Effects of the cognition-enhancing agent ABT-239 on fetal ethanol-induced deficits in dentate gyrus synaptic plasticity

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 1, 2010, Pages 191-198

  Varaschin, Rafael K ^a   Akers, Katherine G ^b   Rosenberg, Martina J ^a   Hamilton, Derek A ^a,b   Savage, Daniel D ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [2 (2 METHYLPYRROLIDINYL)ETHYL]BENZOFURAN 5 YL]BENZONITRILE; 5 (4 CYANOPHENYL) 2 [2 (2 METHYL 1 IMIDAZOLIDINYL)ETHYL]BENZOFURAN; ALCOHOL; HISTAMINE H3 RECEPTOR ANTAGONIST; NOOTROPIC AGENT; UNCLASSIFIED DRUG; URETHAN;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; DENTATE GYRUS; DRINKING; ELECTRODE; ENTORHINAL CORTEX; FEMALE; LEARNING DISORDER; LONG TERM POTENTIATION; LONG TERM POTENTIATION DEFICIT; MALE; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; TETANUS; WEIGHT GAIN;

ALCOHOL DRINKING; ANIMALS; BENZOFURANS; DENTATE GYRUS; ELECTROPHYSIOLOGICAL PHENOMENA; ETHANOL; FEMALE; FETAL DEVELOPMENT; HISTAMINE H3 ANTAGONISTS; LONG-TERM POTENTIATION; MALE; MATERNAL EXPOSURE; NOOTROPIC AGENTS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PYRROLIDINES; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 77953745943     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.165027     Document Type: Article

References (39)

