P.B.3
  • 4
    • 6944237687 scopus 로고    scopus 로고
    • Late thrombosis in drugeluting coronary stents after discontinuation of antiplatelet therapy
    • McFadden EP, Stabile E, Regar E, et al. Late thrombosis in drugeluting coronary stents after discontinuation of antiplatelet therapy. Lancet 2004; 364: 1519-21.
    • (2004) Lancet , vol.364 , pp. 1519-1521
    • McFadden, E.P.1    Stabile, E.2    Regar, E.3
  • 5
    • 24644523719 scopus 로고    scopus 로고
    • Incremental costeffectiveness of drug-eluting stents compared with a third generation bare-metal stents in a real-world setting: Randomised Basel Stent Kosten Effektivitats Trial (BASKET)
    • Kaiser C, Brunner-La Rocca HP, Buser PT, et al. Incremental costeffectiveness of drug-eluting stents compared with a third generation bare-metal stents in a real-world setting: Randomised Basel Stent Kosten Effektivitats Trial (BASKET). Lancet 2005; 366: 921-9.
    • (2005) Lancet , vol.366 , pp. 921-929
    • Kaiser, C.1    Brunner-La Rocca, H.P.2    Buser, P.T.3
  • 6
    • 17844373254 scopus 로고    scopus 로고
    • Incidence, predictors, and outcome of thrombosis after successful implantation of drugeluting stents
    • Iakovou I, Schmidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drugeluting stents. JAMA 2005; 293: 2126-30.
    • (2005) JAMA , vol.293 , pp. 2126-2130
    • Iakovou, I.1    Schmidt, T.2    Bonizzoni, E.3
  • 7
    • 33745966517 scopus 로고    scopus 로고
    • Frequency and risk factors for stent thrombosis after drug-eluting stent omplantation during longterm follow-up
    • Park D-W, Park S-W, Park K-H, et al. Frequency and risk factors for stent thrombosis after drug-eluting stent omplantation during longterm follow-up. Am J Cardiol 2006; 98: 352-6.
    • (2006) Am J Cardiol , vol.98 , pp. 352-356
    • Park, D.-W.1    Park, S.-W.2    Park, K.-H.3
  • 8
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S, Shenkman B, Guetta V, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004; 109: 3171-5.
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3
  • 9
    • 27644465874 scopus 로고    scopus 로고
    • Clopidogrel effect on platelet reactivity in patients with stent thrombosis
    • Gurbel PA, Bliden KP, Samara W, et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis. J Am Coll Cardiol 2005; 46: 1827-32.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1827-1832
    • Gurbel, P.A.1    Bliden, K.P.2    Samara, W.3
  • 10
    • 27644536235 scopus 로고    scopus 로고
    • Platelet reactivity in patients and recurrent events post-stenting
    • Gurbel PA, Bliden KP, Guyer K, et al. Platelet reactivity in patients and recurrent events post-stenting. J Am Coll Cardiol 2005; 46: 1820-6.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1820-1826
    • Gurbel, P.A.1    Bliden, K.P.2    Guyer, K.3
  • 11
    • 20344394411 scopus 로고    scopus 로고
    • Enhanced shear-induced platelet aggregation in patients who experienced stent thrombosis
    • Ajzenberg N, Aubry P, Huisse MG, et al. Enhanced shear-induced platelet aggregation in patients who experienced stent thrombosis. J Am Coll Cardiol 2005; 45: 1753-6.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1753-1756
    • Ajzenberg, N.1    Aubry, P.2    Huisse, M.G.3
  • 12
    • 33645982865 scopus 로고    scopus 로고
    • High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome
    • Cuisset T, Frere C, Quilici J, et al. High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost 2006; 4: 542-9.
    • (2006) J Thromb Haemost , vol.4 , pp. 542-549
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 13
    • 33750479499 scopus 로고    scopus 로고
    • Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    • Hochholzer W, Trenk D, Bestehorn HP, et al. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol 2006; 48: 1742-50.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1742-1750
    • Hochholzer, W.1    Trenk, D.2    Bestehorn, H.P.3
  • 14
    • 34250020766 scopus 로고    scopus 로고
    • Impact of platelet reactivity following clopidogrel administration on drug-eluting stent thrombosis
    • Buonamici P, Marcucci R, Migliorini A, et al. Impact of platelet reactivity following clopidogrel administration on drug-eluting stent thrombosis. J Am Coll Cardiol 2007; 49: 2312-7.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2312-2317
    • Buonamici, P.1    Marcucci, R.2    Migliorini, A.3
  • 15
    • 49349114160 scopus 로고    scopus 로고
    • Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents
    • Gori AM, Marcucci R, Migliorini A, et al. Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents. J Am Coll Cardiol 2008; 52: 734-9.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 734-739
    • Gori, A.M.1    Marcucci, R.2    Migliorini, A.3
  • 16
    • 44949173754 scopus 로고    scopus 로고
    • Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-ofcare assay on thrombotic events after drug-eluting stent implantation
    • Price MJ, Endemann S, Gollapudi RR, et al. Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-ofcare assay on thrombotic events after drug-eluting stent implantation. Eur Heart J 2008; 29: 992-1000.
