Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1 - Implications for steroid-induced myopathy

Clinical Endocrinology

Volumn 73, Issue 1, 2010, Pages 126-132

  Inder, Warrick J ^a,b   Jang, Christina ^a,b   Obeyesekere, Varuni R ^a   Alford, Frank P ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; DEXAMETHASONE; MESSENGER RNA; METFORMIN; MYOSTATIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SULFONYLUREA; TESTOSTERONE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MUSCLE BIOPSY; MYOPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TESTOSTERONE BLOOD LEVEL; VASTUS LATERALIS MUSCLE; BIOSYNTHESIS; BLOOD; CHEMICALLY INDUCED; DOWN REGULATION; DRUG EFFECTS; METABOLISM; MIDDLE AGED; MUSCLE DISEASE; SKELETAL MUSCLE;

DEXAMETHASONE; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUSCULAR DISEASES; RECEPTOR, IGF TYPE 1; RECEPTORS, ANDROGEN; RNA, MESSENGER; TESTOSTERONE;

EID: 77953743373     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03683.x     Document Type: Article

References (45)

1. Ross, E.J. Linch, D.C. (1982) Cushing's syndrome - killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet, 2, 646 649.
2. Batchelor, T.T., Taylor, L.P., Thaler, H.T. et al. (1997) Steroid myopathy in cancer patients. Neurology, 48, 1234 1238.
3. Lee, H.J., Oran, B., Saliba, R.M. et al. (2006) Steroid myopathy in patients with acute graft-versus-host disease treated with high-dose steroid therapy. Bone Marrow Transplantation, 38, 299 303.
4. Khaleeli, A.A., Edwards, R.H., Gohil, K. et al. (1983) Corticosteroid myopathy: a clinical and pathological study. Clinical Endocrinology (Oxford), 18, 155 166.
5. Kanda, F., Okuda, S., Matsushita, T. et al. (2001) Steroid myopathy: pathogenesis and effects of growth hormone and insulin-like growth factor-I administration. Hormone Research, 56, 24 28.
6. Beaufrere, B., Horber, F.F., Schwenk, W.F. et al. (1989) Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. American Journal of Physiology, 257, E712 E721.
7. Schakman, O., Gilson, H. Thissen, J.P. (2008) Mechanisms of glucocorticoid-induced myopathy. Journal of Endocrinology, 197, 1 10.
8. Horber, F.F., Scheidegger, J.R., Grunig, B.E. et al. (1985) Evidence that prednisone-induced myopathy is reversed by physical training. Journal of Clinical Endocrinology and Metabolism, 61, 83 88.
9. Braith, R.W., Welsch, M.A., Mills R.M., Jr. et al. (1998) Resistance exercise prevents glucocorticoid-induced myopathy in heart transplant recipients. Medicine and Science in Sports and Exercise, 30, 483 489.
10. Bhasin, S., Storer, T.W., Berman, N. et al. (1996) The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. New England Journal of Medicine, 335, 1 7.
11. Bhasin, S., Storer, T.W., Berman, N. et al. (1997) Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 82, 407 413. (Pubitemid 27068601)
12. Allan, C.A., Strauss, B.J., Burger, H.G. et al. (2008) Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. Journal of Clinical Endocrinology and Metabolism, 93, 139 146.
13. Wierman, M.E., Basson, R., Davis, S.R. et al. (2006) Androgen therapy in women: an Endocrine Society Clinical Practice guideline. Journal of Clinical Endocrinology and Metabolism, 91, 3697 3710.
14. Dolan, S., Wilkie, S., Aliabadi, N. et al. (2004) Effects of testosterone administration in human immunodeficiency virus-infected women with low weight: a randomized placebo-controlled study. Archives of Internal Medicine, 164, 897 904. (Pubitemid 38520632)
15. Svensson, J., Sunnerhagen, K.S. Johannsson, G. (2003) Five years of growth hormone replacement therapy in adults: age- and gender-related changes in isometric and isokinetic muscle strength. Journal of Clinical Endocrinology and Metabolism, 88, 2061 2069.
16. Lange, K.H., Andersen, J.L., Beyer, N. et al. (2002) GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men. Journal of Clinical Endocrinology and Metabolism, 87, 513 523.
17. Gibney, J., Healy, M.L. Sonksen, P.H. (2007) The growth hormone/insulin-like growth factor-I axis in exercise and sport. Endocrine Reviews, 28, 603 624.
18. Vandenburgh, H.H., Karlisch, P., Shansky, J. et al. (1991) Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture. American Journal of Physiology, 260, C475 C484.
19. Coleman, M.E., DeMayo, F., Yin, K.C. et al. (1995) Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. Journal of Biological Chemistry, 270, 12109 12116.
20. Mauras, N., O'Brien, K.O., Welch, S. et al. (2000) Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism. Journal of Clinical Endocrinology and Metabolism, 85, 1686 1694.
