-
1
-
-
43049145199
-
-
Academy of Medical Sciences and The Royal Academy of Engineering Working Group
-
Academy of Medical Sciences and The Royal Academy of Engineering Working Group. Systems Biology: A Vision for Engineering and Medicine http://www3. imperial.ac.uk/pls/portallive/docs/1/23357696.pdf.
-
Systems Biology: A Vision for Engineering and Medicine
-
-
-
2
-
-
77953811662
-
Network systems biology for drug discovery
-
Arrell, D.K. & Terzic, A. Network systems biology for drug discovery. Clin. Pharmacol. Ther. 88, 120-125 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 120-125
-
-
Arrell, D.K.1
Terzic, A.2
-
3
-
-
77953811826
-
Systems biology: An approach
-
Kohl, P., Crampin, E.J., Quinn, T.A. & Noble, D. Systems biology: an approach. Clin. Pharmacol. Ther. 88, 25-33 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 25-33
-
-
Kohl, P.1
Crampin, E.J.2
Quinn, T.A.3
Noble, D.4
-
4
-
-
31144438390
-
Rescuing drug discovery: In vivo systems pathology and systems pharmacology
-
Van der Greef, J. & McBurney, R.N. Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat. Rev. Drug Discov. 4, 961-967 (2005).
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 961-967
-
-
Van Der Greef, J.1
McBurney, R.N.2
-
5
-
-
0003100554
-
Robustness in the strategy of scientific model building
-
eds. Launer, R.L. & Wilkinson, G.N. Academic Press, New York
-
Box, G.E.P. Robustness in the strategy of scientific model building. In Robustness in Statistics (eds. Launer, R.L. & Wilkinson, G.N.) 231-236 (Academic Press, New York, 1979).
-
(1979)
Robustness in Statistics
, pp. 231-236
-
-
Box, G.E.P.1
-
6
-
-
17744407159
-
Validation of simple and complex models in physiology and medicine
-
Cobelli, C., Carson, E.R., Finkelstein, L. & Leaning, M.S. Validation of simple and complex models in physiology and medicine. Am. J. Physiol. 246, R259-R266 (1984).
-
(1984)
Am. J. Physiol.
, vol.246
-
-
Cobelli, C.1
Carson, E.R.2
Finkelstein, L.3
Leaning, M.S.4
-
7
-
-
0000999661
-
The formulation and testing of models
-
Berman, M. The formulation and testing of models. Ann. NY Acad. Sci. 108, 182-194 (1963).
-
(1963)
Ann. NY Acad. Sci.
, vol.108
, pp. 182-194
-
-
Berman, M.1
-
8
-
-
77953785687
-
The challenge of complexity
-
Dollery, C.T. The challenge of complexity. Clin. Pharmacol. Ther. 88, 13-15 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 13-15
-
-
Dollery, C.T.1
-
9
-
-
77953806651
-
Multiscale modeling in drug discovery and development: Future opportunities and present challenges
-
Vicini, P. Multiscale modeling in drug discovery and development: future opportunities and present challenges. Clin. Pharmacol. Ther. 88, 126-129 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 126-129
-
-
Vicini, P.1
-
10
-
-
67649392513
-
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry biology anatomy physiology and genetics: A tale of "bottom-up" vs. "top-down" recognition of covariates
-
Jamei, M. Dickinson, G.L. & Rostami-Hodjegan, A. A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of "bottom-up" vs. "top-down" recognition of covariates. Drug Metab. Pharmacokinet. 24, 53-75 (2009).
-
(2009)
Drug Metab. Pharmacokinet.
, vol.24
, pp. 53-75
-
-
Jamei, M.1
Dickinson, G.L.2
Rostami-Hodjegan, A.3
-
11
-
-
77953811461
-
The systems biology approach to drug development: Application to toxicity assessment of cardiac drugs
-
Rodriguez, B., Burrage, K., Gavaghan, D., Grau, V., Kohl, P. & Noble, D. The systems biology approach to drug development: application to toxicity assessment of cardiac drugs. Clin. Pharmacol. Ther. 88, 130-134 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 130-134
-
-
Rodriguez, B.1
Burrage, K.2
Gavaghan, D.3
Grau, V.4
Kohl, P.5
Noble, D.6
-
12
-
-
62749161471
-
The liver toxicity biomarker study: Phase i design and preliminary results
-
McBurney, R.N. et al. The liver toxicity biomarker study: phase I design and preliminary results. Toxicol. Pathol. 37, 52-64 (2009).
-
(2009)
Toxicol. Pathol.
, vol.37
, pp. 52-64
-
-
McBurney, R.N.1
-
13
-
-
39449120417
-
Correlation network analysis for data integration and biomarker selection
-
Adourian, A., et al. Correlation network analysis for data integration and biomarker selection. Mol. BioSyst. 4, 249-259 (2008).
-
(2008)
Mol. BioSyst.
, vol.4
, pp. 249-259
-
-
Adourian, A.1
-
15
-
-
5044229321
-
The impact of systems approaches on biological problems in drug discovery
-
Hood, L. & Perlmutter, M. The impact of systems approaches on biological problems in drug discovery. Nat. Biotechnol. 22,1215-1217 (2004).
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1215-1217
-
-
Hood, L.1
Perlmutter, M.2
-
16
-
-
35449004951
-
Molecular systems biology in drug development
-
Silver, P.A. & Way, J.C. Molecular systems biology in drug development. Clin. Pharmacol. Ther. 82, 586-590 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.82
, pp. 586-590
-
-
Silver, P.A.1
Way, J.C.2
-
17
-
-
77149144465
-
An integrated model for the glucose-insulin system
-
Silber, H.E., Jauslin, P.M., Frey, N. & Karlsson, M.O. An integrated model for the glucose-insulin system. Basic Clin. Pharmacol. Toxicol. 106, 189-194 (2009).
-
(2009)
Basic Clin. Pharmacol. Toxicol.
, vol.106
, pp. 189-194
-
-
Silber, H.E.1
Jauslin, P.M.2
Frey, N.3
Karlsson, M.O.4
-
18
-
-
77953802464
-
Systems biology and pharmacology
-
Berg, J.M., Rogers, M.E. & Lyster, P.M. Systems biology and pharmacology. Clin. Pharmacol. Ther. 88, 17-19 (2010)
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 17-19
-
-
Berg, J.M.1
Rogers, M.E.2
Lyster, P.M.3
-
19
-
-
77953790081
-
Training in systems pharmacology: Predoctoral program in pharmacology and systems biology at Mount Sinai School of Medicine
-
Sobie, E.A., Jenkins, S.L., Iyengar, R. & Krulwich, T.A. Training in systems pharmacology: predoctoral program in pharmacology and systems biology at Mount Sinai School of Medicine. Clin. Pharmacol. Ther. 88, 19-22 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 19-22
-
-
Sobie, E.A.1
Jenkins, S.L.2
Iyengar, R.3
Krulwich, T.A.4
-
20
-
-
77953809572
-
Next-generation model-based drug discovery and development: Quantitative and systems pharmacology
-
Allerheiligen, S.R.B. Next-generation model-based drug discovery and development: quantitative and systems pharmacology. Clin. Pharmacol. Ther. 88, 135-137 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 135-137
-
-
Allerheiligen, S.R.B.1
|