    • (2008) Eur Heart J , vol.29 , pp. 992-1000
    • Price, M.J.1    Endemann, S.2    Gollapudi, R.R.3
  • 17
    • 59849120163 scopus 로고    scopus 로고
    • Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: A 12-month followup
    • Marcucci R, Gori AM, Paniccia R, et al. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month followup. Circulation 2009; 119: 237-42.
    • (2009) Circulation , vol.119 , pp. 237-242
    • Marcucci, R.1    Gori, A.M.2    Paniccia, R.3
  • 18
    • 60949083948 scopus 로고    scopus 로고
    • Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    • Sibbing D, Braun S, Morath T, et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol 2009; 53: 849-56.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 849-856
    • Sibbing, D.1    Braun, S.2    Morath, T.3
  • 19
    • 77952075376 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness and risk of cardiovascular morbidity: An updated meta-analysis
    • In press
    • Sofi F, Marcucci R, Gori AM, et al. Clopidogrel nonresponsiveness and risk of cardiovascular morbidity: an updated meta-analysis. Thromb Haemost 2010; In press.
    • (2010) Thromb Haemost
    • Sofi, F.1    Marcucci, R.2    Gori, A.M.3
  • 20
    • 68149180722 scopus 로고    scopus 로고
    • Recent developments in clopidogrel pharmacology and their relation to clinical outcomes
    • Gurbel PA, Antonino MJ, Tantry US. Recent developments in clopidogrel pharmacology and their relation to clinical outcomes. Expert Opin Drug Metab Toxicol 2009; 5: 989-1004.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 989-1004
    • Gurbel, P.A.1    Antonino, M.J.2    Tantry, U.S.3
  • 21
    • 62649164844 scopus 로고    scopus 로고
    • A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    • Juurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ 2009; 180: 713-8.
    • (2009) CMAJ , vol.180 , pp. 713-718
    • Juurlink, D.N.1    Gomes, T.2    Ko, D.T.3
  • 22
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials
    • O'Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 2009; 374: 989-97.
    • (2009) Lancet , vol.374 , pp. 989-997
    • O'Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 23
    • 64849087438 scopus 로고    scopus 로고
    • Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel
    • Sibbing D, Morath T, Stegherr J, et al. Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thromb Haemost 2009; 101: 714-9.
    • (2009) Thromb Haemost , vol.101 , pp. 714-719
    • Sibbing, D.1    Morath, T.2    Stegherr, J.3
  • 24
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA 2009; 301: 937-44.
    • (2009) JAMA , vol.301 , pp. 937-944
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3
  • 25
    • 57649176643 scopus 로고    scopus 로고
    • The balance between pro and anti-inflammatory cytokines is associated with platelet aggregability in acute coronary syndrome patients
    • Gori AM, Cesari F, Marcucci R, et al. The balance between pro and anti-inflammatory cytokines is associated with platelet aggregability in acute coronary syndrome patients. Atherosclerosis 2009; 202: 255-62.
    • (2009) Atherosclerosis , vol.202 , pp. 255-262
    • Gori, A.M.1    Cesari, F.2    Marcucci, R.3
  • 26
    • 43949115561 scopus 로고    scopus 로고
    • Relationship between high platelet turnover and platelet function in high-risk patients with coronary artery disease on dual antiplatelet therapy
    • Cesari F, Marcucci R, Caporale R, et al. Relationship between high platelet turnover and platelet function in high-risk patients with coronary artery disease on dual antiplatelet therapy. Thromb Haemost 2008; 99: 930-5.
    • (2008) Thromb Haemost , vol.99 , pp. 930-935
    • Cesari, F.1    Marcucci, R.2    Caporale, R.3
  • 27
    • 58149189837 scopus 로고    scopus 로고
    • The genetics of antiplatelet drug resistance
    • Feher G, Feher A, Pusch G, et al. The genetics of antiplatelet drug resistance. Clin Genet 2009; 75: 1-18.
    • (2009) Clin Genet , vol.75 , pp. 1-18
    • Feher, G.1    Feher, A.2    Pusch, G.3
  • 28
    • 74049089873 scopus 로고    scopus 로고
    • Clopidogrel Pharmacogenetics and Its Clinical Implications
    • [Epub ahead of print]
    • Singh M, Thapa B, Arora R. Clopidogrel Pharmacogenetics and Its Clinical Implications. Am J Ther 2009. [Epub ahead of print].
    • (2009) Am J Ther
    • Singh, M.1    Thapa, B.2    Arora, R.3
  • 29
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-offunction polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot JS, Bura A, Villard E, et al. Cytochrome P450 2C19 loss-offunction polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 2006; 108: 2244-7.
