Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-α Using Oriented Peptide Library Screening

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 19935-19946

  Yang, Sundy N Y ^a,b,e   Takeda, Agnes A S ^a,c   Fontes, Marcos R M ^a,c   Harris, Jonathan M ^d   Jans, David A ^b   Kobe, Boštjan ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e Bernard O'Brien Institute of Microsurgery   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ASSAYS; BINDING MODES; NANOMOLAR AFFINITY; NOVEL PROTEINS; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SEQUENCES; OPTIMAL SEQUENCE; PARALOGS; PEPTIDE LIBRARY; SEQUENCE DETERMINANTS; SIMIAN VIRUS; STRUCTURAL INFORMATION; STRUCTURAL STUDIES;

AMINO ACIDS; BINDING ENERGY; CRYSTAL STRUCTURE; OPTIMIZATION; ORGANIC ACIDS; VIRUSES;

PEPTIDES;

KARYOPHERIN ALPHA; KARYOPHERIN ALPHA2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME SPECIFICITY; GEL ELECTROPHORESIS; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DATABASE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE, TUMOR; CELL NUCLEUS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; MICE; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; NUCLEAR LOCALIZATION SIGNALS; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

SIMIAN VIRUS 40;

EID: 77953750360     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.079574     Document Type: Article

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