1. Andrews JS (1996) Possible confounding influence of strain, age and gender on cognitive performance in rats. Brain Res Cogn Brain Res 3:251-267.
2. Arrang JM, Garbarg M, and Schwartz JC (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832-837. (Pubitemid 13125123)
3. Bekkers JM (1993) Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus. Science 261:104-106. (Pubitemid 23265388)
4. Bliss TV and Gardner-Medwin AR (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path. J Physiol 232:357-374.
5. Bliss TV and Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232:331-356.
6. 3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro. J Physiol 496 (Pt 1):175-184.
7. 3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes. Br J Pharmacol 107:919-923.
8. Costa ET, Savage DD, and Valenzuela CF (2000) A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels. Alcohol Clin Exp Res 24:706-715.
9. Esbenshade TA, Fox GB, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Pan L, Wetter J, et al. (2005) Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties. J Pharmacol Exp Ther 313:165-175.
10. Foley AG, Prendergast A, Barry C, Scully D, Upton N, Medhurst AD, and Regan CM (2009) H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-toposition paradigms. Neuropsychopharmacology 34:2585-2600.
11. 3 receptor antagonist. J Pharmacol Exp Ther 313:176-190.
12. Fox GB, Pan JB, Faghih R, Esbenshade TA, Lewis A, Bitner RS, Black LA, Bennani YL, Decker MW, and Hancock AA (2003) Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats. Inflamm Res 52 (Suppl 1):S31-S32.
13. Galindo R, Frausto S, Wolff C, Caldwell KK, Perrone-Bizzozero NI, and Savage DD (2004) Prenatal ethanol exposure reduces mGluR5 receptor number and function in the dentate gyrus of adult offspring. Alcohol Clin Exp Res 28:1587-1597.
14. Haas HL (1984) Histamine potentiates neuronal excitation by blocking a calcium-dependent potassium conductance. Agents Actions 14:534-537.
15. Hamilton DA, Kodituwakku P, Sutherland RJ, and Savage DD (2003) Children with fetal alcohol syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task. Behav Brain Res 143:85-94.
16. Jacobson JL, Jacobson SW, Sokol RJ, and Ager JW Jr (1998) Relation of maternal age and pattern of pregnancy drinking to functionally significant cognitive deficit in infancy. Alcohol Clin Exp Res 22:345-351.
17. Jones KL and Smith DW (1973) Recognition of the fetal alcohol syndrome in early infancy. Lancet 302:999-1001.
18. Kodituwakku PW (2009) Neurocognitive profile in children with fetal alcohol spectrum disorders. Dev Disabil Res Rev 15:218-224.
19. Lemoine P, Haronsseau H, Borteryu JP, and Menuet JC (1968) Les enfants de parents alcooliques: anomalies observees a propos de 127 cas. Ouest Med 25:476-482.
20. Lundquist F, Fugmann U, Klaning E, and Rasmussen H (1959) The metabolism of acetaldehyde in mammalian tissues: reactions in rat-liver suspensions under anaerobic conditions. Biochem J 72:409-419.
21. Manahan-Vaughan D, Reymann KG, and Brown RE (1998) In vivo electrophysiological investigations into the role of histamine in the dentate gyrus of the rat. Neuroscience 84:783-790.
22. 3 receptor ligands. Assay Drug Dev Technol 6:339-349.
23. Naie K and Manahan-Vaughan D (2005) Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long-term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N-methyl-D-aspartate and metabotropic glutamate receptor-dependent mechanisms. Eur J Neurosci 21:411-421.
24. Paxinos G and Watson C (1986) The Rat Brain: In Stereotaxic Coordinates, Academic Press, Sydney.
25. Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, and Wilkinson CW (2000) Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcohol Clin Exp Res 24:1836-1849. (Pubitemid 32001855)
26. Raymond CR (2007) LTP forms 1, 2 and 3: different mechanisms for the "long" in long-term potentiation. Trends Neurosci 30:167-175.
27. Raymond CR, Thompson VL, Tate WP, and Abraham WC (2000) Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation. J Neurosci 20:969-976.
28. Reymann KG and Frey JU (2007) The late maintenance of hippocampal LTP: requirements, phases, 'synaptic tagging', 'late-associativity' and implications. Neuropharmacology 52:24-40.
29. Savage DD, Cruz LL, Duran LM, and Paxton LL (1998) Prenatal ethanol exposure diminishes activity-dependent potentiation of amino acid neurotransmitter release in adult rat offspring. Alcohol Clin Exp Res 22:1771-1777.
30. Savage DD, Rosenberg MJ, Wolff CR, Akers KG, El-Emawy A, Staples MC, Varaschin RK, Wright CA, Seidel JL, Caldwell KK, and Hamilton DA (2010) Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits. Alcohol Clin Exp Res DOI: 10.1111/j.1530-0277.2010.01266.x
31. Schlicker E, Betz R, and Göthert M (1988) Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 337:588-590.
32. Schlicker E, Fink K, Detzner M, and Göthert M (1993) Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm Gen Sect 93:1-10. (Pubitemid 23235613)
33. 3 receptors. Naunyn Schmiedebergs Arch Pharmacol 340:633-638.
34. Streissguth AP, Barr HM, and Sampson PD (1990) Moderate prenatal alcohol exposure: effects on child IQ and learning problems at age 7 1/2 years. Alcohol Clin Exp Res 14:662-669.
35. Streissguth AP, Sampson PD, Olson HC, Bookstein FL, Barr HM, Scott M, Feldman J, and Mirsky AF (1994) Maternal drinking during pregnancy: attention and short-term memory in 14-year-old offspring - a longitudinal prospective study. Alcohol Clin Exp Res 18:202-218.
36. Sutherland RJ, McDonald RJ, and Savage DD (1997) Prenatal exposure to moderate levels of ethanol can have long-lasting effects on hippocampal synaptic plasticity in adult offspring. Hippocampus 7:232-238.
37. Sutherland RJ, McDonald RJ, and Savage DD (2000) Prenatal exposure to moderate levels of ethanol can have long-lasting effects on learning and memory of adult rat offspring. Psychobiology 28:532-539.
38. Taube JS and Schwartzkroin PA (1988) Mechanisms of long-term potentiation: EPSP/spike dissociation, intradendritic recordings, and glutamate sensitivity. J Neurosci 8:1632-1644.
39. Weeber EJ, Savage DD, Sutherland RJ, and Caldwell KK (2001) Fear conditioning-induced alterations of phospholipase C-β1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex. Neurobiol Learn Mem 76: 151-182.