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1    Bura, A.2    Villard, E.3
  • 30
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • Brandt JT, Close SL, Iturria SJ, et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost 2007; 5: 2429-36.
    • (2007) J Thromb Haemost , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3
  • 31
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • Giusti B, Gori AM, Marcucci R, et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet Genomics 2007; 17: 1057-64.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 1057-1064
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3
  • 32
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • Trenk D, Hochholzer W, Fromm MF, et al. Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J Am Coll Cardiol 2008; 51: 1925-34.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3
  • 33
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360: 363-75.
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 34
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360: 354-62.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 35
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet JP, Hulot JS, Pena A, et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 2009; 373: 309-17.
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3
  • 36
    • 61349191612 scopus 로고    scopus 로고
    • Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drugeluting coronary stent thrombosis
    • Giusti B, Gori AM, Marcucci R, et al. Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drugeluting coronary stent thrombosis. Am J Cardiol 2009; 103: 806-11.
    • (2009) Am J Cardiol , vol.103 , pp. 806-811
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3
  • 37
    • 65249145201 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 lossof-function polymorphism and stent thrombosis following percutaneous coronary intervention
    • Sibbing D, Stegherr J, Latz W, et al. Cytochrome P450 2C19 lossof-function polymorphism and stent thrombosis following percutaneous coronary intervention. Eur Heart J 2009; 30: 916-22.
    • (2009) Eur Heart J , vol.30 , pp. 916-922
    • Sibbing, D.1    Stegherr, J.2    Latz, W.3
  • 38
    • 42249102617 scopus 로고    scopus 로고
    • P2 receptors, platelet function and pharmacological implications
    • Gachet C. P2 receptors, platelet function and pharmacological implications. Thromb Haemost 2008; 99: 466-72.
    • (2008) Thromb Haemost , vol.99 , pp. 466-472
    • Gachet, C.1
  • 39
    • 0032493295 scopus 로고    scopus 로고
    • Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
    • Jin J, Kunapuli SP. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci USA 1998; 95: 8070-4.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8070-8074
    • Jin, J.1    Kunapuli, S.P.2
  • 40
    • 18644372477 scopus 로고    scopus 로고
    • Structure and stereochemistry of the active metabolite of clopidogrel
    • Pereillo JM, Maftouh M, Andrieu A, et al. Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 2002; 30: 1288-95.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1288-1295
    • Pereillo, J.M.1    Maftouh, M.2    Andrieu, A.3
  • 41
    • 33746659807 scopus 로고    scopus 로고
    • The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts
    • Savi P, Zachayus JL, Delesque-Touchard N, et al. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci USA 2006; 103: 11069-74.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11069-11074
    • Savi, P.1    Zachayus, J.L.2    Delesque-Touchard, N.3
  • 42
    • 0037588974 scopus 로고    scopus 로고
    • Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270
    • Ding Z, Kim S, Dorsam RT, et al. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. Blood 2003; 101: 3908-14.
    • (2003) Blood , vol.101 , pp. 3908-3914
    • Ding, Z.1    Kim, S.2    Dorsam, R.T.3
  • 43
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • doi:10.1124/dmd.109.029132
    • Kazui M, Nishiya Y, Ishizuka T, et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos 2009 doi:10.1124/dmd.109.029132.
    • (2009) Drug Metab Dispos
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 44
    • 17144370263 scopus 로고    scopus 로고
    • Resistance to clopidogrel: A review of the evidence
    • Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: a review of the evidence. J Am Coll Cardiol 2005; 45: 1157-64.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1157-1164
    • Nguyen, T.A.1    Diodati, J.G.2    Pharand, C.3
  • 45
    • 34548075511 scopus 로고    scopus 로고
    • Different methodologies for evaluating the effect of clopidogrel on platelet function in highrisk coronary artery disease patients
    • Paniccia R, Antonucci E, Gori AM, et al. Different methodologies for evaluating the effect of clopidogrel on platelet function in highrisk coronary artery disease patients. J Thromb Haemost 2007; 5: 1839-47.
    • (2007) J Thromb Haemost , vol.5 , pp. 1839-1847
    • Paniccia, R.1    Antonucci, E.2    Gori, A.M.3
  • 46
    • 34547104001 scopus 로고    scopus 로고
    • Comparison of different methods to evaluate the effect of aspirin on platelet function in high-risk patients with ischemic heart disease receiving dual antiplatelet treatment
    • Paniccia R, Antonucci E, Gori AM, et al. Comparison of different methods to evaluate the effect of aspirin on platelet function in high-risk patients with ischemic heart disease receiving dual antiplatelet treatment. Am J Clin Pathol 2007; 128: 143-9.
    • (2007) Am J Clin Pathol , vol.128 , pp. 143-149
    • Paniccia, R.1    Antonucci, E.2    Gori, A.M.3
  • 47
    • 34447576539 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis
    • Snoep JD, Hovens MM, Eikenboom JC, et al. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am Heart J 2007; 154: 221-31.
