Targeting cell surface F1F0 ATP synthase in cancer therapy

Cancer Biology and Therapy

Volumn 7, Issue 11, 2008, Pages 1836-1838

  Mowery, Yvonne M ^a   Pizzo, Salvatore V ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Angiostatin; mAb; Tumor pH; Tumor therapy; subunit of F1F0 ATP synthase

Indexed keywords

ANGIOSTATIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6F2C4; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ACIDIFICATION; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BETA CHAIN; BREAST CARCINOMA; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER MODEL; CANCER THERAPY; CELL PH; CELL PROLIFERATION; CELL SURFACE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; LIVER CELL CARCINOMA; METASTASIS; NONHUMAN; NOTE; ANIMAL; CANCER TRANSPLANTATION; CHEMISTRY; ENZYMOLOGY; IMMUNOTHERAPY; METABOLISM; METHODOLOGY; MOUSE; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PH; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; VASCULAR ENDOTHELIUM;

ADENOSINE TRIPHOSPHATE; ANGIOSTATINS; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOTHERAPY; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN STRUCTURE, TERTIARY; PROTON-TRANSLOCATING ATPASES;

EID: 77953735130     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.11.7155     Document Type: Note

References (25)

1. Chi SL, Pizzo SV. Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. Cancer Res 2006; 66:875-82.
2. + transporting ATP synthase on the surface of tumor cell lines. J Exp Med 1994; 180:273-81.
3. Jung KH, Song SH, Paik JY, Koh BH, Choe YS, Lee EJ, Kim BT, Lee KH. Direct targeting of tumor cell F(1)F(0) ATP-synthase by radioiodine angiostatin in vitro and in vivo. Cancer Biother Radiopharm 2007; 22:704-12.
4. Vantourout P, Martinez LO, Fabre A, Collet X, Champagne E. Ecto-F1-ATPase and MHCclass I close association on cell membranes. Mol Immunol 2008; 45:485-92.
5. Yonally SK, Capaldi RA. The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study. Mitochondrion 2006; 6:305-14.
6. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79:315-28.
7. O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996; 2:689-92.
8. Ji WR, Castellino FJ, Chang Y, Deford ME, Gray H, Villarreal X, Kondri ME, Marti DN, Llinas M, Schaller J, Kramer RA, Trail PA. Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis. Faseb J 1998; 12:1731-8.
9. Moser TL, Stack MS, Asplin I, Enghild JJ, Hojrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV. Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci USA 1999; 96:2811-6.
10. Wahl ML, Kenan DJ, Gonzalez-Gronow M, Pizzo SV. Angiostatin's molecular mechanism: aspects of specificity and regulation elucidated. J Cell Biochem 2005; 96:242-61.
11. 0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci USA 2001; 98:6656-61.
12. Wahl ML, Grant DS. Effects of microenvironmental extracellular pH and extracellular matrix proteins on angiostatin's activity and on intracellular pH. Gen Pharmacol 2000; 35:277-85.
13. Wahl ML, Owen CS, Grant DS. Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH. Endothelium 2002; 9:205-16.
14. 0 ATP synthase on both HUVEC and tumor cells. Acta Pharmacol Sin 2008; 29:942-50.
15. Wang JB, Han Y, Liang J, Cheng X, Yan L, Wang Y, Liu J, Luo G, Cheng X, Zhao L, Zhou X, Wu W, Fan D. Effect of a novel inhibitory mAb antibody against beta-subunit of F1F0 ATPase on HCC. Cancer Biology and Therapy 2008.
16. Goretzki L, Lombardo CR, Stallcup WB. Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen). J Biol Chem 2000; 275:28625-33.
17. Wajih N, Sane DC. Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells. Blood 2003; 101:1857-63.
18. Tuszynski GP, Sharma MR, Rothman VL, Sharma MC. Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells. Microvasc Res 2002; 64:448-62.
19. Troyanovsky B, Levchenko T, Mansson G, Matvijenko O, Holmgren L. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Biol 2001; 152:1247-54.
20. Tarui T, Miles LA, Takada Y. Specific interaction of angiostatin with integrin alpha(v) beta(3) in endothelial cells. J Biol Chem 2001; 276:39562-8.
21. 0 ATP synthase. Cancer Res 2007; 67:4716-24.
22. Komi Y, Ohno O, Suzuki Y, Shimamura M, Shimokado K, Umezawa K, Kojima S. Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin. Jpn J Clin Oncol 2007; 37:867-73.
23. Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezon E, Champagne E, Pineau T, Georgeaud V, Walker JE, Terce F, Collet X, Perret B, Barbaras R. Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 2003; 421:75-9.
24. Zhang LH, Kamanna VS, Zhang MC, Kashyap ML. Niacin inhibits surface expression of ATP synthase beta chain in HepG2 cells: implications for raising HDL. J Lipid Res 2008; 49:1195-201.
25. Yamamoto K, Shimizu N, Obi S, Kumagaya S, Taketani Y, Kamiya A, Ando J. Involvement of cell surface ATP synthase in flow-induced ATP release by vascular endothelial cells. Am J Physiol Heart Circ Physiol 2007; 293:1646-53.