21. Berneis, K., Ninnis, R., Girard, J. et al. (1997) Effects of insulin-like growth factor I combined with growth hormone on glucocorticoid-induced whole-body protein catabolism in man. Journal of Clinical Endocrinology and Metabolism, 82, 2528 2534.
22. Corrales, J.J., Burgo, R.M., Garca-Berrocal, B. et al. (2004) Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control. Metabolism, 53, 666 672.
23. Dhindsa, S., Prabhakar, S., Sethi, M. et al. (2004) Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 89, 5462 5468.
24. Grossmann, M., Thomas, M.C., Panagiotopoulos, S. et al. (2008) Low testosterone levels are common and associated with insulin resistance in men with diabetes. Journal of Clinical Endocrinology and Metabolism, 93, 1834 1840.
25. Ding, E.L., Song, Y., Malik, V.S. et al. (2006) Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA, 295, 1288 1299.
26. Jang, C., Obeyesekere, V.R., Dilley, R.J. et al. (2006) 11Beta hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle. Clinical Endocrinology (Oxford), 65, 800 805.
27. Burnstein, K.L., Maiorino, C.A., Dai, J.L. et al. (1995) Androgen and glucocorticoid regulation of androgen receptor cDNA expression. Molecular and Cellular Endocrinology, 115, 177 186.
28. Esposito, T., Astore, E., Cardone, A. et al. (2002) Regulation of androgen receptor mRNA expression in primary culture of Harderian gland cells: cross-talk between steroid hormones. Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology, 132, 97 105.
29. Grad, J.M., Dai, J.L., Wu, S. et al. (1999) Multiple androgen response elements and a Myc consensus site in the androgen receptor (AR) coding region are involved in androgen-mediated up-regulation of AR messenger RNA. Molecular Endocrinology, 13, 1896 1911.
30. Sinha-Hikim, I., Taylor, W.E., Gonzalez-Cadavid, N.F. et al. (2004) Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. Journal of Clinical Endocrinology and Metabolism, 89, 5245 5255.
31. Bhasin, S., Calof, O.M., Storer, T.W. et al. (2006) Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nature Clinical Practice. Endocrinology and Metabolism, 2, 146 159.
32. Snochowski, M., Dahlberg, E. Gustafsson, J.A. (1980) Characterization and quantification of the androgen and glucocorticoid receptors in cytosol from rat skeletal muscle. European Journal of Biochemistry, 111, 603 616.
33. Gilson, H., Schakman, O., Combaret, L. et al. (2007) Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology, 148, 452 460.
34. Ma, K., Mallidis, C., Bhasin, S. et al. (2003) Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. American Journal of Physiology. Endocrinology and Metabolism, 285, E363 E371.
35. Reid, I.R., Wattie, D.J., Evans, M.C. et al. (1996) Testosterone therapy in glucocorticoid-treated men. Archives of Internal Medicine, 156, 1173 1177.
36. Crawford, B.A., Liu, P.Y., Kean, M.T. et al. (2003) Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. Journal of Clinical Endocrinology and Metabolism, 88, 3167 3176.
37. Burt, M.G., Johannsson, G., Umpleby, A.M. et al. (2008) Impact of growth hormone and dehydroepiandrosterone on protein metabolism in glucocorticoid- treated patients. Journal of Clinical Endocrinology and Metabolism, 93, 688 695.
38. Davis, S.R., McCloud, P., Strauss, B.J. et al. (1995) Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas, 21, 227 236.
39. Blackman, M.R., Sorkin, J.D., Munzer, T. et al. (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA, 288, 2282 2292. (Pubitemid 35291758)
40. Giannoulis, M.G., Sonksen, P.H., Umpleby, M. et al. (2006) The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. Journal of Clinical Endocrinology and Metabolism, 91, 477 484.
41. Sjogren, K., Leung, K.C., Kaplan, W. et al. (2007) Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men. American Journal of Physiology. Endocrinology and Metabolism, 293, E364 E371.
42. Kanda, F., Takatani, K., Okuda, S. et al. (1999) Preventive effects of insulin like growth factor-I on steroid-induced muscle atrophy. Muscle and Nerve, 22, 213 217.
43. Veldhuis, J.D., Lizarralde, G. Iranmanesh, A. (1992) Divergent effects of short term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men. Journal of Clinical Endocrinology and Metabolism, 74, 96 102.
44. Ferrando, A.A., Sheffield-Moore, M., Yeckel, C.W. et al. (2002) Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. American Journal of Physiology. Endocrinology and Metabolism, 282, E601 E607.
45. Wu, Y., Zhao, W., Zhao, J. et al. (2007) Identification of androgen response elements in the insulin-like growth factor I upstream promoter. Endocrinology, 148, 2984 2993.