    • (2007) Am Heart J , vol.154 , pp. 221-231
    • Snoep, J.D.1    Hovens, M.M.2    Eikenboom, J.C.3
  • 48
    • 51649108832 scopus 로고    scopus 로고
    • Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention: Results of the ARMYDA-PRO (Antiplatelet therapy for reduction of Myocardial Damage during Angioplasty-Platelet Ractivity Predicts Outcome) study
    • Patti G, Nusca A, Mangiacapra F, et al. Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention: results of the ARMYDA-PRO (Antiplatelet therapy for reduction of Myocardial Damage during Angioplasty-Platelet Ractivity Predicts Outcome) study. J Am Coll Cardiol 2008; 52: 1128-33.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1128-1133
    • Patti, G.1    Nusca, A.2    Mangiacapra, F.3
  • 49
    • 18144371221 scopus 로고    scopus 로고
    • The relation of dosing to clopidogrel responsiveness and the incidence of high posttreatment platelet aggregation in patients undergoing coronary stenting
    • Gurbel PA, Bliden KP, Hayes KM, et al. The relation of dosing to clopidogrel responsiveness and the incidence of high posttreatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol 2005; 45: 1392-6.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1392-1396
    • Gurbel, P.A.1    Bliden, K.P.2    Hayes, K.M.3
  • 50
    • 27744516843 scopus 로고    scopus 로고
    • Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (Intra coronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial
    • von Beckerath N, Taubert D, Pogatsa-Murray G, et al. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intra coronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation 2005; 112: 2946-50.
    • (2005) Circulation , vol.112 , pp. 2946-2950
    • von Beckerath, N.1    Taubert, D.2    Pogatsa-Murray, G.3
  • 51
    • 33847130538 scopus 로고    scopus 로고
    • Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study
    • Angiolillo DJ, Shoemaker SB, Desai B, et al. Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study. Circulation 2007; 115: 708-16.
    • (2007) Circulation , vol.115 , pp. 708-716
    • Angiolillo, D.J.1    Shoemaker, S.B.2    Desai, B.3
  • 52
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • Lau WC, Gurbel PA, Watkins PB, et al. Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation 2004; 109: 166-71.
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3
  • 53
    • 40049105525 scopus 로고    scopus 로고
    • Prasugrel, a third generation thienopyridine and potent platelet inhibitor
    • Gurbel PA, Tantry US. Prasugrel, a third generation thienopyridine and potent platelet inhibitor. Curr Opin Investig Drugs 2008; 9: 324-36.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 324-336
    • Gurbel, P.A.1    Tantry, U.S.2
  • 54
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-15.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 55
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-57.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 56
    • 33645311266 scopus 로고    scopus 로고
    • Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus and paclitaxel-eluting stents
    • Kuchulakanti PK, Chu WW, Torguson R, et al. Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus and paclitaxel-eluting stents. Circulation 2006; 113: 1108-13.
    • (2006) Circulation , vol.113 , pp. 1108-1113
    • Kuchulakanti, P.K.1    Chu, W.W.2    Torguson, R.3
  • 57
    • 0037261957 scopus 로고    scopus 로고
    • Adherence to secondary stroke prevention strategies-results from the German Stroke Data Bank
    • Hamann GF, Weimar C, Glahn J, et al. Adherence to secondary stroke prevention strategies-results from the German Stroke Data Bank. Cerebrovasc Dis 2003; 15: 282-8.
    • (2003) Cerebrovasc Dis , vol.15 , pp. 282-288
    • Hamann, G.F.1    Weimar, C.2    Glahn, J.3
  • 58
    • 34548420989 scopus 로고    scopus 로고
    • The clopidogrel resistance trap
    • Serebruany VL. The clopidogrel resistance trap. Am J Cardiol 2007; 100: 1044-6.
    • (2007) Am J Cardiol , vol.100 , pp. 1044-1046
    • Serebruany, V.L.1
  • 59
    • 0037422534 scopus 로고    scopus 로고
    • Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drugdrug interaction
    • Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drugdrug interaction. Circulation 2003; 107: 32-7.
    • (2003) Circulation , vol.107 , pp. 32-37
    • Lau, W.C.1    Waskell, L.A.2    Watkins, P.B.3
  • 60
    • 0042780283 scopus 로고    scopus 로고
    • Lack of adverse clopidogrelatorvastatin clinical interaction from secondary analysis of a randomized placebo-controlled clopidogrel trial
    • Saw J, Steinhubl SR, Berger PB, et al. Lack of adverse clopidogrelatorvastatin clinical interaction from secondary analysis of a randomized placebo-controlled clopidogrel trial. Circulation 2003; 108: 921-4.
