Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells

Acta Pharmacologica Sinica

Volumn 29, Issue 8, 2008, Pages 942-950

  Zhang, Xia ^a,b   Gao, Feng ^c   Yu, Li Li ^a,b   Peng, Yan ^b,d   Liu, Hong Hai ^b   Liu, Jin Ying ^b   Yin, Ming ^a   Ni, Jian ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Suzhou Industrial Park   (China)

^c SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cell migration; Doxorubicin; F1F0 ATP synthase; Human umbilical vein endothelial cells; Monoclonal antibody; Tube formation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CELL SURFACE PROTEIN; DOXORUBICIN; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 178 5G10; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC THERAPY; ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BETA CHAIN; BREAST ADENOCARCINOMA; CELL ASSAY; CELL MIGRATION; CELL PROLIFERATION; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYBRIDOMA CELL CULTURE; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SYNTHESIS; TUMOR CELL; UMBILICAL VEIN;

ADENOSINE TRIPHOSPHATE; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL; ANTIGENS, SURFACE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; ENDOTHELIAL CELLS; FEMALE; HUMANS; KINETICS; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; UMBILICAL VEINS;

EID: 49249136184     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00830.x     Document Type: Article

References (24)

1. Cross RL. Molecular motors: turning the ATP motor. Nature 2004 427 : 407 8.
2. Chi SL, Pizzo SV. Cell surface F0F1 ATP synthase: a new paradigm Ann Med 2006 38 : 429 38.
3. Moser TL, Kenan DJ, Ashley TA, Roy JA, Goodman MD, Misra UK, et al. Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci USA 2001 98 : 6656 61.
4. Moser TL, Stack MS, Asplin I, Enghild JJ, Højrup P, Everitt L, et al. Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci USA 1999 96 : 2811 6.
5. Chi SL, Wahl ML, Mowery YM, Shan S, Mukhopadhyay S, Hilderbrand SC, et al. Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. Cancer Res 2007 67 : 4716 24.
6. Chi SL, Pizzo SV. Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. Cancer Res 2006 66 : 875 82.
7. Zhao Y, Zhang W, Kho Y, Zhao Y. Proteomic analysis of integral plasma membrane proteins. Anal Chem 2004 76 : 1817 23.
8. Li Y, Tang Y, Ye L, Liu B, Liu K, Chen J, Xue Q. Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol 2003 129 : 43 51.
9. Peng Y, Zhang X, Wang K, Jiang P, Jiao BH, Ni J. Proteome analysis of hepatocellular carcinoma cell lines with different metastasis potentials by two-dimensional liquid chromatography. World J Digestol 2007 15 : 1482 7.
10. Aggeler R, Coons J, Taylor SW, Ghosh SS, Garcia JJ, Capaldi RA, et al. A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines, Subunit structure and activity studies. J Biol Chem 2002 277 : 33 906 12.
11. Sakaguchi N, Kimura T, Matsushita S, Fujimura S, Shibata J, Araki M, et al. Generation of high-affinity antibody against T cell-dependent antigen in the Ganp gene-transgenic mouse. J. Immunol 2005 174 : 4485 94.
12. Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975 256 : 495 7.
13. Bueno C, Rodriguez-Caballero A, García-Montero A, Pandiella A, Almeida J, Orfao A. A new method for detecting TNF-alpha-secreting cells using direct-immunofluorescence surface membrane stainings. J Immunol Methods 2002 264 : 77 87.
14. Zucker RM, Jeffay SC. Confocal laser scanning microscopy of whole mouse ovaries: excellent morphology, apoptosis detection, and spectroscopy. Cytometry A 2006 69 : 930 9.
15. Burwick NR, Wahl ML, Fang J, Zhong Z, Moser TL, Li B, et al. An inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. J Biol Chem 2005 280 : 1740 5.
16. Lukong KE, Richard S. Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. Cell Signal 2008 20 : 432 42.
17. Guo K, Li J, Wang H, Osato M, Tang JP, Quah SY, et al. PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res 2006 66 : 9625 35.
18. Kirley TL. Complementary DNA cloning and sequencing of the chicken muscle ecto-ATPase: Homology with the lymphoid cell activation antigen CD39. J Biol Chem 1997 272 : 1076 81.
19. Scotet E, Martinez LO, Grant E, Barbaras R, Jeno P, Guiraud M, et al. Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity 2005 22 : 71 80.
20. Cloos PA, Christgau S. Post-translational modifications of proteins: implications for aging, antigen recognition, and autoimmunity. 2004 5 : 139 58.
21. Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezón E, Champagne E, et al. Ectopic beta-chain of AT P synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 2003 421 : 75 9.
22. Das B, Mondragon MO, Sadeghian M, Hatcher VB, Norin AJ. A novel ligand in lymphocyte-mediated cytotoxic: expression of the beta-subunit of H+ transporting ATP synthase on the surface of tumor cell lines. J Exp Med 1994 180 : 273 81.
23. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994 79 : 315 28.
24. Kenanl DJ, Wahl ML. Ectopic localization of mitochondrial ATP synthase: a target for anti-angiogenesis intervention J Bioenerg Biomembr 2005 37 : 461 5.