    • (2003) Circulation , vol.108 , pp. 921-924
    • Saw, J.1    Steinhubl, S.R.2    Berger, P.B.3
  • 61
    • 6344226832 scopus 로고    scopus 로고
    • Absence of interaction between atorvastatin or other statin and clopidogrel: Results from the interaction study
    • Serebruany VL, Midei MG, Malinin AI, et al. Absence of interaction between atorvastatin or other statin and clopidogrel: results from the interaction study. Arch Intern Med 2004; 164: 2051-7.
    • (2004) Arch Intern Med , vol.164 , pp. 2051-2057
    • Serebruany, V.L.1    Midei, M.G.2    Malinin, A.I.3
  • 62
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol 2008; 51: 256-60.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 63
    • 57149104093 scopus 로고    scopus 로고
    • Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel
    • Siller-Matula JM, Spiel AO, Lang IM, et al. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am Heart J 2009; 157: 148. e1-5.
    • (2009) Am Heart J , vol.157 , Issue.148
    • Siller-Matula, J.M.1    Spiel, A.O.2    Lang, I.M.3
  • 64
    • 67651097806 scopus 로고    scopus 로고
    • Drug-drug interaction between clopidogrel and the proton pump inhibitors
    • Norgard NB, Mathews KD, Wall GC. Drug-drug interaction between clopidogrel and the proton pump inhibitors. Ann Pharmacother 2009; 43: 1266-74.
    • (2009) Ann Pharmacother , vol.43 , pp. 1266-1274
    • Norgard, N.B.1    Mathews, K.D.2    Wall, G.C.3
  • 65
  • 67
    • 33750079553 scopus 로고    scopus 로고
    • Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin
    • Gilard M, Arnaud B, Le Gal G, et al. Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin. J Thromb Haemost 2006; 4: 2508-9.
    • (2006) J Thromb Haemost , vol.4 , pp. 2508-2509
    • Gilard, M.1    Arnaud, B.2    Le Gal, G.3
  • 68
    • 70049098599 scopus 로고    scopus 로고
    • Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study
    • Cuisset T, Frere C, Quilici J, et al. Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study. J Am Coll Cardiol 2009; 54: 1149-53.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1149-1153
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 69
    • 4444353174 scopus 로고    scopus 로고
    • Pharmacokinetics of clopidogrel after administration of a high loading dose
    • Taubert D, Kastrati A, Harlfinger S, et al. Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost 2004; 92: 311-6.
    • (2004) Thromb Haemost , vol.92 , pp. 311-316
    • Taubert, D.1    Kastrati, A.2    Harlfinger, S.3
  • 70
    • 37549006004 scopus 로고    scopus 로고
    • The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score
    • Geisler T, Grass D, Bigalke B, et al. The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score. J Thromb Haemost 2008; 6: 54-61.
    • (2008) J Thromb Haemost , vol.6 , pp. 54-61
    • Geisler, T.1    Grass, D.2    Bigalke, B.3
  • 71
    • 68649097104 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation with prasugrel and clopidogrel: An integrated analysis in 846 subjects
    • Li YG, Ni L, Brandt JT, et al. Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects. Platelets 2009; 20: 316-27.
    • (2009) Platelets , vol.20 , pp. 316-327
    • Li, Y.G.1    Ni, L.2    Brandt, J.T.3
  • 72
    • 73049113504 scopus 로고    scopus 로고
    • Adenosine diphosphateinducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel
    • doi:10.1111/j.1538-7836.2009.03644
    • Gremmel T, Steiner S, Seidinger D, et al. Adenosine diphosphateinducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel. J Thromb Haemost 2009; doi:10.1111/j.1538-7836.2009.03644.
    • (2009) J Thromb Haemost
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3
  • 73
    • 65449170730 scopus 로고    scopus 로고
    • Predictors of heightened platelet reactivity despite dual-antiplatelet therapy in patients undergoing percutaneous coronary intervention
    • Price MJ, Nayak KR, Barker CM, et al. Predictors of heightened platelet reactivity despite dual-antiplatelet therapy in patients undergoing percutaneous coronary intervention. Am J Cardiol 2009; 103: 1339-43.
    • (2009) Am J Cardiol , vol.103 , pp. 1339-1343
    • Price, M.J.1    Nayak, K.R.2    Barker, C.M.3
  • 74
  • 75
    • 33745815689 scopus 로고    scopus 로고
    • Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
    • Angiolillo DJ, Bernardo E, Ramírez C, et al. Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J Am Coll Cardiol 2006; 48: 298-304.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 298-304
    • Angiolillo, D.J.1    Bernardo, E.2    Ramírez, C.3
  • 76
    • 33846656039 scopus 로고    scopus 로고
    • Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation
    • Geisler T, Anders N, Paterok M, et al. Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation. Diabetes Care 2007; 30: 372-4.
    • (2007) Diabetes Care , vol.30 , pp. 372-374
    • Geisler, T.1    Anders, N.2    Paterok, M.3
  • 77
    • 46749087824 scopus 로고    scopus 로고
    • Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease
    • Serebruany V, Pokov I, Kuliczkowski W, et al. Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease. Thromb Haemost 2008; 100: 76-82.
    • (2008) Thromb Haemost , vol.100 , pp. 76-82
    • Serebruany, V.1    Pokov, I.2    Kuliczkowski, W.3
  • 78
    • 35248878504 scopus 로고    scopus 로고
    • Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy
    • Marcucci R, Gori AM, Paniccia R, et al. Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy. Atherosclerosis 2007; 195: e217-23.
    • (2007) Atherosclerosis , vol.195
    • Marcucci, R.1    Gori, A.M.2    Paniccia, R.3
  • 79
    • 65649099288 scopus 로고    scopus 로고
    • Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting
    • Antonino MJ, Mahla E, Bliden KP, et al. Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting. Am J Cardiol 2009; 103: 1546-50.
    • (2009) Am J Cardiol , vol.103 , pp. 1546-1550
    • Antonino, M.J.1    Mahla, E.2    Bliden, K.P.3
  • 80
    • 34247574729 scopus 로고    scopus 로고
    • Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin
    • Guthikonda S, Lev EI, Patel R, et al. Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. J Thromb Haemost 2007; 5: 490-6.
    • (2007) J Thromb Haemost , vol.5 , pp. 490-496
    • Guthikonda, S.1    Lev, E.I.2    Patel, R.3
  • 81
    • 49349102948 scopus 로고    scopus 로고
    • Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease
    • Guthikonda S, Alviar CL, Vaduganathan M, et al. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease. J Am Coll Cardiol 2008; 52: 743-9.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 743-749
    • Guthikonda, S.1    Alviar, C.L.2    Vaduganathan, M.3
  • 82
    • 8144228106 scopus 로고    scopus 로고
    • Reticulated platelets in acute coronary syndrome: A marker of platelet activity
    • Lakkis N, Dokainish H, Abuzahra M, et al. Reticulated platelets in acute coronary syndrome: a marker of platelet activity. J Am Coll Cardiol 2004; 44: 2091-3.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 2091-2093
    • Lakkis, N.1    Dokainish, H.2    Abuzahra, M.3
  • 83
    • 28344435221 scopus 로고    scopus 로고
    • Cleavage of ultralarge von Willebrand factor by ADAMTS-13 under flow conditions
    • Dong JF. Cleavage of ultralarge von Willebrand factor by ADAMTS-13 under flow conditions. J Thromb Haemost 2005; 3: 2536-44.
    • (2005) J Thromb Haemost , vol.3 , pp. 2536-2544
    • Dong, J.F.1
  • 84
    • 33646771330 scopus 로고    scopus 로고
    • Von Willebrand factor, endothelial dysfunction and cardiovascular disease
    • Vischer UM. Von Willebrand factor, endothelial dysfunction and cardiovascular disease. J Thromb Haemost 2006; 4: 1186-3.
    • (2006) J Thromb Haemost , vol.4 , pp. 1186-1183
    • Vischer, U.M.1
  • 85
    • 0036624844 scopus 로고    scopus 로고
    • Ultralarge multimers of von Willebrand factor form spontaneous high-strenght bonds with the platelet glycoprotein Ib-IX complex: Studies using optical tweezers
    • Arya M, Anvari B, Romo GM, et al. Ultralarge multimers of von Willebrand factor form spontaneous high-strenght bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. Blood 2002; 99: 3971-7.
    • (2002) Blood , vol.99 , pp. 3971-3977
    • Arya, M.1    Anvari, B.2    Romo, G.M.3
  • 86
    • 0029907370 scopus 로고    scopus 로고
    • Von Willebrand factor: Molecular size and functional activity
    • Furlan M. Von Willebrand factor: molecular size and functional activity. Ann Hematol 1996; 76: 341-8.
    • (1996) Ann Hematol , vol.76 , pp. 341-348
    • Furlan, M.1
  • 87
    • 54149097918 scopus 로고    scopus 로고
    • ADAMTS-13 activity in the presence of elevated von Willebrand factor levels as a novel mechanism of residual platelet reactivity in high risk coronary patients on antiplatelet treatment
    • Marcucci R, Cesari F, Cinotti S, et al. ADAMTS-13 activity in the presence of elevated von Willebrand factor levels as a novel mechanism of residual platelet reactivity in high risk coronary patients on antiplatelet treatment. Thromb Res 2008; 123: 130-6.
    • (2008) Thromb Res , vol.123 , pp. 130-136
    • Marcucci, R.1    Cesari, F.2    Cinotti, S.3
  • 88
    • 33746444276 scopus 로고    scopus 로고
    • Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients
    • Mannini L, Marcucci R, Paniccia R, et al. Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients. Clin Hemorheol Microcirc 2006; 35: 175-81.
    • (2006) Clin Hemorheol Microcirc , vol.35 , pp. 175-181
    • Mannini, L.1    Marcucci, R.2    Paniccia, R.3
  • 89
    • 69449107151 scopus 로고    scopus 로고
    • Effect of blood hematocrit and erythrocyte deformability on adenosine 5'-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy
    • Cecchi E, Marcucci R, Paniccia R, et al. Effect of blood hematocrit and erythrocyte deformability on adenosine 5'-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy. Am J Cardiol 2009; 104: 764-8.
    • (2009) Am J Cardiol , vol.104 , pp. 764-768
    • Cecchi, E.1    Marcucci, R.2    Paniccia, R.3
  • 90
    • 0034283493 scopus 로고    scopus 로고
    • Inhibitory activity of aspirin on von Willebrand factor-induced platelet aggregation
    • Homoncik M, Jilma B, Eichelberger B, et al. Inhibitory activity of aspirin on von Willebrand factor-induced platelet aggregation. Thromb Res 2000; 99: 461-6.
    • (2000) Thromb Res , vol.99 , pp. 461-466
    • Homoncik, M.1    Jilma, B.2    Eichelberger, B.3
  • 92
    • 38049181066 scopus 로고    scopus 로고
    • Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment
    • Giusti B, Gori AM, Marcucci R, et al. Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment. Atherosclerosis 2008; 196: 341-8.
    • (2008) Atherosclerosis , vol.196 , pp. 341-348
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3
  • 93
    • 78751611887 scopus 로고    scopus 로고
    • Platelet aggregability is modulated by eNOS locus in non-type 2 diabetic patients with acute coronary syndrome
    • doi:10.1016/j.numecd.2009.07.001
    • Fatini C, Sticchi E, Bolli P, et al. Platelet aggregability is modulated by eNOS locus in non-type 2 diabetic patients with acute coronary syndrome. Nutr Metab Cardiovasc Dis 2009; doi:10.1016/j.numecd.2009.07.001.
    • (2009) Nutr Metab Cardiovasc Dis
    • Fatini, C.1    Sticchi, E.2    Bolli, P.3
  • 94
    • 26244439864 scopus 로고    scopus 로고
    • Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene. Am J Cardiol 2005; 96: 1095-9.
    • (2005) Am J Cardiol , vol.96 , pp. 1095-1099
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 95
    • 3142512587 scopus 로고    scopus 로고
    • 807 C/T polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. 807 C/T polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment. Blood Coagul Fibrinolysis 2004; 15: 427-33.
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 427-433
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 96
    • 33845490833 scopus 로고    scopus 로고
    • Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel
    • Lev EI, Patel RT, Guthikonda S, et al. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. Thromb Res 2007; 119: 355-60.
    • (2007) Thromb Res , vol.119 , pp. 355-360
    • Lev, E.I.1    Patel, R.T.2    Guthikonda, S.3
  • 97
    • 67649522036 scopus 로고    scopus 로고
    • High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: A genetic substudy of PRAGUE-8 trial
    • Motovska Z, Widimsky P, Kvasnicka J, et al. High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial. Blood Coagul Fibrinolysis 2009; 20: 257-62.
    • (2009) Blood Coagul Fibrinolysis , vol.20 , pp. 257-262
    • Motovska, Z.1    Widimsky, P.2    Kvasnicka, J.3
  • 98
    • 64849087639 scopus 로고    scopus 로고
    • Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases
    • Sirotkina OV, Zabotina AM, Berkovich OA, et al. Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases. Genetika 2009; 45: 247-53.
    • (2009) Genetika , vol.45 , pp. 247-253
    • Sirotkina, O.V.1    Zabotina, A.M.2    Berkovich, O.A.3
  • 99
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais SM, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 1994; 269: 15419-22.
    • (1994) J Biol Chem , vol.269 , pp. 15419-15422
    • de Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 100
    • 0035028479 scopus 로고    scopus 로고
    • Molecular basis of ethnic differences in drug disposition and response
    • Xie HG, Kim RB, Wood AJ, et al. Molecular basis of ethnic differences in drug disposition and response. Ann Rev Pharmacol Toxicol 2001; 41: 815-50.
    • (2001) Ann Rev Pharmacol Toxicol , vol.41 , pp. 815-850
    • Xie, H.G.1    Kim, R.B.2    Wood, A.J.3
  • 101
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • Sim SC, Risinger C, Dahl ML, et al. A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther 2006; 79: 103-13.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.L.3
  • 102
    • 77958462931 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement
    • doi:10.1161/circulationaha.109. 885194
    • Sibbing D, Koch W, Gebhard D, et al. Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement. Circulation 2010; doi:10.1161/circulationaha.109. 885194.
    • (2010) Circulation
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 103
    • 34548858712 scopus 로고    scopus 로고
    • Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects
    • Fontana P, Hulot JS, De Moerloose P, et al. Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects. J Thromb Haemost 2007; 5: 2153-5.
    • (2007) J Thromb Haemost , vol.5 , pp. 2153-2155
    • Fontana, P.1    Hulot, J.S.2    de Moerloose, P.3
  • 104
    • 45249088224 scopus 로고    scopus 로고
    • The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance
    • Kim KA, Park PW, Hong SJ, et al. The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance. Clin Pharmacol Ther 2008; 84: 236-42.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3
  • 105
    • 47649111604 scopus 로고    scopus 로고
    • The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects
    • Umemura K, Furuta T, Kondo K. The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects. J Thromb Haemost 2008; 6: 1439-41.
    • (2008) J Thromb Haemost , vol.6 , pp. 1439-1441
    • Umemura, K.1    Furuta, T.2    Kondo, K.3
  • 106
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner AR, O'Connell JR, Bliden KP, et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 2009; 302: 849-57.
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 107
    • 41349113774 scopus 로고    scopus 로고
    • Effect of cytochrome P450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome
    • Frere C, Cuisset T, Morange PE, et al. Effect of cytochrome P450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome. Am J Cardiol 2008; 101: 1088-93.
    • (2008) Am J Cardiol , vol.101 , pp. 1088-1093
    • Frere, C.1    Cuisset, T.2    Morange, P.E.3
  • 108
    • 55449137355 scopus 로고    scopus 로고
    • CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    • Geisler T, Schaeffeler E, Dippon J, et al. CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. Pharmacogenomics 2008; 9: 1251-9.
    • (2008) Pharmacogenomics , vol.9 , pp. 1251-1259
    • Geisler, T.1    Schaeffeler, E.2    Dippon, J.3
  • 109
    • 57549092687 scopus 로고    scopus 로고
    • The pharmacogenetics and pharmacodynamics of clopidogrel response: An analysis from the PRINC (Plavix Response in Coronary Intervention) trial
    • Gladding P, Webster M, Zeng I, et al. The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial. JACC Cardiovasc Interv 2008; 1: 620-7.
    • (2008) JACC Cardiovasc Interv , vol.1 , pp. 620-627
    • Gladding, P.1    Webster, M.2    Zeng, I.3
  • 110
    • 69049091101 scopus 로고    scopus 로고
    • Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan
    • Jinnai T, Horiuchi H, Makiyama T, et al. Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan. Circ J 2009; 73: 1498-503.
    • (2009) Circ J , vol.73 , pp. 1498-1503
    • Jinnai, T.1    Horiuchi, H.2    Makiyama, T.3
  • 111
    • 77949895257 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism and cardiovascular recurrences in patients under clopidogrel treatment: A meta-analysis
    • Sofi F, Giusti B, Gori AM, et al. Cytochrome P450 2C19 polymorphism and cardiovascular recurrences in patients under clopidogrel treatment: a meta-analysis. J Thromb Haemost 2009; 7(Suppl. 2): 105.
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 2 , pp. 105
    • Sofi, F.1    Giusti, B.2    Gori, A.M.3
  • 112
    • 58149476444 scopus 로고    scopus 로고
    • Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis
    • Bonello L, Camoin-Jau L, Armero S, et al. Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis. Am J Cardiol 2009; 103: 5-10.
    • (2009) Am J Cardiol , vol.103 , pp. 5-10
    • Bonello, L.1    Camoin-Jau, L.2    Armero, S.3
  • 113
    • 41249093357 scopus 로고    scopus 로고
    • Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study
    • Bonello L, Camoin-Jau L, Arques S, et al. Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study. J Am Coll Cardiol 2008; 51: 1404-11.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1404-1411
    • Bonello, L.1    Camoin-Jau, L.2    Arques, S.3
  • 114
    • 78049465814 scopus 로고    scopus 로고
    • Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2 loss-of-function polymorphism
    • doi:10.1016/ j.ijcard.2009.07.033
    • Bonello L, Palot-Bonello N, Armero S, et al. Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2 loss-of-function polymorphism. Int J Cardiol 2009; doi:10.1016/ j.ijcard.2009.07.033.
    • (2009) Int J Cardiol
    • Bonello, L.1    Palot-Bonello, N.2    Armero, S.3
  • 115
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 2009; 119: 2553-60.
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 116
    • 57349114626 scopus 로고    scopus 로고
    • Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function
    • Gori AM, Marcucci R, Paniccia R, et al. Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function. Thromb Haemost 2008; 100: 1136-45.
    • (2008) Thromb Haemost , vol.100 , pp. 1136-1145
    • Gori, A.M.1    Marcucci, R.2    Paniccia, R.3
  • 117
    • 67149089211 scopus 로고    scopus 로고
    • Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy
    • Paniccia R, Antonucci E, Maggini N, et al. Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. Am J Clin Pathol 2009; 131: 834-42.
    • (2009) Am J Clin Pathol , vol.131 , pp. 834-842
    • Paniccia, R.1    Antonucci, E.2    Maggini, N.3


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